LOCUS       NM_011122               3268 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
            (Plod1), mRNA.
ACCESSION   NM_011122
VERSION     NM_011122.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Li,L., Hua,R., Hu,K., Chen,H., Yin,Y., Shi,X., Peng,K., Huang,Q.,
            Qiu,Y., Li,X., Liu,Q., Liu,S. and Wang,Z.
  TITLE     SIRT6 deficiency causes ovarian hypoplasia by affecting
            Plod1-related collagen formation
  JOURNAL   Aging Cell 23 (2), e14031 (2024)
   PUBMED   37936548
  REMARK    GeneRIF: SIRT6 deficiency causes ovarian hypoplasia by affecting
            Plod1-related collagen formation.
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Yang,Z., Zhou,L., Si,T., Chen,S., Liu,C., Ng,K.K., Wang,Z.,
            Chen,Z., Qiu,C., Liu,G., Wang,Q., Zhou,X., Zhang,L., Yao,Z., He,S.,
            Yang,M. and Zhou,Z.
  TITLE     Lysyl hydroxylase LH1 promotes confined migration and metastasis of
            cancer cells by stabilizing Septin2 to enhance actin network
  JOURNAL   Mol Cancer 22 (1), 21 (2023)
   PUBMED   36721170
  REMARK    GeneRIF: Lysyl hydroxylase LH1 promotes confined migration and
            metastasis of cancer cells by stabilizing Septin2 to enhance actin
            network.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Li,H., Xu,H., Wen,H., Wang,H., Zhao,R., Sun,Y., Bai,C., Ping,J.,
            Song,L., Luo,M. and Chen,J.
  TITLE     Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang
            II)-induced dissecting abdominal aortic aneurysm
  JOURNAL   Theranostics 11 (19), 9587-9604 (2021)
   PUBMED   34646388
  REMARK    GeneRIF: Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin
            II (Ang II)-induced dissecting abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Hjalt,T.A., Amendt,B.A. and Murray,J.C.
  TITLE     PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene
            expression: implications for the pathology of Rieger syndrome
  JOURNAL   J Cell Biol 152 (3), 545-552 (2001)
   PUBMED   11157981
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Sipila,L., Szatanik,M., Vainionpaa,H., Ruotsalainen,H., Myllyla,R.
            and Guenet,J.L.
  TITLE     The genes encoding mouse lysyl hydroxylase isoforms map to
            chromosomes 4,5, and 9
  JOURNAL   Mamm Genome 11 (12), 1132-1134 (2000)
   PUBMED   11130984
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Ruotsalainen,H., Sipila,L., Kerkela,E., Pospiech,H. and Myllyla,R.
  TITLE     Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3,
            their phylogenetic analysis and tissue-specific expression in the
            mouse
  JOURNAL   Matrix Biol 18 (3), 325-329 (1999)
   PUBMED   10429951
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   McClive,P.J. and Morahan,G.
  TITLE     Assignment of the mouse homologues of 6 loci from HSA1p to
            chromosomes 3 and 4
  JOURNAL   Genomics 23 (1), 243-246 (1994)
   PUBMED   7829080
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Hautala,T., Byers,M.G., Eddy,R.L., Shows,T.B., Kivirikko,K.I. and
            Myllyla,R.
  TITLE     Cloning of human lysyl hydroxylase: complete cDNA-derived amino
            acid sequence and assignment of the gene (PLOD) to chromosome
            1p36.3----p36.2
  JOURNAL   Genomics 13 (1), 62-69 (1992)
   PUBMED   1577494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY312508.1, AK137480.1, AK003529.1 and AI834765.1.
