LOCUS       NP_035253                277 aa            linear   ROD 12-JUN-2025
DEFINITION  myelin proteolipid protein isoform 1 [Mus musculus].
ACCESSION   NP_035253
VERSION     NP_035253.1
DBSOURCE    REFSEQ: accession NM_011123.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 277)
  AUTHORS   Gadek,M., Shaw,C.K., Abdulai-Saiku,S., Saloner,R., Marino,F.,
            Wang,D., Bonham,L.W., Yokoyama,J.S., Panning,B., Benayoun,B.A.,
            Casaletto,K.B., Ramani,V. and Dubal,D.B.
  TITLE     Aging activates escape of the silent X chromosome in the female
            mouse hippocampus
  JOURNAL   Sci Adv 11 (10), eads8169 (2025)
   PUBMED   40043106
REFERENCE   2  (residues 1 to 277)
  AUTHORS   Yamada,M., Sasaki,B., Yamada,N., Hayashi,C., Tsumoto,K., de Vega,S.
            and Suzuki,N.
  TITLE     The pericellular function of Fibulin-7 in the adhesion of
            oligodendrocyte lineage cells to neuronal axons during CNS
            myelination
  JOURNAL   Biochem Biophys Res Commun 748, 151271 (2025)
   PUBMED   39809135
REFERENCE   3  (residues 1 to 277)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   4  (residues 1 to 277)
  AUTHORS   Spate,E., Zhou,B., Sun,T., Kusch,K., Asadollahi,E., Siems,S.B.,
            Depp,C., Werner,H.B., Saher,G., Hirrlinger,J., Mobius,W., Nave,K.A.
            and Goebbels,S.
  TITLE     Downregulated expression of lactate dehydrogenase in adult
            oligodendrocytes and its implication for the transfer of glycolysis
            products to axons
  JOURNAL   Glia 72 (8), 1374-1391 (2024)
   PUBMED   38587131
REFERENCE   5  (residues 1 to 277)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   6  (residues 1 to 277)
  AUTHORS   Rawal,N., Lee,Y.J., Paik,W.K. and Kim,S.
  TITLE     Studies on NG-methylarginine derivatives in myelin basic protein
            from developing and mutant mouse brain
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 929-935 (1992)
   PUBMED   1280107
REFERENCE   7  (residues 1 to 277)
  AUTHORS   Doolittle,D.P. and Schweikart,K.M.
  TITLE     Myelin deficient, a new neurological mutant in the mouse
  JOURNAL   J Hered 68 (5), 331-332 (1977)
   PUBMED   599283
REFERENCE   8  (residues 1 to 277)
  AUTHORS   Kirschner,D.A. and Sidman,R.L.
  TITLE     X-ray diffraction study of myelin structure in immature and mutant
            mice
  JOURNAL   Biochim Biophys Acta 448 (1), 73-87 (1976)
   PUBMED   971429
REFERENCE   9  (residues 1 to 277)
  AUTHORS   Meier,C. and Bischoff,A.
  TITLE     Oligodendroglial cell development in jimpy mice and controls. An
            electron-microscopic study in the optic nerve
  JOURNAL   J Neurol Sci 26 (4), 517-528 (1975)
   PUBMED   1206429
REFERENCE   10 (residues 1 to 277)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160872.1, BC027010.1 and AL672008.8.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027010.1, AK160872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     Protein         1..277
                     /product="myelin proteolipid protein isoform 1"
                     /note="lipophilin; rump shaker; myelin synthesis
                     deficiency; myelin proteolipid protein"
                     /calculated_mol_wt=29946
     Region          5..273
                     /region_name="Myelin_PLP"
                     /note="Myelin proteolipid protein (PLP or lipophilin);
                     pfam01275"
                     /db_xref="CDD:460144"
     Site            10..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60202.2)"
     Site            64..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60202.2)"
     Site            114
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60203; propagated from
                     UniProtKB/Swiss-Prot (P60202.2)"
     Site            116
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60203; propagated from
                     UniProtKB/Swiss-Prot (P60202.2)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60203; propagated from
                     UniProtKB/Swiss-Prot (P60202.2)"
     Site            152..177
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60202.2)"
     Site            234..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60202.2)"
     CDS             1..277
                     /gene="Plp1"
                     /gene_synonym="DM20; jimpy; jp; msd; Plp; rsh"
                     /coded_by="NM_011123.4:157..990"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30424.1"
                     /db_xref="GeneID:18823"
                     /db_xref="MGI:MGI:97623"
ORIGIN      
        1 mglleccarc lvgapfaslv atglcffgva lfcgcgheal tgtekliety fsknyqdyey
       61 linvihafqy viygtasfff lygalllaeg fyttgavrqi fgdyktticg kglsatvtgg
      121 qkgrgsrgqh qahslervch clgkwlghpd kfvgityalt vvwllvfacs avpvyiyfnt
      181 wttcqsiafp sktsasigsl cadarmygvl pwnafpgkvc gsnllsickt aefqmtfhlf
      241 iaafvgaaat lvslltfmia atynfavlkl mgrgtkf
//
