LOCUS       NM_178756               3762 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase related 1 (Plppr1), mRNA.
ACCESSION   NM_178756 XM_977213
VERSION     NM_178756.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3762)
  AUTHORS   Gross,I., Tschigor,T., Salman,A.L., Yang,F., Luo,J., Vonk,D.,
            Hipp,M.S., Neidhardt,J. and Brauer,A.U.
  TITLE     Systematic expression analysis of plasticity-related genes in mouse
            brain development brings PRG4 into play
  JOURNAL   Dev Dyn 251 (4), 714-728 (2022)
   PUBMED   34622503
REFERENCE   2  (bases 1 to 3762)
  AUTHORS   Agbaegbu Iweka,C., Hussein,R.K., Yu,P., Katagiri,Y. and Geller,H.M.
  TITLE     The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1
            to modulate RhoA activation in response to axon growth inhibitory
            molecules
  JOURNAL   J Neurochem 157 (3), 494-507 (2021)
   PUBMED   33320336
  REMARK    GeneRIF: The lipid phosphatase-like protein PLPPR1 associates with
            RhoGDI1 to modulate RhoA activation in response to axon growth
            inhibitory molecules.
REFERENCE   3  (bases 1 to 3762)
  AUTHORS   Tilve,S., Iweka,C.A., Bao,J., Hawken,N., Mencio,C.P. and
            Geller,H.M.
  TITLE     Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion
            through modulation of Rac1 activity
  JOURNAL   Exp Cell Res 389 (2), 111911 (2020)
   PUBMED   32061832
  REMARK    GeneRIF: Phospholipid phosphatase related 1 (PLPPR1) increases cell
            adhesion through modulation of Rac1 activity.
REFERENCE   4  (bases 1 to 3762)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 3762)
  AUTHORS   Velmans,T., Battefeld,A., Geist,B., Farres,A.S., Strauss,U. and
            Brauer,A.U.
  TITLE     Plasticity-related gene 3 promotes neurite shaft protrusion
  JOURNAL   BMC Neurosci 14, 36 (2013)
   PUBMED   23506325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3762)
  AUTHORS   Wang,W.Z. and Molnar,Z.
  TITLE     Dynamic pattern of mRNA expression of plasticity-related gene-3
            (PRG-3) in the mouse cerebral cortex during development
  JOURNAL   Brain Res Bull 66 (4-6), 454-460 (2005)
   PUBMED   16144631
  REMARK    GeneRIF: This study demonstrated that plasticity-related gene-3
            (PRG-3) is differentially expressed between the dorsal and lateral
            cortex at P6.
REFERENCE   7  (bases 1 to 3762)
  AUTHORS   Savaskan,N.E., Brauer,A.U. and Nitsch,R.
  TITLE     Molecular cloning and expression regulation of PRG-3, a new member
            of the plasticity-related gene family
  JOURNAL   Eur J Neurosci 19 (1), 212-220 (2004)
   PUBMED   14750979
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL691417.10,
            AL928612.7, AL808138.27 and BX537352.18.
