LOCUS       NM_028922               2906 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phospholipid phosphatase 6 (Plpp6), mRNA.
ACCESSION   NM_028922 XM_892534 XM_913700
VERSION     NM_028922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Bruggemann,T.R., Carlo,T., Krishnamoorthy,N., Duvall,M.G.,
            Abdulnour,R.E., Nijmeh,J., Peh,H.Y., Filippakis,H., Croze,R.H.,
            Goh,B., Oh,S.F. and Levy,B.D.
  TITLE     Mouse phospholipid phosphatase 6 regulates dendritic cell
            cholesterol, macropinocytosis, and allergen sensitization
  JOURNAL   iScience 25 (10), 105185 (2022)
   PUBMED   36238896
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2906)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2906)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2906)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016572.1, AK149181.1 and BC052412.1.
            
            On Oct 22, 2009 this sequence version replaced NM_028922.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1319              AK016572.1         2-1320
            1320-2031           AK149181.1         1088-1799
            2032-2906           BC052412.1         1999-2873
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.61 cM"
     gene            1..2906
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /note="phospholipid phosphatase 6"
                     /db_xref="GeneID:74411"
                     /db_xref="MGI:MGI:1921661"
     exon            1..2882
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..960
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /EC_number="3.6.1.68"
                     /note="presqualene diphosphate phosphatase; phosphatidic
                     acid phosphatase type 2 domain-containing protein 2;
                     phosphatidic acid phosphatase type 2 domain containing 2"
                     /codon_start=1
                     /product="polyisoprenoid diphosphate/phosphate
                     phosphohydrolase PLPP6"
                     /protein_id="NP_083198.1"
                     /db_xref="CCDS:CCDS29728.1"
                     /db_xref="GeneID:74411"
                     /db_xref="MGI:MGI:1921661"
                     /translation="MPSPRRTIEGRPLGSSGGSSVPGSPAHGGGSGGGRFEFQSLLNC
                     RAGADPACARLRASDSPVHRRGSFPLAASGPAQAAPAPPPEDARMNLNPSFLGIALRS
                     LLAIDLWLSKKLGVCAGESSAWGSVRPLMKLLEISGHGIPWLLGTLYCLLRSDSWAGR
                     EVLMNLLFALLLDLLLVAVIKGLVRRRRPAHNQKDMFFTLSVDRYSFPSGHATRAALV
                     SRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCW
                     LSPHNVPVLFVLWNQQ"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /note="hexamer: AGTAAA"
     polyA_site      1376
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /note="hexamer: ATTAAA"
     polyA_site      2882
                     /gene="Plpp6"
                     /gene_synonym="4932443D16Rik; Ppapdc2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggaag cggaagaggc tgacgggctg ggaagcctgt ctccggtctg cccgggtccc
       61 cgggaccggc ctccctccgc gatgccgagc ccccggagga ccatcgaggg acggccgctg
      121 ggctcctcgg gcggaagcag cgtcccgggc agcccggccc acggcggtgg cagcggcggc
      181 ggcaggttcg agttccaatc gctgctgaac tgccgcgcgg gcgcggaccc cgcctgcgct
      241 cggctgcgcg cgtccgacag cccggtgcac cggcgcggct ccttcccgct ggccgcctcg
