LOCUS       NM_080555               3162 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phospholipid phosphatase 3 (Plpp3), mRNA.
ACCESSION   NM_080555
VERSION     NM_080555.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3162)
  AUTHORS   Tripathi,H., Shindo,K., Donahue,R.R., Gao,E., Kuppa,A.,
            ElKammar,M., Morris,A.J., Smyth,S.S. and Abdel-Latif,A.
  TITLE     Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3)
            Increases Cardiac Inflammation After Myocardial Infarction
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (2), 379-381 (2023)
   PUBMED   36453277
  REMARK    GeneRIF: Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate
            Phosphatase 3) Increases Cardiac Inflammation After Myocardial
            Infarction.
REFERENCE   3  (bases 1 to 3162)
  AUTHORS   Li,B., Xi,W., Bai,Y., Liu,X., Zhang,Y., Li,L., Bian,L., Liu,C.,
            Tang,Y., Shen,L., Yang,L., Gu,X., Xie,J., Zhou,Z., Wang,Y., Yu,X.,
            Wang,J., Chao,J., Han,B. and Yao,H.
  TITLE     FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated
            vascular repair and functional recovery following stroke
  JOURNAL   Nat Commun 14 (1), 489 (2023)
   PUBMED   36717587
  REMARK    GeneRIF: FTO-dependent m[6]A modification of Plpp3 in
            circSCMH1-regulated vascular repair and functional recovery
            following stroke.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3162)
  AUTHORS   Montane-Romero,M.E., Martinez-Silva,A.V., Poot-Hernandez,A.C. and
            Escalante-Alcalde,D.
  TITLE     Plpp3, a novel regulator of pluripotency exit and endodermal
            differentiation of mouse embryonic stem cells
  JOURNAL   Biol Open 12 (1) (2023)
   PUBMED   36504260
  REMARK    GeneRIF: Plpp3, a novel regulator of pluripotency exit and
            endodermal differentiation of mouse embryonic stem cells.
REFERENCE   5  (bases 1 to 3162)
  AUTHORS   Van Hoose,P.M., Yang,L., Kraemer,M., Ubele,M., Morris,A.J. and
            Smyth,S.S.
  TITLE     Lipid phosphate phosphatase 3 in smooth muscle cells regulates
            angiotensin II-induced abdominal aortic aneurysm formation
  JOURNAL   Sci Rep 12 (1), 5664 (2022)
   PUBMED   35383201
  REMARK    GeneRIF: Lipid phosphate phosphatase 3 in smooth muscle cells
            regulates angiotensin II-induced abdominal aortic aneurysm
            formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3162)
  AUTHORS   Escalante-Alcalde,D., Sanchez-Sanchez,R. and Stewart,C.L.
  TITLE     Generation of a conditional Ppap2b/Lpp3 null allele
  JOURNAL   Genesis 45 (7), 465-469 (2007)
   PUBMED   17610274
  REMARK    GeneRIF: Targeted inactivation results in embryonic lethality
            because of defects in extraembryonic vascular development and
            gastrulation.
REFERENCE   7  (bases 1 to 3162)
  AUTHORS   Humtsoe,J.O., Bowling,R.A. Jr., Feng,S. and Wary,K.K.
  TITLE     Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated
            integrin ligand
  JOURNAL   Biochem Biophys Res Commun 335 (3), 906-919 (2005)
   PUBMED   16099422
  REMARK    GeneRIF: provide a mechanism for the function of LPP3 in cell-cell
            interactions in both human and mouse
REFERENCE   8  (bases 1 to 3162)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3162)
  AUTHORS   Escalante-Alcalde,D., Hernandez,L., Le Stunff,H., Maeda,R.,
            Lee,H.S., Jr-Gang-Cheng, Sciorra,V.A., Daar,I., Spiegel,S.,
            Morris,A.J. and Stewart,C.L.
  TITLE     The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis
            and axis patterning
  JOURNAL   Development 130 (19), 4623-4637 (2003)
   PUBMED   12925589
  REMARK    GeneRIF: Data show that mouse embryos deficient for lipid phosphate
            phosphatase 3 fail to form a chorio-allantoic placenta and yolk sac
            vasculature.
