LOCUS       NM_023129               2353 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus phospholamban (Pln), transcript variant 2, mRNA.
ACCESSION   NM_023129
VERSION     NM_023129.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2353)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2353)
  AUTHORS   Klocke,B., Britzolaki,A., Saurine,J., Ott,H., Krone,K.,
            Bahamonde,K., Thelen,C., Tzimas,C., Sanoudou,D., Kranias,E.G. and
            Pitychoutis,P.M.
  TITLE     A novel role for phospholamban in the thalamic reticular nucleus
  JOURNAL   Sci Rep 14 (1), 6376 (2024)
   PUBMED   38493225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2353)
  AUTHORS   Stege,N.M., Oliveira Nunes Teixeira,V., Zijlstra,S.N.,
            Feringa,A.M., de Boer,R.A. and Sillje,H.H.W.
  TITLE     Deletion of DWORF does not affect cardiac function in aging and in
            PLN-R14del cardiomyopathy
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (3), H870-H876 (2024)
   PUBMED   38334971
REFERENCE   4  (bases 1 to 2353)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (bases 1 to 2353)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   6  (bases 1 to 2353)
  AUTHORS   Kadambi,V.J., Ponniah,S., Harrer,J.M., Hoit,B.D., Dorn,G.W. 2nd,
            Walsh,R.A. and Kranias,E.G.
  TITLE     Cardiac-specific overexpression of phospholamban alters calcium
            kinetics and resultant cardiomyocyte mechanics in transgenic mice
  JOURNAL   J Clin Invest 97 (2), 533-539 (1996)
   PUBMED   8567978
REFERENCE   7  (bases 1 to 2353)
  AUTHORS   Hoit,B.D., Khoury,S.F., Kranias,E.G., Ball,N. and Walsh,R.A.
  TITLE     In vivo echocardiographic detection of enhanced left ventricular
            function in gene-targeted mice with phospholamban deficiency
  JOURNAL   Circ Res 77 (3), 632-637 (1995)
   PUBMED   7641333
REFERENCE   8  (bases 1 to 2353)
  AUTHORS   Koss,K.L., Ponniah,S., Jones,W.K., Grupp,I.L. and Kranias,E.G.
  TITLE     Differential phospholamban gene expression in murine cardiac
            compartments. Molecular and physiological analyses
  JOURNAL   Circ Res 77 (2), 342-353 (1995)
   PUBMED   7542181
  REMARK    Erratum:[Circ Res 1995 Nov;77(5):1036]
REFERENCE   9  (bases 1 to 2353)
  AUTHORS   Luo,W., Grupp,I.L., Harrer,J., Ponniah,S., Grupp,G., Duffy,J.J.,
            Doetschman,T. and Kranias,E.G.
  TITLE     Targeted ablation of the phospholamban gene is associated with
            markedly enhanced myocardial contractility and loss of beta-agonist
            stimulation
  JOURNAL   Circ Res 75 (3), 401-409 (1994)
   PUBMED   8062415
REFERENCE   10 (bases 1 to 2353)
  AUTHORS   Ganim,J.R., Luo,W., Ponniah,S., Grupp,I., Kim,H.W., Ferguson,D.G.,
            Kadambi,V., Neumann,J.C., Doetschman,T. and Kranias,E.G.
  TITLE     Mouse phospholamban gene expression during development in vivo and
            in vitro
  JOURNAL   Circ Res 71 (5), 1021-1030 (1992)
   PUBMED   1394867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658675.1, AK002622.1 and BM123812.2.
            
            On Nov 20, 2008 this sequence version replaced NM_023129.4.
