LOCUS       NM_177664               5690 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase related 4 (Plppr4), mRNA.
ACCESSION   NM_177664 XM_912622
VERSION     NM_177664.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5690)
  AUTHORS   Knierim,E., Vogt,J., Kintscher,M., Ponomarenko,A., Baumgart,J.,
            Beed,P., Korotkova,T., Trimbuch,T., Panzer,A., Steinlein,O.K.,
            Stephani,U., Escayg,A., Koko,M., Liu,Y., Lerche,H., Schmitz,D.,
            Nitsch,R. and Schuelke,M.
  TITLE     Mutations in plasticity-related-gene-1 (PRG-1) protein contribute
            to hippocampal seizure susceptibility and modify epileptic
            phenotype
  JOURNAL   Cereb Cortex 33 (12), 7454-7467 (2023)
   PUBMED   36977636
  REMARK    GeneRIF: Mutations in plasticity-related-gene-1 (PRG-1) protein
            contribute to hippocampal seizure susceptibility and modify
            epileptic phenotype.
REFERENCE   2  (bases 1 to 5690)
  AUTHORS   Gross,I., Tschigor,T., Salman,A.L., Yang,F., Luo,J., Vonk,D.,
            Hipp,M.S., Neidhardt,J. and Brauer,A.U.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   3  (bases 1 to 5690)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 5690)
  AUTHORS   Schneider,P., Petzold,S., Sommer,A., Nitsch,R., Schwegler,H.,
            Vogt,J. and Roskoden,T.
  TITLE     Altered synaptic phospholipid signaling in PRG-1 deficient mice
            induces exploratory behavior and motor hyperactivity resembling
            psychiatric disorders
  JOURNAL   Behav Brain Res 336, 1-7 (2018)
   PUBMED   28843862
REFERENCE   5  (bases 1 to 5690)
  AUTHORS   Vogt,J., Kirischuk,S., Unichenko,P., Schluter,L., Pelosi,A.,
            Endle,H., Yang,J.W., Schmarowski,N., Cheng,J., Thalman,C.,
            Strauss,U., Prokudin,A., Bharati,B.S., Aoki,J., Chun,J., Lutz,B.,
            Luhmann,H.J. and Nitsch,R.
  TITLE     Synaptic Phospholipid Signaling Modulates Axon Outgrowth via
            Glutamate-dependent Ca2+-mediated Molecular Pathways
  JOURNAL   Cereb Cortex 27 (1), 131-145 (2017)
   PUBMED   27909001
REFERENCE   6  (bases 1 to 5690)
  AUTHORS   Trimbuch,T., Beed,P., Vogt,J., Schuchmann,S., Maier,N.,
            Kintscher,M., Breustedt,J., Schuelke,M., Streu,N., Kieselmann,O.,
            Brunk,I., Laube,G., Strauss,U., Battefeld,A., Wende,H.,
            Birchmeier,C., Wiese,S., Sendtner,M., Kawabe,H., Kishimoto-Suga,M.,
            Brose,N., Baumgart,J., Geist,B., Aoki,J., Savaskan,N.E.,
            Brauer,A.U., Chun,J., Ninnemann,O., Schmitz,D. and Nitsch,R.
  TITLE     Synaptic PRG-1 modulates excitatory transmission via lipid
            phosphate-mediated signaling
  JOURNAL   Cell 138 (6), 1222-1235 (2009)
   PUBMED   19766573
  REMARK    GeneRIF: PRG-1 as an important player in the modulatory control of
            hippocampal excitability dependent on presynaptic LPA(2) receptor
            signaling.
            Erratum:[Cell. 2011 Sep 16;146(6):1043]
REFERENCE   7  (bases 1 to 5690)
  AUTHORS   Cheng,T.W. and Gong,Q.
  TITLE     Secreted TARSH regulates olfactory mitral cell dendritic complexity
  JOURNAL   Eur J Neurosci 29 (6), 1083-1095 (2009)
   PUBMED   19302145
REFERENCE   8  (bases 1 to 5690)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5690)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
REFERENCE   10 (bases 1 to 5690)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165162.4.