            
            On Jun 21, 2007 this sequence version replaced NM_178756.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087514.1, AY345342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL691417.10        49565-49720
            157-264             AL928612.7         5499-5606
            265-453             AL808138.27        35448-35636
            454-586             AL808138.27        54113-54245
            587-837             AL808138.27        72953-73203
            838-1014            AL808138.27        76540-76716
            1015-1146           AL808138.27        78811-78942
            1147-3762           BX537352.18        8133-10748
FEATURES             Location/Qualifiers
     source          1..3762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.27 cM"
     gene            1..3762
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /note="phospholipid phosphatase related 1"
                     /db_xref="GeneID:272031"
                     /db_xref="MGI:MGI:2445015"
     exon            1..156
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            157..264
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1179
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /note="plasticity-related protein 3; plasticity-related
                     gene 3 protein; lipid phosphate phosphatase-related
                     protein type 1; inactive 2-lysophosphatidate phosphatase
                     PLPPR1"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 1"
                     /protein_id="NP_848871.1"
                     /db_xref="CCDS:CCDS18170.1"
                     /db_xref="GeneID:272031"
                     /db_xref="MGI:MGI:2445015"
                     /translation="MAVENNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVH
                     IQGFFCQDGDLMKPYPGTEEESFISPLVLYCVLAATPTAIIFIGEISMYFIKSTRESL
                     IAEEKMILTGDCCYLSPLLRRIIRFIGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVC
                     QPNYTSTDCRAHQQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITST
                     IKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVV
                     HNFRGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT"
     exon            265..453
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            454..586
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..837
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1014
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1146
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..3762
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /note="hexamer: AATAAA"
     polyA_site      1552
                     /gene="Plppr1"
                     /gene_synonym="E130309F12Rik; Lppr1; mKIAA4247; PRG-3"
                     /note="major polyA site"
ORIGIN      
        1 atacgcccgt gccgcgcgct cgcccgctcg ctctcccacg caagcggaat gcagcagcgc
       61 ctgaggagct cgtctgcagc cgctgcctga atgcacctcg ccgcctgcag tccgtccgcc
      121 caatagggcg caaggaagga agcttggccg ccaaagcctg gacagtttct gacagtgcag
      181 tctcaccaca tgatttgaga aatggctgta gaaaacaaca ctcaacgcag ttactccatc
      241 attccatgtt ttatatttgt tgagcttgtc atcatggctg ggaccgtgct gcttgcctac
      301 tacttcgaat gcactgacac ctttcaggtg catatccaag gattcttctg tcaggacgga
      361 gacttaatga agccttaccc ggggacagag gaggaaagtt tcatcagccc tctggtgctc
      421 tactgcgttc tggctgccac tccaactgct attattttca ttggtgaaat atccatgtat
      481 ttcataaagt caacaaggga gtccctgatt gctgaggaga aaatgatcct gacaggggac
      541 tgctgctacc tgagcccctt actccgaagg atcatcaggt tcatcggggt atttgcattt
      601 ggactttttg ctactgacat ttttgtaaac gcggggcaag tcgtcactgg tcacctaaca
      661 ccatacttcc tgacagtgtg ccagccaaac tataccagta cagactgccg ggcacaccaa
      721 cagttcatca acaatggcaa catctgcact ggggacctgg aagtgataga aaaagctcgg
