LOCUS       NM_001142916            3719 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
            (Plod2), transcript variant 1, mRNA.
ACCESSION   NM_001142916
VERSION     NM_001142916.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Kot,A., Chun,C., Martin,J.H., Wachtell,D., Hudson,D., Weis,M.,
            Marks,H., Srivastava,S., Eyre,D.R., Duran,I., Zieba,J. and
            Krakow,D.
  TITLE     Loss of the long form of Plod2 phenocopies contractures of Bruck
            syndrome-osteogenesis imperfecta
  JOURNAL   J Bone Miner Res 39 (9), 1240-1252 (2024)
   PUBMED   39088537
  REMARK    GeneRIF: Loss of the long form of Plod2 phenocopies contractures of
            Bruck syndrome-osteogenesis imperfecta.
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Yue,W., Zhang,H., Gao,Y., Ding,J., Xue,R., Dong,C., Liu,F.,
            Yang,L., Yang,L. and Li,L.
  TITLE     Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen
            cross-linking and ECM stiffening to induce liver fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167205 (2024)
   PUBMED   38696846
  REMARK    GeneRIF: Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes
            collagen cross-linking and ECM stiffening to induce liver fibrosis.
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Kang,H., Strong,A.L., Sun,Y., Guo,L., Juan,C., Bancroft,A.C.,
            Choi,J.H., Pagani,C.A., Fernandes,A.A., Woodard,M., Lee,J.,
            Ramesh,S., James,A.W., Hudson,D., Dalby,K.N., Xu,L., Tower,R.J. and
            Levi,B.
  TITLE     The HIF-1alpha/PLOD2 axis integrates extracellular matrix
            organization and cell metabolism leading to aberrant
            musculoskeletal repair
  JOURNAL   Bone Res 12 (1), 17 (2024)
   PUBMED   38472175
  REMARK    GeneRIF: The HIF-1alpha/PLOD2 axis integrates extracellular matrix
            organization and cell metabolism leading to aberrant
            musculoskeletal repair.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Bahraoui,S., Tejedor,G., Mausset-Bonnefont,A.L., Autelitano,F.,
            Barthelaix,A., Terraza-Aguirre,C., Gisbert,V., Arribat,Y.,
            Jorgensen,C., Wei,M. and Djouad,F.
  TITLE     PLOD2, a key factor for MRL MSC metabolism and chondroprotective
            properties
  JOURNAL   Stem Cell Res Ther 15 (1), 70 (2024)
   PUBMED   38454524
  REMARK    GeneRIF: PLOD2, a key factor for MRL MSC metabolism and
            chondroprotective properties.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3719)
  AUTHORS   Wang,C., Risteli,M., Heikkinen,J., Hussa,A.K., Uitto,L. and
            Myllyla,R.
  TITLE     Identification of amino acids important for the catalytic activity
            of the collagen glucosyltransferase associated with the
            multifunctional lysyl hydroxylase 3 (LH3)
  JOURNAL   J Biol Chem 277 (21), 18568-18573 (2002)
   PUBMED   11896059
REFERENCE   7  (bases 1 to 3719)
  AUTHORS   Ruotsalainen,H., Vanhatupa,S., Tampio,M., Sipila,L., Valtavaara,M.
            and Myllyla,R.
  TITLE     Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl
            hydroxylase 3/collagen glucosyltransferase
  JOURNAL   Matrix Biol 20 (2), 137-146 (2001)
   PUBMED   11334715
REFERENCE   8  (bases 1 to 3719)
  AUTHORS   Hjalt,T.A., Amendt,B.A. and Murray,J.C.
  TITLE     PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene
            expression: implications for the pathology of Rieger syndrome
  JOURNAL   J Cell Biol 152 (3), 545-552 (2001)
   PUBMED   11157981
REFERENCE   9  (bases 1 to 3719)
  AUTHORS   Sipila,L., Szatanik,M., Vainionpaa,H., Ruotsalainen,H., Myllyla,R.
            and Guenet,J.L.
  TITLE     The genes encoding mouse lysyl hydroxylase isoforms map to
            chromosomes 4,5, and 9
  JOURNAL   Mamm Genome 11 (12), 1132-1134 (2000)
   PUBMED   11130984
REFERENCE   10 (bases 1 to 3719)
  AUTHORS   Ruotsalainen,H., Sipila,L., Kerkela,E., Pospiech,H. and Myllyla,R.
