LOCUS       NM_011962               3278 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
            (Plod3), mRNA.
ACCESSION   NM_011962
VERSION     NM_011962.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3278)
  AUTHORS   Li,H., Xu,H., Wen,H., Liu,T., Sun,Y., Xiao,N., Bai,C., Ge,J.,
            Wang,X., Song,L., Song,Y., Zhang,Y. and Chen,J.
  TITLE     Overexpression of LH3 reduces the incidence of hypertensive
            intracerebral hemorrhage in mice
  JOURNAL   J Cereb Blood Flow Metab 39 (3), 547-561 (2019)
   PUBMED   30516406
  REMARK    GeneRIF: results indicate that LH3 overexpression attenuates
            susceptibility to hypertensive intracerebral hemorrhage
REFERENCE   4  (bases 1 to 3278)
  AUTHORS   Geister,K.A., Timms,A.E. and Beier,D.R.
  TITLE     Optimizing Genomic Methods for Mapping and Identification of
            Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice
  JOURNAL   G3 (Bethesda) 8 (2), 401-409 (2018)
   PUBMED   29208648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3278)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3278)
  AUTHORS   Rautavuoma,K., Takaluoma,K., Sormunen,R., Myllyharju,J.,
            Kivirikko,K.I. and Soininen,R.
  TITLE     Premature aggregation of type IV collagen and early lethality in
            lysyl hydroxylase 3 null mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (39), 14120-14125 (2004)
   PUBMED   15377789
  REMARK    GeneRIF: results demonstrate that LH3 is indispensable for
            biosynthesis of type IV collagen and for basement membrane
            stability during early development and that loss of LH3's functions
            leads to embryonic lethality
REFERENCE   7  (bases 1 to 3278)
  AUTHORS   Wang,C., Risteli,M., Heikkinen,J., Hussa,A.K., Uitto,L. and
            Myllyla,R.
  TITLE     Identification of amino acids important for the catalytic activity
            of the collagen glucosyltransferase associated with the
            multifunctional lysyl hydroxylase 3 (LH3)
  JOURNAL   J Biol Chem 277 (21), 18568-18573 (2002)
   PUBMED   11896059
REFERENCE   8  (bases 1 to 3278)
  AUTHORS   Ruotsalainen,H., Vanhatupa,S., Tampio,M., Sipila,L., Valtavaara,M.
            and Myllyla,R.
  TITLE     Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl
            hydroxylase 3/collagen glucosyltransferase
  JOURNAL   Matrix Biol 20 (2), 137-146 (2001)
   PUBMED   11334715
REFERENCE   9  (bases 1 to 3278)
  AUTHORS   Sipila,L., Szatanik,M., Vainionpaa,H., Ruotsalainen,H., Myllyla,R.
            and Guenet,J.L.
  TITLE     The genes encoding mouse lysyl hydroxylase isoforms map to
            chromosomes 4,5, and 9
  JOURNAL   Mamm Genome 11 (12), 1132-1134 (2000)
   PUBMED   11130984
REFERENCE   10 (bases 1 to 3278)
  AUTHORS   Ruotsalainen,H., Sipila,L., Kerkela,E., Pospiech,H. and Myllyla,R.
  TITLE     Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3,
            their phylogenetic analysis and tissue-specific expression in the
            mouse
  JOURNAL   Matrix Biol 18 (3), 325-329 (1999)
   PUBMED   10429951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054734.1 and BB692664.1.
