LOCUS       NM_013807               2485 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus polo like kinase 3 (Plk3), transcript variant 1, mRNA.
ACCESSION   NM_013807
VERSION     NM_013807.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2485)
  AUTHORS   Fu,J., Ling,J., Li,C.F., Tsai,C.L., Yin,W., Hou,J., Chen,P.,
            Cao,Y., Kang,Y., Sun,Y., Xia,X., Jiang,Z., Furukawa,K., Lu,Y.,
            Wu,M., Huang,Q., Yao,J., Hawke,D.H., Pan,B.F., Zhao,J., Huang,J.,
            Wang,H., Bahassi,E.I.M., Stambrook,P.J., Huang,P., Fleming,J.B.,
            Maitra,A., Tainer,J.A., Hung,M.C., Lin,C. and Chiao,P.J.
  TITLE     Nardilysin-regulated scission mechanism activates polo-like kinase
            3 to suppress the development of pancreatic cancer
  JOURNAL   Nat Commun 15 (1), 3149 (2024)
   PUBMED   38605037
  REMARK    GeneRIF: Nardilysin-regulated scission mechanism activates
            polo-like kinase 3 to suppress the development of pancreatic
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2485)
  AUTHORS   Wen,J., Wang,Q., Zhang,W. and Wang,W.
  TITLE     TUBA1A licenses APC/C-mediated mitotic progression to drive
            glioblastoma growth by inhibiting PLK3
  JOURNAL   FEBS Lett 597 (24), 3072-3086 (2023)
   PUBMED   37873730
  REMARK    GeneRIF: TUBA1A licenses APC/C-mediated mitotic progression to
            drive glioblastoma growth by inhibiting PLK3.
REFERENCE   3  (bases 1 to 2485)
  AUTHORS   Deng,W., Wei,X., Xie,Z., Zhang,R., Dong,Z., Zhang,J., Luo,Y.,
            Cheng,Q., Wang,R., Li,H. and Na,N.
  TITLE     Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis
            after Renal Ischemia-Reperfusion Injury by Blocking the
            ATM/P53-Mediated DNA Damage Response
  JOURNAL   Oxid Med Cell Longev 2022, 4201287 (2022)
   PUBMED   35783188
  REMARK    GeneRIF: Inhibition of PLK3 Attenuates Tubular Epithelial Cell
            Apoptosis after Renal Ischemia-Reperfusion Injury by Blocking the
            ATM/P53-Mediated DNA Damage Response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2485)
  AUTHORS   Myer,D.L., Robbins,S.B., Yin,M., Boivin,G.P., Liu,Y., Greis,K.D.,
            Bahassi el,M. and Stambrook,P.J.
  TITLE     Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA
            damage but is not sufficient to produce tumors
  JOURNAL   Mutat Res 714 (1-2), 1-10 (2011)
   PUBMED   21376736
REFERENCE   5  (bases 1 to 2485)
  AUTHORS   Xu,D., Yao,Y., Jiang,X., Lu,L. and Dai,W.
  TITLE     Regulation of PTEN stability and activity by Plk3
  JOURNAL   J Biol Chem 285 (51), 39935-39942 (2010)
   PUBMED   20940307
  REMARK    GeneRIF: Plk3 as a new player in the regulation of the
            PI3K/PDK1/Akt signaling axis by phosphorylation and stabilization
            of PTEN.
REFERENCE   6  (bases 1 to 2485)
  AUTHORS   Yang,Y., Bai,J., Shen,R., Brown,S.A., Komissarova,E., Huang,Y.,
            Jiang,N., Alberts,G.F., Costa,M., Lu,L., Winkles,J.A. and Dai,W.
  TITLE     Polo-like kinase 3 functions as a tumor suppressor and is a
            negative regulator of hypoxia-inducible factor-1 alpha under
            hypoxic conditions
  JOURNAL   Cancer Res 68 (11), 4077-4085 (2008)
   PUBMED   18519666
  REMARK    GeneRIF: Ectopic expression of the Plk3-kinase domain (Plk3-KD),
            but not its Polo-box domain or a Plk3-KD mutant, suppressed the
            nuclear accumulation of HIF-1 alpha induced by nickel or cobalt
            ions
REFERENCE   7  (bases 1 to 2485)
  AUTHORS   Zimmerman,W.C. and Erikson,R.L.
