LOCUS       NM_008903               1626 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phospholipid phosphatase 1 (Plpp1), transcript variant
            2, mRNA.
ACCESSION   NM_008903
VERSION     NM_008903.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Taddeo,E.P., Hargett,S.R., Lahiri,S., Nelson,M.E., Liao,J.A.,
            Li,C., Slack-Davis,J.K., Tomsig,J.L., Lynch,K.R., Yan,Z.,
            Harris,T.E. and Hoehn,K.L.
  TITLE     Lysophosphatidic acid counteracts glucagon-induced hepatocyte
            glucose production via STAT3
  JOURNAL   Sci Rep 7 (1), 127 (2017)
   PUBMED   28273928
  REMARK    GeneRIF: Data identify a novel role for phospholipid phosphate
            phosphatase type 1 activity and hepatocyte lysophosphatidic acid
            levels in glucagon sensitivity via a mechanism involving STAT3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Cheng,J., Sahani,S., Hausrat,T.J., Yang,J.W., Ji,H.,
            Schmarowski,N., Endle,H., Liu,X., Li,Y., Bottche,R., Radyushkin,K.,
            Maric,H.M., Hoerder-Suabedissen,A., Molnar,Z., Prouvot,P.H.,
            Trimbuch,T., Ninnemann,O., Huai,J., Fan,W., Visentin,B.,
            Sabbadini,R., Stromgaard,K., Stroh,A., Luhmann,H.J., Kneussel,M.,
            Nitsch,R. and Vogt,J.
  TITLE     Precise Somatotopic Thalamocortical Axon Guidance Depends on
            LPA-Mediated PRG-2/Radixin Signaling
  JOURNAL   Neuron 92 (1), 126-142 (2016)
   PUBMED   27641493
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Nakayama,J., Raines,T.A., Lynch,K.R. and Slack-Davis,J.K.
  TITLE     Decreased peritoneal ovarian cancer growth in mice lacking
            expression of lipid phosphate phosphohydrolase 1
  JOURNAL   PLoS One 10 (3), e0120071 (2015)
   PUBMED   25769037
  REMARK    GeneRIF: Decreased peritoneal ovarian cancer growth in mice lacking
            expression of lipid phosphate phosphohydrolase 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Tang,X., Benesch,M.G., Dewald,J., Zhao,Y.Y., Patwardhan,N.,
            Santos,W.L., Curtis,J.M., McMullen,T.P. and Brindley,D.N.
  TITLE     Lipid phosphate phosphatase-1 expression in cancer cells attenuates
            tumor growth and metastasis in mice
  JOURNAL   J Lipid Res 55 (11), 2389-2400 (2014)
   PUBMED   25210149
  REMARK    GeneRIF: increasing the LPP1 activity in three lines of aggressive
            cancer cells decreases their abilities to produce tumors and
            metastases
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Waggoner,D.W., Xu,J., Singh,I., Jasinska,R., Zhang,Q.X. and
            Brindley,D.N.
  TITLE     Structural organization of mammalian lipid phosphate phosphatases:
            implications for signal transduction
  JOURNAL   Biochim Biophys Acta 1439 (2), 299-316 (1999)
   PUBMED   10425403
  REMARK    Review article
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Jasinska,R., Zhang,Q.X., Pilquil,C., Singh,I., Xu,J., Dewald,J.,
            Dillon,D.A., Berthiaume,L.G., Carman,G.M., Waggoner,D.W. and
            Brindley,D.N.
  TITLE     Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid
            and sphingolipid phosphate esters
  JOURNAL   Biochem J 340 (Pt 3) (Pt 3), 677-686 (1999)
   PUBMED   10359651
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Brindley,D.N. and Waggoner,D.W.
  TITLE     Mammalian lipid phosphate phosphohydrolases
  JOURNAL   J Biol Chem 273 (38), 24281-24284 (1998)
   PUBMED   9733709
  REMARK    Review article
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Kai,M., Wada,I., Imai,S., Sakane,F. and Kanoh,H.
  TITLE     Identification and cDNA cloning of 35-kDa phosphatidic acid
            phosphatase (type 2) bound to plasma membranes. Polymerase chain
            reaction amplification of mouse H2O2-inducible hic53 clone yielded
            the cDNA encoding phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 271 (31), 18931-18938 (1996)
   PUBMED   8702556
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Egawa,K., Yoshiwara,M., Shibanuma,M. and Nose,K.
  TITLE     Isolation of a novel ras-recision gene that is induced by hydrogen
            peroxide from a mouse osteoblastic cell line, MC3T3-E1
  JOURNAL   FEBS Lett 372 (1), 74-77 (1995)
   PUBMED   7556647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB851583.1, BY094239.1, D84376.1 and CD742481.1.
            
            On Sep 25, 2013 this sequence version replaced NM_008903.1.
