LOCUS       NM_054057               3619 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pyridoxal phosphate binding protein (Plpbp),
            transcript variant 1, mRNA.
ACCESSION   NM_054057
VERSION     NM_054057.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of human and mouse PROSC (proline
            synthetase co-transcribed) genes
  JOURNAL   J Hum Genet 44 (5), 337-342 (1999)
   PUBMED   10496079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065041.1, AK032308.1, AC115820.11 and AW490496.1.
            
            On Dec 21, 2006 this sequence version replaced NM_054057.3.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice junction in the 3' end compared to variant 4. The resulting
            isoform (a) has the same N- and C-termini but is shorter compared
            to isoform d.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032308.1, SRR1660821.26675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY065041.1         1-51
            52-1113             AK032308.1         2-1063
            1114-3320           AC115820.11        47776-49982         c
            3321-3619           AW490496.1         1-299               c
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     gene            1..3619
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="pyridoxal phosphate binding protein"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
     exon            1..159
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..885
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="isoform a is encoded by transcript variant 1;
                     proline synthetase co-transcribed bacterial homolog
                     protein; proline synthase co-transcribed bacterial homolog
                     protein; PLP homeostasis protein; pyridoxal phosphate
                     homeostasis protein"
                     /codon_start=1
                     /product="pyridoxal phosphate homeostasis protein isoform
                     a"
                     /protein_id="NP_473398.1"
                     /db_xref="CCDS:CCDS40310.1"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
                     /translation="MLRGGSMTAELGVGFALRAVNERVQQSVARRPRDLPAIQPRLVA
                     VSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSSCPEIKWHFIGHLQKQNV
                     NKLMAVPNLSMLETVDSVKLADKVNSSWQKKGPTEPLKVMVQINTSGEDSKHGLLPSE
                     TIAVVEHIKASCPSLEFVGLMTIGSFGHDLSQGPNPDFQRLLTLRRELCEKLGIPVEQ
                     VELSMGMSMDFQHAIEVGSTNVRIGSTIFGERDYSKKPALDKTADAKASVPLVQGH"
     exon            160..267
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            268..303
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            304..379
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            380..514
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            515..657
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            658..756
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            757..3603
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="hexamer: ATTAAA"
     polyA_site      2039
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="major polyA site"
     regulatory      3582..3587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="hexamer: AATAAA"
     polyA_site      3603
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
ORIGIN      
        1 gggggcggga ccggaaggtg ggctcggtga gtcgcgggtc ctccgggcat cctcttggga
       61 atgttgagag gtggcagcat gacggcggag ctgggagtcg ggttcgcgct gcgggccgtg
      121 aacgagcgag tccagcagag tgtggcgcgg cggccgcggg acctcccagc catccaaccc
      181 cggctcgttg cggtcagcaa aacaaaacct gcagacatgg tgatcgaggc ctatggccac
      241 ggccagcgca cttttggaga gaactatgtt caggaactac tagaaaaagc atcaaaccct
      301 aagattctgt cttcctgtcc cgagatcaag tggcacttca ttggtcattt acagaaacaa
      361 aacgtcaaca aactgatggc cgtccccaac ctctctatgc tggaaaccgt agactcggtg
      421 aagctggcag acaaggtgaa tagctcctgg cagaagaaag gtcctacaga accactgaag
