LOCUS       NM_001410453            1607 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phospholipid scramblase 1 (Plscr1), transcript variant
            2, mRNA.
ACCESSION   NM_001410453 XM_006511052
VERSION     NM_001410453.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Gao,S., Sun,Y., Jia,S. and Meng,C.
  TITLE     Transcriptome analysis unveils PLSCR1 associated with microglial
            polarization in neuropathic pain
  JOURNAL   Gene 933, 148961 (2025)
   PUBMED   39312982
  REMARK    GeneRIF: Transcriptome analysis unveils PLSCR1 associated with
            microglial polarization in neuropathic pain.
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Hernandez-Gutierrez,A., Majid,S., Eberle,A., Choi,A., Sorkhdini,P.,
            Yang,D., Yang,A.X., Norbrun,C., He,C.H., Lee,C.M., Lee,C.G.,
            Elias,J.A. and Zhou,Y.
  TITLE     Phospholipid scramblase-1 regulates innate type 2 inflammation in
            mouse lungs via CRTH2-dependent mechanisms
  JOURNAL   J Clin Invest 133 (15), e169583 (2023)
   PUBMED   37289545
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Xu,D., Jiang,W., Wu,L., Gaudet,R.G., Park,E.S., Su,M.,
            Cheppali,S.K., Cheemarla,N.R., Kumar,P., Uchil,P.D., Grover,J.R.,
            Foxman,E.F., Brown,C.M., Stansfeld,P.J., Bewersdorf,J., Mothes,W.,
            Karatekin,E., Wilen,C.B. and MacMicking,J.D.
  TITLE     PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2
            infection
  JOURNAL   Nature 619 (7971), 819-827 (2023)
   PUBMED   37438530
  REMARK    GeneRIF: PLSCR1 is a cell-autonomous defence factor against
            SARS-CoV-2 infection.
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Liu,Y., Lin,S., Xie,Y., Zhao,L., Du,H., Yang,S., Yin,B., Li,G.,
            Zhao,Z., Huang,Z., Xu,Z. and Wu,J.
  TITLE     ILDR1 promotes influenza A virus replication through binding to
            PLSCR1
  JOURNAL   Sci Rep 12 (1), 8515 (2022)
   PUBMED   35595813
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Pastorelli,C., Veiga,J., Charles,N., Voignier,E., Moussu,H.,
            Monteiro,R.C. and Benhamou,M.
  TITLE     IgE receptor type I-dependent tyrosine phosphorylation of
            phospholipid scramblase
  JOURNAL   J Biol Chem 276 (23), 20407-20412 (2001)
   PUBMED   11259432
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Wiedmer,T., Zhou,Q., Kwoh,D.Y. and Sims,P.J.
  TITLE     Identification of three new members of the phospholipid scramblase
            gene family
  JOURNAL   Biochim Biophys Acta 1467 (1), 244-253 (2000)
   PUBMED   10930526
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   Kasukabe,T., Kobayashi,H., Kaneko,Y., Okabe-Kado,J. and Honma,Y.
  TITLE     Identity of human normal counterpart (MmTRA1b) of mouse
            leukemogenesis-associated gene (MmTRA1a) product as plasma membrane
            phospholipid scramblase and chromosome mapping of the human
            MmTRA1b/phospholipid scramblase gene
  JOURNAL   Biochem Biophys Res Commun 249 (2), 449-455 (1998)
   PUBMED   9712717
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Zhou,Q., Sims,P.J. and Wiedmer,T.
  TITLE     Identity of a conserved motif in phospholipid scramblase that is
            required for Ca2+-accelerated transbilayer movement of membrane
            phospholipids
  JOURNAL   Biochemistry 37 (8), 2356-2360 (1998)
   PUBMED   9485382
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Kasukabe,T., Okabe-Kado,J. and Honma,Y.
  TITLE     TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic
            sublines but not in nonleukemogenic sublines
  JOURNAL   Blood 89 (8), 2975-2985 (1997)
   PUBMED   9108418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111125.11.
