LOCUS       NM_011123               3461 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus proteolipid protein (myelin) 1 (Plp1), transcript
            variant 1, mRNA.
ACCESSION   NM_011123
VERSION     NM_011123.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Spate,E., Zhou,B., Sun,T., Kusch,K., Asadollahi,E., Siems,S.B.,
            Depp,C., Werner,H.B., Saher,G., Hirrlinger,J., Mobius,W., Nave,K.A.
            and Goebbels,S.
  TITLE     Downregulated expression of lactate dehydrogenase in adult
            oligodendrocytes and its implication for the transfer of glycolysis
            products to axons
  JOURNAL   Glia 72 (8), 1374-1391 (2024)
   PUBMED   38587131
REFERENCE   3  (bases 1 to 3461)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   4  (bases 1 to 3461)
  AUTHORS   Groh,J., Abdelwahab,T., Kattimani,Y., Horner,M., Loserth,S.,
            Gudi,V., Adalbert,R., Imdahl,F., Saliba,A.E., Coleman,M.,
            Stangel,M., Simons,M. and Martini,R.
  TITLE     Microglia-mediated demyelination protects against CD8+ T
            cell-driven axon degeneration in mice carrying PLP defects
  JOURNAL   Nat Commun 14 (1), 6911 (2023)
   PUBMED   37903797
  REMARK    GeneRIF: Microglia-mediated demyelination protects against CD8[+] T
            cell-driven axon degeneration in mice carrying PLP defects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3461)
  AUTHORS   Talley,M.J., Nardini,D., Ehrman,L.A., Lu,Q.R. and Waclaw,R.R.
  TITLE     Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte
            development in the mouse telencephalon
  JOURNAL   Neural Dev 18 (1), 5 (2023)
   PUBMED   37684687
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3461)
  AUTHORS   Rawal,N., Lee,Y.J., Paik,W.K. and Kim,S.
  TITLE     Studies on NG-methylarginine derivatives in myelin basic protein
            from developing and mutant mouse brain
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 929-935 (1992)
   PUBMED   1280107
REFERENCE   7  (bases 1 to 3461)
  AUTHORS   Doolittle,D.P. and Schweikart,K.M.
  TITLE     Myelin deficient, a new neurological mutant in the mouse
  JOURNAL   J Hered 68 (5), 331-332 (1977)
   PUBMED   599283
REFERENCE   8  (bases 1 to 3461)
  AUTHORS   Kirschner,D.A. and Sidman,R.L.
  TITLE     X-ray diffraction study of myelin structure in immature and mutant
            mice
  JOURNAL   Biochim Biophys Acta 448 (1), 73-87 (1976)
   PUBMED   971429
REFERENCE   9  (bases 1 to 3461)
  AUTHORS   Meier,C. and Bischoff,A.
  TITLE     Oligodendroglial cell development in jimpy mice and controls. An
            electron-microscopic study in the optic nerve
  JOURNAL   J Neurol Sci 26 (4), 517-528 (1975)
   PUBMED   1206429
REFERENCE   10 (bases 1 to 3461)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160872.1, BC027010.1 and AL672008.8.
            
            On Dec 21, 2017 this sequence version replaced NM_011123.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027010.1, AK160872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2016              AK160872.1         8-2023
            2017-2622           BC027010.1         1939-2544
            2623-3461           AL672008.8         2400-3238
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..3461
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="proteolipid protein (myelin) 1"
                     /db_xref="GeneID:18823"
                     /db_xref="MGI:MGI:97623"
     exon            1..160
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..990
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipophilin; rump shaker; myelin synthesis deficiency;
                     myelin proteolipid protein"
                     /codon_start=1
                     /product="myelin proteolipid protein isoform 1"
                     /protein_id="NP_035253.1"
                     /db_xref="CCDS:CCDS30424.1"
                     /db_xref="GeneID:18823"
                     /db_xref="MGI:MGI:97623"
                     /translation="MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTE
                     KLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFG
                     DYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALT
                     VVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGK
                     VCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTK
                     F"
     exon            161..347
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     exon            348..609
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     exon            610..778
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     exon            779..852
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     exon            853..918
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     exon            919..3461