            
            On Apr 28, 2009 this sequence version replaced NM_011122.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137480.1, AF046782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY312508.1         1-51
            52-1173             AK137480.1         2-1123
            1174-2205           AK137480.1         1125-2156
            2206-2945           AK137480.1         2158-2897
            2946-3248           AK003529.1         507-809
            3249-3268           AI834765.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.57 cM"
     gene            1..3268
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /note="procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1"
                     /db_xref="GeneID:18822"
                     /db_xref="MGI:MGI:99907"
     exon            1..175
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2286
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /EC_number="1.14.11.4"
                     /codon_start=1
                     /product="procollagen-lysine,2-oxoglutarate 5-dioxygenase
                     1 precursor"
                     /protein_id="NP_035252.1"
                     /db_xref="CCDS:CCDS18924.1"
                     /db_xref="GeneID:18822"
                     /db_xref="MGI:MGI:99907"
                     /translation="MRSLLLLAPLAWLLLVQAKDDAKLEDNLLVLTVATKETEGFRRF
                     KRSAQFFNYKIQSLGLGEDWSVDGGPAAAGGGQKVRLLKKALEKHADKEDLVILFVDS
                     YDVVFASGPRELLKKFQQAKSQVVFSAEEHIYPDRRLEAKYPTVPDGKRFLGSGGFIG
                     YAPSLSKLVAEWEGQDSDSDQLFYTKIFLNPEKREQINISLDHRCRIFQNLDGALDEV
                     VLKFEMGHVRARNLAYDTLPVVVHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLR
                     SLKGIGDEALPTVLVGVFIEQPTPFLSLFFLRLLRLRYPQKQMRLFIHNQERHHKLQV
                     EQFLAEHGSEYQSVKLVGPEVRMANADARNMGADLCRQDQTCTYYFSVDADVALTEPN
                     SLRLLIEQNKNVIAPLMTRHGRLWSNFWGGLSADGYYARSEDYVDIVQGRRVGVWNVP
                     YISNIYLIKGSALRAELQNVDLFHYSKLDSDMSFCANVRQQEVFMFLTNRHTFGHLLS
                     LDNYQTTHLHNDLWEVFSNPEDWKEKYIHENYTKALAGKLVETPCPDVYWFPIFTEAA
                     CDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDIHMNQITFEREWHKFLVEYIAPM
                     TEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTVNIALNRVGEDYEGGGCR
                     FLRYNCSVRAPRKGWALLHPGRLTHYHEGLPTTKGTRYIAVSFVDP"
     exon            176..267
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            268..404
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            405..568
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            569..681
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            682..745
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            746..843
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            844..945
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1077
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1199
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1304
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1430
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1572
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1686
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1752
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1857
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2004
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2130
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..3252
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /note="hexamer: ATTAAA"
     polyA_site      2945
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /note="major polyA site"
     regulatory      3209..3214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="Plod1"
                     /gene_synonym="2410042F05Rik; Lh1; Plod"
ORIGIN      
        1 ggggcgggct cagtgcgtgg cagcgcccgc cggccccgtc gcgaagtttc cagttcagct
       61 tctgtctcag tgccggcggg ttgttcccga gactccgcta tgcggtccct gctgctcctg
