LOCUS       NM_015817               1651 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase 2 (Plpp2), transcript variant
            1, mRNA.
ACCESSION   NM_015817
VERSION     NM_015817.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Escalante-Alcalde,D., Hernandez,L., Le Stunff,H., Maeda,R.,
            Lee,H.S., Jr-Gang-Cheng, Sciorra,V.A., Daar,I., Spiegel,S.,
            Morris,A.J. and Stewart,C.L.
  TITLE     The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis
            and axis patterning
  JOURNAL   Development 130 (19), 4623-4637 (2003)
   PUBMED   12925589
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Zhang,N., Sundberg,J.P. and Gridley,T.
  TITLE     Mice mutant for Ppap2c, a homolog of the germ cell migration
            regulator wunen, are viable and fertile
  JOURNAL   Genesis 27 (4), 137-140 (2000)
   PUBMED   10992322
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Zhang,N., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Gridley,T.
  TITLE     Cloning, expression, and chromosomal localization of a mouse gene
            homologous to the germ cell migration regulator wunen and to type 2
            phosphatidic acid phosphatases
  JOURNAL   Genomics 63 (1), 142-144 (2000)
   PUBMED   10662554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB868752.1, AK049581.1 and
            BB737982.1.
            
            On Oct 22, 2014 this sequence version replaced NM_015817.2.
            
            Summary: The protein encoded by this gene is a lipid phosphate
            phosphohydrolase. It is an integral membrane protein that catalyzes
            the conversion of phosphatidic acid to diacylglycerol and inorganic
            phosphate. The transcript is expressed at high levels in lung,
            liver, and kidney and at low levels in brain and heart. Null mutant
            mice are viable and fertile and display no overt phenotypic
            defects. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049581.1, BC010332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB868752.1         2-4
            4-1633              AK049581.1         2-1631
            1634-1651           BB737982.1         376-393
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1651
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /note="phospholipid phosphatase 2"
                     /db_xref="GeneID:50784"
                     /db_xref="MGI:MGI:1354945"
     exon            1..164
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..943
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /EC_number="3.1.3.4"
                     /note="isoform 1 is encoded by transcript variant 1; lipid
                     phosphate phosphohydrolase 2; phosphatidic acid
                     phosphatase 2c; phosphatidate phosphohydrolase type 2c;
                     phosphatidic acid phosphatase type 2C"
                     /codon_start=1
                     /product="phospholipid phosphatase 2 isoform 1"
                     /protein_id="NP_056632.2"
                     /db_xref="CCDS:CCDS35966.1"
                     /db_xref="GeneID:50784"
                     /db_xref="MGI:MGI:1354945"
                     /translation="MERRWVFVLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIR
                     YPYRPDTITHGLMAGVIITATVILVSLGEAYLVYTDRLYSRSNFNNYVAAIYKVLGTF
                     LFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSQVNCSGYVQLEVCRGSPANVTEAR
                     LSFYSGHSSFGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDHK
                     HHWSDVLVGLLQGALVACLTVRYVSDFFKSRPPQPCQEDEVPERKPSLSLTLTLGDRP
                     "
     exon            165..316
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            317..591
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            592..649
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            650..826
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1651
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /note="hexamer: TATAAA"
     polyA_site      1636
                     /gene="Plpp2"
                     /gene_synonym="Lpp2; PAP2-G; PAP2-gamma; PAP2c; Ppap2c"
                     /note="major polyA site"
ORIGIN      
        1 gtcaagccct gccctttccc tgggtccggc agtctccacc gccatgtgat cctggggctg
       61 ccgggacagc tggggcaagc gggggtcgcg ggcgtccctg ggccggggcg acatggagcg
      121 gaggtgggtc ttcgtgctgc tggacgtgct gtgcgtgttg gtcgcctctc tgcctttcat
      181 catcctgacc ctggtgaatg caccatataa gcgggggttc tactgtggag atgactccat
      241 ccggtaccca taccgtccag acacgatcac ccacggactc atggctgggg tcatcatcac
      301 agctactgtc atccttgtct cattgggaga agcctacctg gtgtacacag accgtcttta
      361 ttcgcgatcc aacttcaaca actatgtagc tgccatctac aaggtgctgg gaacctttct
      421 gttcggggct gctgtgagcc agtctctcac cgacctggcc aagtacatga ttggccgtct
      481 tcgacccagt ttcttggctg tctgtgaccc tgactggagc caggtcaact gttctggcta
      541 tgtgcagctg gaggtgtgca ggggcagccc tgctaatgtc acggaggcca ggctgtcctt
      601 ctactctggc cactcctcct ttggcatgta ttgcatgttg ttcctggcgc tatatgtgca
      661 ggcccggctc tgctggaagt gggcacggct gctgaggccc actgttcagt tcttcttggt
      721 ggcctttgca atctatgtgg gctatacccg agtgtctgac cacaagcacc actggagtga
      781 tgtccttgtc ggcctcctgc agggagccct ggtggcctgc ctcacggtcc gctatgtttc
      841 agatttcttc aaatcccggc caccccagcc ctgccaggag gatgaagtgc cggagcgcaa
      901 gcccagtctg tcactgacgc tgacccttgg tgaccgaccc tagctgctat gaacaccctg
      961 tctcttcctg ctttggaagc tgggaagtca cctgtgggcc agtcatgtgt tgaccctttg
     1021 cccctgatca ggcactactg acgttggagc tatcccagag tcctggctgg tgactgtgga
     1081 ccaggatctt gggtgcctgt ctggccctga gtgttggcag ggcccatcct cttcatttct
     1141 tgctatcaca tgacttcaaa agatgtggtc gtgctctgag ggctgtctcc catctccagt
     1201 gggttttcaa ggagggccat cccagcatgg ccccggaagt ggtttgtctg agactgttca
     1261 tgaagacagc accctccttg acggccctga aggtgatgaa catcttgttt gcctgggtgg
     1321 ggaagttgac cttgggcaag gatcacaagt gtgaagacag ctgccaaccc ttggggctgc
     1381 ctaggagtcc aggttgccca gaaagtcaca catagttttg gtctgaatcc ttttctcaag
     1441 cctgtggaag attaccactc gaggccccca agcctctccc tcaggcttga tgttctgtcc
     1501 tgtccccact ctgtccatat ggaccaaatg tgtagccaag cattggaagt aggtcccgga
     1561 tctgccattc ccatctgttt caaaacactt caagttactg tttcatggga gggtgtgtta
     1621 taaactttgt accaaatgtc tctgccatgc a
//