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2545..2550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="hexamer: AAGAAA"
     polyA_site      2558
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="major polyA site"
     polyA_site      2562
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /note="hexamer: AGTAAA"
     polyA_site      3461
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
ORIGIN      
        1 cttttcattg caggagaaga ggacaaagat actcagagag aaaaagtaaa ggacagaaga
       61 aggagactgg agagaccagg atccttccag ctgagcaaag tcagccgcaa aacagactag
      121 ccaacaggct acaattggag tcagagtgcc aaagacatgg gcttgttaga gtgttgtgct
      181 agatgtctgg taggggcccc ctttgcttcc ctggtggcca ctggattgtg tttctttgga
      241 gtggcactgt tctgtggatg tggacatgaa gctctcactg gtacagaaaa gctaattgag
      301 acctatttct ccaaaaacta ccaggactat gagtatctca ttaatgtgat tcatgctttc
      361 cagtatgtca tctatggaac tgcctctttc ttcttccttt atggggccct cctgctggct
      421 gagggcttct acaccaccgg cgctgtcagg cagatctttg gcgactacaa gaccaccatc
      481 tgcggcaagg gcctgagcgc aacggtaaca gggggccaga aggggagggg ttccagaggc
      541 caacatcaag ctcattcttt ggagcgggtg tgtcattgtt tgggaaaatg gctaggacat
      601 cccgacaagt ttgtgggcat cacctatgcc ctgactgttg tatggctcct ggtgtttgcc
      661 tgctcggctg tacctgtgta catttacttc aatacctgga ccacctgtca gtctattgcc
      721 ttccctagca agacctctgc cagtataggc agtctctgcg ctgatgccag aatgtatggt
      781 gttctcccat ggaatgcttt ccctggcaag gtttgtggct ccaaccttct gtccatctgc
      841 aaaacagctg agttccaaat gaccttccac ctgtttattg ctgcgtttgt gggtgctgcg
      901 gccacactag tttccctgct caccttcatg attgctgcca cttacaactt cgccgtcctt
      961 aaactcatgg gccgaggcac caagttctga gctcccatag aaactcccct ttgtctaata
     1021 gcaaggctct aaccacacag cctacagtgt tgtgttttaa ctctgccttt gccactgatt
     1081 ggccctcttc ttacttgatg agtataacaa gaaaggagag tcttgcagtg attaatctct
     1141 ctctgtggac tctccctctt agtacctctt ttagtcattt tgctccacag caggctcctg
     1201 ctagaaatgg gggatgcctg agaaggtgac tccccagctg caagtcgcag aggagtgaaa
     1261 gctctaattg attttgcaag catctcctga agaccaggat gtgcttcctt ctcaaagggc
     1321 acttccaact gaggagagca gaacggaaag gttctcaggt agagagcaga aatgtccctg
     1381 gtcttcttgc catcagtagg agtcaaatac attctctttg atgcacaaaa ccaagaactc
     1441 actcttacct tcctgtttcc actgaagaca gaagaaaata aaaagaatgc tagcagagca
     1501 atatagcatt tgcccaaatc tgcctcctgc agctgggaga agggtgtcaa agcaaggatc
     1561 tttcgccctt agaaagagag ctctgacgcc agtggcaatg gactatttaa gccctaactc
     1621 agccaacctt ccttacggca attagggagc acagtgcctg tatagacaaa gcggggcgga
     1681 gggggggggc atcatctgtc cttatagctc attaggaaga gaaacagtgt tgtcaggatc
     1741 atctcactcc cttctccttg ataacagcta ccatgacaac cttgtggttt ccaaggagct
     1801 gagaatagaa aggaactagc ttatttgaaa taagactgtg acctaaggag catcagttgg
     1861 tggatgctaa aggtgtaatt tgaaatggcc ttcgggtaaa tgcaagatac ttaactcttt
     1921 ggatagcatg tgttcttccc ccacccctat ccgctagttc tggcccctgg cctctggcat
     1981 aatatcttca caatggtgct ttttttcctg gggttttatc cattcactca tagcaggtga
     2041 ttagacgatc ttgattagtt tcatatttcc caattgttta tctcttgttt ggagttgtat
     2101 cagaaagacc tggaggatga ttctttgagc atagttcttt ttgaaaacaa gaaagagaaa
     2161 ctgggcagaa agcatcacaa aaatatttga aattgtacgg tcccatgaaa ttattgggaa
     2221 ttcccccaag tagtctacca tttgtagaac taggcttgat aaatttgaac ctcaatttga
     2281 ataattggtc tggtattttc ttttctaata aatgacagat gattttactt gctaatatta
     2341 tctcagcatt ttgataattt aggcttacca tagaagttac tgtctcttgg tatatatagg
     2401 tcacataata gattctgcca gctgttagct gttcagttca taagcttcca tagagctctg
     2461 gagccgcaga gaggacaggc agaatttgaa acctaaagaa ctcccagatt tcaggcttat
     2521 cctgtatttg ttaactttgg gtgaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     2581 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaaaagaaa
     2641 ggaaggaagg aaggaaggaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa
     2701 gaaagaaaga aagaaagaaa gagaaaaaaa aagcccctga tcgaatttcc tggaggaaaa
     2761 gttattgtag ctgtttcatt gtagatttgt gctgtcattc cccaaagtgc tttctgctgt
     2821 gttgaaagag atataagaat ttacaagaag acacttgaga cttgttcttg ggccaatata
     2881 taaggtaaac aagcaggatg cacaagagtg aggagagcta aaaggacatg taagaaacca
     2941 atcaagatca aggaaggtga aataatctat atcttttatt ttgttttggt ttaatataac
     3001 agataaccaa ccattccctt aaaaatctca catgcacaca cacacacaca cacacacaca
     3061 cgtacaaaga gagttaatca actgcaagtg tttccttcat ttctgataga gaattttgat
     3121 tttaacaaca taaaggataa acttttagaa actcatctta caaaatgtat tttataaaat
     3181 taaagaaaat aaaattaaga atgttctcaa tcaaacatcg tgtcctttga gtgaattgtt
     3241 ctatttgacc tcaataacag gtacttaatt atagttagct cgaggtgctc atgtatcttt
     3301 caggccatgt aagttattct tatactactt ctatgaaaaa tgtaatagat aatgcattat
     3361 tattattatt gtttcttttt tatactaaag atatgaaaaa atatatgcaa aatgcaaaac
     3421 aattaccgaa agaaactcag taaatacttg tctcaaattg a
//
