LOCUS       NM_001290299            2669 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase related 2 (Plppr2),
            transcript variant 2, mRNA.
ACCESSION   NM_001290299 XM_006510186
VERSION     NM_001290299.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Gross,I., Tschigor,T., Salman,A.L., Yang,F., Luo,J., Vonk,D.,
            Hipp,M.S., Neidhardt,J. and Brauer,A.U.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Amano,K., Densmore,M.J. and Lanske,B.
  TITLE     Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results
            in Complete Loss of Growth Plate Formation but Allows Mature
            Osteoblast Differentiation
  JOURNAL   J Bone Miner Res 30 (12), 2262-2272 (2015)
   PUBMED   26094741
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Schierloh,A., Deussing,J., Wurst,W., Zieglgansberger,W. and
            Rammes,G.
  TITLE     Corticotropin-releasing factor (CRF) receptor type 1-dependent
            modulation of synaptic plasticity
  JOURNAL   Neurosci Lett 416 (1), 82-86 (2007)
   PUBMED   17316992
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Savaskan,N.E., Brauer,A.U. and Nitsch,R.
  TITLE     Molecular cloning and expression regulation of PRG-3, a new member
            of the plasticity-related gene family
  JOURNAL   Eur J Neurosci 19 (1), 212-220 (2004)
   PUBMED   14750979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX122376.1, AK082453.1 and AY438023.1.
            
            On Mar 9, 2014 this sequence version replaced XM_006510186.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the central coding region, which results in a frameshift,
            compared to variant 1. The encoded isoform (2) has a longer and
            distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023082.1, AK082453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CX122376.1         1-38
            39-2645             AK082453.1         2-2608
            2646-2669           AY438023.1         2602-2625
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.92 cM"
     gene            1..2669
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /note="phospholipid phosphatase related 2"
                     /db_xref="GeneID:235044"
                     /db_xref="MGI:MGI:2384575"
     exon            1..149
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            150..319
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            320..399
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1692
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /EC_number="3.1.3.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     plasticity-related gene 4 protein; lipid phosphate
                     phosphatase-related protein type 2; phospholipid
                     phosphatase-related protein type 2; inactive phospholipid
                     phosphatase PLPPR2"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 2
                     isoform 2"
                     /protein_id="NP_001277228.1"
                     /db_xref="CCDS:CCDS72203.1"
                     /db_xref="GeneID:235044"
                     /db_xref="MGI:MGI:2384575"
                     /translation="MAGGRPHLKRSFSIIPCFVFVESVLLGIVVLLAYRLEFTDTFPV
                     HTQGFFCYDSAYAKPYPGPEAASRAPPALIYALVTAGPTLTILLGELARAFFPAPPSS
                     SPVSGESTIVSGACCRFSPPLRRLVRFLGVYSFGLFTTTIFANAGQVVTGNPTPHFLS
                     VCRPNYTALGCPPPSPDRPGPDRFVTDQSACAGSPSLVAAARRAFPCKDAALCAYAVT
                     YTAMYVTLVFRVKGSRLVKPSLCLALLCPAFLVGVVRVAEYRNHWSDVLAGFLTGAAI
                     ATFLVTCVVHNFQSRPHSGRRLSPWEDLSQAPTMDSPLEKLSVAQEPETCRPHSTPAR
                     LTPSKPQNCARRGHLIPSCVSSRAPAMCSSPRVPRPRLRSEPTPLPLPLPLPAPTPSQ
                     GPSPSSPGPGGPGGGGGRGRKLLLPTPLLRDLYTLSGLHPSPFHRDNFSPYLFASRDH
                     LL"
     exon            400..588
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            589..724