      781 aggtcctttc cctccaaaca tgctgctctg agcatttact ccgccttata tgccacgatg
      841 tacatcacaa gcacaatcaa gacgaagagc agtcggctgg ccaagccagt gctgtgcttg
      901 gggaccctct gtaccgcctt cctgacaggc ctcaaccgcg tctcagagta ccggaaccac
      961 tgttccgacg tgatcgccgg cttcatcctg ggcaccgcag tggccctgtt tttgggaatg
     1021 tgtgtggttc ataacttcag aggaacccaa ggctctcctt ccaaacccaa acccgaggat
     1081 ccccgcggag ttcccctgat ggctttccca aggatagaga gcccgctgga aaccttaagt
     1141 gcacagaatc actccgcctc catgaccgaa gtcacctgag atgaatgaag acatgcagct
     1201 gtttagggat tgtttggttt ttgttttgtt ttttttccag caaccttcca gttcaattct
     1261 tcaaaacaca cagatactca agtcaaactg tgaagacaag tattacattt gtctagttag
     1321 aggctaatgt tttgtacatt ttttgtatga agaagtgatg tagcttgccc tgatcttttt
     1381 ttgtcagctt taatatattt atgccagatt tttaaaacca acaaaatttt cctgttgttc
     1441 aagtgtgcat tgaagaatca catttatcca atggttgacg ttgttttgtg atatttgtac
     1501 acaaattttt ctcagtttta tagacacaaa taaagcaaac aacccacttt aaccctttat
     1561 taccacagtt gctgcctcct ccagaagttt tgaattttaa tggaagttaa acttttgagt
     1621 tacaggaagg accgtggtgg ttaattgtaa atctcaaagt caatcgtgga aaaaaaaata
     1681 ttggaagaga acattgtgtt ctgctttgta aatagttgac tgcattccca gttaaagcaa
     1741 caggggcata ctagtgaaga gttctagttg cccaactatt ggcacagaag cctatatttg
     1801 gaggaagagt actttggtta tatgatgctt tcttagataa tggcctcgcc atcctacaga
     1861 gcacaaggtc agtctgggat tctgaccttg ggcaggtgac accgtggcct actatccaag
     1921 agagcagcaa gcaccagcct ttcctgtcaa ctcaacagtt ttgtatatca tattgtatgg
     1981 actttttatg aaaaagaata ttttacagtt tgcacagtat tattttacag aaaggctatc
     2041 agagcatcta catgtagagc ccagagcaac ggcttcacta tggggctttt aactgttctt
     2101 agattttaac tgcatcccat tttttctagc atggtgataa tgtgtccctc ctttgggaga
     2161 aggagttccc tttctgtatc tatcaaaatg tttctcaccc ttgtcaggtc ttcttagctt
     2221 tttttgtaca tatttttttt tctaaagaga agaaaaaaaa agttatcaca aaatgtagtc
     2281 tggctcctgt gctctgtgtt tcatttcagt tggcggtgtt tgaagaactg tggagtgtct
     2341 gtgcttctca gtccatgaga gaggggatta gatgaaccat taaacagggg catgctgaaa
     2401 ggtcattcag agtaagcaga cagaagcagg gggcgaagga atgactgtac acaaataggc
     2461 atacatatgt gttaaaataa ggtgaaagaa ttccttcatt tattaagata ctcaaatcaa
     2521 atgcattttc tggattctta gtgtgatgcc atagtcttca acctgttctg aaatttccaa
     2581 gttttcagta aacaattagt cttttttttt ttttaggaac aaaagtcacc tctgataaaa
     2641 ctttcctggg agtttcctga actgtactca tacacatgtt ctaagtagta tctgactaaa
     2701 gtcagagaaa agagctgtta aggctctgtt catcacaagt gttaaccacc tgccctcaca
     2761 tatataatgc atctgttgtt ttcagggcaa tgaacccagg gagggatata aactctaaaa
     2821 cactgtgaca tacactagtt ccaacatctt ggtcgagctc tgccccattc ttatttctat
     2881 ttctgttaca tgatgcctct gaatcaagtt tagcccttct tggtgtgatg tgtctactga
     2941 gatggttcat ggatgctaca gacaaaagga agtcccagga aagaatgatt tgtagactct
     3001 gagctctgtc ttctgtcctg tatgctaagt gtgaagtcat ccagtgtctg ggcgacacat
     3061 tttatttact taaacacatg gtatttttaa agaaaattag taatgggctc tctttagttt
     3121 acttttccta aaacatcaga aatgagggta gacaaaattg atgtttatta cctacttcat
     3181 gtcacacgta gttatcagct tttcttgtca ccaaattgta ttttgaagaa aaatcaagtc
     3241 aacaacacgg atcactacct ttgaactcct cttttctagg tttgattctg ggaagatcac
     3301 ttgttacttc aaaatctgtg gtcacagact ctgcttccat agcccagggt gtatagggta
     3361 ttctctggca agctatgctc tatatcagtt acaactgagg gatttctttc tgttctgttc
     3421 cctggatctc tgagttagtc taccctctgc attatgccac tttaataaag cctctgcgta
     3481 cccttaagat attcagtggc ctcaggttga gggtaaacct tccaatctag catgtgagat
     3541 tcattcctca ggtttggatg tccctacttg gtttttctga caaagacaaa gctttttgtt
     3601 caaacaggac aaataatgac tataacctaa gagaaataaa ttctggagtg aatgctgttc
     3661 ctctttttta gtggattgca gaaatgcctg agaaagtctg gcttgctgtg gaaagggatt
     3721 ggaaaggaac aagacgaata aagtgttttg attttatgcc ac
//
