LOCUS       NM_016784               1771 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pleiotropic regulator 1 (Plrg1), mRNA.
ACCESSION   NM_016784
VERSION     NM_016784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Kleinridders,A., Pogoda,H.M., Irlenbusch,S., Smyth,N., Koncz,C.,
            Hammerschmidt,M. and Bruning,J.C.
  TITLE     PLRG1 is an essential regulator of cell proliferation and apoptosis
            during vertebrate development and tissue homeostasis
  JOURNAL   Mol Cell Biol 29 (11), 3173-3185 (2009)
   PUBMED   19307306
  REMARK    GeneRIF: PLRG1 is a critical nuclear regulator of p53-dependent
            cell cycle progression and apoptosis during both embryonic
            development and adult tissue homeostasis.
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK077197.1.
            
            On Apr 5, 2007 this sequence version replaced NM_016784.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077197.1, AK075993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1771              AK077197.1         2-1772
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.99 cM"
     gene            1..1771
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /note="pleiotropic regulator 1"
                     /db_xref="GeneID:53317"
                     /db_xref="MGI:MGI:1858197"
     exon            1..117
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1650
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /note="pleiotropic regulator 1, PRL1 homolog"
                     /codon_start=1
                     /product="pleiotropic regulator 1"
                     /protein_id="NP_058064.2"
                     /db_xref="CCDS:CCDS17433.1"
                     /db_xref="GeneID:53317"
                     /db_xref="MGI:MGI:1858197"
                     /translation="MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKM
                     AIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYPHKQYPANQGQDVEYLVTGTHPYPA
                     GPGVALTADTKIQRMPSESAAQSLAVALPSQTRVDANRTGPAGSEYRHPGASDRSQPT
                     AMNSIMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWF
                     VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY
                     NKVIRHYHGHLSAVYGLDLHPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVAT
                     VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLLYTFASGSPD
                     NIKQWKFPDGGFIQNLSGHNAIINTLAVNADGVLVSGADNGTMHLWDWRTGYNFQRVH
                     AAVQPGSLDSESGIFACAFDRSESRLLTAEADKTIKVYREDETATEETHPVSWKPEII
                     KRKRF"
     exon            118..224
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            225..367
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..421
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            422..512
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..600
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..699
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            700..792
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            793..942
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1044
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1147
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1256
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1396
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1590
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1771
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1771
                     /gene="Plrg1"
                     /gene_synonym="Tango4"
                     /note="putative"
ORIGIN      
        1 ggcgacgggc cccaatctcc ggaaagagct gccgaatagt ggcggcgttt tctgcggcga
       61 ttatttgagt tccttcgctg ctggaggggt agactaaacg gcggcgacat ggtggaggag
      121 gtacagaagc attctgtaca cacactggtg ttcaggtcat tgaagaggac ccatgacatg
      181 tttgtggctg ataatggaaa acccgtgcct ttggatgaag agagtcacaa gcggaaaatg
      241 gcaatcaagc ttcgcaatga gtatggtcct gtgctgcata tgcctacttc aaaagagaac
      301 cttaaggaga agggacctca gaacgcaaca gactcatatc ctcataagca gtatcccgcc
      361 aaccaaggac aagatgttga gtatttggtg acaggcaccc atccataccc agcaggaccc
      421 ggtgttgcct tgactgctga tactaagatc cagagaatgc caagtgagtc agctgcacag
      481 tccctcgctg tggcgttacc gtcccagacc agagttgatg caaatcgtac tgggcctgct
      541 ggaagtgagt accgacaccc aggggcttct gaccgttccc agcccacagc aatgaattct
      601 attatggaga ccggcaacac taagaactct gcactaatgg cgaaaaaagc ccctacgatg
      661 cccaaacccc agtggcaccc accgtggaaa ctctacaggg ttatcagtgg gcatcttggc
      721 tgggttcggt gtatcgctgt ggaacctgga aatcagtggt tcgttacagg atctgctgac
      781 agaaccataa agatttggga cttggctagt ggcaaattaa agctgtcgtt gactggccac
      841 atcagtacag tgcgtggtgt gatcgtgagc acgaggagtc cttatttgtt ctcttgtgga
      901 gaagacaaac aagtgaagtg ctgggatctt gaatataaca aggtgatacg gcactatcat
      961 ggccatctaa gtgcagtgta tggtctggat ttgcacccaa cattggatgt cctggtgact
     1021 tgtagtcgag attccactgc tcggatctgg gacgtgagaa ctaaagccag tgtacacact
     1081 ttgtctggac acacaaatgc agttgctacc gtgagatgcc aggctgcaga gccacagatc
     1141 attacaggaa gtcacgatac cacaatacga ttatgggatc tagtggctgg aaagacacga
     1201 gtgacactga cgaaccataa gaaatcagtg agggctgtgg tcttacatcc gctactttac
     1261 acatttgcgt ctggttctcc agataacata aagcagtgga aattccccga tggaggcttc
     1321 attcaaaatc tctctggtca caatgcaatc attaacacgc tggcggtcaa tgctgatgga
     1381 gtgcttgtgt ctggagctga caatggcacc atgcaccttt gggactggag aactggctat
     1441 aattttcagc gcgtccatgc agctgtacag cctgggtctt tggacagtga gtcaggaata
     1501 tttgcttgtg ctttcgatcg gtcagaaagt cggttactaa cggctgaagc tgataaaacc
     1561 attaaagttt acagagagga tgagactgcg acagaagaaa ctcacccagt cagctggaaa
     1621 ccagaaatta tcaagagaaa gcgattttag tgtcttcatg gctgtcctgt tcgtgcttgg
     1681 tgttgatgag gatatccggt ctttcatgaa agctcacttg cagaaaacat tgctgctttg
     1741 tattttacaa taaactgctc ccatgtccct c
//
