LOCUS       NM_152804               2802 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus polo like kinase 2 (Plk2), mRNA.
ACCESSION   NM_152804
VERSION     NM_152804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Cheng,J., Wu,L., Chen,X., Li,S., Xu,Z., Sun,R., Huang,Y., Wang,P.,
            Ouyang,J., Pei,P., Yang,H., Wang,G., Zhen,X. and Zheng,L.T.
  TITLE     Polo-like kinase 2 promotes microglial activation via regulation of
            the HSP90alpha/IKKbeta pathway
  JOURNAL   Cell Rep 43 (10), 114827 (2024)
   PUBMED   39383034
  REMARK    GeneRIF: Polo-like kinase 2 promotes microglial activation via
            regulation of the HSP90alpha/IKKbeta pathway.
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Kim,D.E., Byeon,H.E., Kim,D.H., Kim,S.G. and Yim,H.
  TITLE     Plk2-mediated phosphorylation and translocalization of Nrf2
            activates anti-inflammation through p53/Plk2/p21cip1 signaling in
            acute kidney injury
  JOURNAL   Cell Biol Toxicol 39 (4), 1509-1529 (2023)
   PUBMED   35842499
  REMARK    GeneRIF: Plk2-mediated phosphorylation and translocalization of
            Nrf2 activates anti-inflammation through p53/Plk2/p21[cip1]
            signaling in acute kidney injury.
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Li,J. and Ma,F.
  TITLE     Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular
            Matrix Accumulation, and Oxidative Stress of Mesangial Cells in
            Diabetic Nephropathy through p38-MAPK Signaling
  JOURNAL   Ann Clin Lab Sci 53 (2), 192-199 (2023)
   PUBMED   37094847
  REMARK    GeneRIF: Polo-Like Kinase 2 Is Identified in Hypertrophy,
            Extracellular Matrix Accumulation, and Oxidative Stress of
            Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Du,H., Wang,Z., Guo,R., Yang,L., Liu,G., Zhang,Z., Xu,Z., Tian,Y.,
            Yang,Z., Li,X. and Chen,B.
  TITLE     Transcription factors Bcl11a and Bcl11b are required for the
            production and differentiation of cortical projection neurons
  JOURNAL   Cereb Cortex 32 (17), 3611-3632 (2022)
   PUBMED   34963132
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Elfarrash,S., Jensen,N.M., Ferreira,N., Schmidt,S.I., Gregersen,E.,
            Vestergaard,M.V., Nabavi,S., Meyer,M. and Jensen,P.H.
  TITLE     Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of
            physiological nuclear alpha-synuclein but not of the aggregated
            alpha-synuclein
  JOURNAL   PLoS One 16 (10), e0252635 (2021)
   PUBMED   34613964
  REMARK    GeneRIF: Polo-like kinase 2 inhibition reduces serine-129
            phosphorylation of physiological nuclear alpha-synuclein but not of
            the aggregated alpha-synuclein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Ma,S., Charron,J. and Erikson,R.L.
  TITLE     Role of Plk2 (Snk) in mouse development and cell proliferation
  JOURNAL   Mol Cell Biol 23 (19), 6936-6943 (2003)
   PUBMED   12972611
  REMARK    GeneRIF: Embryos of Plk2(Snk)-deficient mice show retarded growth
            and skeletal development late in gestation.
REFERENCE   7  (bases 1 to 2802)
  AUTHORS   Burns,T.F., Fei,P., Scata,K.A., Dicker,D.T. and El-Deiry,W.S.
  TITLE     Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic
            catastrophe in paclitaxel (taxol)-exposed cells
  JOURNAL   Mol Cell Biol 23 (16), 5556-5571 (2003)
   PUBMED   12897130
  REMARK    GeneRIF: there is a mitotic checkpoint wherein p53-dependent
            activation of Snk/Plk2 prevents mitotic catastrophe following
            spindle damage
REFERENCE   8  (bases 1 to 2802)
  AUTHORS   Ma,S., Liu,M.A., Yuan,Y.L. and Erikson,R.L.
