LOCUS       NM_145521               1942 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase 7 (inactive) (Plpp7),
            transcript variant 1, mRNA.
ACCESSION   NM_145521
VERSION     NM_145521.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Zhang,Y., Ramirez-Martinez,A., Chen,K., McAnally,J.R., Cai,C.,
            Durbacz,M.Z., Chemello,F., Wang,Z., Xu,L., Bassel-Duby,R., Liu,N.
            and Olson,E.N.
  TITLE     Net39 protects muscle nuclei from mechanical stress during the
            pathogenesis of Emery-Dreifuss muscular dystrophy
  JOURNAL   J Clin Invest 133 (13), e163333 (2023)
   PUBMED   37395273
  REMARK    GeneRIF: Net39 protects muscle nuclei from mechanical stress during
            the pathogenesis of Emery-Dreifuss muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Ramirez-Martinez,A., Zhang,Y., Chen,K., Kim,J., Cenik,B.K.,
            McAnally,J.R., Cai,C., Shelton,J.M., Huang,J., Brennan,A.,
            Evers,B.M., Mammen,P.P.A., Xu,L., Bassel-Duby,R., Liu,N. and
            Olson,E.N.
  TITLE     The nuclear envelope protein Net39 is essential for muscle nuclear
            integrity and chromatin organization
  JOURNAL   Nat Commun 12 (1), 690 (2021)
   PUBMED   33514739
  REMARK    GeneRIF: The nuclear envelope protein Net39 is essential for muscle
            nuclear integrity and chromatin organization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Robson,M.I., de Las Heras,J.I., Czapiewski,R., Le Thanh,P.,
            Booth,D.G., Kelly,D.A., Webb,S., Kerr,A.R.W. and Schirmer,E.C.
  TITLE     Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane
            Proteins Enhances Repression of Critical Developmental Genes during
            Myogenesis
  JOURNAL   Mol Cell 62 (6), 834-847 (2016)
   PUBMED   27264872
  REMARK    GeneRIF: Three muscle-specific nuclear membrane proteins, NET39,
            Tmem38A, and WFS1, direct specific myogenic genes to the nuclear
            periphery to facilitate their repression during myogenesis.
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Liu,G.H., Guan,T., Datta,K., Coppinger,J., Yates,J. 3rd and
            Gerace,L.
  TITLE     Regulation of myoblast differentiation by the nuclear envelope
            protein NET39
  JOURNAL   Mol Cell Biol 29 (21), 5800-5812 (2009)
   PUBMED   19704009
  REMARK    GeneRIF: The nuclear lamina-associated nuclear envelope
            transmembrane protein NET39 (Ppapdc3) functions as a negative
            regulator of myoblast differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134638.1 and AK052883.1.
            
            On Sep 20, 2017 this sequence version replaced NM_145521.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016136.1, AK134638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1156              AK134638.1         2-1157
            1157-1942           AK052883.1         1035-1820
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.02 cM"
     gene            1..1942
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /note="phospholipid phosphatase 7 (inactive)"
                     /db_xref="GeneID:227721"
                     /db_xref="MGI:MGI:2445183"
     exon            1..735
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1100
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /EC_number="3.1.3.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable lipid phosphate phosphatase PPAPDC3; nuclear
                     envelope transmembrane protein 39; phosphatidic acid
                     phosphatase type 2 domain-containing protein 3;
