LOCUS       NP_859009                716 aa            linear   ROD 01-MAY-2025
DEFINITION  phospholipid phosphatase-related protein type 3 isoform 1 [Mus
            musculus].
ACCESSION   NP_859009
VERSION     NP_859009.2
DBSOURCE    REFSEQ: accession NM_181681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 716)
  AUTHORS   Gross,I., Tschigor,T., Salman,A.L., Yang,F., Luo,J., Vonk,D.,
            Hipp,M.S., Neidhardt,J. and Brauer,A.U.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   2  (residues 1 to 716)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 716)
  AUTHORS   Broggini,T., Schnell,L., Ghoochani,A., Mateos,J.M., Buchfelder,M.,
            Wiendieck,K., Schafer,M.K., Eyupoglu,I.Y. and Savaskan,N.E.
  TITLE     Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth
            inhibition and promotes functional recovery after spinal cord
            injury
  JOURNAL   Aging (Albany NY) 8 (10), 2463-2487 (2016)
   PUBMED   27744421
  REMARK    GeneRIF: PRG3 emerges as a developmental RasGRF1-dependent
            conductor of filopodia formation and axonal growth enhancer.
            PRG3-induced neurites resist brain injury-associated outgrowth
            inhibitors and contribute to functional recovery after spinal cord
            lesions.
REFERENCE   4  (residues 1 to 716)
  AUTHORS   Cheng,J., Sahani,S., Hausrat,T.J., Yang,J.W., Ji,H.,
            Schmarowski,N., Endle,H., Liu,X., Li,Y., Bottche,R., Radyushkin,K.,
            Maric,H.M., Hoerder-Suabedissen,A., Molnar,Z., Prouvot,P.H.,
            Trimbuch,T., Ninnemann,O., Huai,J., Fan,W., Visentin,B.,
            Sabbadini,R., Stromgaard,K., Stroh,A., Luhmann,H.J., Kneussel,M.,
            Nitsch,R. and Vogt,J.
  TITLE     Precise Somatotopic Thalamocortical Axon Guidance Depends on
            LPA-Mediated PRG-2/Radixin Signaling
  JOURNAL   Neuron 92 (1), 126-142 (2016)
   PUBMED   27641493
REFERENCE   5  (residues 1 to 716)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (residues 1 to 716)
  AUTHORS   Yaguchi,H., Okumura,F., Takahashi,H., Kano,T., Kameda,H.,
            Uchigashima,M., Tanaka,S., Watanabe,M., Sasaki,H. and Hatakeyama,S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
REFERENCE   7  (residues 1 to 716)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151846.3.
            
            On Jan 15, 2010 this sequence version replaced NP_859009.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF541278.1, BC066006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     Protein         1..716
                     /product="phospholipid phosphatase-related protein type 3
                     isoform 1"
                     /EC_number="3.1.3.4"
                     /note="plasticity related gene 2; PRG-2;
                     plasticity-related gene 2 protein; lipid phosphate
                     phosphatase-related protein type 3; phospholipid
                     phosphatase-related protein type 3; inactive phospholipid
                     phosphatase PLPPR3"
                     /calculated_mol_wt=76594
     Site            18..38
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            70..90
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          127..276
                     /region_name="PAP2_wunen"
                     /note="PAP2, wunen subfamily. Most likely a family of
                     membrane associated phosphatidic acid phosphatases. Wunen
                     is a drosophila protein expressed in the central nervous
                     system, which provides repellent activity towards
                     primordial germ cells (PGCs), controls the...; cd03384"
                     /db_xref="CDD:239479"
     Site            131..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            order(150,157,203..205,250,256,260)
                     /site_type="active"
                     /db_xref="CDD:239479"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            205..225
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            231..251
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            261..281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          311..335
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            316
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            351
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          416..515
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            426
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            505
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          548..589
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          630..651
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TPB0.1)"
     Region          663..693
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPB0.1)"
     CDS             1..716
                     /gene="Plppr3"
                     /gene_synonym="Lppr3; Prg2"
                     /coded_by="NM_181681.3:485..2635"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35971.1"
                     /db_xref="GeneID:216152"
                     /db_xref="MGI:MGI:2388640"
ORIGIN      
        1 mlamkeknkt pkdsmtllpc fyfvelpiva ssivslyfle ltdlfkpakv gfqcydrals
       61 mpyvetneel ipllmllsla faapaasimv gegmvyclqs rlwgrgpggv egsinaggcn
      121 fnsflrrtvr fvgvhvfglc atalvtdviq latgyhtpff ltvckpnytl lgtscesnpy
      181 itqdicsghd thailsarkt fpsqhatlsa faavyvsmyf navisdttkl lkpilvfafa
      241 iaagvcgltq itqyrshpvd vyagfligag iaaylachav gnfqappaek vptpapakda
      301 lraltqrghe smyqqnksvs tdelgppgrl egvprpvare ktslgslkra svdvdllapr
      361 spmgkegmvt fsntlprvst pslddparrh mtihvpldas rsrqligewk qkslegrglg
      421 lpdeaspvhl rapaeqvaee eeeeeeeeee eeeeeeeegp vppslyptvq arpglgprvi
      481 lpprpgpqpl vhipeegvqa gaglspksss ssvrakwlsm aekgggpvav apsqprvanp
      541 prllqviams kaaggpkaet assssassds sqyrspsdrd sasivtidah aphhpvvhls
      601 agstpwewka kvvegegsye lgdlargfrs sckqpgmgpg spvsdvdqee prfgavatvn
      661 latgeglppp gasegalgag srestlrrqv gglaerevea eaesyyrrmq arryqd
//
