LOCUS       NM_001347124            2117 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polo like kinase 5 (Plk5), transcript variant 2, mRNA.
ACCESSION   NM_001347124 XM_006513499
VERSION     NM_001347124.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Petitpre,C., Faure,L., Uhl,P., Fontanet,P., Filova,I.,
            Pavlinkova,G., Adameyko,I., Hadjab,S. and Lallemend,F.
  TITLE     Single-cell RNA-sequencing analysis of the developing mouse inner
            ear identifies molecular logic of auditory neuron diversification
  JOURNAL   Nat Commun 13 (1), 3878 (2022)
   PUBMED   35790771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
  REMARK    GeneRIF: Plk5 is mostly expressed in the brain of both mice and
            humans, and it modulates the formation of neuritic processes upon
            stimulation of the brain-derived neurotrophic factor (BDNF)/nerve
            growth factor (NGF)-Ras pathway in neurons.
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
  REMARK    GeneRIF: DNA and protein sequence analyses show that Plk5 shares
            more similarities with Plk2 and Plk3 than with Plk1 and Plk4.
REFERENCE   6  (bases 1 to 2117)
  AUTHORS   Lein,E.S., Hawrylycz,M.J., Ao,N., Ayres,M., Bensinger,A.,
            Bernard,A., Boe,A.F., Boguski,M.S., Brockway,K.S., Byrnes,E.J.,
            Chen,L., Chen,L., Chen,T.M., Chin,M.C., Chong,J., Crook,B.E.,
            Czaplinska,A., Dang,C.N., Datta,S., Dee,N.R., Desaki,A.L.,
            Desta,T., Diep,E., Dolbeare,T.A., Donelan,M.J., Dong,H.W.,
            Dougherty,J.G., Duncan,B.J., Ebbert,A.J., Eichele,G., Estin,L.K.,
            Faber,C., Facer,B.A., Fields,R., Fischer,S.R., Fliss,T.P.,
            Frensley,C., Gates,S.N., Glattfelder,K.J., Halverson,K.R.,
            Hart,M.R., Hohmann,J.G., Howell,M.P., Jeung,D.P., Johnson,R.A.,
            Karr,P.T., Kawal,R., Kidney,J.M., Knapik,R.H., Kuan,C.L.,
            Lake,J.H., Laramee,A.R., Larsen,K.D., Lau,C., Lemon,T.A.,
            Liang,A.J., Liu,Y., Luong,L.T., Michaels,J., Morgan,J.J.,
            Morgan,R.J., Mortrud,M.T., Mosqueda,N.F., Ng,L.L., Ng,R.,
            Orta,G.J., Overly,C.C., Pak,T.H., Parry,S.E., Pathak,S.D.,
            Pearson,O.C., Puchalski,R.B., Riley,Z.L., Rockett,H.R.,
            Rowland,S.A., Royall,J.J., Ruiz,M.J., Sarno,N.R., Schaffnit,K.,
            Shapovalova,N.V., Sivisay,T., Slaughterbeck,C.R., Smith,S.C.,
            Smith,K.A., Smith,B.I., Sodt,A.J., Stewart,N.N., Stumpf,K.R.,
            Sunkin,S.M., Sutram,M., Tam,A., Teemer,C.D., Thaller,C.,
            Thompson,C.L., Varnam,L.R., Visel,A., Whitlock,R.M.,
            Wohnoutka,P.E., Wolkey,C.K., Wong,V.Y., Wood,M., Yaylaoglu,M.B.,
            Young,R.C., Youngstrom,B.L., Yuan,X.F., Zhang,B., Zwingman,T.A. and
            Jones,A.R.
  TITLE     Genome-wide atlas of gene expression in the adult mouse brain
  JOURNAL   Nature 445 (7124), 168-176 (2007)
   PUBMED   17151600
REFERENCE   7  (bases 1 to 2117)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB622163.1, AC152062.6, BE654673.1, BC086684.1 and BE985967.1.
            
            [WARNING] On Sep 5, 2024 this sequence was replaced by
            NM_001347124.2.