                     phosphatidic acid phosphatase type 2 domain containing 3;
                     inactive phospholipid phosphatase 7"
                     /codon_start=1
                     /product="inactive phospholipid phosphatase 7 isoform 1"
                     /protein_id="NP_663496.1"
                     /db_xref="CCDS:CCDS15906.1"
                     /db_xref="GeneID:227721"
                     /db_xref="MGI:MGI:2445183"
                     /translation="MPASQSRARARDRNNVLNRAEFLSLNQPPKGTQEPRSSGRKASG
                     PSTQPPPSSDGARERRQSQQLPEEDCMQLNPSFKGIAFNSLLAIDICMSKRLGVCAGR
                     AASWASARSMVKLIGITGHGIPWIGGTILCLVRSSTLAGQEVLMNLLLALLLDIMTVA
                     GVQKLIKRRGPYETSPGLLDYLTMDIYAFPAGHASRAAMVSKFFLSHLVLAVPLRVLL
                     VLWAFCVGLSRVMIGRHHITDVISGFIIGYFQFRLVELVWMSSNTCQMLISAW"
     exon            736..1942
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /note="hexamer: AATACA"
     polyA_site      1942
                     /gene="Plpp7"
                     /gene_synonym="D830019K17Rik; NET39; Ppapdc3"
                     /note="major polyA site"
ORIGIN      
        1 agatttaaat agcccaggcc cgaggcagcc aggcctcagc tgtggattca tctgcctgtc
       61 cgtggctcta ttggcgctgg ccctgtaagg gtgggctcta ttgactgccc agctgtcatt
      121 gacgtcccca acggagccgg gtggcagctg gaggtaaata gccatgtgca agtctcctct
      181 ctatatttaa cagctgctac agagaaggtg gtggctcctg tcttctggga gaaggccctt
      241 ggaactgggc tgggactggc cttctcatag taagtgaggt caccatgcca gcttcccaga
      301 gccgggcccg tgccagggat cgcaacaatg tcctcaaccg ggctgagttc ctgtccctga
      361 accagccccc caaggggacc caggagccca gaagctcagg taggaaggcc tcggggccct
      421 caacacaacc cccaccctcc agcgacgggg cacgggagcg tcgccagtca cagcagctgc
      481 ccgaggagga ctgcatgcag ctgaacccct cattcaaggg catcgccttc aactccctgc
      541 tggctattga catctgcatg tccaagcgac tgggggtgtg tgccggccgg gctgcatcct
      601 gggccagcgc ccgctccatg gtcaagctca ttggcatcac aggccacggc attccttgga
      661 tcgggggcac catcctctgc ctggtgagaa gcagcaccct ggctggccaa gaggtgctca
      721 tgaacctgct gctagccctg ctcttggaca tcatgacagt ggctggagtc cagaagctca
      781 tcaagcgccg cggcccatat gagaccagcc ctgggctcct ggactacctc accatggaca
      841 tctatgcctt ccctgccggc cacgccagcc gtgccgccat ggtgtccaag ttcttcctga
      901 gccacctggt gctggcggtg ccactgcgcg tgctgctggt gctctgggcc ttctgcgtgg
      961 gcttgtctcg ggtgatgatc ggacgccacc acattacaga cgtcatctca ggcttcatca
     1021 tcggctactt ccagttccgc ctggtggagc tcgtgtggat gtcctccaac acctgccaga
     1081 tgctcatctc tgcctggtga gccgccactc accacccccc tgggctctgg gcagagctgg
     1141 ccccagagag gtggctagag gtgggtcagt gagtggggac ggaccgactc aacttcccca
     1201 acctggtcgg aggctggttt cttagtactg tggggcttgt ctttctcact ggactctgcc
     1261 tcctcagagg cagccggaac aactcacgtg ggcagtcgtg tttaccctcc attccttgtc
     1321 tgaaggcaac agacaagaac aagatggccg taggaggggc agagtcttgt caactcgtca
     1381 ccatgacagc agtagctgta ctgtgctacc acaccatggc acaaagttcg gggaagtatg
     1441 cccaccactc atccaacaca ggtcaccgac ggcttagggt agcacgttcc aaagggtgcc
     1501 tgggggccct ggcccactag atacttctcc gaaaaggctt ttgtggtcca gtacatttgg
     1561 ggaagtcctg cacactcgcc ctcacagtga atgttcacga gaggcaccca gccactgaag
     1621 tcttgtttag ctcagcatct ccgaaattta cctgaccata ggagccttct cttcagacat
     1681 tactattagc ccaccaggaa cctattgaat ctgggaagct gctgcccagg agccagaggg
     1741 cctggggtgt gagctagcct ctcccagcac tcagccctga ggcctgggga aggcaggtgc
     1801 ccacagcaag gcctgcagaa ggttcctgcc atggtctctg ggcgtcgatg ccgctttggc
     1861 ccccaggggc tggactctgt gtgacctaat aggtcgtttc caagtcaaac acttagggac
     1921 aatacagtga tatgcaaatg aa
//