  TITLE     The serum-inducible protein kinase Snk is a G1 phase polo-like
            kinase that is inhibited by the calcium- and integrin-binding
            protein CIB
  JOURNAL   Mol Cancer Res 1 (5), 376-384 (2003)
   PUBMED   12651910
  REMARK    GeneRIF: CIB co-immunoprecipitated with Snk and inhibited the
            kinase activity of Snk, suggesting that CIB is a negative regulator
            for Snk kinase activity.
REFERENCE   9  (bases 1 to 2802)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2802)
  AUTHORS   Simmons,D.L., Neel,B.G., Stevens,R., Evett,G. and Erikson,R.L.
  TITLE     Identification of an early-growth-response gene encoding a novel
            putative protein kinase
  JOURNAL   Mol Cell Biol 12 (9), 4164-4169 (1992)
   PUBMED   1508211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ063842.1, BM947259.1, AK164365.1, AK160441.1 and BP765662.1.
            
            On Jan 18, 2008 this sequence version replaced NM_152804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034513.1, AK133962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CJ063842.1         555-612
            59-815              BM947259.1         1-757
            816-2241            AK164365.1         815-2240
            2242-2710           AK160441.1         428-896
            2711-2802           BP765662.1         19-110              c
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 61.97 cM"
     gene            1..2802
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /note="polo like kinase 2"
                     /db_xref="GeneID:20620"
                     /db_xref="MGI:MGI:1099790"
     exon            1..394
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2182
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /EC_number="2.7.11.21"
                     /note="PLK-2; serine/threonine-protein kinase SNK;
                     serum-inducible kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK2"
                     /protein_id="NP_690017.2"
                     /db_xref="CCDS:CCDS26767.1"
                     /db_xref="GeneID:20620"
                     /db_xref="MGI:MGI:1099790"
                     /translation="MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQP
                     QAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN
                     KVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCS
                     RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKV
                     GDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP
                     FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQG
                     FTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDI
                     YKLRHDLKKVSITQQPSKHRADEEPQPPPTTVARSGTSAVENKQQIGDAIRMIVRGTL
                     GSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYS
                     NKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQV
                     TVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYH
                     DHTKIIICNQSEEYLLTYINEDRISTTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN
                     "
     exon            395..502
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            503..619
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            620..749
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            750..837
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            838..933
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1132
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1280
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1378
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1508
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1749
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1879
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1990
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2802
