LOCUS       NM_019755               1178 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus proteolipid protein 2 (Plp2), mRNA.
ACCESSION   NM_019755 XM_973130
VERSION     NM_019755.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Zhang,L., Wang,T. and Valle,D.
  TITLE     Reduced PLP2 expression increases ER-stress-induced neuronal
            apoptosis and risk for adverse neurological outcomes after hypoxia
            ischemia injury
  JOURNAL   Hum Mol Genet 24 (25), 7221-7226 (2015)
   PUBMED   26512060
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Sonoda,Y., Warita,M., Suzuki,T., Ozawa,H., Fukuda,Y.,
            Funakoshi-Tago,M. and Kasahara,T.
  TITLE     Proteolipid protein 2 is associated with melanoma metastasis
  JOURNAL   Oncol Rep 23 (2), 371-376 (2010)
   PUBMED   20043097
  REMARK    GeneRIF: PLP2 enhanced proliferation, adhesion, invasion, and MMP-2
            secretion in vitro, and tumor metastasis in vivo.
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Chen,Y.T., Hims,M.M., Shetty,R.S., Mull,J., Liu,L., Leyne,M. and
            Slaugenhaupt,S.A.
  TITLE     Loss of mouse Ikbkap, a subunit of elongator, leads to
            transcriptional deficits and embryonic lethality that can be
            rescued by human IKBKAP
  JOURNAL   Mol Cell Biol 29 (3), 736-744 (2009)
   PUBMED   19015235
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B.,
            Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and
            Ramsdell,F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY254069.1, AK003522.1 and AI595418.1.
            
            On Aug 25, 2015 this sequence version replaced NM_019755.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092095.1, SRR1660813.336029.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN02415138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BY254069.1         1-58
            59-1152             AK003522.1         2-1095
            1153-1178           AI595418.1         8-33                c
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.45 cM"
     gene            1..1178
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /note="proteolipid protein 2"
                     /db_xref="GeneID:18824"
                     /db_xref="MGI:MGI:1298382"
     exon            1..248
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..611
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /codon_start=1
                     /product="proteolipid protein 2"
                     /protein_id="NP_062729.1"
                     /db_xref="CCDS:CCDS40842.1"
                     /db_xref="GeneID:18824"
                     /db_xref="MGI:MGI:1298382"
                     /translation="MADSERLSAPGCWLACTSFSRTKKGILLFAEIILCLVILICFSA
                     STTSAYSSLSVIEMICAAVLLVFYTCDLHSKISFINWPWTDFFRSLIATILYLITSIV
                     VLVEGRGSSRVVAGILGLLATLLFGYDAYITFPLKQQRHTAAPTDPTDGP"
     exon            249..404
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /inference="alignment:Splign:2.1.0"
     exon            405..500
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /inference="alignment:Splign:2.1.0"
     exon            501..591
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1157
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /note="hexamer: AATAAT"
     polyA_site      1157
                     /gene="Plp2"
                     /gene_synonym="mIMA4"
                     /note="major polyA site"
ORIGIN      
        1 tgctttgcta ggcgcggtga ttcattccct cctttgcccg gggggccccc ttcccggcca
       61 gacggcggga cagacggctg ggtgtgcagc gacctcgaac ccgtgagcca gaaagcagag
      121 cttctgcgtc ccagggactc cagtacacca ccatggcgga ttctgagcgt ctctcggccc
      181 ccggctgctg gttagcctgc accagcttct cgcgcaccaa aaagggaatt ctcctgtttg
      241 ctgagattat actgtgcctg gtgatcttga tttgcttcag tgcatctaca acatcggcct
      301 actcctccct gtcggtgatt gagatgatct gtgctgctgt cttacttgtc ttctacacgt
      361 gtgacctgca ctccaagata tcattcatca actggccttg gactgacttc ttcagatccc
      421 tcatagcaac catcctgtac ctgatcacct ccattgttgt ccttgtagaa ggaagaggca
      481 gctccagagt tgtcgctggg atactgggct tacttgctac gttgctcttt ggctacgatg
      541 catacatcac cttccctcta aagcagcaaa gacatacagc agctcccact gaccccactg
      601 atggcccgtg atcgtctttc agctgtctct gctacctgtc aatagctcct ccatcaaaaa
      661 ctttcctcct gtcgggcggt ggtggtgctc gcctttcctc caagctctca ggaggcagag
      721 gcaggtggat ccctgtgagt ttgaggccag ggctacacag tgagatcctg tctctaaaac
      781 aattccttct ccggtttcca caacactcca gccaattctc tgaccccatt gaaagtgctt
      841 atggtacaag agattgaacc tagagccgtg tgcatactag gcaagtattc tccactgagc
      901 tacatccctg taaaagtgcc tttattggga gttttgtctt ccagcctgcc aatcaaccca
      961 tctgggtgtg gccaccttta tgggtgtgcc tagattcccc tttgctctgc agtaccagca
     1021 gccgacatca gttctgcttg aaccatatcc ccacataagc tacaaaatga gtgacccact
     1081 acaaataacc tttttctctg tgtggggtga gctgtgaagg gctaaataaa caataaaaat
     1141 aatgtttaag tctataaaaa aaaaaaaaaa aaaaaaaa
//