  TITLE     Polo-like kinase 3 is required for entry into S phase
  JOURNAL   Proc Natl Acad Sci U S A 104 (6), 1847-1852 (2007)
   PUBMED   17264206
  REMARK    GeneRIF: Plk3 localizes to the nucleolus and is involved in
            regulation of the G1/S phase transition.
REFERENCE   8  (bases 1 to 2485)
  AUTHORS   Kauselmann,G., Weiler,M., Wulff,P., Jessberger,S., Konietzko,U.,
            Scafidi,J., Staubli,U., Bereiter-Hahn,J., Strebhardt,K. and Kuhl,D.
  TITLE     The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-
            and integrin-binding protein and are regulated dynamically with
            synaptic plasticity
  JOURNAL   EMBO J 18 (20), 5528-5539 (1999)
   PUBMED   10523297
REFERENCE   9  (bases 1 to 2485)
  AUTHORS   Chase,D., Feng,Y., Hanshew,B., Winkles,J.A., Longo,D.L. and
            Ferris,D.K.
  TITLE     Expression and phosphorylation of
            fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle
            progression
  JOURNAL   Biochem J 333 (Pt 3) (Pt 3), 655-660 (1998)
   PUBMED   9677325
REFERENCE   10 (bases 1 to 2485)
  AUTHORS   Donohue,P.J., Alberts,G.F., Guo,Y. and Winkles,J.A.
  TITLE     Identification by targeted differential display of an immediate
            early gene encoding a putative serine/threonine kinase
  JOURNAL   J Biol Chem 270 (17), 10351-10357 (1995)
   PUBMED   7730342
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL671866.8 and BC063051.1.
            
            On Sep 11, 2015 this sequence version replaced NM_013807.2.
            
            Summary: This gene encodes a member of the highly conserved
            polo-like kinase family of serine/threonine kinases. Members of
            this family are characterized by an amino-terminal catalytic domain
            and a carboxy-terminal bipartite polo box domain that functions as
            a substrate-binding motif and a cellular localization signal.
            Polo-like kinases have primarily been implicated in cell cycle
            regulation. In mouse, this protein that has been reported to
            localize to the nucleolus during interphase but is undetectable
            during mitosis, following nucleolus dissociation during prophase.
            The protein relocalizes to the nucleolus just prior to cytokinesis
            and peak levels are detected during G1 of interphase. This gene has
            been implicated in regulation of entry into S phase, with
            RNAi-induced depletion resulting in failure to re-enter the cell
            cycle. Mice deficient for this gene exhibit increased weight and
            tumor development at advanced age. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063051.1, AK156754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL671866.8         125805-125815
            12-2485             BC063051.1         1-2474
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.41 cM"
     gene            1..2485
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /note="polo like kinase 3"
                     /db_xref="GeneID:12795"
                     /db_xref="MGI:MGI:109604"
     exon            1..312
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2046
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /EC_number="2.7.11.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase PLK3; FGF-inducible
                     kinase; cytokine-inducible serine/threonine-protein
                     kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK3 isoform 1"
                     /protein_id="NP_038835.2"
                     /db_xref="CCDS:CCDS18529.1"
                     /db_xref="GeneID:12795"
                     /db_xref="MGI:MGI:109604"
                     /translation="MEPAAGFLSPRPFPRAAAPSAPPAGPGPPANASPRSEPEVLAGP
                     RAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKP
                     HQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLE
                     PEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRK
                     KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV
                     HYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPD
                     LTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLVSGLMRTSIGHPDVRPEAP
                     VVSGQAPASLVETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPA
