LOCUS       NM_001039077            1463 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pyridoxal phosphate binding protein (Plpbp),
            transcript variant 2, mRNA.
ACCESSION   NM_001039077
VERSION     NM_001039077.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of human and mouse PROSC (proline
            synthetase co-transcribed) genes
  JOURNAL   J Hum Genet 44 (5), 337-342 (1999)
   PUBMED   10496079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065041.1, BC061045.1 and BC047992.1.
            
            On Dec 21, 2006 this sequence version replaced NM_001039077.1.
            
            Transcript Variant: This variant (2) uses a different splice site
            in the 3' coding region and lacks several segments in the coding
            region, compared to variant 4. The resulting protein (isoform b)
            has a shorter and distinct C-terminus when it is compared to
            isoform d.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061045.1, BU953095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY065041.1         1-6
            7-693               BC061045.1         1-687
            694-1463            BC047992.1         615-1384
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     gene            1..1463
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="pyridoxal phosphate binding protein"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
     exon            1..159
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..522
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="isoform b is encoded by transcript variant 2;
                     proline synthetase co-transcribed bacterial homolog
                     protein; proline synthase co-transcribed bacterial homolog
                     protein; PLP homeostasis protein; pyridoxal phosphate
                     homeostasis protein"
                     /codon_start=1
                     /product="pyridoxal phosphate homeostasis protein isoform
                     b"
                     /protein_id="NP_001034166.1"
                     /db_xref="CCDS:CCDS85519.1"
                     /db_xref="GeneID:114863"
                     /db_xref="MGI:MGI:1891207"
                     /translation="MLRGGSMTAELGVGFALRAVNERVQQSVARRPRDLPAIQPRLVA
                     VSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSSCPEIKWHFIGHLQKQNV
                     NKLMAVPNLSMLETVDSVKLADKVNSSWQKKGPTEPLKVMVQINTSGEDSK"
     exon            160..267
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            268..303
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            304..379
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     exon            380..1447
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="hexamer: CATAAA"
     polyA_site      1447
                     /gene="Plpbp"
                     /gene_synonym="1700024N20Rik; 2200002F22Rik; Prosc"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggga ccggaaggtg ggctcggtga gtcgcgggtc ctccgggcat cctcttggga
       61 atgttgagag gtggcagcat gacggcggag ctgggagtcg ggttcgcgct gcgggccgtg
      121 aacgagcgag tccagcagag tgtggcgcgg cggccgcggg acctcccagc catccaaccc
      181 cggctcgttg cggtcagcaa aacaaaacct gcagacatgg tgatcgaggc ctatggccac
      241 ggccagcgca cttttggaga gaactatgtt caggaactac tagaaaaagc atcaaaccct
      301 aagattctgt cttcctgtcc cgagatcaag tggcacttca ttggtcattt acagaaacaa
      361 aacgtcaaca aactgatggc cgtccccaac ctctctatgc tggaaaccgt agactcggtg
      421 aagctggcag acaaggtgaa tagctcctgg cagaagaaag gtcctacaga accactgaag
      481 gtgatggtcc agattaacac cagcggagag gacagtaagt gactaggcct gaccatggag
      541 gtttgctctc ttgagatggc tgaggctcgg ggagagtgtg agtgtaagca tctgctgagg
      601 agactgtgag gagaagctcc agcctcctgg tgagctgctt cgtcaagatt caccagtgtg
      661 atgacccaat ataattcttt aatatatttc ggcttgttcg gtattgattt ggaagaatta
      721 taactttgat gtcctggaaa ttccctcctg gaagggattg ggaattgtat gtgtcatact
      781 tcttaggaca attacccagt actttattgg gcaagagtag gaaaaaaaaa atgctgctgt
      841 acaccagtga gtgactgtct catggggcct ggcttagcag tgtggccatg aattacagag
      901 aaccgtgact ttgacatcag acaaatgtct gcctgcgctc caccactttc tagcattgga
      961 actttgcgtc agttacctaa gctctctgta cctgagtttc ctcctgtggc agtgtcatcg
     1021 gggagtgccc gttgttagag ggtgtggtga ggattctgtg cagtgagtga tccagaaccc
     1081 cggatttctt acttgctcac tttctgttaa gagtgaatgg caggcactgg cttacaactg
     1141 tcttctaggc actcacacgt agcagatctt ggcacgaagg agctcagtac agacatctgt
     1201 tttccagatg cgccctgcac tcaaatctca ggtgcacagt tctcgtccat aaacttagga
     1261 aaagacttag cccacctgcc ttagtttcct ctgaaaactg gtataagtaa gaatatttag
     1321 agtttctgta tgaaatgaaa agtcgtgggg ctggcacagt ggtcagtaga ttaccagtta
     1381 ccattataat gttatatgca tgctccctga ctatggcttc attgcataaa agcagataca
     1441 aaattgaaaa aaaaaaaaaa aaa
//
