LOCUS       NM_001033210            3697 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus plastin 1 (I-isoform) (Pls1), mRNA.
ACCESSION   NM_001033210 XM_110660 XM_886418 XM_905243 XM_919257
VERSION     NM_001033210.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Morandell,J., Schwarz,L.A., Basilico,B., Tasciyan,S., Dimchev,G.,
            Nicolas,A., Sommer,C., Kreuzinger,C., Dotter,C.P., Knaus,L.S.,
            Dobler,Z., Cacci,E., Schur,F.K.M., Danzl,J.G. and Novarino,G.
  TITLE     Cul3 regulates cytoskeleton protein homeostasis and cell migration
            during a critical window of brain development
  JOURNAL   Nat Commun 12 (1), 3058 (2021)
   PUBMED   34031387
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Krey,J.F., Krystofiak,E.S., Dumont,R.A., Vijayakumar,S., Choi,D.,
            Rivero,F., Kachar,B., Jones,S.M. and Barr-Gillespie,P.G.
  TITLE     Plastin 1 widens stereocilia by transforming actin filament packing
            from hexagonal to liquid
  JOURNAL   J Cell Biol 215 (4), 467-482 (2016)
   PUBMED   27811163
  REMARK    GeneRIF: PLS1 biases actin toward liquid packing, which allows
            stereocilia to grow to a greater diameter.
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Zhou,J.Y., Szasz,T.P., Stewart-Hutchinson,P.J., Sivapalan,J.,
            Todd,E.M., Deady,L.E., Cooper,J.A., Onken,M.D. and Morley,S.C.
  TITLE     L-Plastin promotes podosome longevity and supports macrophage
            motility
  JOURNAL   Mol Immunol 78, 79-88 (2016)
   PUBMED   27614263
  REMARK    GeneRIF: we have identified a role for L-plastin in stabilizing
            long-lived podosomes and in enabling macrophage motility
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Taylor,R., Bullen,A., Johnson,S.L., Grimm-Gunter,E.M., Rivero,F.,
            Marcotti,W., Forge,A. and Daudet,N.
  TITLE     Absence of plastin 1 causes abnormal maintenance of hair cell
            stereocilia and a moderate form of hearing loss in mice
  JOURNAL   Hum Mol Genet 24 (1), 37-49 (2015)
   PUBMED   25124451
  REMARK    GeneRIF: Results show that plastin 1 is dispensable for the initial
            formation of stereocilia.
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Gao,N. and Kaestner,K.H.
  TITLE     Cdx2 regulates endo-lysosomal function and epithelial cell polarity
  JOURNAL   Genes Dev 24 (12), 1295-1305 (2010)
   PUBMED   20551175
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   Grimm-Gunter,E.M., Revenu,C., Ramos,S., Hurbain,I., Smyth,N.,
            Ferrary,E., Louvard,D., Robine,S. and Rivero,F.
  TITLE     Plastin 1 binds to keratin and is required for terminal web
            assembly in the intestinal epithelium
  JOURNAL   Mol Biol Cell 20 (10), 2549-2562 (2009)
   PUBMED   19321664
  REMARK    GeneRIF: Plastin 1 accumulates in the terminal web and interacts
            with keratin 19, possibly contributing to anchoring the rootlets to
            the keratin network.
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Ohsawa,K., Imai,Y., Sasaki,Y. and Kohsaka,S.
  TITLE     Microglia/macrophage-specific protein Iba1 binds to fimbrin and
            enhances its actin-bundling activity
  JOURNAL   J Neurochem 88 (4), 844-856 (2004)
   PUBMED   14756805
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   10 (bases 1 to 3697)
  AUTHORS   Ezzell,R.M., Chafel,M.M. and Matsudaira,P.T.
  TITLE     Differential localization of villin and fimbrin during development
            of the mouse visceral endoderm and intestinal epithelium
  JOURNAL   Development 106 (2), 407-419 (1989)
   PUBMED   2686960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI526519.1, AK133070.1, AW124763.1, AK030875.1 and CJ229558.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by
            NM_001033210.4.
