LOCUS       NM_001080963            1249 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phospholipid phosphatase 4 (Plpp4), transcript variant
            1, mRNA.
ACCESSION   NM_001080963 XM_355946 XM_987251
VERSION     NM_001080963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100956.9 and AC109182.14.
            
            On Mar 31, 2023 this sequence version replaced NM_001080963.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081292.1, BC120497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC100956.9         183151-183282
            133-241             AC100956.9         233737-233845
            242-332             AC100956.9         242381-242471
            333-396             AC109182.14        184859-184922       c
            397-521             AC109182.14        182924-183048       c
            522-692             AC109182.14        126894-127064       c
            693-1249            AC109182.14        114999-115555       c
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 71.63 cM"
     gene            1..1249
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /note="phospholipid phosphatase 4"
                     /db_xref="GeneID:381925"
                     /db_xref="MGI:MGI:2685936"
     exon            1..132
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..892
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /EC_number="3.1.3.4"
                     /EC_number="3.6.1.75"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidate phosphatase PPAPDC1A; phosphatidic acid
                     phosphatase type 2 domain-containing protein 1A;
                     phosphatidic acid phosphatase type 2 domain containing 1A"
                     /codon_start=1
                     /product="phospholipid phosphatase 4 isoform 1"
                     /protein_id="NP_001074432.1"
                     /db_xref="CCDS:CCDS40154.1"
                     /db_xref="GeneID:381925"
                     /db_xref="MGI:MGI:2685936"
                     /translation="MRELAIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLV
                     QSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIK
                     LIVGRPRPDFFYRCFPDGVMNSEMRCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFY
                     LAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFA
                     YICYRQHYPPLANTACHKPYVSLRVPTSLKKEERPTADSAPSLPLEGITEGPV"
     exon            133..241
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            242..332
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            333..396
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            397..521
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            522..692
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1249
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /note="hexamer: AATAAA"
     polyA_site      1249
                     /gene="Plpp4"
                     /gene_synonym="C030048B12Rik; Gm1090; Ppapdc1a"
                     /note="major polyA site"
ORIGIN      
        1 ggagagccgc tccggccgag ccgtgggagc cacggacagc gccagctgcc gctgcgggag
       61 ctactccggc tgcaccatgc gggagctggc catcgagatc ggggtgcgag cccttctctt
      121 cggggtcttt gtttttacag aatttttgga tccattccag agagtcatcc agccggaaga
      181 gatctggctc tataaaaatc ctttggtgca gtcagacaac atacctaccc gcctcatgtt
      241 tgcaatttct ttcctcacac ccttggctgt tatttgcgtg gtgaaaatta tccggcggac
      301 agacaagact gaaattaagg aagccttctt agcagtgtcc ttggctcttg ctttgaatgg
      361 agtctgcaca aacactatta aactaatagt gggaagacct cgccccgatt tcttttaccg
      421 ctgctttcca gatggggtga tgaattcgga gatgcgctgc acaggtgacc ctgacctggt
      481 gtcggagggc cgcaaaagct tccccagcat ccattcctcc tttgccttct cgggcctcgg
      541 tttcacaaca ttctacctgg ctggcaagct gcactgcttc accgagagtg ggcgggggaa
      601 gagctggagg ctctgtgctg ccatcttgcc cttgtactgt gccatgatga tcgccctgtc
      661 ccgcatgtgt gactacaagc atcattggca agattctttt gttggaggag tgattggcct
      721 catttttgcc tatatttgct acagacaaca ttatcctcct ctggccaaca cagcatgcca
      781 caaaccgtat gtcagccttc gagtgcccac ttcactgaag aaggaagaga ggcctacagc
      841 cgacagtgcg cccagcttgc ccctggaggg gatcaccgag ggccccgtat gatgggtgtc
      901 tagggagaat ggacactgag cccctggcac attcttctat tctgatgtca taacacagtg
      961 gaaaggattt cctgtaatgt gattctcatc agctactcta aagtcccctc cgcttccgtt
     1021 ctgtggatgg tgttcttgcc actctccatg tctcctttca acactttgga tttgtaaagt
     1081 tgggacacca ggaccagtct ctgagagacc catgcacaag gaaggaggat tcaagggtgg
     1141 ggtgggcatg ctagctcctc cagtgattcc tttacctgag gtgtttgctg tagcacccac
     1201 cctcctccgt gttcatgttg tgaaacataa taaagtctcc cacccagaa
//