  TITLE     Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3,
            their phylogenetic analysis and tissue-specific expression in the
            mouse
  JOURNAL   Matrix Biol 18 (3), 325-329 (1999)
   PUBMED   10429951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB644981.1, AK033363.1, AC165156.3, AF080572.1, CF615856.1 and
            AV488215.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as LH2b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157207.1, AK033363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BB644981.1         1-41
            42-655              AK033363.1         2-615
            656-656             AC165156.3         157569-157569
            657-2738            AK033363.1         616-2697
            2739-3107           AF080572.1         2447-2815
            3108-3637           CF615856.1         126-655
            3638-3719           AV488215.1         164-245
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 48.4 cM"
     gene            1..3719
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /note="procollagen lysine, 2-oxoglutarate 5-dioxygenase 2"
                     /db_xref="GeneID:26432"
                     /db_xref="MGI:MGI:1347007"
     exon            1..346
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..438
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..575
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..739
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..852
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..916
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1014
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1116
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1242
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1364
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1469
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1595
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1737
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1800
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1914
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1980
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2085
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2232
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2358
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..3712
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3692..3697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /note="hexamer: AATAAA"
     polyA_site      3712
                     /gene="Plod2"
                     /gene_synonym="D530025C14Rik; LH2; Plod-2"
                     /note="major polyA site"
ORIGIN      
        1 tccttggctg ctcttaagcc cgcgccgcgg gcgcctccgg ttccgtcgtc cgctccttgc
       61 gctcggactc cgccgaagtc cgctcaatcc tctccgtgct cttcggtacc cacgcagtcc
      121 tcccagtccg ccctccgctc cagccccggg ctcacgtctg gtcctgcgct cttcggggtc
      181 tcagcgtctc gcgagaagtc ctcgccacag gccttcggct cccgggttca ggggcggatg
      241 ggggaccgcg gagcgaggcc ggggcggctg atgcccatgc tcgccctgct ctcctgggcg
      301 gccggcctgg gcgtggcgga ggagacgccc gggcgcatcc ctgcagataa attattagtc
      361 ataactgtcg caacaaaaga aaatgatgga ttccacagat ttatgaattc agccaagtat
      421 ttcaattaca ctgtgaaggt tcttggtcaa ggtcaggagt ggagaggcgg tgatggaatg
      481 aacagtatcg gagggggcca gaaggtgaga ttactgaaag aagctatgga gcactacgcc
      541 agtcaggaag atctggtcat cttgtttacc gagtgttttg atgttgtatt tgctggtggg
      601 cctgaagaag ttcttaaaaa gttccaaaag acaaatcata aaatcgtctt tgcagcggac
      661 gggctgctgt ggccagataa gcggctggca gacaagtacc ctgttgtgca cattgggaaa
      721 cgctacctga attctggagg ctttattggc tatgccccgt acatcagccg tctggtccag
