LOCUS       NM_029425               4280 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phospholipid phosphatase related 5 (Plppr5),
            transcript variant 2, mRNA.
ACCESSION   NM_029425 XM_131156
VERSION     NM_029425.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Wang,D., Liu,Y., Zhao,D., Jin,M., Li,L. and Ni,H.
  TITLE     Plppr5 gene inactivation causes a more severe neurological
            phenotype and abnormal mitochondrial homeostasis in a mouse model
            of juvenile seizure
  JOURNAL   Epilepsy Res 183, 106944 (2022)
   PUBMED   35617916
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Gross,I., Brandt,N., Vonk,D., Koper,F., Wohlbrand,L., Rabus,R.,
            Witt,M., Heep,A., Plosch,T., Hipp,M.S. and Brauer,A.U.
  TITLE     Plasticity-Related Gene 5 Is Expressed in a Late Phase of
            Neurodifferentiation After Neuronal Cell-Fate Determination
  JOURNAL   Front Cell Neurosci 16, 797588 (2022)
   PUBMED   35496908
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Gross,I., Tschigor,T., Salman,A.L., Yang,F., Luo,J., Vonk,D.,
            Hipp,M.S., Neidhardt,J. and Brauer,A.U.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Sun,Y., Jin,M.F., Li,L., Liu,Y., Wang,D. and Ni,H.
  TITLE     Genetic Inhibition of Plppr5 Aggravates Hypoxic-Ischemie-Induced
            Cortical Damage and Excitotoxic Phenotype
  JOURNAL   Front Neurosci 16, 751489 (2022)
   PUBMED   35401091
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Wang,D., Jin,M.F., Li,L., Liu,Y., Sun,Y. and Ni,H.
  TITLE     PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to
            Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal
            Zinc Signaling-Mediated Mitochondrial Damage
  JOURNAL   Front Neurosci 15, 715555 (2021)
   PUBMED   34512249
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Sun,Y., Ma,L., Jin,M., Zheng,Y., Wang,D. and Ni,H.
  TITLE     Effects of Melatonin on Neurobehavior and Cognition in a Cerebral
            Palsy Model of plppr5-/- Mice
  JOURNAL   Front Endocrinol (Lausanne) 12, 598788 (2021)
   PUBMED   33692754
  REMARK    GeneRIF: Effects of Melatonin on Neurobehavior and Cognition in a
            Cerebral Palsy Model of plppr5-/- Mice.
            Erratum:[Front Endocrinol (Lausanne). 2022 Mar 14;13:879685. doi:
            10.3389/fendo.2022.879685.. PMID: 35370970]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Coiro,P., Stoenica,L., Strauss,U. and Brauer,A.U.
  TITLE     Plasticity-related gene 5 promotes spine formation in murine
            hippocampal neurons
  JOURNAL   J Biol Chem 289 (36), 24956-24970 (2014)
   PUBMED   25074937
  REMARK    GeneRIF: Data indicate that plasticity-related genes 5 (PRG5)
            expression is involved in proper spine formation.
REFERENCE   10 (bases 1 to 4280)
  AUTHORS   Broggini,T., Nitsch,R. and Savaskan,N.E.
  TITLE     Plasticity-related gene 5 (PRG5) induces filopodia and neurite
            growth and impedes lysophosphatidic acid- and nogo-A-mediated
            axonal retraction
  JOURNAL   Mol Biol Cell 21 (4), 521-537 (2010)
   PUBMED   20032306
  REMARK    GeneRIF: Data show that PRG5 induces filopodia growth independently
            of Cdc42, and that axon collapse and RhoA activation induced by LPA
            and myelin-associated neurite inhibitor Nogo-A is attenuated in the
            presence of PRG5.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB722774.1, BB622243.1, BB611685.1, AK043629.1, AK014763.1,
            BB351291.1 and AC122030.3.