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..996
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1173
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1296
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1348
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..2652
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /note="hexamer: AATAAA"
     polyA_site      2652
                     /gene="Plppr2"
                     /gene_synonym="Lppr2; PRG-4"
                     /note="major polyA site"
ORIGIN      
        1 cgatcacgga gtctgcgcgg agcggcaagt ccggcggtcc agacttcatc tcggtgtccg
       61 cctgcctgac cagcgatcta tctgactgtt ctacggcgcc gggaccgtgt agagggagcg
      121 agggttcagg cggcggcggc ctagacaggg cctcaatgga gccctggatg cacagtaccc
      181 accttcatct gcctgggcct cagtttccac atccgtgcaa tggagatgaa tgttcttgcc
      241 ttgctggcct cacggagtgg ctgtgagttg gtggcagtgg aggtggatgc ctggaagaag
      301 ccctagggct ctttcacagg ccccagcttc gccatggctg gagggagacc tcacctgaag
      361 cggagtttct ctatcatccc ttgcttcgtc tttgtggagt ctgtgttgct aggcatcgtg
      421 gtccttcttg cgtaccgcct ggagttcacg gacaccttcc ctgtgcacac ccagggcttc
      481 ttctgctatg acagcgctta tgccaagccg tatcccgggc ctgaggctgc cagccgagcg
      541 ccccctgccc tcatctatgc cttggtcact gctgggccca ccctcacgat cctgctgggg
      601 gagctggccc gtgccttctt ccctgcgcca ccctcctcca gtcctgtcag tggggagagc
      661 accatcgtgt ccggggcctg ctgccgcttc agtcccccac tgaggaggct ggtccgtttc
      721 ctgggggtgt actcttttgg cctcttcacc acgaccattt ttgcaaatgc gggacaagtg
      781 gtgaccggta accccacacc tcacttcctg tcggtgtgtc gccccaacta cacggccctg
      841 ggctgcccac caccgtctcc tgaccggcca gggcctgacc gcttcgtcac ggaccagagc
      901 gcctgtgcag gcagtcccag cttggtggcc gccgcacgcc gcgcctttcc ctgcaaggat
      961 gcggccctgt gcgcctacgc tgtcacctat actgcgatgt acgtgaccct agtgttccgc
     1021 gtgaagggct ctcgcctggt gaaaccttcc ctctgcctgg ccctgctgtg ccccgccttc
     1081 ctggtgggcg tggtccgcgt ggcggagtat cgcaaccatt ggtcggacgt gctggctggc
     1141 tttctgacgg gagcagccat cgccaccttt ttggtcacct gtgttgtgca caatttccag
     1201 agccgacccc actctggtcg aaggctctcc ccctgggagg acctgagcca ggcccccacc
     1261 atggacagcc ccctcgaaaa gttaagtgtg gctcaggaac ccgagacctg caggccgcat
     1321 tcgacaccgg cacggctcac cccatccaag ccgcagaact gtgcccgccg tggccacctg
     1381 attcccagct gtgtgtcctc cagggcgcca gctatgtgct cctcgccccg tgtgccccgc
     1441 cctcgactga ggtctgagcc aacacccctg cctctgccgc tgcctcttcc tgcaccgact
     1501 cccagtcagg gtccctcgcc ttcctcccct ggacccgggg gcccaggcgg gggaggtggg
     1561 cggggccgga agctgctgct gcccacgccc ctgctaaggg acctgtacac cctcagtgga
     1621 ctccatccct cccctttcca ccgcgacaac ttcagccctt atctgtttgc cagccgcgac
     1681 cacctgctgt gagatccacc acctagaatc tacccagtga ccgtttcccc cctgccacgc
     1741 gtgtgtgtgg catgtgagtg ctaaaggccc ctgccctcca aaccagccag gcccacccag
     1801 cgtcagaaga tggctggaag ggacgcttca aggcagggaa tctcttggct gctctttggc
     1861 cttttgggat atctgggtag gcaaaaataa ccaggtgggc ccatgtcccc aggatttccc
     1921 ttttaacggc tgatgcttga cctaattgac cattgcctag ccagtgagag ctctgagtta
     1981 tcagaattca acccaaaagt ttacaaaagt ttatgggaac ctctcacttc ttagcttcct
     2041 caagcaggag ggtgctactg tggccggtgt tcaagtgtct aaacagccaa taagagccct
     2101 tggcgttcag aattgcagag agtgggtggg aatgattcca gtcaatgggg gaccgcccgt
     2161 gtcaaagcca agtcaaagcc aaggagggct atccagctct cctcgggaac acggaatcca
     2221 gctggagagg gggggggcag gctcccccac agcagagtcc tgcggcaccc cttcccttct
     2281 agaccttccc ccaggtgcac catctcacac cctccaactc cctacttaag tagggcttgc
     2341 cccagttcac aggttttaga attctggacg ctgtctccct tggctgtgcc tagggcacct
     2401 ccccccactc cccgccaaac cttctattat tactagggct gtggaaaatg actttatttt
     2461 ctcgggaccc acccttcttc ttcacactgc ccccatgcct cagtctcatg cagttgtgcc
     2521 atcttggggg gcatgggtgg agcagaaggg ggttccccta ccctgaatag ccaaaggcag
     2581 tgggcagatg agacactgtc cccctttcct gcccccctcc tcatctttaa taaagacctg
     2641 tttgtaacag aaaaaaaaaa aaaaaaaaa
//