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB658675.1, AK002622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BB658675.1         1-21
            22-2094             AK002622.1         2-2074
            2095-2353           BM123812.2         1-259               c
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 27.11 cM"
     gene            1..2353
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /note="phospholamban"
                     /db_xref="GeneID:18821"
                     /db_xref="MGI:MGI:97622"
     exon            1..110
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /inference="alignment:Splign:2.1.0"
     exon            111..2353
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      606..611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /note="hexamer: CATAAA"
     polyA_site      626
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /note="major polyA site"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /note="hexamer: ATTAAA"
     polyA_site      2210
                     /gene="Pln"
                     /gene_synonym="Plb"
     regulatory      2335..2340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /note="hexamer: TATAAA"
     polyA_site      2341
                     /gene="Pln"
                     /gene_synonym="Plb"
ORIGIN      
        1 acctactgca gctgctccca taaacctggg aacagaaaac tgcccagcta agctcccata
       61 agacttcata cagcttcatg ctctgcactg tgacgatcac cgaagccaag gtctcctaaa
      121 agaagacagc tcacatttgg ctgcctgttg tcaacttttt atctttctct tgaccactta
      181 gaaaaacttg tctccctact tttgccttcc tggcataatg gaaaaagtgc aatacctcac
      241 tcgctcggct atcaggagag cctccactat tgaaatgcct cagcaagcac gtcagaatct
      301 ccagaaccta tttatcaatt tctgcctcat cttgatatgt ctgctgctga tctgcatcat
      361 tgtgatgctt ctgtgaagag ctgccgccac tccagacctg caacatgcca actcagctta
      421 aagccgagca ctccgtcatg ggggaagcaa cgcaccgctg ccttccggct gagaacagct
      481 ttgtgagggt cacgattaag agtgaaacta attgttagcc agtgtattca tctgctggat
      541 cttgtaaaca aactttacag tggctaagtg tgcataatgt agctgccaat ttcctcaaca
      601 tggctcataa atttctttcc taaatatttc tgacaatgaa gtatgagttt taattttgaa
      661 acaccactac caaaaaagtt cactttctat atccaactct agcaaggtca ctttatagct
      721 ccagtctggg gaataaatgg aatatatact gcattgccac tacctttttt ataggaacta
      781 agtgttcttc agttctccac aaagtagaaa atagtcattt aaatgaagtg ttcttattga
      841 aaatagctca ctgggtcctc acatagatga cacaatgatg acgatgatga tgatgacgac
      901 gatgatgatg atgacgacga ttcaaatctc ttggtcacta ctgtcagaac aaataccttg
      961 aaaaaatgtt gtgccctttt tctacacact agtattttta agcttatgag agttaaaggg
     1021 ggaaatgtaa gaacatattc tcatataaaa ttattcacta attttgctca agggctgtgt
     1081 acatgtacat gtacattaac cacaaatctg ctctctctag ggtttgatca acaagcagga
     1141 acatcttgct gtgttggctg tgataatcac taaagatcca gagtctcacc tgaagcttgt
     1201 cgctctcatg tatctccttg gtttaatagc gtttctcaaa taatgaagat aacagtaata
     1261 accaagctgt agtaagacac agctctttct tttcctgatc tcccagagag gaagtggttg
     1321 tcccctaact ttagaagtag aactagagag ctagtgtata attcttactg accatggttt
     1381 caatttccct ttctaagttt ctactatctc tcaataacta ctaaaataga agcaaaaaat
     1441 agattggaaa atatattcac caaaatttag tgacttaaac tggatcaagt acaaaacagt
     1501 ttatgcctaa ctttgcaaac ccacaatttt taagtccagt tcaaaacatg ctactaacat
     1561 agcaattatt aaggaagaga attgtaatta gatatatttt ccataaccat tactacaaag
     1621 acataaaaca tcagtattca ctttggtctt tagcagagca gctgaaggct gctgatttaa
     1681 actgtttgaa cccctggtag aaaggaagct gttcgggttc agaaattatc taaagagtag
     1741 cccctaaagg agtccaatgg taacaggggg tctcttcata aaggctggag gggcccatca
     1801 cagaaactat aaaacatgga tgacatcatc tctaactcag tggtatttaa cgttcccttt
     1861 ctgacgctgt ggccctttta tatagttcct catgttgtgg tgatacccaa caataaaatc
     1921 atttttgttg ctatttcata actgtaattt cgcctcctta cctccactat gaattgtaaa
     1981 tattttggaa acaggtttgc atgaggggtt gcaacccaca ggttgagaac cactggtaag
     2041 aggtctgtaa aaaatacata agttgtgtag ttggccatgc tgagagaaac gtgacgctga
     2101 agctgaaaag caccaggcat ttgttatatt gctcactacc acatcaactt caaggtataa
     2161 actgtcagct cataaggctc ttctcattaa acatttaatg ctgcctttta catttttagt
     2221 agtttatttg tagtttatct gtaactgttt atctgtaaaa tgaaattgga atgacctata
     2281 ttcaaatgga gttttgattt tggtgaaatt actatacaat tatattctat tgactataaa
     2341 atgttgtctt gtt
//