            
            Transcript Variant: This variant (2) lacks one exon and contains an
            alternate in-frame exon in the 5' coding region, compared to
            variant 1. The encoded isoform (2) is shorter, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84376.1, SRR1660815.316139.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BB851583.1         2-25
            25-146              BY094239.1         2-123
            147-1358            D84376.1           1-1212
            1359-1626           CD742481.1         1-268               c
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..1626
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /note="phospholipid phosphatase 1"
                     /db_xref="GeneID:19012"
                     /db_xref="MGI:MGI:108412"
     exon            1..490
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1284
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /EC_number="3.1.3.4"
                     /EC_number="3.1.3.106"
                     /EC_number="3.6.1.75"
                     /note="isoform 2 is encoded by transcript variant 2; lipid
                     phosphate phosphohydrolase 1; hydrogen peroxide inducible
                     protein 53; 35 kDa PAP; phosphatidic acid phosphatase type
                     2A; phosphatidate phosphohydrolase type 2a; phosphatidic
                     acid phosphatase 2a"
                     /codon_start=1
                     /product="phospholipid phosphatase 1 isoform 2"
                     /protein_id="NP_032929.1"
                     /db_xref="CCDS:CCDS26777.1"
                     /db_xref="GeneID:19012"
                     /db_xref="MGI:MGI:108412"
                     /translation="MFDKTRLPYVALDVICVLLAGLPFAILTSRHTPFQRGIFCNDDS
                     IKYPYKEDTIPYALLGGIVIPFCIIVMSIGESLSVYFNVLHSNSFVGNPYIATIYKAV
                     GAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGYIEDYICQGNEEKV
                     KEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRV
                     SDYKHHWSDVTVGLIQGAAMAILVALYVSDFFKDTHSYKERKEEDPHTTLHETASSRN
                     YSTNHEP"
     exon            491..642
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            643..923
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            924..981
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1158
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1610
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /note="hexamer: AATGAA"
     polyA_site      1487
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /note="hexamer: AATAAA"
     polyA_site      1601
                     /gene="Plpp1"
                     /gene_synonym="Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a;
                     PAP2-alpha; PAP2a; Ppap2a"
                     /note="major polyA site"
ORIGIN      
        1 tcgtccccgc gcgctgcagc cggcgagacc gcgcactggc cggagcggcg cgcctggggc
       61 gggaggagcg gtgttcctcc agtcctcatc cttagagctc gcccggcctg ttggagaggg
      121 cacagggcag cggagggcga ttggccgcga cgagccagca ctgagagagc aggcgcctga
      181 ggcgacagat cggcggccac tggcccagta ccgggtccgt gaagggaaaa gtccgggaca
      241 cgattgccct cggtggcagg gcggcccaat ccaaactgcc ctggtccctg ctcccgtcag
      301 tctaagaggc tcgcagtcgc ttggggcggc cgccatcccg agggcggggc tctgggaatt
      361 gggtatctgg accgccgcgg tctgttcctc ccgccactcg caccaggtgg tgacaccatc
      421 cagccggtga ccatgttcga caagacgcgg ctgccgtacg tggccctcga tgtgatttgc
      481 gtgttgctgg ctggattgcc ttttgcaatt cttacttcaa ggcatacccc cttccagcga
      541 ggaatattct gtaatgatga ctccatcaag tacccttaca aggaagacac cataccttat
      601 gccttattag gtggaatagt cattccattc tgtattatcg ttatgagtat tggagaatct
      661 ctgtctgttt actttaatgt cttgcattcg aattcctttg tcggcaatcc ctacatagcc
      721 accatttaca aagccgtcgg agcctttttg ttcggagtct cagctagtca gtccttgact
      781 gacatcgcta agtatactat aggcagtttg cggccgcact tcttggctat ctgtaaccca
      841 gactggtcaa aaatcaactg cagtgatggc tatattgagg actacatatg tcaagggaat
      901 gaagagaaag tcaaggaggg caggttgtct ttctactcgg gacactcttc attctctatg
      961 tactgcatgc tgtttgtcgc actttatctt caagccagga tgaagggaga ctgggcaaga
     1021 ctcttacgac ccatgctcca gtttgggctc attgcttttt ccatatatgt gggcctttct
     1081 cgagtgtctg actacaaaca ccactggagt gacgtcacag ttggactcat tcagggagct
     1141 gctatggcta tactggttgc tttgtatgta tccgatttct tcaaggacac acattcttac
     1201 aaagagagaa aggaagagga tccacacacg actctccatg aaaccgccag ttcacggaac
     1261 tactcaacca atcacgagcc ctgaagggta caggggcgct ggcccgcttc aaaggcaaca
     1321 gctggaggct aaaggcaggg ggatgcgtat tacttcctgc tgtacagacc attctataaa
     1381 ggactgctgc tatctatacc tcctggatgc ccattttatg tgtgtacagt tacttctaac
     1441 acaatgagta acagttcaat taaagaaaat gaagcctgtc actaaaacac tgtcccacct
     1501 gtacattttt attgaaagac gctatgtaca aatgtgtatg ttacatgcct tctcagaatg
     1561 atgttgactt aaatataata aaaagcttgt gaaccactga acactgggaa aaaaaaaaaa
     1621 aaaaaa
//
