LOCUS       NM_001166453            3137 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus plastin 3 (T-isoform) (Pls3), transcript variant 2,
            mRNA.
ACCESSION   NM_001166453
VERSION     NM_001166453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Maus,I., Dreiner,M., Zetzsche,S., Metzen,F., Ross,B.C., Mahlich,D.,
            Koch,M., Niehoff,A. and Wirth,B.
  TITLE     Osteoclast-specific Plastin 3 knockout in mice fail to develop
            osteoporosis despite dramatic increased osteoclast resorption
            activity
  JOURNAL   JBMR Plus 8 (1), ziad009 (2024)
   PUBMED   38549711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Petit,F., Longoni,M., Wells,J., Maser,R.S., Bogenschutz,E.L.,
            Dysart,M.J., Contreras,H.T.M., Frenois,F., Pober,B.R., Clark,R.D.,
            Giampietro,P.F., Ropers,H.H., Hu,H., Loscertales,M., Wagner,R.,
            Ai,X., Brand,H., Jourdain,A.S., Delrue,M.A., Gilbert-Dussardier,B.,
            Devisme,L., Keren,B., McCulley,D.J., Qiao,L., Hernan,R., Wynn,J.,
            Scott,T.M., Calame,D.G., Coban-Akdemir,Z., Hernandez,P.,
            Hernandez-Garcia,A., Yonath,H., Lupski,J.R., Shen,Y., Chung,W.K.,
            Scott,D.A., Bult,C.J., Donahoe,P.K. and High,F.A.
  TITLE     PLS3 missense variants affecting the actin-binding domains cause
            X-linked congenital diaphragmatic hernia and body-wall defects
  JOURNAL   Am J Hum Genet 110 (10), 1787-1803 (2023)
   PUBMED   37751738
  REMARK    GeneRIF: PLS3 missense variants affecting the actin-binding domains
            cause X-linked congenital diaphragmatic hernia and body-wall
            defects.
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Morandell,J., Schwarz,L.A., Basilico,B., Tasciyan,S., Dimchev,G.,
            Nicolas,A., Sommer,C., Kreuzinger,C., Dotter,C.P., Knaus,L.S.,
            Dobler,Z., Cacci,E., Schur,F.K.M., Danzl,J.G. and Novarino,G.
  TITLE     Cul3 regulates cytoskeleton protein homeostasis and cell migration
            during a critical window of brain development
  JOURNAL   Nat Commun 12 (1), 3058 (2021)
   PUBMED   34031387
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Gao,N. and Kaestner,K.H.
  TITLE     Cdx2 regulates endo-lysosomal function and epithelial cell polarity
  JOURNAL   Genes Dev 24 (12), 1295-1305 (2010)
   PUBMED   20551175
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Toyooka,K., Liu,F., Ishii,M., Saito,S., Kirikae,T., Asano,Y. and
            Shinomiya,H.
  TITLE     Generation and characterization of monoclonal antibodies that
            specifically recognize p65/L-plastin isoform but not T-plastin
            isoform
  JOURNAL   Biosci Biotechnol Biochem 70 (6), 1402-1407 (2006)
   PUBMED   16794320
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Ezzell,R.M., Chafel,M.M. and Matsudaira,P.T.
  TITLE     Differential localization of villin and fimbrin during development
            of the mouse visceral endoderm and intestinal epithelium
  JOURNAL   Development 106 (2), 407-419 (1989)
   PUBMED   2686960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872046.1, AK160501.1, AK146455.1 and BY619251.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165540.1, SRR1660817.204724.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BB872046.1         1-57
            58-1301             AK160501.1         1-1244
            1302-2443           AK146455.1         1219-2360
            2444-3126           AK160501.1         2387-3069
            3127-3137           BY619251.1         401-411
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.3 cM"
     gene            1..3137
                     /gene="Pls3"
                     /note="plastin 3 (T-isoform)"
                     /db_xref="GeneID:102866"
                     /db_xref="MGI:MGI:104807"
     exon            1..123
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            124..204
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2024
                     /gene="Pls3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     plastin-3; T-plastin; plastin 3, T; T-fimbrin"
                     /codon_start=1
                     /product="plastin-3 isoform 1"
                     /protein_id="NP_001159925.1"
                     /db_xref="CCDS:CCDS30243.1"
                     /db_xref="GeneID:102866"
                     /db_xref="MGI:MGI:104807"
                     /translation="MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEA
                     NMPLPGYKVREIIQKLMVDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEG
                     ICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAV
                     GDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAED
                     LRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRW
                     ANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDL
                     KRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTL
                     LEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPY
                     PKLGANMKKLENCNYAVELGKNPAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLN
                     VLEDLGEGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGC
                     INYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMG
                     RGMKRV"
     exon            205..368
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..498
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..631
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            632..713
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..879
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1022
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1118
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1314
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1393
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1508
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1642
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1766
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1891
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..3137
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pls3"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="Pls3"
                     /note="major polyA site"
ORIGIN      
        1 gctggcaaga ggggagggag cgctggcttt agaagcacag ctgcagagat tcctaggggc
       61 agaagttgtc tgagtgcttg gtcggaagct gtagagccag atcagcgact ctgcgacttt
      121 tacatcttta catggatgag atggcgacca cccagatttc caaagatgag cttgatgaac
      181 tcaaagaagc ctttgcaaaa gttgatctca acagcaatgg attcatttgc gactatgagc
      241 ttcatgagct tttcaaggaa gctaatatgc cactgcccgg atataaagtg agagaaatta
      301 ttcagaaact catggtggat ggtgacagaa ataaagatgg gaagatcagc tttaatgagt
      361 ttgtttatat tttccaagag gtaaagagca gtgatatcgc taaaaccttc cgaaaggcca
      421 tcaacaggaa agaagggatt tgtgctctgg gagggacatc agagttgtcc agtgaaggga
      481 cccagcattc ctattcagag gaagaaaaat atgcttttgt taactggata aacaaagctt
      541 tggaaaatga tcccgattgt agacatgtca tacccatgaa cccaaatact gatgacctgt
      601 tcaaagcagt tggtgatggg atcgtgctct gcaaaatgat caacctttca gttcctgata
      661 caattgacga gagagcaatc aataagaaga agcttacacc cttcatcatt caggaaaact
      721 tgaacttggc cctgaactct gcttctgcca ttgggtgtca cgttgtgaac attggtgccg
      781 aagatctgcg ggccgggaaa cctcacctgg ttttgggact gctttggcag attattaaga
      841 ttggcctgtt tgctgacatt gaattaagca ggaatgaagc actggcagct ttgcttcgag
      901 atggtgagac actggaggag cttatgaaat tgtctccaga agagcttctg ctgagatggg
      961 ccaacttcca tctggaaaac tcaggctggc aaaagatcaa caacttcagc gctgacatca
     1021 aggattccaa agcctatttc catctgctca atcaaatcgc accgaaggga cagaaagaag
     1081 gggagccacg gatagatatt aacatgtcag gtttcaatga aactgatgat ttaaagagag
     1141 ccgaaagtat gcttcaacaa gcagataaat taggttgcag acagttcgtt actccagctg
     1201 atgttgtcag cggaaacccc aaactgaact tggcctttgt agctaacctc ttcaataaat
     1261 atccagcact aactaaacct gaaaaccagg atattgactg gactcttcta gaaggggaaa
     1321 ctcgggaaga aagaaccttc cgcaactgga tgaactctct tggtgttaat ccccacgtca
     1381 accatctcta tgctgacctg caggatgctc tggtgatcct acagctgtat gagaggatta
     1441 aagttcctgt ggactggagt aaagttaaca agcctccata cccaaagctg ggggccaaca
     1501 tgaagaagtt agaaaactgc aactatgcag ttgaattagg gaagaatcca gctaaattct
     1561 ccttggttgg cattggagga caagacctga acgatggcaa ccctaccttg accttggctg
     1621 tagtctggca gctgatgaga agatataccc ttaatgttct ggaagatctt ggagagggtc
     1681 agaaagcaaa tgatgacatc attgtaaact gggtcaacag aacattgagt gaagctggaa
     1741 agtcaacttc cattcagagt tttaaggaca agaccatcag ctccagtttg gcggttgtgg
     1801 atttaattga cgccatccaa ccaggctgca ttaactatga ccttgtgaag agtgggaatc
     1861 taacagaaga tgacaagcac aataacgcca agtacgcagt atcgatggct agaagaatcg
     1921 gagccagagt atatgccctc cctgaagacc ttgtggaagt aaaaccgaag atggtcatga
     1981 ctgtgtttgc ctgtttgatg ggcagaggga tgaagagagt gtaaaacaac caatctcaat
     2041 agaaccaacc ttactctccg gtgcatgatt accaagtcag ctagtcccag gtgaagtgct
     2101 catggcttca gaagtcttgg tcatttaaag gacttttagt tttgattagc aaaactaatt
     2161 aatcgtgaca gcctttggag aaagcatttt agtaaacaag caactcctct ttcccgtaga
     2221 gctgatctgt tcagcacacc tgaacatgct cacagccaac cttttgcact ctcctcctag
     2281 aatgctgccc ttgacattcc ggcttgcttt gtattatcta tgtatctttt ccctcctggg
     2341 atatccatct cttgagactt gcctagatgt gtagatagga atattcttag ctcatccttt
     2401 tgctttccac attctagcag ttctttctgg agaatcctgc tctgatgctg tgtggagatg
     2461 agtgttcttt gtttactctg tagtgctgaa aatccgctga agtaactggc tgtgcagaat
     2521 gtactagaag cttttctcat tcttttagtc ttaaaatcag tatcttttta cagtattctt
     2581 tctacatgga tattttttgt acatttaaga atattttgat tacatccgac acgtctgctg
     2641 atttgctact ttttaaaaaa ggggtcttca tgtaagtaaa acatacaaaa gcataaatta
     2701 taggtggaag aaagtggacc ctaaggttgc atttccccct cacacccagg ctcaaaggaa
     2761 atgaaatatt ttgtcttcaa taagttggtc cgatacatgc ttgtttgttt ggaaatcttt
     2821 atcacaaaac tctttttcag tctaaaatgc tgttgaacat gacacttttg aagagagggt
     2881 gggctcagaa tttagacggg aatttgataa gcaaagaatg ctaaaatgta caatggattt
     2941 ttaattttac acctataaca aggagatgtg gtctcagaaa tgggaaagta tgtatgtcgg
     3001 acttgatgta ctcttgctct gtcaagctct ttgctatagt tctcaatatc attatgttaa
     3061 tctaaatctg aaaagtgatg taatctggta gcatcatagt agtccaaata aaggcatttg
     3121 cataataatt attctct
//