            
            On Nov 16, 2016 this sequence version replaced XM_006513499.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2), has the same N- and C-termini, but is shorter
            than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099679.1, SRR6116558.106526.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               BB622163.1         2-435
            435-595             BB622163.1         448-608
            596-605             AC152062.6         77837-77846         c
            606-691             BE654673.1         1-86
            692-2098            BC086684.1         1-1407
            2099-2117           BE985967.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2117
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /note="polo like kinase 5"
                     /db_xref="GeneID:216166"
                     /db_xref="MGI:MGI:3026984"
     exon            1..209
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1892
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /EC_number="2.7.11.21"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase PLK5; PLK-5; inactive
                     serine/threonine-protein kinase PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5
                     isoform 2"
                     /protein_id="NP_001334053.1"
                     /db_xref="CCDS:CCDS83729.1"
                     /db_xref="GeneID:216166"
                     /db_xref="MGI:MGI:3026984"
                     /translation="MEPRSRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYM
                     VLEYCSRQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNK
                     NMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTV
                     LTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQD
                     DFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQLLLTQCRPPCPFTSKEASGP
                     GEEGTEPDHMEAGNEERDPLCTEGRIHLLTLGTPRTGLAGPKGSLALQLEVATRKLFL
                     CLDAGPMAGQDPPGEQRPVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPQ
                     GGHVSYQPDQGTLWTFTLRDVPSPLRAKLAVLRLFACYMQRRLREEGTVPMPATPASP
                     DISLLSFIADSQAMVMLFSNGTVQVSLKTSQTQLVLSGEDEDLLLTLQEPGGPAVGVS
                     YTLDVLRSHGFTLAVHHHLRHGLHLLQSV"
     exon            210..317
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            318..434
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..564
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            565..652
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            653..748
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..947
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1074
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1151
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1224
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1302
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1459
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1589
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1700
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..2100
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2096
                     /gene="Plk5"
                     /gene_synonym="6330514A18Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagacccgct cccgctgctc cccggctcag atcggcagcg ctgcaggcag cactggcttg
       61 cgcagtcccc gcgcgcgctg cgcactcagg cccaacctgc gcagatggag ccccggtccc
      121 ggcggcggcg gagccgccag cttgtggcca ccttcctgcg cgacccaggc tcggggcgcg
      181 tgtaccggcg cgggaagctg atcggcaagg gagccttcag ccgctgctac aagctcacgg
      241 acatgtccac cagcgctgtg ttcgctctta aggtggtgcc aaggggcgga gcggggcggc
      301 tgcgcctgcg cgggaaggtg gagcgtgaga tcgccctgca cagccgcctg cgccaccgca
      361 acatcgtggc cttccacgca cactttgctg accgcgatca cgtgtacatg gtgctggagt
      421 attgtagccg ccagtccttg gctcatgtgc tgaaagtgcg gcggactctg acagagcctg
      481 aagtgcgcta ttaccttcgg ggcctggtca gcggcctgcg ctacttgcac caacaacgca
      541 tcgtgcacag ggacctgaaa cccagtaatt tcttccttaa caagaacatg gaggttaaga
      601 taggtgacct ggggctggct gcccgtgtgg ggcctgctgg tcgctgccac agggtgctct
      661 gcgggactcc aaacttccag gcacctgaag tggtgtcccg aaatggacac tcgtgcaaat
      721 ctgacatctg ggctctggga tgcatcatgt acacggtgct gacaggcacg ccaccctttg
      781 ccgcggcacc cttgtcagag atgtaccaaa acatccgtga cggccactac ctcgagccta
      841 ctcacctgtc gcccagcgcc cgcagcctca ttgcacggct cctggcaccg gaccccgccg
      901 agcggcccag cctggaccac ttactgcaag atgacttctt cagtcagggc ttcaccccgg
      961 agcggctgcc tccacattcc tgccacagcc cacctgtgtt tgcctttccc ccacctctgg
     1021 gcaggttgtt ccggaaggtg ggccagctcc tgctgaccca gtgccggcca ccttgtccct
     1081 ttacctcaaa agaggcctca ggccctggag aagagggcac agaaccagac cacatggaag
     1141 ccggcaacga ggaaagggat cctctctgca ccgagggccg aatccacctc ctcacccttg
     1201 ggaccccgcg gactggcctg gcgggcccaa aagggagctt ggctctgcag ctggaagtgg
     1261 caaccagaaa actgttcctc tgcttggacg caggacctat ggctggacag gaccccccag
     1321 gggagcagcg gcctgttctc tgggctccta agtgggtgga ttactccctc aagtatggct
     1381 tcggctacca gctgtcggat gggggcagtg gggtgctgtt tcgggatggc tcccacatgg
     1441 ccctgcgccc ccaaggcggc catgtctcct accaacctga ccaagggact ctctggacct
     1501 tcaccctgag ggacgtcccc agcccacttc gtgccaagct ggctgtcctg cggctctttg
     1561 cctgctatat gcagcggcgt ctgcgggagg aggggactgt gcccatgcct gccacacctg
     1621 cctctcctga catctctctg ctgagcttca ttgctgactc ccaggctatg gtcatgctgt
     1681 ttagcaatgg gacagtgcag gtcagcctca aaacctccca aacccagctg gtgctaagtg
     1741 gggaggacga ggacctcctg ctcaccctcc aggagccagg gggacccgct gtgggcgtct
     1801 cctacacact cgatgtcctg cggagccatg gcttcaccct tgcagtccac catcacctgc
     1861 gccatggcct gcatctgcta cagagtgtct gaagtctgag cagacctctt cgtgctggcg
     1921 tggagacctg ggaacctggg atctgtttct gtctgtgtta atgcgctgca gccagtgttc
     1981 atggagggtt gacacaacgg ggccactgat gggtaggggt ctttgattat ttatagtatg
     2041 actattcaag ctagaatttt gttggatttt cactaaataa aacagaatcc tttaaactgg
     2101 aaaaaaaaaa aaaaaaa
//
