LOCUS       NM_011121               2214 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus polo like kinase 1 (Plk1), mRNA.
ACCESSION   NM_011121
VERSION     NM_011121.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2214)
  AUTHORS   Kong,Y., Li,C., Liu,J., Wu,S., Zhang,M., Allison,D.B., Hassan,F.,
            He,D., Wang,X., Mao,F., Zhang,Q., Zhang,Y., Li,Z., Wang,C. and
            Liu,X.
  TITLE     Single-cell analysis identifies PLK1 as a driver of
            immunosuppressive tumor microenvironment in LUAD
  JOURNAL   PLoS Genet 20 (6), e1011309 (2024)
   PUBMED   38885192
  REMARK    GeneRIF: Single-cell analysis identifies PLK1 as a driver of
            immunosuppressive tumor microenvironment in LUAD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2214)
  AUTHORS   Kolesova,H., Hrabalova,P., Bohuslavova,R., Abaffy,P.,
            Fabriciova,V., Sedmera,D. and Pavlinkova,G.
  TITLE     Reprogramming of the developing heart by Hif1a-deficient
            sympathetic system and maternal diabetes exposure
  JOURNAL   Front Endocrinol (Lausanne) 15, 1344074 (2024)
   PUBMED   38505753
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2214)
  AUTHORS   Liao,Z., Zhang,Q., Yang,L., Li,H., Mo,W., Song,Z., Huang,X.,
            Wen,S., Cheng,X. and He,M.
  TITLE     Increased hsa-miR-100-5p Expression Improves Hepatocellular
            Carcinoma Prognosis in the Asian Population with PLK1 Variant
            rs27770A>G
  JOURNAL   Cancers (Basel) 16 (1), 129 (2023)
   PUBMED   38201556
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2214)
  AUTHORS   Gao,Z., Zheng,C., Xing,Y., Zhang,X., Bai,Y., Chen,C., Zheng,Y.,
            Wang,W., Zhang,H. and Meng,Y.
  TITLE     Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111074 (2023)
   PUBMED   37879229
  REMARK    GeneRIF: Polo-like kinase 1 promotes sepsis-induced myocardial
            dysfunction.
REFERENCE   6  (bases 1 to 2214)
  AUTHORS   Brauninger,A., Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     Identification and functional characterization of the human and
            murine polo-like kinase (Plk) promoter
  JOURNAL   Oncogene 11 (9), 1793-1800 (1995)
   PUBMED   7478607
REFERENCE   7  (bases 1 to 2214)
  AUTHORS   Matsubara,N., Yanagisawa,M., Nishimune,Y., Obinata,M. and Matsui,Y.
  TITLE     Murine polo like kinase 1 gene is expressed in meiotic testicular
            germ cells and oocytes
  JOURNAL   Mol Reprod Dev 41 (4), 407-415 (1995)
   PUBMED   7576608
REFERENCE   8  (bases 1 to 2214)
  AUTHORS   Ruiz,J.C., Conlon,F.L. and Robertson,E.J.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
REFERENCE   9  (bases 1 to 2214)
  AUTHORS   Hamanaka,R., Maloid,S., Smith,M.R., O'Connell,C.D., Longo,D.L. and
            Ferris,D.K.
  TITLE     Cloning and characterization of human and murine homologues of the
            Drosophila polo serine-threonine kinase
  JOURNAL   Cell Growth Differ 5 (3), 249-257 (1994)
   PUBMED   8018557
REFERENCE   10 (bases 1 to 2214)
  AUTHORS   Lake,R.J. and Jelinek,W.R.
  TITLE     Cell cycle- and terminal differentiation-associated regulation of
            the mouse mRNA encoding a conserved mitotic protein kinase
  JOURNAL   Mol Cell Biol 13 (12), 7793-7801 (1993)
   PUBMED   7902533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ072470.1, AK164027.1 and
            BG065076.2.
            
            On Sep 10, 2015 this sequence version replaced NM_011121.3.
