LOCUS       NM_181681               2790 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus phospholipid phosphatase related 3 (Plppr3),
            transcript variant 1, mRNA.
ACCESSION   NM_181681
VERSION     NM_181681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Gross I, Tschigor T, Salman AL, Yang F, Luo J, Vonk D, Hipp MS,
            Neidhardt J and Brauer AU.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Broggini T, Schnell L, Ghoochani A, Mateos JM, Buchfelder M,
            Wiendieck K, Schafer MK, Eyupoglu IY and Savaskan NE.
  TITLE     Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth
            inhibition and promotes functional recovery after spinal cord
            injury
  JOURNAL   Aging (Albany NY) 8 (10), 2463-2487 (2016)
   PUBMED   27744421
  REMARK    GeneRIF: PRG3 emerges as a developmental RasGRF1-dependent
            conductor of filopodia formation and axonal growth enhancer.
            PRG3-induced neurites resist brain injury-associated outgrowth
            inhibitors and contribute to functional recovery after spinal cord
            lesions.
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle
            H, Liu X, Li Y, Bottche R, Radyushkin K, Maric HM,
            Hoerder-Suabedissen A, Molnar Z, Prouvot PH, Trimbuch T, Ninnemann
            O, Huai J, Fan W, Visentin B, Sabbadini R, Stromgaard K, Stroh A,
            Luhmann HJ, Kneussel M, Nitsch R and Vogt J.
  TITLE     Precise Somatotopic Thalamocortical Axon Guidance Depends on
            LPA-Mediated PRG-2/Radixin Signaling
  JOURNAL   Neuron 92 (1), 126-142 (2016)
   PUBMED   27641493
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S,
            Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ,
            Jones AR, Amaral DG, Sestan N, Gage FH and Lein ES.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Yaguchi H, Okumura F, Takahashi H, Kano T, Kameda H, Uchigashima M,
            Tanaka S, Watanabe M, Sasaki H and Hatakeyama S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Brauer AU, Savaskan NE, Kuhn H, Prehn S, Ninnemann O and Nitsch R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF541278.1 and BC066006.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_181681.3.
            
            On Jan 15, 2010 this sequence version replaced NM_181681.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF541278.1, SRR1660811.16121.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AF541278.1         1-405
            406-2790            BC066006.1         1-2385
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10"
     gene            1..2790
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /note="phospholipid phosphatase related 3"
                     /db_xref="GeneID:216152"
                     /db_xref="MGI:MGI:2388640"
     exon            1..615
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..2691
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /EC_number="3.1.3.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     plasticity related gene 2; PRG-2; plasticity-related gene
                     2 protein; lipid phosphate phosphatase-related protein
                     type 3; phospholipid phosphatase-related protein type 3;
                     inactive phospholipid phosphatase PLPPR3"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 3
                     isoform 1"
                     /protein_id="NP_859009.2"
                     /db_xref="CCDS:CCDS35971.1"
                     /db_xref="GeneID:216152"
                     /db_xref="MGI:MGI:2388640"
                     /translation="MLAMKEKNKTPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDL
                     FKPAKVGFQCYDRALSMPYVETNEELIPLLMLLSLAFAAPAASIMVGEGMVYCLQSRL
                     WGRGPGGVEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFF
                     LTVCKPNYTLLGTSCESNPYITQDICSGHDTHAILSARKTFPSQHATLSAFAAVYVSM
                     YFNAVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLA
                     CHAVGNFQAPPAEKVPTPAPAKDALRALTQRGHESMYQQNKSVSTDELGPPGRLEGVP
                     RPVAREKTSLGSLKRASVDVDLLAPRSPMGKEGMVTFSNTLPRVSTPSLDDPARRHMT
                     IHVPLDASRSRQLIGEWKQKSLEGRGLGLPDEASPVHLRAPAEQVAEEEEEEEEEEEE