            
            On Mar 19, 2008 this sequence version replaced NM_177664.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF541279.1, AK129149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-853               AC165162.4         196427-197279       c
            854-1039            AC165162.4         171809-171994       c
            1040-1169           AC165162.4         168051-168180       c
            1170-1365           AC165162.4         164594-164789       c
            1366-1423           AC165162.4         163088-163145       c
            1424-1597           AC165162.4         162193-162366       c
            1598-5690           AC165162.4         155548-159640       c
FEATURES             Location/Qualifiers
     source          1..5690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.57 cM"
     gene            1..5690
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /note="phospholipid phosphatase related 4"
                     /db_xref="GeneID:229791"
                     /db_xref="MGI:MGI:106530"
     exon            1..853
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..2929
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /EC_number="3.1.3.106"
                     /note="plasticity related gene 1; plasticity-related gene
                     1 protein; brain-specific phosphatidic acid
                     phosphatase-like protein 1; lipid phosphate
                     phosphatase-related protein type 4; 2-lysophosphatidate
                     phosphatase PLPPR4; inactive 2-lysophosphatidate
                     phosphatase PLPPR4"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 4"
                     /protein_id="NP_808332.3"
                     /db_xref="CCDS:CCDS17795.1"
                     /db_xref="GeneID:229791"
                     /db_xref="MGI:MGI:106530"
                     /translation="MQRAGSSGARGECDISGAGRLRLEQAARLGGRTVHTSPGGGLGA
                     RQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGF
                     SCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEP
                     NINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTS
                     LNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSS
                     KLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPS
                     EDSMLQHRDALRSLTDLNQDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKR
                     ANADVEIITPRSPMGKESMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLT
                     QWKSKNESRKMSLQVMDTEPEGQSPPRSIEMRSSSEPSRVGVNGDHHVPGNQYLKIQP
                     GTVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKT
                     VACNRSNNQPRIMQVIAMSKQQGVLQSSPKNAEGSTVTCTGSIRYKTLTDHEPSGIVR
                     VEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSLRQTYELNDLNRDSESCESLKDS
                     FGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSVSSSRDSTLRRKGNIILI
                     PERSNSPENTRNIFYKGTSPTRAYKD"
     exon            854..1039
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1169
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1365
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1423
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1597
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..5690
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3574..3579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /note="hexamer: AATAGA"
     polyA_site      3616
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
     regulatory      5664..5669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /note="hexamer: AATAAA"
     polyA_site      5690