REFERENCE   10 (bases 1 to 3162)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY129827.1, AK160056.1, AK159136.1 and AV018880.1.
            
            On Feb 1, 2006 this sequence version replaced NM_080555.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159136.1, SRR1660815.189997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BY129827.1         2-103
            103-1551            AK160056.1         3-1451
            1552-1552           AK159136.1         1638-1638
            1553-3153           AK160056.1         1452-3052
            3154-3162           AV018880.1         282-290
FEATURES             Location/Qualifiers
     source          1..3162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.18 cM"
     gene            1..3162
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /note="phospholipid phosphatase 3"
                     /db_xref="GeneID:67916"
                     /db_xref="MGI:MGI:1915166"
     exon            1..617
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..1417
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /EC_number="3.1.3.4"
                     /note="lipid phosphate phosphohydrolase 3; PAP2b; PAP-2b;
                     PAP2-beta; phosphatidic acid phosphatase 2b; phosphatidate
                     phosphohydrolase type 2b; phosphatidic acid phosphatase
                     type 2B"
                     /codon_start=1
                     /product="phospholipid phosphatase 3"
                     /protein_id="NP_542122.1"
                     /db_xref="CCDS:CCDS18417.1"
                     /db_xref="GeneID:67916"
                     /db_xref="MGI:MGI:1915166"
                     /translation="MQSYKYDKAIVPESKNGGSPALNNNPRKGGSKRVLLICLDLFCL
                     FMAALPFLIIETSTIKPYRRGFYCNDESIKYPLKVSETINDAVLCAVGIVIAILAIIT
                     GEFYRIYYLKEKSRSTTQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFL
                     SVCDPDFSQINCSEGYIQNYRCRGEDSKVQEARKSFFSGHASFSMFTMLYLVLYLQAR
                     FTWRGARLLRPLLQFTLLMMAFYTGLSRVSDYKHHPSDVLAGFAQGALVACCIVFFVS
                     DLFKTKTSLSLPAPAIRREILSPVDIIDRNNHHNMV"
     exon            618..775
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1056
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1114
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1291
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..3162
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /note="hexamer: AATAAA"
     polyA_site      3155
                     /gene="Plpp3"
                     /gene_synonym="1110003O22Rik; 2610002D05Rik; D4Bwg0538e;
                     D4Bwg1535e; Lpp3; Ppab2b; Ppap2b; PRG-2"
                     /note="major polyA site"
ORIGIN      
        1 agaaaacaaa ccgagcgatc acagcggcag cccgggcggc agcagcagga ggaggaggag
       61 caggaggagg aggcagagtt ggagttgggc agacgctgag gagagctagc tgcaggacgc
      121 tgcggagttg cagggctccg cgctgctcca ttcattaagt agctgcggag gatcgtggcg
      181 ggacgccgac gctgcccact cgcaaactcc agcacgcaga cgcacgccag ccggacgcgt
      241 ccggggcagc acagttctgc aaaagttcct gctcgggatt tggctctctt ccccttggac
      301 tagcgaacag tttggggttg agaggaaagc agaggcgccc agaggggaaa cctacccgcg
      361 tctgcagttg gaactactcc gccgggctgc actctcgccg ccgcgtcccg agcccgcata
      421 cccgctcctg agcagcggcg gcccgcatcg ccccgggagg ctccccgcag ccagcgccat