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2692..2697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="Plk2"
                     /gene_synonym="Snk"
     regulatory      2781..2786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /note="hexamer: AATAAA"
     polyA_site      2802
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /note="major polyA site"
ORIGIN      
        1 gctcgcacaa gcgaagcagg acgtcagact agagagtagg gagagagact ggtgctcgag
       61 ggacagggct agcccggacg cttgtccgcg cctcggaggt ggcaagtagg cagtgtcggg
      121 tggcgaggca acgatggagc tcctgcggac tatcacctac cagccggccg ccggcaccaa
      181 gatgtgcgag caggctctgg gcaaagcttg cggcggggac tcaaagaaga agcgaccgca
      241 gcagccttct gaagatgggc agccccaagc ccaggtgacc ccggcggccc cgcaccacca
      301 tcaccaccat tcccactcgg gacccgagat ctcgcggatt atagtcgacc ccacgacggg
      361 gaagcgctac tgccggggca aagtgctggg caagggtgga tttgcaaagt gttacgaaat
      421 gacagatctg acaaacaaca aagtctacgc tgcaaaaatt attcctcaca gcagagtagc
      481 taaacctcat cagagggaaa agatcgacaa agaaatcgag cttcacagac tactgcacca
      541 taagcatgtc gtgcagtttt accactactt tgaagacaaa gaaaacattt acattctctt
      601 ggaatactgc agtagaaggt ccatggctca catcttgaaa gcaagaaagg tgttgacaga
      661 gccagaagtc cgatactacc tcaggcagat tgtgtcagga ctcaagtatc ttcacgaaca
      721 agaaatcttg cacagggatc tcaagctagg gaactttttt attaatgaag ccatggagct
      781 gaaggtggga gactttggtt tggcagccag actggaacca ctggaacaca gaaggagaac
      841 aatatgtgga accccaaatt atctctcccc cgaagtcctc aacaaacaag gacacggctg
      901 tgaatcagac atctgggcct taggctgtgt aatgtatacg atgctgctag gaagacctcc
      961 attcgaaacc acaaatctga aagaaacgta caggtgcata agggaagcaa ggtataccat
     1021 gccatcctca ttgctggccc ctgctaagca cttgatagct agcatgctgt ccaaaaaccc
     1081 agaggaccgc cccagtttgg atgacatcat tcggcatgac ttcttcctgc agggtttcac
     1141 tccggacaga ctctcttcca gctgttgcca cacagttcca gatttccact tgtcaagccc
     1201 agccaagaat ttctttaaga aagccgcagc cgctcttttt ggtggcaaga aggacaaagc
     1261 aagatataac gacacacaca ataaggtgtc taaggaagat gaagacattt acaagcttcg
     1321 gcatgatttg aagaaagtgt cgataaccca gcagcctagc aaacacagag cagatgagga
     1381 gccccagccg cctcccacta ctgttgccag atctggaacg tccgcagtgg aaaacaaaca
     1441 gcagattggg gatgcaatcc ggatgatagt cagggggact ctcggcagct gcagcagcag
     1501 cagcgaatgc cttgaagaca gcaccatggg aagtgtggca gacacagtgg caagagtcct
     1561 tcgaggatgt ctagaaaaca tgccggaagc tgactgtatc cccaaagagc agctgagcac
     1621 gtcctttcag tgggtcacca agtgggtcga ctactccaac aaatacggct ttgggtacca
     1681 gctctcggac cacactgttg gcgtcctttt caacaacggg gctcacatga gcctccttcc
     1741 ggacaaaaag acagttcact attatgcgga acttggccaa tgctctgttt tcccagcaac
     1801 agatgcccct gaacaattta ttagtcaagt gacggtgctg aaatactttt ctcattacat
     1861 ggaggagaac ctcatggatg gtggtgatct cccgagtgtt actgacattc gaagacctcg
     1921 gctctacctc ctgcagtggt taaagtctga taaagcctta atgatgctct tcaatgacgg
     1981 cacatttcag gtgaatttct accacgatca tacaaaaatc atcatctgta accagagtga
     2041 agaatacctt ctcacctaca tcaatgagga caggatctct acaactttca gactgacgac
     2101 tctgctgatg tctggctgtt cgttagaatt gaaaaatcga atggaatatg ccctgaacat
     2161 gctcttacag agatgtaact gaaaacatta ttattattat tattataatt atttcgagcg
     2221 gacctcatgg gactcttttc cactgtgaga tcaacaggga agccagcgga aagatacaga
     2281 gcatgttaga gaagtcggac aggtggtggt acgaatacaa ttcctctgtg gcctgctgga
     2341 ctgctggaac cagaccagcc taaggtgtag agttgacttt ggacaatcct gagtgtggag
     2401 ccgagtgcag ttttccctga gatacctgtc gtgaaaaggt ttatgggaca gtttttcaga
     2461 aagatgcatt gactctgaag ttctctctgt tgagagcgtc ttcagttgga agacttggaa
     2521 ctgtgaatac acttcctgaa ggggagggag aagggaggtt gctcccttgc tgtttaaagg
     2581 ctacaatcag agcagctttt ggctgcttaa ctgtgaacta tggccataca tttttttttt
     2641 tttttggtta tttttgaata cacttgtggt tggaaaagtg cattccttgt taataaactt
     2701 tttatttatt acagccccaa gagcagtatt tattatcaag atgttctctt tttttatgtt
     2761 gaccatttca aactcttggc aataaagagt atgacataga aa
//