            
            On Mar 13, 2015 this sequence version replaced NM_029425.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. It encodes isoform 2, which is
            shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043629.1, AK076176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               CB722774.1         392-572
            182-234             BB622243.1         181-233
            235-373             BB611685.1         2-140
            374-671             AK043629.1         1-298
            672-2130            AK014763.1         309-1767
            2131-2863           AK043629.1         1758-2490
            2864-4252           AK043629.1         2492-3880
            4253-4278           BB351291.1         256-281
            4279-4280           AC122030.3         35546-35547         c
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 51.21 cM"
     gene            1..4280
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="phospholipid phosphatase related 5"
                     /db_xref="GeneID:75769"
                     /db_xref="MGI:MGI:1923019"
     exon            1..706
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..1420
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phospholipid phosphatase-related protein type 5;
                     phosphatidic acid phosphatase type 2d; plasticity-related
                     gene 5 protein; lipid phosphate phosphatase-related
                     protein type 5"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 5
                     isoform 2"
                     /protein_id="NP_083701.2"
                     /db_xref="CCDS:CCDS17796.1"
                     /db_xref="GeneID:75769"
                     /db_xref="MGI:MGI:1923019"
                     /translation="MPLLPVALISSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFF
                     CHDSAYRKPYPGPEDSSAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLATRDFENQEK
                     TILTGDCCYINPLVRRTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYT
                     ALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLTMYITSTIKAKG
                     TRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVNNFKG
                     RQPENGHIHRDNVARMPMTNIPRVESPLEKNHVTAFAEVT"
     exon            707..839
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1090
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1267
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1387
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..4280
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1708..1713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="hexamer: AATAAA"
     polyA_site      1737
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="major polyA site"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="hexamer: ATTAAA"
     polyA_site      2132
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
     regulatory      4259..4264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
                     /note="hexamer: AATAAA"
     polyA_site      4279
                     /gene="Plppr5"
                     /gene_synonym="4833424O15Rik; Lppr5; Pap2d; PRG-5"
ORIGIN      
        1 ccccttcaga tttggaattt taccctctcc aggcagctgc tccagctata caacatccgc
       61 ccgccctccg aggggacgag gtgccaccga cgccgcttgc ctcgggccgg tccgagggct
      121 tgaccacagt gccgcggtgt cgcggatgct cccgagctgg ggctggggac tccccgccct
      181 tgcgcgcgac cccgcggccg ggcaggcggc gcttgcagcg ggcagggggc gggcagggca
      241 gatgggactc gtccgggggt agcctcctcc tctgcatcct gcccgcgcat cccgaagccc
      301 agtcgcatcc tccgcctctg cctcggcggc tgccagcctc cgcctcgcgc cacctcggcc
      361 tgccgccgcc cccgccgccg cgcccccggt ggctgtgcct cggcggagcc cggagggggc
      421 ctgtggcgcg tcgaccgccc gctcggctcg gcttggccag gaggcgtgca tgcccctgct
      481 gcccgtggcg ctcatcagca gcatgctcta tttccagatg gtgatcatgg cagggacggt
      541 gatgctggct tactacttcg aatacacaga cacgttcact gtgaacgtgc agggattctt
      601 ctgccacgac agcgcctacc gtaagcccta cccgggccca gaggacagca gcgcggtgcc
      661 cccggtgctc ctctactcgc tggccgctgg cgtcccggtg cttgtgataa tagttggaga
      721 aactgcagtg ttttgcctgc aattagccac aagagatttt gaaaaccagg aaaaaaccat
      781 tttaactgga gattgttgct atataaaccc actggtacgc cgaaccgtcc gatttcttgg