      481 gtgatggtcc agattaacac cagcggagag gacagtaaac acggcctgct gccttcagag
      541 accatagctg tcgtggaaca cataaaggcc agttgtccca gcctggagtt cgtgggtctc
      601 atgaccatag gaagctttgg acatgatcta agtcaaggac caaacccaga cttccagagg
      661 ctgctgaccc tgcggcggga gctgtgtgaa aagctgggca ttccggtgga gcaggtggaa
      721 cttagcatgg gcatgtccat ggacttccag catgctattg aagtaggatc tacaaatgtc
      781 cggataggga gcactatttt tggagagcgg gactactcaa agaagcctgc cctagacaag
      841 acagcagacg cgaaggcctc agtaccactg gtgcaaggac actgaggcca agccgctcag
      901 ggtcaaccat gcaccagcct agttcatttg gtgtccgcat gtccccagtc acactcttcc
      961 gtggcctttg tagagcgctg aagattatac atgttgacgg gaatcacccg tgcttagctt
     1021 cggctatagg aagctcgggt caagcagtga cttaggctgt gagacttcag aaccgacacc
     1081 aatttagcca ggacctgagt tcggttgagc actgctcagg aatacccagc ccctcacaaa
     1141 tgcgtgtccc caagtgactt ttgggttgct ggtgtctata attgagaaaa tcagaggggt
     1201 tccattttcc atctaataga acaccctgct gtccccgcta ctctggagtg aggtgattct
     1261 gctcccagtt tccatcctgg ccttagatgt ctccaatcac agctcctctg tggcactgac
     1321 tgaaattcca gggtaacttg taaactgctc ttgggccttt cttgctgtaa aagagggact
     1381 tggagcttat tcctcgagga ccacggtgat ggaaagtgga tgacaggatt tcttcaccat
     1441 cataatccct ttctggtttt tagtaaagac ttggagatga aagcctccag tcctggcgca
     1501 tggtttcagc aagcctcact tgcttttcct cctctgggga tcagctatcc ccaggacaca
     1561 ctgtattcac aagccagaat ggtgcagctc ctgactgttc acagtgccgt aagagctcca
     1621 aaaatgagga aacagctggg cctagtagca cctgcccgta accccaacat ttgtgggatg
     1681 cagccaggaa gatcaggagt tcaaggataa acaaagacta agtcagactc ttctttatct
     1741 aaaaacaaca ataaaccaga aagcacagtt ctgcagtgat cacaacggct tgcgtgtggg
     1801 ctgcttagct tatttcctga tagcttttcc gcttgtttcc tccagccctc acatccttca
     1861 tttaacaaat aacttcagaa cccgttgctg ctgaatgtaa tttccagact taaaccacta
     1921 tgattcttgt tctgtttcaa tcaaagctag cgcggtcttt cagtttgtta aatacaaatg
     1981 tgagcttgaa ttataccatc tgtgccaact ctaaagccat taaagattta tttttatgat
     2041 ctggtgtgat gagtgaattg gcacgggggg cattggagct gatggcaagc accttgtcta
     2101 gcctcatgcc tggctctgga gaggtccatc cttgcgtcag agatgccacc aaagccacac
     2161 cattacgtgc aagaagggtt ctgaacttca tgagcaagaa agtgtcttca cggagcttca
     2221 tgacatgcct gtaaatacaa cacacagaag gtggcaaatt caaaaccagc cagggctaca
     2281 tagccagttt tatgccacct ggcttgtaca ttgagaccct gtctcaaaaa aagagtaaat
     2341 gaagtgttag ctggcttgtt tggcagttat tggaaaagtg cctgcttcct gttgtatgaa
     2401 attcttttga ttgcctctag gtggcgacat tggttggcct gaggaacagg ccaacttgtg
     2461 aaaagcacac atatttggca cacacatatt tggtcagcag tttgccctag tagggcctat
     2521 tcagtcttac tctctttatg aatagaagcg gagggcatgg aagacatgtt ccccccggtg
     2581 acacatggac ttgcaggctc aggtggtttt gtcaatgcta cgtcttgatt aagggatctg
     2641 aggacaactc tggaagcttt ggggaaaccg caatggttaa gccgtgaaag gtctccctgg
     2701 cttgtgcctg gggagtaaga gcacagtaga ggagaagcca ggagagaact ttagtccaga
     2761 tgaaggaaag aagcccgact atatccacaa cgggacggct ctcttgagaa cattcagcca
     2821 ggctatgaga ctattgtttc atgtgagaca gctgcttggg ttactcccag gttttaatag
     2881 cagcagtgac agcatcaggg caagtttaaa gtcagaccca cccagccagt aactgcctct
     2941 ccccaacagc ccatgccctg gtgtgtgtgt gtgtgcatgc cctgtattaa agttctctaa
     3001 ggaacgacag acagataaaa tgaacacaca cacacacaca cacacgggat ttattagagt
     3061 ggcttacagg ctgaagtcca gacagtccaa cagtagacag ataggtaagg gatccagtaa
     3121 ttgctcattc cttaagactg gacatctctt cagcgcaggt gctggaatcc cagggagacc
     3181 ctaaagagct gccagttttc attccacatt ggaatcccaa aaggaagtag gcttacttcc
     3241 agcagaggaa tggctcagaa tagatgatct gccccaagag agtcgggcaa gcagacagag
     3301 agcacaagct tccttcttcc aagtcctttt atgtgggtca ccgccaggag gtgcggccca
     3361 gagttcgggt gggtcttctg accgcaaaac atccagactt aaatgggtct tcccacttca
     3421 gaatttcaac caaggaaagt ccctcgcagg tgtgcccagc tgcttgggtt ttagttggtt
     3481 ccaaacgttg tcgaggtgac aaccaagata agccatcgag tatcccaaat ccagcatcag
     3541 gtttgagagg ctcaggaggc cttgtattct tttctctttc aaataaagca tttaagcctt
     3601 ttaaaaaaaa aaaaaaaaa
//