                     EEEEEEEEGPVPPSLYPTVQARPGLGPRVILPPRPGPQPLVHIPEEGVQAGAGLSPKS
                     SSSSVRAKWLSMAEKGGGPVAVAPSQPRVANPPRLLQVIAMSKAAGGPKAETASSSSA
                     SSDSSQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGSTPWEWKAKVVEGEGSYELGDL
                     ARGFRSSCKQPGMGPGSPVSDVDQEEPRFGAVATVNLATGEGLPPPGASEGALGAGSR
                     ESTLRRQVGGLAEREVEAEAESYYRRMQARRYQD"
     exon            616..801
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..937
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1133
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1191
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1365
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..2766
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggggc gcgggatctc gccttcccca cactgcgccg cgcgctccta ggtcccggag
       61 atcaaccgtg ctcgcgcaag gcgcacagaa ggcacgcgca aggggcaggg acgagaccca
      121 gattgcggtc cccgcgcagg gccagagacc ctgagacccg cagagtggga ggcggaggcg
      181 cccaagccgg gggcggggtt ggggcggggc cgagcgggct gcagagcgcg cagacaaaga
      241 gctcacgcgc cgcacaccgc gcccgggcct cgcgtccctc ccacgcgggg accctggctt
      301 tgtgtccgcg ctttgcaagg gactccgccc tccttgctcc ctccaggtga acgagccgcg
      361 tgcgcgcgcg ggggctccgg cctctccctt ccccaagttc cccctctgct ccagcctcag
      421 tttccccgag ccctcttggc taacccttat ctccccacct ggagactcca tctgcgcagc
      481 tcctagtctc cagcctgcct ttgtccccct gcaatctcgg cctacagcgc caacgtcacc
      541 atgcttgcta tgaaggagaa gaataaaacg ccgaaggaca gcatgacact cctgccttgc
      601 ttttatttcg tggagctacc catcgtggct tcctccattg tgtctctgta cttcctggag
      661 ctgactgacc tgttcaagcc ggccaaggtg ggctttcagt gctacgaccg cgccctgtcc
      721 atgccctatg tggagacaaa tgaagagctg atcccattgc tcatgctgct gagcctggcc
      781 ttcgctgcac ctgcggcctc aatcatggtc ggcgagggca tggtctactg tctgcagtcc
      841 aggctctggg gccgtggtcc agggggcgtg gagggcagca tcaacgctgg tggctgcaac
      901 ttcaactcct tcctccggcg cacagtgcgc tttgtgggtg tacacgtgtt tggcctgtgt
      961 gccacggctc tggtgacaga tgtcatccag ctggccaccg gctaccacac acctttcttc
     1021 ttaacggtct gcaaacccaa ttacaccctg ctgggcactt cctgtgagtc gaacccttac
     1081 atcacacagg acatctgctc tggccacgat acccatgcca tcctgtcagc aaggaagacc
     1141 ttcccgtccc agcacgccac tctgtcagcc tttgctgctg tctacgtgtc gatgtacttc
     1201 aacgcggtta tctcggacac cacgaagctg ctgaagccca tccttgtgtt tgccttcgcc
     1261 attgctgcgg gcgtctgcgg cctcacacag atcacccagt atcgaagcca ccctgtggac
     1321 gtctacgctg gctttcttat cggtgctggc atcgctgcct acctggcctg ccacgctgtg
     1381 ggcaacttcc aggcaccacc tgcagaaaag gttcctaccc cagctcctgc caaggacgcc
     1441 ctgcgagcgc tgacacagcg gggccatgag tccatgtatc agcagaataa gtctgtcagt
     1501 accgatgagc tgggccctcc agggaggcta gagggcgtgc ctcggcctgt ggctcgagag
     1561 aagacatctc ttggcagcct gaagcgagcc agcgtggatg tggacctgct ggccccacgt
     1621 agccccatgg gcaaagaagg catggtcacc ttcagcaaca cactgccccg ggtcagcacg
     1681 ccctcgctgg atgaccctgc acggcgccac atgactatcc acgtgcccct tgatgcctcc
     1741 cgttccaggc agcttatcgg tgagtggaag caaaaatccc tggagggacg tggcctgggt
     1801 ctgcctgatg aagccagccc tgtgcatctg agggccccag cagagcaggt agcagaggag
     1861 gaagaggaag aggaggagga ggaggaagaa gaggaggaag aggaggaaga ggaagggcct
     1921 gttccaccct cactctaccc tactgtccag gctcggccag gccttgggcc ccgagtcatc
     1981 ctgcctccaa ggccagggcc ccagcccctc gtacacatcc ctgaggaagg cgttcaggct
     2041 ggagctggcc tgtcacccaa gagcagcagc tcatcagtga gggccaagtg gctgtcaatg
     2101 gctgagaagg gtgggggccc agtggctgtg gctccatccc agccccgggt ggccaaccca
     2161 cccaggctac tacaggtcat cgctatgtcc aaggcggcag ggggccccaa ggctgagaca
     2221 gcttcgtcct ccagtgccag ctccgactct tcccagtaca ggtccccgtc agaccgtgac
     2281 tctgccagca ttgttacaat cgatgcccat gcacctcacc atccagtggt gcacctgtct
     2341 gctggcagca caccctggga gtggaaggct aaagtagtgg agggtgaggg tagctatgag
     2401 ctgggggacc tggcacgcgg cttcagaagc agctgtaaac agcctggaat gggcccgggg
     2461 tctccagtca gtgatgtgga ccaggaagaa ccccggtttg gggcagtggc cactgtcaac
     2521 ctggccactg gggagggtct gcccccacca ggtgcaagtg aaggggccct aggtgcaggc
     2581 agcagagaat ccaccctaag gcgccaggtg ggcgggctgg cagagagaga agtggaggct
     2641 gaggcagaaa gttattatag gaggatgcag gccaggaggt accaggacta agcctggcaa
     2701 aactgtgatg gggattaggg gagctggggg tgtctacagc cccaccaata aaaacttatg
     2761 ctattaaaaa aaaaaaaaaa aaaaaaaaaa
//