      841 aatttatgca tttggactgt ttgctacaga tatctttgta aatgctgggc aagtggttac
      901 aggaaaccta gctccacact ttctggcttt gtgtaagcca aactacacag cgctcggatg
      961 tcagcagtac acacagttta tcagtgggga ggaagcatgc acaggcaacc cagacctcat
     1021 catgcgagca cggaaaacat tcccatccaa ggaagctgcc ctgagtgtct acgctgccac
     1081 gtatctgacg atgtacatta ccagcactat caaagccaaa ggaaccagac ttgctaagcc
     1141 tgtcctgtgc ttgggattaa tgtgtttggc ctttcttact ggactcaaca gagtagcgga
     1201 atatcgaaat cattggtcag atgtgatagc aggcttccta gtcggaatat ctatagcagt
     1261 atttctggtt gtatgcgtgg taaacaattt taaaggaaga caaccagaaa atgggcatat
     1321 acacagggac aatgtggccc ggatgccaat gaccaacatt cctcgagtag aaagcccttt
     1381 ggaaaagaac cacgtcactg cctttgcgga agtcacatga tgttgaagca gacggttttt
     1441 ccctgcactg gacatcatcc ctatttacca tacattcata acagagttta tttgattaca
     1501 caggaaattt ataaagatgt aggacacttt ttataatttt aaaacttgac agcaccctct
     1561 ctgccccgcc ctcccacgag actgtgagct cctcaagagc aggaccatgg cttcctcttc
     1621 tgcatccccg ccacccacga caaagcccag cacaaagtgt gggtgttcag tgaaaacacg
     1681 atgataaaac gaacaagtca actcttaaat aaaatggttg ctttagtttc tcaaaaagaa
     1741 tctctgtgac tatgtggaaa gaaaccccca catgggttat atttgtataa aagaaaccct
     1801 ctattttggg ctagttaagt ctttttaatt tttcatatat ctattcagca gtatagcata
     1861 tttaatttga agtgaatttt gaaagttctg gggacttttt attatgcagc atgacattat
     1921 ttccatttta acagatttca gtgtgtggaa tcactttact tttagaaagt atgtcctata
     1981 ctaaattgtt tgctcattat attatgctat atttcactta aaacaccatt catactacat
     2041 attctaagac tggtgcttct gcttttaaag gggaaaatgc caatttttac tgtcactgag
     2101 taatgtatca taattaaaat tatttatttg gactttttct ttgacagttg tggtttaatg
     2161 gttgtgctgc aatttttttt aatgcaggca atatttagaa tacattaagg taaatccagc
     2221 catgatacct tgttattgag tagccttcca tcattaacag tgtctcaaaa tggctatggt
     2281 ccattattaa attttctaat tggtccagaa ctcaaataat ttaaatgaga aagaaccaca
     2341 ccttaaaata ctatcatgaa aatactagaa atatgattaa tgtatttttg taattgtcta
     2401 atactttaat taaacgtatt tatagttatc atttaatcct tatggcaatc ctgtataaat
     2461 attgaaagat gactttattt acatatgata aaaataaagc caagactgat aacatgccca
     2521 gtccatacca ctagtcaagg gaagagttaa atctaaattc agatttaccc tgaaactctt
     2581 atttttctca aatatgccac agttgcctca acattcatga cactgaggcc attaagaggc
     2641 cattagggtt ctgagaaact acctatcttt aagaaaaaaa aatgaagaaa tgctaaagtt
     2701 aggaacagaa ggtctgcagt attttaaaag cttacttaca tggaggaaca taaaacatct
     2761 ctttcaaacg cagagctatt taggattcta tttataatcc tattttaaaa taatgacatt
     2821 ctagtgtctg aatgtgaggc ttttggtaga agagaggtcc aaatgaagat tctcatctct
     2881 gcatctcagc tacctctcag gaaaggggct gagggacagg ttatacagtg accatgtaag
     2941 ttaaagatga aaacagtctc cacagaagaa ggaggatcaa gtcatgagtc actctgcaat
     3001 ctctaaggct aacccaagat actttgactt aaatgtgcag aaaaatgatt tcttttaatc
     3061 tttctagtct aaacatttag tttgctctct taatttcaac agaaatcagc aaataattaa
     3121 aaccaaaggc ttctctgtta cttccaaatg gatttcagtt gcccaatttc aattctgaag
     3181 aggtcaaaat atgtcaactg aaagccaaat taaaaaaaaa tctcatttct atgaattgca
     3241 aatctctata gcagttttat tcttttggaa atgtagagca aactttgcat gtcttgacaa
     3301 tctttaaaga cattgtttag aaagcattag caatggcaaa tttgcttcct aggattgaaa
     3361 taaaggatat gaccataatg ccaagcaaag gcagggtagc tgactaggtc tatacagttg
     3421 ctcaaggcta ctggtcctat acccattcaa aaggacccag acgggagtga atttcccctt
     3481 ggaggcctta acattacata agtcagtgat aaagtttttc accttcctaa acctggtcag
     3541 attaaaagag ttataaatta aagaactaat cagggtcaaa gttaaatcac ttctgctatt
     3601 acatttaagc atcatgaacc caaggttgta caatgataaa gtccaggaaa aaattaaaga
     3661 tgcatgcgaa ttaaccaaac tcagccaaga gtgcttaacc atgatgcaac tacttagaac
     3721 tattttaaaa tttatacctt tcagaaaacg tcagaacaat ggctggagct ggaattcagt
     3781 ggtacggcac ttgcctagca tgcacaggcc ctgggttcaa tccctaggac ctgtataaga
     3841 aagcactaat atcaatatat aaatatgtac atacatagta aaagcaggca atcacatgcc
     3901 tttccgatag agactctcat ttttattctg cttctttggg gcccaggtca acgtaaattg
     3961 ttcaagatga aaacttcagt agtatctgtt tgcatggcag aagttctgca caagtcttat
     4021 ccgatgatgc ctaaggtaac ttaaaaggct cttttatgtt aaaagagagg tgagccttct
     4081 ttgatagagt ttgtctattc gacttctaac tgggcctctc tttttctcag gatctatcct
     4141 agccaaatat ctcgttacat ttccacagtt ttctttgtga aagaacagtg ggggaggaaa
     4201 gaattctctg ctgtgtattg tatttttcaa ataaaaaatt aaaaactaaa ttaaaaaaaa
     4261 taaatttctt tttccctcat
//