                     /gene="Plppr4"
                     /gene_synonym="A330086D10; D3Bwg0562e; Lppr4; mKIAA0455;
                     PRG-1"
                     /note="major polyA site"
ORIGIN      
        1 agcgatgatg ccccatttac cctttctctt cagatgcagg aaattttcac tctgttcccc
       61 agctgattgg agctttttct aggtgcttcc ctgggagtta cctccctaga gatcagcagg
      121 cagggctgtc acgcttgggt agcagccagc tcccagtgaa ttccttctgt ggcctacttg
      181 tccttatgaa gtccgagttt taattttgca caggtaggag gtctcttttg ctatggatag
      241 ggcggataac ggtgctacca ttagaaaaca ggcttctgtt ttctaggaag gcaagaggaa
      301 ccccaggtag gggaccttgt gagaccaggt gacttggctc ctcagccttg cttctacaga
      361 aaccaggagt gcttcccccc actcttccct atttttgacg tcaagctcaa ccagccagca
      421 gaggagcctc acggcttggg cggtggagag agagcccagg gagagtggca gggaggggaa
      481 gccatctcag caacagcttg gagagggagc tgctatccct tgcccgcaaa acacggacta
      541 aagccaggct gaagaagacc tgcgggctcg ggctcgggga tccgcggggt tactgcaaag
      601 aggggcgggg aaaaggcggg ggcgctgcat gcagcgcgct ggttccagcg gtgcccgcgg
      661 ggaatgtgac atcagcggcg ccgggcgctt gcggctggag caggcagctc gcctcggtgg
      721 ccgcacggtg cacacctcgc ccgggggagg acttggagcc cggcaggcgg ccgggatgtc
      781 ggcgaaggag aggccaaagg gcaaagtgat caaggacagc gtcaccctcc tgccctgttt
      841 ttatttcgtt gagttgccta tattggcatc atcagtggtt agcctctact tcttggaact
      901 cacagatgtc ttcaaacctg tgcactctgg attcagttgc tatgatagga gtcttagcat
      961 gccgtacatt gagccaaccc aggaggccat accattcctt atgttgctta gcttggcttt
     1021 tgctggacct gcaattacga tcatggtggg tgaagggatt ctatactgct gcctctccaa
     1081 aagaagaaac ggagctggat tggagcctaa catcaacgcc ggaggctgca acttcaactc
     1141 ctttctcagg agagccgtca gattcgttgg tgtccatgtg tttggactgt gctccacagc
     1201 tctcattaca gatatcatac agctctccac aggatatcag gcaccatact ttctgactgt
     1261 gtgcaagcca aactatacct ctctgaatgt atcctgcaaa gaaaactcct acatcgtgga
     1321 agatatttgt tcaggatctg accttacagt catcaacagt ggcagaaagt cattcccatc
     1381 ccaacatgcg accctcgctg cctttgccgc tgtgtatgtg tccatgtact tcaattccac
     1441 attaaccgat tcctctaagc tcctgaaacc tctcttggtc ttcacattta tcatctgtgg
     1501 gatcatctgc ggactaacac ggataactca atataagaac catccagtcg atgtctattg
     1561 tggcttttta ataggaggag gaatcgcact atatttgggc ctgtatgctg tagggaattt
     1621 tctgcctagt gaagacagta tgcttcagca cagagatgcc ctcaggtcac tgacagacct
     1681 caatcaagac cccagcaggg ttttatcagc taaaaatggt agcagtggtg atggaattgc
     1741 tcacacagag ggtatcctca accgaaacca cagggatgca agctccttga caaatctcaa
     1801 gagggccaac gctgacgtag aaatcatcac tcctaggagc cccatgggga aggaaagcat
     1861 ggtgaccttc agcaacacgc tgcccagggc caacaccccc tccgtggaag acccagtgag
     1921 aagaaatgcg agcatccatg cctctatgga ttctgcccgg tccaaacagc tccttaccca
     1981 gtggaagagc aagaatgaga gtcgtaagat gtccctacag gttatggaca ctgaaccaga
     2041 aggccagtca ccacccaggt ccatagaaat gaggtccagc tcagagccct cgagggtggg
     2101 ggtgaacgga gatcaccatg tcccgggcaa tcagtacctc aagatacagc ctggcacagt
     2161 ccccgggtgc aacaatagta tgccgggagg gccacgcgtg tccatccagt cccgccctgg
     2221 ctcttcccaa ttggtgcaca tccccgagga gacccaggaa aacataagca cctcgcccaa
     2281 gagcagttct gcgcgagcca agtggctgaa agcagctgag aagaccgtgg cctgtaaccg
     2341 gagcaacaac cagccacgca tcatgcaggt catcgccatg tccaagcagc agggcgtgct
     2401 gcagagcagc cccaagaatg ccgaaggtag cactgtcacc tgcacaggct ccatccgcta
     2461 caaaaccctg actgaccatg agcccagcgg catcgtgcga gtggaggctc atcccgagaa
     2521 caacaggccc atcattcaga tcccgtcgtc cactgagggt gaaggcagcg gctcctggaa
     2581 gtggaaagct ccggagaaaa gtagtctgcg ccaaacctat gagctcaacg acctcaacag
     2641 ggactcagaa agctgtgagt ccctcaaaga cagctttggt tctggagatc gcaaaagaag
     2701 caacatcgac agcaatgagc accaccacca cggcatcacc accatccgag tgaccccggt