            
            Summary: The Ser/Thr protein kinase encoded by this gene belongs to
            the CDC5/Polo subfamily. It is highly expressed during mitosis and
            may play a role in DNA replication during S phase. This gene is
            expressed in all embryonic tissues, but restricted to thymus and
            ovaries in adult tissues. Homozygous knockout mice were embryonic
            lethal, suggesting that this gene is important for early embryonic
            development. This gene is thought to be a potential oncogene
            because it is overexpressed in a variety of tumors and tumor cell
            lines. Depletion of this protein in cancer cells has been shown to
            inhibit cell proliferation and suppress oncogenic transformation;
            hence, it is a target for cancer therapy. [provided by RefSeq, Sep
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148076.1, L19558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CJ072470.1         1-33
            34-2170             AK164027.1         2-2138
            2171-2214           BG065076.2         1-44                c
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.52 cM"
     gene            1..2214
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /note="polo like kinase 1"
                     /db_xref="GeneID:18817"
                     /db_xref="MGI:MGI:97621"
     exon            1..516
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1920
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /EC_number="2.7.11.21"
                     /note="PLK-1; serine/threonine-protein kinase 13"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK1"
                     /protein_id="NP_035251.3"
                     /db_xref="CCDS:CCDS21812.1"
                     /db_xref="GeneID:18817"
                     /db_xref="MGI:MGI:97621"
                     /translation="MNAAAKAGKLARAPADLGKGGVPGDAVPGAPVAAPLAKEIPEVL
                     VDPRSRRQYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEI
                     SIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQI
                     VLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYI
                     APEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP
                     VAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDP
                     SSRKPLKVLNKGVENPLPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSER
                     GLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
                     LQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARL
                     PYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSL
                     LEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS"
     exon            517..685
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            686..830
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            831..924
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1144
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1300
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1378
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1533
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1716
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2214
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /note="hexamer: ATTAAA"
     polyA_site      2207
                     /gene="Plk1"
                     /gene_synonym="Plk; STPK13"
                     /note="major polyA site"
ORIGIN      
        1 gcaggccctt gtaacgttcc cagcgccgcg tttgaattcg gggaggagcg gagcagagca
       61 ggaccctctg caccgactca gccaggttcg tggagcaact tcggcatcat gaatgcagcg
      121 gccaaagctg gaaagctggc tcgagcacca gccgacctcg ggaaaggtgg ggttccggga
      181 gatgcagttc ccggtgcccc agtggccgcc ccgctggcga aagaaattcc ggaggtccta
      241 gtggacccac gcagccggcg gcagtatgta cgggggcgct ttctgggtaa aggaggcttc
      301 gccaaatgct tcgagatctc agacgcagac acaaaagagg tgttcgcagg caagatcgtg
      361 cctaagtctt tgctgctcaa gccccaccag aaggagaaga tgtctatgga gatctcaatt
      421 caccgcagcc tagcacacca acacgtcgta ggcttccatg acttttttga ggacagcgac
      481 tttgtatttg tagttttgga gctctgtcgc aggaggtccc tcctggagct gcacaagagg
      541 aggaaggcac tgaccgagcc tgaggcccgc tactacctgc gacagatagt cctgggctgc
      601 cagtacctgc accgcaatca ggtcattcac agggacctca agctgggcaa cctcttcctg
      661 aacgaggatc tggaggtgaa aataggggat tttggcttgg caaccaaagt ggaatatgaa
      721 ggggaacgaa agaagacctt gtgtggcact cctaactaca tagctcctga ggtgctgagc
      781 aagaagggac acagttttga ggtggatgtg tggtccattg ggtgcatcat gtataccttg
      841 ctagtgggca agcctccctt tgagacctcg tgcctaaaag agacctacct ccggatcaag
      901 aaaaatgaat acagtattcc caagcacatc aacccagtgg ccgcctccct catccagaag
      961 atgcttcaga cagaccccac tgcccgcccc accattcacg agttgctcaa tgacgagttc
     1021 ttcacttctg gctacatccc cgcccgtctc cctattacct gcctcaccat cccaccaagg
     1081 ttttcaatcg ctcccagcag cctggacccc agcagcagga aacctctcaa agtcctcaat
     1141 aaaggtgtgg agaaccccct gcctgaccgt ccccgggaga aagaggaacc ggtggtccgg
     1201 gagacaaatg aggccattga gtgccacctt agtgacttgc tacagcagct gaccagtgtc
     1261 aacgcctcca agccctcgga gcgcgggctg gtgcggcaag aggaggctga ggatcctgcc
     1321 tgcatcccca tcttctgggt cagcaagtgg gtggactatt cggacaagta tggccttggg
     1381 tatcagctgt gtgacaacag tgtgggggtg ctttttaatg actcaacacg cctgattctc
     1441 tacaatgacg gggacagcct gcagtacata gagcgtgatg gcacggagtc ctatctcact
     1501 gtgagctccc atcccaattc cttgatgaag aagatcactc tcctcaacta tttccgcaat
     1561 tacatgagtg agcacctgct gaaggcaggg gccaacatca caccccggga aggcgacgag
     1621 ctggcccggc tgccctacct acgaacgtgg ttccgcacac gcagcgccat catcctgcac
     1681 ctcagcaacg gcaccgtgca gattaacttc ttccaggacc acaccaaact tatcctgtgc
     1741 cccctgatgg cagcggtgac ctacatcaac gagaagaggg acttccaaac gtaccgcctg
     1801 agcctcctgg aggagtatgg ctgctgcaag gagctggcca gccgcctccg ctacgcccgc
     1861 accatggtag acaagctgct gagctcgcgc tccgccagca accgcctcaa ggcctcctag
     1921 gtctctctcc ttcggactgg tgccccttca ctctgctagc tctgagcctg cactgtaggc
     1981 tcctgggggc tgctgttcag tgcccctggc cctgggggct gggcaggagc agggccccct
     2041 ttgaaggggt tgctgtgtgt aagttatttt gtacatgtct gggtgtgggt ttacatctgc
     2101 ttccctgccc tcgctcagcc cactgtatga attgtataaa tgtttctatt aaattgggac
     2161 tgctctttcc ttagctttat atatattaaa atgtgtacat ctctctctct cttt
//