            
            On Oct 23, 2009 this sequence version replaced NM_001033210.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.92981.1, AK133070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AI526519.1         1-19
            20-2214             AK133070.1         2-2196
            2215-2445           AW124763.1         8-238               c
            2446-3692           AK030875.1         1441-2687
            3693-3697           CJ229558.1         419-423
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.22 cM"
     gene            1..3697
                     /gene="Pls1"
                     /note="plastin 1 (I-isoform)"
                     /db_xref="GeneID:102502"
                     /db_xref="MGI:MGI:104809"
     exon            1..109
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..214
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2037
                     /gene="Pls1"
                     /note="I-fimbrin; plastin 1, I"
                     /codon_start=1
                     /product="plastin-1"
                     /protein_id="NP_001028382.1"
                     /db_xref="CCDS:CCDS23412.1"
                     /db_xref="GeneID:102502"
                     /db_xref="MGI:MGI:104809"
                     /translation="MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEAS
                     LPLPGYKVREIVEKILVVADNNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGI
                     TAIGGTSSISSEGTQHSYSEEEKVAFVNWINKALENDADCSHLLPMNPNDGSLFKSLA
                     DGILLCKMINLSEPDTIDERAINKKKLTPFTVSENLNLALNSASAIGCTVVNIGAQDL
                     KEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLKDGEDLEELMKLSPEELLLRWV
                     NYHLTNAGWRTINNFSQDIKDSKAYFHLLNQIAPKGDRDDGPAVAIDLSGFNEKNDLK
                     RAGFMLQEADKLGCRQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPDNNDIDLNLL
                     EGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSQVNKPPYP
                     ALGGNMKKIENCNYAVELGKNEAKFSLVGIAGQDLNEGNATLTLALVWQLMRRYTLKV
                     LSDLGEGEKVTDDIIIKWVNQTLKSANKSTSISSFKDKSISTSLPVLDLIDAIAPNAV
                     RQEMIKREHLTDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGK
                     GLNRLK"
     exon            215..378
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..508
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..641
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..723
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..889
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1032
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1128
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1324
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1403
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1518
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1652
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1776
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1901
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..3697
                     /gene="Pls1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pls1"
                     /note="hexamer: AATAAA"
     polyA_site      3694
                     /gene="Pls1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgcgag cgcaggagca aggaggcggg tgagtggcag ccgcagcgga gcggaccaga
       61 ccagcgggcg cggggatccc gggcaggagc tgccgaacgg ccgccgcaga tataaagact
      121 tgaagtagcc cttccagtct aaagatggaa aacagtacca ccaccatttc tcgggaggag
      181 cttgaagagc tacaagaagc gtttaataaa atagatattg acaacagtgg atatgttagt
      241 gactatgaac ttcaggacct atttaaggag gcaagccttc cccttcctgg gtacaaggtg
      301 cgcgagattg tggagaaaat attagtagtt gccgacaaca acaaagatgg taaaatcagt
      361 tttgaggagt tcgtgtcgct gatgcaagag ctaaaaagca aagatatcag caaaacgttt
      421 cgaaaaataa ttaacaaaag ggaagggatc actgccatcg gggggacgtc atccatctcc
      481 agcgagggca cccagcattc gtactcagag gaagaaaaag tggcttttgt gaactggata