      781 cagtggaatc tgcaggataa tgatgatgat cagctctttt acacgaaagt ttacatcgac
      841 ccactgaaga gggaagcttt taacatcaca ctggatcaca aatgcaaaat tttccaggcc
      901 ttgaatggag ctacagatga agttgtttta aagtttgaaa atggtaaaag cagagtgaag
      961 aatacatttt atgaaacact gccagtggca attaatggaa atgggcccac caagattctc
     1021 ctgaattact ttggaaacta tgttccaaac tcatggacac aggaaaatgg ctgtgcgctt
     1081 tgtgatgttg acacaattga cttgtctaca gtagatgtcc ctcccaaggt tacactgggt
     1141 gtttttattg aacaaccaac cccctttcta cctcgattcc tgaacttact gttaacactg
     1201 gattatccca aagaagccct tcaactcttt attcataata aagaagttta tcatgaaaag
     1261 gacatcaaag tgtttgttga taaagctaag catgacatca gctctataaa aatagtagga
     1321 ccagaggaga acctaagtca agcagaagcc aggaacatgg gcatggattt ctgccgtcag
     1381 gatgaaaagt gtgattacta ctttagtgtg gatgcagatg ttgttttgac aaacccaaga
     1441 actttaaaat ttttgattga acaaaacagg aaaatcattg ctcctcttgt gacacgtcat
     1501 ggaaagttgt ggtccaactt ttggggagca ctgagtcctg atgggtacta tgctcgctct
     1561 gaagattacg tggatattgt tcaggggaac agagtaggaa tctggaatgt cccatatatg
     1621 gctaatgtgt acttaattca aggaaagaca ctccgatctg agatgaatga aaggaactat
     1681 tttgtccgtg ataagttgga tcccgatatg gctctttgcc gcaatgctag agatatgacc
     1741 ttacaaaggg aaaaagactc ccctactccg gaaacattcc aaatgctcag ccccccaaag
     1801 ggtgtgttta tgtacatttc taacagacat gaatttggac ggctgatatc aactgctaat
     1861 tacaacactt cccatcttaa caatgacttc tggcagattt ttgaaaatcc cgtggattgg
     1921 aaggaaaaat atataaatcg tgattattca aagattttca ctgaaaatat agtcgagcag
     1981 ccttgtccag atgtcttctg gtttcccata ttttctgaac gagcctgtga tgagttggta
     2041 gaagaaatgg agcattatgg caagtggtcc ggcggaaagc atcacgatag ccgcatatcg
     2101 ggtggttatg aaaatgtccc gactgacgat attcatatga agcagatcgg gctggagaat
     2161 gtttggcttc atttcatccg agagttcatt gctccagtca cactgaaggt cttcgcaggc
     2221 tattatacaa agggatttgc actgctgaat tttgtagtaa agtactcacc tgaaagacag
     2281 cgctcgctcc gtccccacca cgatgcctca acctttacca tcaacattgc tctgaataat
     2341 gtaggagagg attttcaggg aggtggatgc aaatttctga ggtataattg ctccattgag
     2401 tccccacgaa aaggctggag cttcatgcat cctgggaggc tcacacattt gcacgaagga
     2461 cttcctgtta aaaatggaac acgatacatt gcagtgtcat ttatagatcc ctaagttatt
     2521 tacgtaactc aaactgaatg gctctctgag atggatgact ggcgtgaaca tgtctctgaa
     2581 gttgtacttg agaagacaag aagaataatg tcaacagaac aacatcactt tgggccaagc
     2641 atttgaacac tttttatata aaattgtgtg atgtctcttt atgtctgctc tgagccttaa
     2701 aacacaggtt gaagaagaaa agaaaggaaa aaaaagtgaa agttggtatt tatttctgtg
     2761 ctttaattgt ctctgaaaat aatgacagtt tataaaatgt ttaggtacaa aggcataaat
     2821 gataataagt aagcctggta atatgttctt atttaagaag aacctgagaa ggttttattt
     2881 atcggtgggg gaagtatagc aaacggttct aaatgaaaat cagcaaacct gaaagcctgg
     2941 gattctgacg cctactggct ctatgtaatt attaagtcac attgacctct gtgtagggct
     3001 gttttccagg aattaggaag aaaacccaaa gaaaatattg cacaaaggtt tccctcagga
     3061 aacctagtgc agatagccat ggaagcatag ccactggaaa ggaacagtgc atgaggcaga
     3121 tgttcgtttc tggtggaaat tgggcccctg tgttcctcca gggcaagtct caggggaagc
     3181 tcatgtcttt ctgctttaca aagtgcttca agcgtcagct ccaagtgtcc ttatgtcagc
     3241 aggatttgtt tccttctagt cccccccccc cccattatag aaaatagtaa ggaaaaataa
     3301 cagtttcatt gagatcagta gtaaatttta ctatgttttt tttaaagctt acgtacttga
     3361 attttatatc aggaagatgg tttttgagcc tgttccttac ccttgactat agttggtagt
     3421 tggtctcttt tttcccccta ggggaggggt ttttctttcc ctcactgcaa tctattttct
     3481 cattcttagt ctccttaatt acttttcctc taccctactt gttaaaagtt cccacagcaa
     3541 aattttttat ttcaattttt aatatttctc caaatgaggt ttaaatatac tatagctact
     3601 gtttttaatt taaaggttaa acttgaagaa agtctttatt cacggtgcca aaattcattt
     3661 ttctaactct gtgtgttagg aaataatgaa aaataaaata atttaaaata aaaaaaaaa
//