                     EQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHY
                     NPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLL
                     QWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQ
                     LGCSPDLRQRLRYALRLLRDQSPA"
     exon            313..420
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            421..537
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            538..667
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            668..755
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            756..851
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1050
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1177
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1269
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1363
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1447
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1610
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1740
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1854
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2378
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /note="hexamer: AATAAA"
     polyA_site      2378
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk; PLK-3; PRK"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgatcg cagcgtagag aaaccaggca gcgccacgcg cggccggggc cgggcggaac
       61 cgagaaccag ctcggcaggc gctgcgccgc gccgtccgca tggagcccgc cgccggcttc
      121 ttgtctccgc gccccttccc gcgcgcggct gccccgtccg cgccccccgc cggcccgggg
      181 ccgcctgcca atgcctcccc gcgatcggaa cctgaggtgc tggccgggcc acgggcgccg
      241 gatcctcctg gtcgcctcat caccgaccct ctcagcggcc gtacctacac caagggtcgc
      301 ttgttgggca aggggggctt cgcacgctgc tatgaagcca ctgacaccga gtctggtata
      361 gcctacgcgg tcaaagtcat cccacagagt cgcgtcgcca agccgcatca gcgcgagaag
      421 atcctaaatg agatagagtt gcaccgagac ctacagcacc gccatatcgt tcgcttttca
      481 catcatttcg aggatgctga caacatatac attttcctgg agctctgtag ccgaaagtcc
      541 ctggcccaca tctggaaggc ccgacacacc ctgttggaac cagaggttcg ctactacctg
      601 cgccagatcc tttctggcct caagtacttg caccagaggg gtatcttaca cagagatctc
      661 aagctgggaa attttttcat cacggataac atggaactga aggtggggga ttttgggctg
      721 gcagctcgat tagagccccc agagcagagg aaaaagacca tctgtggcac tcccaactac
      781 gtggctccag aagtgctgct gagacagggc catggccccg aggcagatgt gtggtcgctt
      841 ggttgtgtca tgtacacgct cctgtgtggg agccccccat ttgagactgc tgacctgaag
      901 gagacatacc gctgcatcaa gcaggttcat tacacgctac ctgccagcct ctccctgcct
      961 gcccggcagc tcctggctgc catcctccga gcttcaccca gagaccgccc ttccattgaa
     1021 cagattttac gccatgactt ctttacgaag ggctacaccc ctgatcggct cccggtcagc
     1081 agctgtgtga cagtcccaga tctgacaccc cccaaccctg cgaggagtct gtttgccaaa
     1141 gttaccaaga gcctgtttgg caggaaaaag aacaagaata agaaccattc tgaggaccag
     1201 gataatgtct cctgcttggt gagtggcctc atgcgcacat ccatcggtca tccagatgtc
     1261 aggccggagg ctcctgtagt ttcaggccag gcccctgcca gcttggtaga gacagctgcc
     1321 gaggacagct cgccccgtgg gacactggcc agcagtggag atgggtttga agaaggtttg
     1381 actgtggcca cagtggtaga gtctgccctc tgtgcactga gaaactgtgt ggccttcatg
     1441 cccccagccg aacagaaccc agccccgctg gcacagccag agcctctggt gtgggtcagc
     1501 aagtgggttg actactccaa caagtttggc tttggctatc agctgtccag ccgccgtgta
     1561 gccgtgctct tcaatgatgg cacacacatg gccctgtcag ccaataggaa gacggtgcac
     1621 tacaacccca ccagcacgaa gcacttctcc ttctccatgg gttctgtgcc ccgagctctg
     1681 cagcctcagc tgggcatcct gcggtatttt gcgtcctaca tggaacagca cctcatgaag
     1741 ggtggagatc tgcccagtgt ggaagaggcg gaggtgcctg ccccaccctt gctgctgcag
     1801 tgggtcaaga ctgaccaggc cctcctcatg ctgttcagtg atggcactgt ccaggtgaac
     1861 ttctacgggg accacacgaa gctgatcctc agtggctggg agcctctcct tgtgaccttc
     1921 gtggcccgca atcgcagtgc ttgtacttac ctcgcttccc acctccggca gctgggctgc
     1981 tccccagact tgcggcagcg actgcgctac gctctgcgcc tgctcaggga ccaaagccct
     2041 gcttaggttc caactcggag agcgggctgt gatccagatc ctgggcctga gcctgaaagg
     2101 cttcagggcc ttgcctttgt ggcccttcct gtccctttgg tgcctcactg ggggctcctg
     2161 gctgaatccc cccagggaat cagggaccag ctttactaca gtcggggatg gcctgccctc
     2221 cctgaatctt acccttctct ctgagataag cctgagcctt agctcccagc tagggggcat
     2281 tatttatgga ccacttttat ttattaacag acatttattt attgggatgt gagccccagg
     2341 ggggcctcct cctggggtaa taaaccgttt tttcagaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaa
//