      541 aacaaagctc tggagaatga tgcagactgt agccacctcc tacccatgaa ccccaacgac
      601 ggcagccttt tcaagtcgct ggcagatggc atccttctct gcaaaatgat caacttatcc
      661 gagccagata cgattgacga gagagccatc aataagaaga agctcactcc gttcacggtg
      721 tcggaaaatc tgaacctagc actgaactct gcctcggcca tcggttgcac cgtggtcaac
      781 attggtgctc aggacctcaa ggaaggaaag cctcacttgg tcttggggct tctctggcag
      841 atcatcaaag tgggtctttt tgctgatatc gagatttcca ggaatgaagc cttgatcgcg
      901 ttgctaaaag atggcgagga cctggaggag ctgatgaagc tctctcctga ggaactgctg
      961 ctccgatggg tgaactacca tctgaccaat gcgggctggc gcaccatcaa caacttcagc
     1021 caggacatca aggattcaaa agcctatttc caccttctta atcagattgc tcctaaaggc
     1081 gaccgagatg atgggcctgc cgtagccatt gatctttcag gatttaatga gaaaaacgac
     1141 ctgaagcgtg ctggatttat gctccaggaa gcggataaac ttggctgcag acagtttgtc
     1201 actcctgcag atgtggtttc agggaaccct aagctaaact tagcctttgt agcgaatctt
     1261 tttaacacat acccatgcct acacaagcct gacaataatg acattgatct caacttactg
     1321 gaaggcgaga gcaaggagga gaggacattc cgcaactgga tgaactcgct gggcgtgaac
     1381 ccgtacatca atcacctgta cagtgacctt gcagacgctt tggtgatctt tcagctctac
     1441 gagatgatcc gcgtgccagt caactggagc caggtgaaca agcctccgta ccctgctctg
     1501 ggaggaaaca tgaagaagat tgaaaactgt aactacgcgg tggagcttgg gaagaatgag
     1561 gccaagttct ctttggttgg catcgccggg caggacttaa atgaagggaa cgcaacactt
     1621 accctggcac tggtgtggca gttgatgaga agatacacgc tgaaagtgtt atcagacctt
     1681 ggagaaggtg aaaaagtcac tgatgatatc attattaaat gggtcaacca gacccttaaa
     1741 agtgcaaaca agagcacttc tatttccagc ttcaaggata aatctattag tacaagtttg
     1801 cctgtcttag atctaataga tgccattgca ccaaatgcag tccgtcaaga aatgatcaag
     1861 agagagcact tgactgatga ggacaaactg aacaatgcta aatacgccat ttcagttgct
     1921 cggaagatcg gtgcccggat atacgcgctg cctgacgacc tcgtggaagt gaagccgaag
     1981 atggtgatga ctgtgtttgc ctgcttaatg gggaaaggat tgaacagact gaaataatga
     2041 agcgtttact gtgatctgcc acactgtacg caccaaacgt ctcagtttac agaattttga
     2101 aatgtagtgg gtataaaatc cgaatatctg tatgctcaaa atagttctgt atccagcaat
     2161 gaagaatatc ttgtccatac cagttagaat ttgtcaatct tttttttttt tttttggata
     2221 acacaattac cttaacaatc aataccaatg caggaatgtc ttatcaagct gctatttcat
     2281 aattaaatta ttttatttcc taagagtctt aaccaaaata agactaatca ttctttttca
     2341 tggctcaaaa aagacctgta taaagttttg tcaggtcctt ctattaaatg tgtttggatt
     2401 tttttttttt ttgatgtgtt gtttaaattt tgattaaaaa aaaaatgtac ctaaagtcat
     2461 aatctcactt aatccttttg gtttttctcc ctttagctgt gtaaagtgat ctaaaatttt
     2521 ctgtaaattt ctatatgaca taaaaattta aagggataaa tataatccat caacattaaa
     2581 cttttttaat acgagaacta actcttgaat aacccccacg ttcactctct tgtttaagct
     2641 gtaggagatt tttacttaca gtttgtttgt agctccattg ttacttcaca tgtgctagtc
     2701 tgataacaca gctttgtctc cagcatcaca tgtgctagtc tgataacaca gctttgtctc
     2761 caccatcaag cataatacta tatgttggta ggatgttaca catatgtatt tctctaagtc
     2821 atctgagtta cccacctttt ctaaaatggt atgtattaag tggtcagcca gccgttaagt
     2881 atttattttg cccccacaat gtgtgtgaca cttttcaatt gtggataatc tgatctgtgg
     2941 agatctgttt tgcaaatatt aattctgaat gtgaatatcg ttatttttca cctaactgct
     3001 ttcaaatact tttcagccaa acattggata gaatgtccta actgacacca atcctatcct
     3061 gctagaatca catcacactt actactctca ggctacaggg aaacctacat cactggacat
     3121 gcccaccaaa tggcttctgt agagatctgt gtatataaaa gctaatgtcc gtcgtagttt
     3181 ttcatggtct cctggaaaca gttgaggttt gtgttcctct tttccccaga agttttagca
     3241 gtagagaaat tctgttgctc atagttgaag ccaggaatga gctccccggc cctccacttt
     3301 agtgccagtg agcaatagtg ctatgcaagg aaagtgctgt cacctctctc cgtgtgaatg
     3361 ggttgtccgc ctcctccttg tccactgatc agaacataca gcaggaggga gagtgtctgt
     3421 gtgtttaggg tagactttta taaatgaagt actgacaggt gggattctga aatatattct
     3481 tctacatgaa atgtcttcgc cttttatatt ttggtgattg ttttcttata tgaagacaca
     3541 atgcttccgc tcctttcctg agattattta aatcaaacct ctctgatttt tcccgctgtc
     3601 atatttacta aaacaatctg aattacatgg aatttagcac tttaaggtgt tctttttctc
     3661 acgaaatata tttaataaaa atgctgtgta tgtagaa
//