     2761 ggagggcagc gagataggct cagagacgct gtccgtgtcc tcctcacgcg actccaccct
     2821 gcgcaggaag ggcaacatca tcttgatccc ggaaagaagc aacagccctg aaaacacaag
     2881 aaacatcttc tacaaaggaa cctcccccac gcgggcttat aaggattgag agatggcggc
     2941 ccttcttgtc atcattttga tgacaccccc acctccccat cccccaccct caccccaaga
     3001 ccactcgttt attgtacctt gtgctctttt gggttttttg ttttgttttg tttgggggcc
     3061 tttttttttt ccctagaaga tatggagagc cttcttgtcc aactagattg ttcaccatca
     3121 gcctggaact ctcactgaac caccacagaa atcgtggcga ttttacacca agggaaagga
     3181 aaagcacaaa gcaagacccg aactaaactc atcatcagaa cagttcttaa gacacaggct
     3241 ttgcagaagg tagtattaag ataaagtggt ttcctccgat gtatagtatt taactttctg
     3301 aatgtgccaa cttaatggag tttttttttt tcattataat tagctgtggg aacccaaaac
     3361 acataggttt tcccaacagc agaggccatg cggtattata tattattcat ttttgcagac
     3421 tctgcaccag aagagcagac tgggtggtgc tgattatcac agtgcatcta ccatttaaac
     3481 tctcaaactc tatgtagctg tgaaatagtg gtgtgcaact cctcgtcaga gaaatgctac
     3541 ttcattcaga agacgccagt gactttgtgt tagaatagac cattcttggc ttccctgtag
     3601 tggctctctc acagttgaaa agaaaagaaa agaaaagaaa aagaaaaaga aagagagaga
     3661 gagaaagaga gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     3721 aagaaagaaa gaaagaaaga aagaattgga tgaattggac agggctttga gcatttcttt
     3781 gaaagatgct ttttttcaac atctgaaagc ttgtaggaat gttttcagtg aaacagaata
     3841 actagttctc tgcatcgttt ttcttctttt tatttaagta ttggtaatgc tgctttctgg
     3901 ttttttgttt tttgttttag tgagtgcatt tgcatattta aaatacattg ttttagagaa
     3961 tattttgaaa ttattatgat tacattttcc attttatggc tttaccttag tttattaagt
     4021 tttctgaggt tacacatatt cttctatttt aagaaagcaa aagtgacaac ttgcattctt
     4081 tgtgcaaaat acactgctgt gaggtcctac actagaaatc tgagccaaag gttgaaactg
     4141 tgcgtgccaa tgccagatac gctggtcaag gtcaagatgt ctccaatccg atggcatagg
     4201 ttatcacatc agtaagtaat cccaaaattt cattttgttc cagagcattt cattttcatg
     4261 ttatcttgat aatcaccata ttggagccac agtgggggtg agtttgactc cctttcctga
     4321 cacactttta actgcacacc aacagtaaga atctaggcaa atgctaattg ataaatagat
     4381 gtgtatcaca gtataagttt agaaagcata tcttcaaaat gtcagaccag gtaaagcttt
     4441 cgtgcttaga gtataaccaa cagttttgga tgtctgtctt gaatctagaa ccttaagcct
     4501 aaatcaaagg aaaccttact gttgatagca agaagataac aacatatttt tgaagtggtt
     4561 ttccaagcta gctgtttaaa gtgtggagaa ggatttggtt cttgaaattt ggtattaacc
     4621 ttttttcatg ccatgtctta agaattataa tgtacactca acgattgcca agagaggggg
     4681 agggggagga aaacagccaa cagcagagct ggttggtctg aactcagtgc agttttcaat
     4741 gagaacaaca gctgtccagc aaggaatcat atcatccatt ctcagcttct acattcaaag
     4801 ggcagagctt tttagaaaac tcaacctcct aaggcattag gaactgagct gaaaccagca
     4861 gaattgaaaa ctctggcaat aaaatataga ctcaatcgta acccttctgg caagttcctt
     4921 ctcagagaag gaagtgggag taaaatgtgg ccttccccac ttctttacat cacccctgtc
     4981 acaatgtccc cgctggcctg gccagtttcg agagggaagg gtggactggt tttagtactc
     5041 tgaagaaaac ccaagctgca gtatttgagg tgcagtataa tatttcctaa tctttcctat
     5101 ttcttaacaa aaaaagattt taaagtactt ctctactcat tgaatttttg ttctttacat
     5161 actattgata tattcttttt ctactcaaaa gtgccaaagg ctacagtttt taatgactta
     5221 acaaattgta ccacattgtt aaggaaatat aatgatagac actagaattc agacctctgc
     5281 atgtatattt gataacacat cttttgtaaa aaataaataa ttacaaaaaa tttgtttaca
     5341 ttccacaggt accttaattt aaaataaatc agactaacag gtggtatctc ttcttagtgt
     5401 tctatttatc ttatttgcta atgagaacaa ttcttcttct gttaggctgt gctttattga
     5461 taaaaccaag tattgaataa agagagttaa ttatcttttt aaagtaaatg aaattataaa
     5521 tatataatat atataaagta ttgtgtttaa taaaatgtta tgcaatgttt tccaaactga
     5581 taaagtttgt aaagtgctat aaatgtattt tgttaagtac agatcaaagc tatcgtgtga
     5641 gtatattgtg ctaacatcat agaaataaag attagatttc ttcatcaaaa
//