      481 gcaaagctac aagtacgaca aggcgatcgt ccctgagagt aagaacggcg gcagcccggc
      541 gctcaacaac aacccgagga agggcggcag caagcgggtg ctgctcatct gcctggacct
      601 cttctgcctc ttcatggcgg ctctgccctt cctcatcatc gagacaagca ccattaagcc
      661 ttaccgtcga gggttttact gcaatgacga gagcatcaag tatcccctga aagtcagtga
      721 gactataaac gatgctgtgc tctgtgcggt ggggatcgtc atcgccatcc tggcgatcat
      781 tacaggggaa ttctaccgga tctattacct caaggagaag tcccgctcca ccactcagaa
      841 cccgtatgtg gcagctctct ataagcaagt gggatgcttc cttttcggct gtgccattag
      901 ccagtccttc accgacatcg ccaaagtgtc catcgggcgc ctgaggcctc acttcctgag
      961 cgtctgtgac cctgatttca gtcagatcaa ttgctccgag ggctacattc agaactacag
     1021 gtgcagagga gaagacagca aagtacagga ggccaggaag tccttcttct cgggccacgc
     1081 ctccttctcc atgttcacta tgctgtatct ggtgctctac cttcaggccc gcttcacctg
     1141 gcgcggggcc cgactgctcc gccccctcct gcagttcact ttgctcatga tggccttcta
     1201 cacgggattg tcacgggtat ctgactacaa gcatcatcct agcgatgtcc tggcaggatt
     1261 tgcccaagga gctctggtgg cctgctgcat agtgttcttc gtgtccgacc tcttcaagac
     1321 taagacgagc ctctcactgc ccgcccctgc gatcaggagg gagatcctgt ctcccgtgga
     1381 catcatcgac aggaacaatc accataacat ggtgtagatg ctgcggcctc cggagcgctt
     1441 tctctgaagc gactgcacgt tcctgctgct ctccgatctc atcagacagt agaatgtagg
     1501 gaaaagcttt tgcccgatgg attttgaaaa catttaaaaa aaaaaaaaaa aagccttatc
     1561 ttgtggcctt ccaaaatagg ttgtttgcct gtgtggagac aacagtgcgg gagtcctgag
     1621 tgctggctgt gcagccagtt aagtgttcat gttctagtga gcacgggctt gtcaaggagc
     1681 aaaacactag aataattgag cagaggctgg ggtcatcttt tgtgacccga gaaatcccag
     1741 gccagaacag ctggagctct tatgtagcac acaaggctcg aaccagcacc gaatcagccc
     1801 ctctgcccgc cccactctac tgtgactttg attcaaggaa gtttgtgtgt gtgtgtgtgt
     1861 gtgtgcctca aaattccggg aatgggcaca caatttttca gtcccgtgat cagatcctga
     1921 atcccaaccc ccaagacctg aggcctctgt catctcccca tccccaggct aacaaccaca
     1981 gcccctcact tttagagatt aggagaccct ttgtggaaga gtgaacttca caaatagcac
     2041 aagttcagaa gacacagagg gtgtcttctc acacaccaca ctgtgacgag gaactgccat
     2101 tgcagggtca atcaccaggc acttgcacat gtagaaacct gtagactttg gttactgcta
     2161 tattcccctt gagatccttg ctggatgccg accaggattt catgtgaggg ccagggatgc
     2221 acagacctgg tcaatctttg gctgattgaa agagcctcag taaagagaca aggagagaga
     2281 gaaagggcag aatgaaaaaa aatgaaccaa cattttttgg ctccttggga tcagagagag
     2341 ccagagtagc agagggtctc gtgcccaaaa ggctaccctt caagataagg gagccccgag
     2401 ggtctttgca ggagttgatc ttgctgtgta gagcactatt gtcccggggt tgacccctgg
     2461 ggcagttctt ggtgggttct gctgggcaga acacatgggt taaatctgtg tagagagttt
     2521 tcctcatcct ccatccacaa gtgtccttcc aagcaaggtc cccctctaga cagtagacaa
     2581 ggacccttct actgaacctc caaggaaaag aagaaggaaa agaagaagtg cttttcaaat
     2641 ctttcaaagg gctacatgta accatctgga atgaccacat ctacaccctc ccagactccg
     2701 tcctttcatt tcaacatata gcaagctatg attttatata taaatattat ataaatattg
     2761 tataaaacat taaaagttaa ctatgtaaga tattatttct gaaacagttt tagttatatc
     2821 cactatgatt ataaactgtg tctcgacctg tgttatttac attagctgct taaaggagca
     2881 ttgagttctt tggttttgtt ttgttttgtt tttttttaat ctcaactaaa gatatagttc
     2941 tgtggtagcc attgttttac aatgaaataa ctgcaactag agaaaaaaaa ctgtataaaa
     3001 acattaaatt gtcagtattt ttgtaagatt ccgttttgta aagagaataa tattcaaaca
     3061 cttttgtggc atacaaagta aaaaaaaaaa gtgtatctga gaaactaaac atgtattaaa
     3121 tgtgcttttt aaataaaagc tcataacaca actaaccaag gc
//
