LOCUS       NM_001039078            1427 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pyridoxal phosphate binding protein (Plpbp),
            transcript variant 3, mRNA.
ACCESSION   NM_001039078
VERSION     NM_001039078.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of human and mouse PROSC (proline
            synthetase co-transcribed) genes
  JOURNAL   J Hum Genet 44 (5), 337-342 (1999)
   PUBMED   10496079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065041.1 and BC047992.1.
            
            On Dec 21, 2006 this sequence version replaced NM_001039078.1.
            
            Transcript Variant: This variant (3) uses a different splice site
            in the 3' coding region and lacks several segments in the coding
            region, compared to variant 4. The resulting protein (isoform c)
            has a shorter and distinct C-terminus when it is compared to
            isoform d.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047992.1, BU509924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY065041.1         1-43
            44-1427             BC047992.1         1-1384
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     gene            1..1427
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="pyridoxal phosphate binding protein"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
     exon            1..159
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..486
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="isoform c is encoded by transcript variant 3;
                     proline synthetase co-transcribed bacterial homolog
                     protein; proline synthase co-transcribed bacterial homolog
                     protein; PLP homeostasis protein; pyridoxal phosphate
                     homeostasis protein"
                     /codon_start=1
                     /product="pyridoxal phosphate homeostasis protein isoform
                     c"
                     /protein_id="NP_001034167.1"
                     /db_xref="CCDS:CCDS52533.1"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
                     /translation="MLRGGSMTAELGVGFALRAVNERVQQSVARRPRDLPAIQPRLVA
                     VSKTKPADMVIEAYGHGQRTFGENYILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSML
                     ETVDSVKLADKVNSSWQKKGPTEPLKVMVQINTSGEDSK"
     exon            160..267
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            268..343
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            344..1411
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1389..1394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="hexamer: CATAAA"
     polyA_site      1411
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggga ccggaaggtg ggctcggtga gtcgcgggtc ctccgggcat cctcttggga
       61 atgttgagag gtggcagcat gacggcggag ctgggagtcg ggttcgcgct gcgggccgtg
      121 aacgagcgag tccagcagag tgtggcgcgg cggccgcggg acctcccagc catccaaccc
      181 cggctcgttg cggtcagcaa aacaaaacct gcagacatgg tgatcgaggc ctatggccac
      241 ggccagcgca cttttggaga gaactatatt ctgtcttcct gtcccgagat caagtggcac
      301 ttcattggtc atttacagaa acaaaacgtc aacaaactga tggccgtccc caacctctct
      361 atgctggaaa ccgtagactc ggtgaagctg gcagacaagg tgaatagctc ctggcagaag
      421 aaaggtccta cagaaccact gaaggtgatg gtccagatta acaccagcgg agaggacagt
      481 aagtgactag gcctgaccat ggaggtttgc tctcttgaga tggctgaggc tcggggagag
      541 tgtgagtgta agcatctgct gaggagactg tgaggagaag ctccagcctc ctggtgagct
      601 gcttcgtcaa gattcaccag tgtgatgacc caatataatt ctttaatata tttcggcttg
      661 ttcggtattg atttggaaga attataactt tgatgtcctg gaaattccct cctggaaggg
      721 attgggaatt gtatgtgtca tacttcttag gacaattacc cagtacttta ttgggcaaga
      781 gtaggaaaaa aaaaatgctg ctgtacacca gtgagtgact gtctcatggg gcctggctta
      841 gcagtgtggc catgaattac agagaaccgt gactttgaca tcagacaaat gtctgcctgc
      901 gctccaccac tttctagcat tggaactttg cgtcagttac ctaagctctc tgtacctgag
      961 tttcctcctg tggcagtgtc atcggggagt gcccgttgtt agagggtgtg gtgaggattc
     1021 tgtgcagtga gtgatccaga accccggatt tcttacttgc tcactttctg ttaagagtga
     1081 atggcaggca ctggcttaca actgtcttct aggcactcac acgtagcaga tcttggcacg
     1141 aaggagctca gtacagacat ctgttttcca gatgcgccct gcactcaaat ctcaggtgca
     1201 cagttctcgt ccataaactt aggaaaagac ttagcccacc tgccttagtt tcctctgaaa
     1261 actggtataa gtaagaatat ttagagtttc tgtatgaaat gaaaagtcgt ggggctggca
     1321 cagtggtcag tagattacca gttaccatta taatgttata tgcatgctcc ctgactatgg
     1381 cttcattgca taaaagcaga tacaaaattg aaaaaaaaaa aaaaaaa
//