            
            On Sep 19, 2009 this sequence version replaced NM_011962.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054734.1, BC043047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3171              BC054734.1         1-3171
            3172-3278           BB692664.1         428-534
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.09 cM"
     gene            1..3278
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /note="procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3"
                     /db_xref="GeneID:26433"
                     /db_xref="MGI:MGI:1347008"
     exon            1..785
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             668..2893
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /EC_number="1.14.11.4"
                     /EC_number="2.4.1.50"
                     /EC_number="2.4.1.66"
                     /note="lysyl hydroxylase 3; lysyl hydroxylase 2;
                     multifunctional procollagen lysine hydroxylase and
                     glycosyltransferase LH3"
                     /codon_start=1
                     /product="multifunctional procollagen lysine hydroxylase
                     and glycosyltransferase LH3 precursor"
                     /protein_id="NP_036092.1"
                     /db_xref="CCDS:CCDS19759.1"
                     /db_xref="GeneID:26433"
                     /db_xref="MGI:MGI:1347008"
                     /translation="MAAAGPEPRLLLLLLLLLPPLPPVTSASDRPRGANAVNPDKLLV
                     ITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEK
                     YADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPEWGLAEQYPEV
                     GMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPGLREKLKLSLDHK
                     SRIFQNLNGALDEVILKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGW
                     TPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLF
                     LHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYF
                     SLDADAVLTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVEL
                     VQRKRVGVWNVPYISQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLH
                     LSNQHEFGRLLATSRYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPC
                     PDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYED
                     QWLQLLRTYVGPMTEYLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVAL
                     NHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVD
                     P"
     exon            786..877
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1014
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1178
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1291
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1355
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1453
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1555
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1681
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1803
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1908
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2034
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2176
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2290
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2359
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2464
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2611
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2737
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..3278
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /note="hexamer: AATAAA"
     polyA_site      3171
                     /gene="Plod3"
                     /gene_synonym="LH3"
                     /note="major polyA site"
ORIGIN      
        1 gggcaaacct aattccggtc gcattgtggt tacccaaaaa aaaaaatctg agagccgcct
       61 gcaaatggtc actttttaaa aactggcgtg ggtggtcttt aggggagcgc tcttgtccct