            
            On Aug 8, 2022 this sequence version replaced XM_006511052.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008651.1, SRR7345562.2362194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC111125.11        79575-79787         c
            214-240             AC111125.11        71925-71951         c
            241-321             AC111125.11        70645-70725         c
            322-566             AC111125.11        66722-66966         c
            567-609             AC111125.11        65311-65353         c
            610-830             AC111125.11        63388-63608         c
            831-992             AC111125.11        63126-63287         c
            993-1154            AC111125.11        60023-60184         c
            1155-1607           AC111125.11        58018-58470         c
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 48.35 cM"
     gene            1..1607
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="phospholipid scramblase 1"
                     /db_xref="GeneID:22038"
                     /db_xref="MGI:MGI:893575"
     exon            1..213
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..240
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1214
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="PL scramblase 1; transplantability-associated
                     protein 1; ca(2+)-dependent phospholipid scramblase 1;
                     mg(2+)-dependent nuclease"
                     /codon_start=1
                     /product="phospholipid scramblase 1"
                     /protein_id="NP_001397382.1"
                     /db_xref="GeneID:22038"
                     /db_xref="MGI:MGI:893575"
                     /translation="MENHSKQTEAPHPGTYMPAGYPPPYPPAAFQGPSDHAAYPIPQA
                     GYQGPPGPYPGPQPGYPVPPGGYAGGGPSGFPVQNQPAYNHPGGPGGTPWMPAPPPPL
                     NCPPGLEYLAQIDQLLVHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAVEDTDCCTR
                     NCCGASRPFTLRILDNLGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGVPVGYVTQT
                     WHPCLPKFTLQNEKKQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKISKQWSGFV
                     REAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEEQRSGAWQ"
     exon            241..321
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..566
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..609
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..830
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..992
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1154
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1607
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="hexamer: ATTAAA"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="hexamer: AATATA"
     polyA_site      1602
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="major polyA site"
     polyA_site      1607
                     /gene="Plscr1"
                     /gene_synonym="MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b;
                     Tras1; Tras2"
                     /note="major polyA site"
ORIGIN      
        1 aggcctctgg gcgcagctag aggattcagg agtgcaggca gagctcgcgt cattcagagt
       61 gagtcccctc tgcgagggaa agccgggcta ctgcagcgcc accagcaagg gattgggact
      121 cacggacttc agaacagaag gagcctcagg tgagtcccgc tttctgcgcg ttccgggaca
      181 gagctcgcgg atctgtgcgc acaaaggagc cggaaactgt ttaaatcatg gaaaaccaca
      241 gcaagcaaac tgaggctccc cacccgggaa catatatgcc agctgggtat ccccctccgt
      301 atccaccagc agctttccaa ggaccttcag accatgctgc ttaccccata ccccaggctg
      361 gctaccaagg gcctccgggc ccctatccag ggccccaacc tggctaccca gtcccaccag
      421 gaggttatgc aggtggtggc cctagtggct ttcctgtcca aaatcagcca gcatataatc
      481 atccaggtgg gcctgggggg accccatgga tgccagcccc ccctcctcca ctgaactgtc
      541 caccggggct ggaatactta gctcagattg atcagcttct ggttcatcag caaattgagc
      601 ttctggaagt cttaacaggc tttgaaacaa ataacaaata tgaaatcaag aacagcctcg
      661 ggcagagagt ttactttgca gtggaagata ctgactgctg tacccgaaac tgctgtgggg
      721 cgtctagacc tttcaccttg aggatcctgg ataatctggg ccgagaagtc atgactctgg
      781 agagacctct gagatgcagt agctgctgct tcccctgctg cctccaggag atagaaatcc
      841 aggctcctcc tggggtacca gtaggttatg tgactcagac ctggcaccca tgtctgccca
      901 agttcactct ccaaaatgag aagaagcagg atgtcctgaa agtagttggt ccgtgtgttg
      961 tgtgtagctg ctgttccgac attgactttg agctcaaatc tctagatgaa gaatcagtag
     1021 ttggcaaaat ttctaagcag tggtctggtt ttgtgagaga ggccttcacg gatgcagaca
     1081 attttgggat ccagttcccg ctagacctgg atgtgaagat gaaagctgtg atgcttggtg
     1141 cttgtttcct catagatttc atgttttttg aaagaactgg aaacgaggag caaagatcag
     1201 gagcatggca gtaactccct gagagttctt gaggtttaag gacgacaact ttatggaccc
     1261 tgaatggaaa ctgaggaatc acaaggcaca caccgtggct tcttttcctt tactgaaata
     1321 actttctatc aactcacctg tgatgcctgg gtgccctgtt gtacaattat gctcccaaat
     1381 tagagtttat tttttagaat tctgtcatgt atttgttttt atacattctt aaggttttca
     1441 ctgtgaattt gggaaaacag ttatgtgaat ttatatacat agaaatgatc ttctctatga
     1501 aaacatactt tgactttgtc tttcgtttcc catttttgtg gaaacgtaaa tgctattgta
     1561 atttaatata aaattacaca ttaaatataa ttatgattta cacaaaa
//