      301 ggccccgcac aagcagcccc ggccccgccg ccggaggacg cccgcatgaa cttgaacccg
      361 tccttcctgg gcatcgccct gcgctccctg ctggccatcg acctgtggct gtccaagaag
      421 ctgggggtgt gtgctgggga gagctcggcc tggggcagcg tgcggcccct gatgaagctg
      481 ctggagatct cagggcatgg catcccctgg ctgctgggca ccctctactg cctgcttagg
      541 agcgacagct gggccgggcg cgaagtgctg atgaacctgc tcttcgccct gctgttggac
      601 ctgctgctgg tagctgtgat taaagggctg gtccgcaggc gccgacccgc gcacaatcaa
      661 aaggacatgt ttttcaccct ctcggtggac aggtactcct ttccctcggg ccacgccacg
      721 agggccgccc tggtgtcgcg gtttatccta aaccacctgg tactggccat tccactgagg
      781 gtgctggtgg tcctgtgggc cttcgtcttg ggtctctcta gggtcatgct cgggcggcac
      841 aacgtcactg atgtggcttt tggctttttt ctgggctaca tgcagtacag cattgtggat
      901 tattgctggc tgtcacccca caatgttcca gttctttttg tactgtggaa tcaacagtga
      961 caccatctca ttgattattg acaccttgag gtctgaagga ttccacactc gaggatgctg
     1021 acctaagcca gagccatcta gttgcccctc tgggcaactt tgggaattct gggatcccac
     1081 tgtcttgaca ggttcctaga ccggagcgca tgctggctat tactgaacac ggccatactt
     1141 gagaaacaaa gtctactgtg tatttgacag ctatttatca ccaagacaac tgtaaagaaa
     1201 tcaagctggc tgactgtatg attgctattt acttaaagtt gacaacgtta atgagtaatt
     1261 cccctcaccc cccaaaaaaa caatgttatt acttgtaaat taaaatttaa gagccattag
     1321 ctagataaac catgtgctat tcccaccctt tacctgcagt aaattttaaa caataatttt
     1381 aaagttcaaa acagattttt tttctccaat ttaactctct gaatatgttg ccataattgg
     1441 agctttttcc ttcttctgat tcctttaagc tctcccaccc ttgtggactt ggtagttaag
     1501 aggttccaca gagtattttc ctttctgctc ccagtacctc tcaaacgatc tttagatagt
     1561 taacttctac tactatttaa cgttatcttt tagcactcat agaacaaacc aagatatgga
     1621 agaagacata ttcaaaaggt gggcttgtct aaggttccca cagaaatgta agtatgagcc
     1681 tactgttttg tttcctagtc ccatggacaa gtagcatacc agggggcaag aagctgagct
     1741 gctggggaga gtcaggggaa ctaagagctt agaaggaggc agaccgggaa gtaggccatg
     1801 gccaggggca ggaaatgaag ccctgctgtc ggtcacctct actaaatcaa gcaaatggtc
     1861 ctctattaag taaaaagtag aagagcaatg tggttctttt cagtgtgcct gcatagcgtt
     1921 cctgtgtgta ccccaaggat aactgtatgc tatcctttcc ctatcggtcc cactgtgctg
     1981 tgttcagcac attttaggta acaggacaca acttgaaact tttcaggaga gcctattgcc
     2041 ctacgtgagc attaggtaaa actcttaaat ttctgtttac attgaaagct gttcattcat
     2101 ggcgcccccc cccccccaat cataagacca aagatgacca aataatatgg tagactctga
     2161 ttacagtctg acctagaaag accaaagagg ggtatgctca tgacatctgt aaatgctgct
     2221 gtgtctggaa agaaagtctt taaatcactg gtgaaagtgg catcatcaga taatctcaat
     2281 ggccacttgt tctggcattt ataaatagaa aggactgtga gctgtgggct atggtctaat
     2341 gttcaaagat atgggtggac aggactgtgg aagatggaca tgataaacca gttctcagta
     2401 ggaggaagta ggaccttcga gagtgggagt ctggtacacc cattggaaca agtccttcga
     2461 taaataaaac agttatcaca ttcccacaac aacctaaaca cagactacct ctcccctcat
     2521 cagatcagct aagctgtgag gttctaagag gtctaggtgt gtttaaattt ctgaagatca
     2581 tttttcatta taacattcag gccagacact tgaaagtgac tgtttgttct tatagtgtcc
     2641 ccaagtctgc taattaaggg cccacttcta ctttctagtc gcacttctga aattccatat
     2701 tttgtttgct ggggcctgag tttgctggct tttaaaatat agatcagatc aatttacccg
     2761 acttcatgaa taatcctaaa ttctctggaa taaaaaactg atttctttgt taattacttg
     2821 tacgatgaag gatgccttta aaaaaaaatc aaaataaatt aaactggtaa tgttgaatga
     2881 taaaaaaaaa aaaaaaaaaa aaaaaa
//