      121 gccccgttgg cctggcttct tctggtccag gcgaaggatg acgccaagct agaggacaac
      181 cttctggtcc tcactgtggc cacaaaagag actgagggct tccgccgctt caagcgttca
      241 gctcagttct tcaactacaa gatccagtca ctgggcctgg gggaggactg gagtgtggat
      301 ggaggaccag cagcagcagg tggaggacag aaggttcggc tgctgaagaa ggcactggaa
      361 aagcacgcag acaaggaaga cctggttatt ctcttcgttg acagttatga cgtggtgttt
      421 gcctcgggac cccgggaact cttaaagaag ttccagcagg ccaagagcca ggtggtcttc
      481 tccgcagagg agcatatcta cccggaccgg aggctggagg ccaagtatcc cacagtcccc
      541 gacggcaagc ggttcctggg ctctggaggc ttcattggtt atgcccccag cctcagcaaa
      601 ctggtggccg agtgggaagg ccaggacagt gacagcgacc agctctttta taccaagatc
      661 ttcttgaacc cggagaagag ggagcaaatc aatatcagcc tggaccatcg ctgccgaatc
      721 ttccagaacc tggatggagc cttggatgaa gttgtgctca agtttgaaat gggccacgtg
      781 agagcacgaa atctggccta tgacaccctc ccagtggtcg ttcatggcaa tgggcccacc
      841 aagctgcagc tgaactacct gggcaactac attcctcgat tctggacctt cgagacgggc
      901 tgcaccgtgt gtgacgaggg cctacggagc ctcaagggca ttggggatga agctctcccc
      961 actgtcctgg tcggtgtgtt cattgagcag cccacaccat ttctatcctt gtttttcctg
     1021 cggctgctgc gcctacgata ccctcagaaa cagatgcggc tcttcattca caaccaggaa
     1081 cggcaccaca aacttcaggt agagcagttc ctggcggagc acggcagtga gtaccagtct
     1141 gtgaagctag tgggtcctga ggtgcgcatg gccaacgccg acgccaggaa catgggcgca
     1201 gacctgtgcc gtcaggacca aacttgcacc tactacttca gtgtggatgc tgatgtggct
     1261 ctgacggagc cgaacagcct aaggctcctg attgaacaaa acaagaatgt cattgcgcca
     1321 ctcatgaccc gccacgggag gctctggtcc aacttctggg ggggtctgag tgcagatggg
     1381 tactacgccc gctcagagga ctacgtggac attgtgcagg gccgtcgtgt tggcgtctgg
     1441 aacgtgcctt acatctcaaa catctacctg atcaagggca gtgccctgcg ggctgaactg
     1501 cagaacgtag accttttcca ctacagcaag ctggattccg acatgagttt ctgcgccaat
     1561 gtccgacagc aggaggtgtt catgttcctg accaaccggc acacctttgg ccacctgctt
     1621 tccctggata actaccagac cacccaccta cataatgatc tctgggaggt gttcagcaac
     1681 cctgaggact ggaaagaaaa gtacatccat gagaattaca ccaaggccct ggcggggaag
     1741 ctggtggaga cgccttgtcc ggatgtctac tggttcccca tcttcacgga ggcggcctgt
     1801 gatgagctgg tggaggagat ggaacactat ggccagtggt ctctgggtga taataaggac
     1861 aaccggatcc agggtggcta cgaaaacgtg cccactatcg acatccatat gaaccagatc
     1921 accttcgagc gggagtggca caagttcctg gtggagtaca tcgcccccat gacagagaag
     1981 ctgtaccctg gctactacac tagggcccag tttgatctag ccttcgtcgt ccgctataag
     2041 cccgatgagc agccttcctt gatgccccac catgacgcct ctaccttcac cgtcaacata
     2101 gccctgaaca gggttgggga agattatgag ggcggaggtt gccgatttct gcgctacaac
     2161 tgctccgtga gggcaccaag gaagggctgg gccctcctgc accccgggcg gctcacacac
     2221 tatcacgagg ggcttcctac taccaagggc acgcgctaca ttgctgtgtc tttcgtcgat
     2281 ccctaactgc ccagtgcctg cctctgttcg acctatctca tcgttgacaa ccactgccca
     2341 gcagcccttg gggccaagga acccaatcca acctctgatt cctgaactcc tgtagctctt
     2401 gaagccacca gttggaacga tggggtgcag gccagagatg gggcacccac tccaggactg
     2461 gggctgccca tggtgctccc actaatctca ggagatggta acgctcatct tcaaggagtt
     2521 cccagccccc ctttttcctc tgactttccc tggggccaga cttcgacgga gctgcctggg
     2581 atgctggaga gtcagaagct ttgcctagag cagctctgga agggctagcc cccaggattc
     2641 tgtttcaagt atcagtgcca ccaaggtctg ggtcaaccca cctaccccaa ctccaccccg
     2701 aacctaggac tcttgatgcc cctctctttc aggtttttat caccaagagc aaatagttgt
     2761 ctctattgag actgtaactc gaaatcctcc cggggggcag gaaagacatc tgtgacaatg
     2821 cttggttctc tactgaccct gcttggggga ggggcatatg tccacactgt actgggtcac
     2881 cctgtcccga tgcctctgga gacagggaca gagacgagag ttctattaaa tgtcgttcaa
     2941 accactgtat gagagatgcc tggggtgggc cagcatacat gcgatatcag cagggagcgt
     3001 tgtgagagcc catggctgga aggacagact gtcagtagac tgtgggactc ctgtctctca
     3061 aacccagtgc ctcgtggcct ctagggtgca tagtctctac tatgaactgg gaactggctg
     3121 ggacattcct tttcagttgc ctagacctgc gttacctgtc actgcttctt agagtctttg
     3181 ccagcccttc ctgcagccat gaacatggaa taaagagcag aactttgggt ggcccccacc
     3241 gcaccctgag caaaaaaaaa aaaaaaaa
//