      121 gtgccctttg catccccggt gcgtgtcccc gcgctgcggg acaggatagg caggttcggt
      181 ggctttgttg aacccagacc cacgaggatg tccgcgcgat cccgcctccg gcttcccggc
      241 ccctccgggc ccgtcgcccc cgccgcgcgc caccccaggc cttgctgtcc tgtgttcctc
      301 cgggtcagac ttgtggtcaa gacccgcccc cgcgtcgcct ggaccctcct caaaaggtca
      361 cttcccctcc cggggggatt cggttgctcc ggtgtgagtc aggcagtgcc caggaccgga
      421 ccctcggctc ctccccaccc tccagcccgc gcccgcggga caatccttgc cttgtctcgc
      481 cgtctgcatc tcgggttttc ggtggcctcg ggttacgcct tttttccagg gcggagtccc
      541 gagcacagct cctcctctca gcgggctcgg tttccccttt tcccagaatc ttcccggggc
      601 gtcggaatcc aggcgctcag ctcagcgccg gtgcgggcct gggtgtagcc taagcgtgct
      661 gctagccatg gctgcggcag gcccggaacc ccggcttttg ctcctgctcc tgctgctgct
      721 gccgccgctg ccccccgtaa cttctgcctc cgatcgaccc cggggcgcca atgctgtcaa
      781 cccagacaaa ttgctggtga tcactgtggc tacggcagag acagaggggt accggcgttt
      841 tctgcagtct gcggagttct ttaactacac tgtacggacc ctgggcctgg gacaggagtg
      901 gcgagggggt gatgtggctc gaacagttgg tggaggccag aaggtcaggt ggctcaagaa
      961 ggaaatggag aaatatgcag atcagaaaga catgatcatc atgtttgtgg acagctacga
     1021 cgtgattctg gcaagcagcc cgacagagct gctgaagaag tttgttcaga gtggcagtca
     1081 tctgctgttc tctgctgaga gcttctgctg gcctgagtgg gggctggcag agcagtaccc
     1141 tgaggtgggc atggggaagc gcttcctcaa ctctggtgga ttcatcggct ttgctcccac
     1201 catccatcag attgtccgcc agtggaacta caaagacgac gatgatgatc aattgttcta
     1261 cactcaactg tacctggacc cagggctgcg ggagaaactc aaactgagtc tggaccataa
     1321 atcccggatc tttcagaacc tcaatggagc cttagatgaa gtgatcttaa agtttgacca
     1381 gaatcgtgtg cgcatccgga atgtggccta cgacacactt cctgttgtgg tccatggaaa
     1441 tggtcccact aagctccagc tcaactacct ggggaactat gtccccaatg gctggactcc
     1501 ccagggaggc tgtggattct gcaaccagac cctgaggaca ctcccggggg ggcagcctcc
     1561 cccccgggtg cttctggccg tgtttgtgga gcagcctact cccttcctgc ctcggttcct
     1621 gcagcgccta ctgctcctgg attacccccc ggacaggatc tctctcttcc ttcacaacag
     1681 cgaggtgtac cacgagcctc atattgcaga tgcctggcca cagctccagg accatttttc
     1741 agctgtaaag ctggtggggc cagaggaggc cctgagcgca ggggaggcca gggacatggc
     1801 catggacagc tgtcggcaga accctgagtg tgagttctac tttagcctgg atgctgatgc
     1861 cgtccttacg aacccggaga ccttgcgtgt cttgattgaa caaaacagga aggtaatagc
     1921 tcccatgctt tcccgccatg gcaagctctg gtccaacttc tggggtgccc tgagccccaa
     1981 tgagtactac gcccgctccg aagactacgt ggaactggtg cagcggaagc gagtgggcgt
     2041 gtggaatgta ccctacatat ctcaggcata tgtgatccgc ggggagaccc tgaggactga
     2101 actgccccaa aaggaggtat tctccagcag cgacacagac ccagatatgg ctttctgcaa
     2161 gagcgtccgg gacaagggca tcttcctcca cctcagcaac cagcacgagt ttggccggct
     2221 gctggctact tctcgctatg acacagacca cctacaccca gacctctggc agatctttga
     2281 caaccctgtg gactggagag aacagtacat tcacgagaat tacagccggg ccctggatgg
     2341 ggaagggcta gtggaacagc catgcccaga tgtgtactgg ttcccactgc tgaccgagca
     2401 gatgtgtgat gagctggtgg aggaaatgga acactatggc cagtggtctg gaggccggca
     2461 cgaggattcc aggttggctg gaggatacga gaatgttccc accgttgata tccacatgaa
     2521 acaggtggga tacgaggacc agtggcttca gctgctgcgg acatatgtgg ggcccatgac
     2581 ggagtacctg ttccctggct accacaccaa gacacgggca gtgatgaact tcgtggtccg
     2641 ctaccggcca gatgagcagc cctcgcttcg gccacaccat gactcgtcca ccttcactct
     2701 caatgtcgcc ctcaaccaca agggtgtaga ttatgaggga ggcggctgcc gcttcctgcg
     2761 ttacgactgc agaatctcct ctccgaggaa aggctgggcc ctcctgcacc ctggccgcct
     2821 cacacactac catgaggggc tgcccaccac ccggggtact cgatacatca tggtgtcctt
     2881 tgttgacccc tgacactcaa ccagtctgcc aaaccttctc tgccactgtg ccttgttgga
     2941 caacctgggt cgccattctc agagagaggg gacgctgccc gtctcatctc ccgagagtgt
     3001 ctgtgtgcct gggatggaat gtgctggtcc caacagtcct caggaggtcc ctggagtctt
     3061 ccacttgccc actgacccca tggactcagg gaaagtggac ttctgagggt cccctgcctg
     3121 ataaattatt aagcttcctc agcctcactt tcaataaaag gatgtttgta accattgagt
     3181 ccgtgagtcc aatataaaga cagggtctca tgtgtcccat gctggcctcc caccatgcac
     3241 aaatacacat gattaaaatt tttttttaaa atctgcaa
//
