LOCUS       NM_001077348            1994 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus perilipin 5 (Plin5), transcript variant 2, mRNA.
ACCESSION   NM_001077348
VERSION     NM_001077348.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Krizanac,M., Stancl,P., Mass-Sanchez,P.B., Karlic,R., Moeckel,D.,
            Lammers,T., Asimakopoulos,A. and Weiskirchen,R.
  TITLE     The influence of perilipin 5 deficiency on gut microbiome profiles
            in murine metabolic dysfunction-associated fatty liver disease
            (MAFLD) and MAFLD-hepatocellular carcinoma
  JOURNAL   Front Cell Infect Microbiol 14, 1443654 (2024)
   PUBMED   39469452
  REMARK    GeneRIF: The influence of perilipin 5 deficiency on gut microbiome
            profiles in murine metabolic dysfunction-associated fatty liver
            disease (MAFLD) and MAFLD-hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Shen,X., Zhang,J., Zhou,Z. and Yu,R.
  TITLE     PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via
            Modulating PIR/NF-kappaB Axis
  JOURNAL   Int Heart J 65 (3), 537-547 (2024)
   PUBMED   38749744
  REMARK    GeneRIF: PLIN5 Suppresses Lipotoxicity and Ferroptosis in
            Cardiomyocyte via Modulating PIR/NF-kappaB Axis.
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Gao,X., Jian,L., Zhang,L., Xu,Y., Zhao,Y., Yang,Y., Yuan,Y.,
            Wang,Y., Xu,S., Ren,B., Li,Z., Wang,C., Li,J., Gu,Y. and Ye,J.
  TITLE     Perilipin 5 protects the mitochondrial oxidative functions and
            improves the alcoholic liver injury in mice
  JOURNAL   Liver Int 44 (2), 357-369 (2024)
   PUBMED   37933091
  REMARK    GeneRIF: Perilipin 5 protects the mitochondrial oxidative functions
            and improves the alcoholic liver injury in mice.
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Jian,L., Gao,X., Wang,C., Sun,X., Xu,Y., Han,R., Wang,Y., Xu,S.,
            Ding,L., Zhou,J., Gu,Y., Zhao,Y., Yang,Y., Yuan,Y., Ye,J. and
            Zhang,L.
  TITLE     Perilipin 5 deficiency aggravates cardiac hypertrophy by
            stimulating lactate production in leptin-deficient mice
  JOURNAL   Biol Direct 18 (1), 54 (2023)
   PUBMED   37667357
  REMARK    GeneRIF: Perilipin 5 deficiency aggravates cardiac hypertrophy by
            stimulating lactate production in leptin-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Miner,G.E., So,C.M., Edwards,W., Ragusa,J.V., Wine,J.T., Wong
            Gutierrez,D., Airola,M.V., Herring,L.E., Coleman,R.A., Klett,E.L.
            and Cohen,S.
  TITLE     PLIN5 interacts with FATP4 at membrane contact sites to promote
            lipid droplet-to-mitochondria fatty acid transport
  JOURNAL   Dev Cell 58 (14), 1250-1265 (2023)
   PUBMED   37290445
  REMARK    GeneRIF: PLIN5 interacts with FATP4 at membrane contact sites to
            promote lipid droplet-to-mitochondria fatty acid transport.
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Schaiff,W.T., Knapp,F.F. Jr., Barak,Y., Biron-Shental,T.,
            Nelson,D.M. and Sadovsky,Y.
  TITLE     Ligand-activated peroxisome proliferator activated receptor gamma
            alters placental morphology and placental fatty acid uptake in mice
  JOURNAL   Endocrinology 148 (8), 3625-3634 (2007)
   PUBMED   17463056
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Dalen,K.T., Dahl,T., Holter,E., Arntsen,B., Londos,C., Sztalryd,C.
            and Nebb,H.I.
  TITLE     LSDP5 is a PAT protein specifically expressed in fatty acid
            oxidizing tissues
  JOURNAL   Biochim Biophys Acta 1771 (2), 210-227 (2007)
   PUBMED   17234449
  REMARK    GeneRIF: we have characterized a novel PAT protein, lipid storage
            droplet protein 5 (LSDP5) of 463 residues.The LSDP5 gene is
            primarily transcribed in cells that actively oxidize fatty acids,
            such as heart, red muscle and liver.
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Wolins,N.E., Quaynor,B.K., Skinner,J.R., Tzekov,A., Croce,M.A.,
            Gropler,M.C., Varma,V., Yao-Borengasser,A., Rasouli,N., Kern,P.A.,
            Finck,B.N. and Bickel,P.E.
  TITLE     OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes
            fatty acid utilization
  JOURNAL   Diabetes 55 (12), 3418-3428 (2006)
   PUBMED   17130488
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Yamaguchi,T., Matsushita,S., Motojima,K., Hirose,F. and Osumi,T.
  TITLE     MLDP, a novel PAT family protein localized to lipid droplets and
            enriched in the heart, is regulated by peroxisome
            proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 281 (20), 14232-14240 (2006)
   PUBMED   16571721
  REMARK    GeneRIF: MLDP is a novel PAT family protein localized to lipid
            droplets and enriched in the heart, and regulated by peroxisome
            proliferator-activated receptor alpha
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Miura,S., Gan,J.W., Brzostowski,J., Parisi,M.J., Schultz,C.J.,
            Londos,C., Oliver,B. and Kimmel,A.R.
  TITLE     Functional conservation for lipid storage droplet association among
            Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals,
            Drosophila, and Dictyostelium
  JOURNAL   J Biol Chem 277 (35), 32253-32257 (2002)
   PUBMED   12077142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009719.10, AY919875.1 and DQ473305.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            encodes the same protein, compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY919875.1, SRR7345562.4819460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CT009719.10        161426-161486       c
            62-1986             AY919875.1         21-1945
            1987-1994           DQ473305.1         1913-1920
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.16 cM"
     gene            1..1994
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /note="perilipin 5"
                     /db_xref="GeneID:66968"
                     /db_xref="MGI:MGI:1914218"
     exon            1..216
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1564
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /note="lipid droplet associated protein; lipid storage
                     droplet protein 5; myocardial LD protein; lipid
                     droplet-associated protein PAT-1"
                     /codon_start=1
                     /product="perilipin-5"
                     /protein_id="NP_001070816.1"
                     /db_xref="CCDS:CCDS37662.1"
                     /db_xref="GeneID:66968"
                     /db_xref="MGI:MGI:1914218"
                     /translation="MDQRGEDTTLAPHSRMSGDQTAQDPGSSLGELDQQNVVNRVVAL
                     PLVKATCTAVSSAYNSAKDRHPLLGSACRLAEHCVCSVTTCALDHAQPLLEHLQPQLA
                     TVNDLACRGLDKLEEKLPFLQQPSDMVVTSAKDTVAKSVTGMVDLAQRGRRWSGELRR
                     SMSQAMDMVLGKSEKLVDRFLPMTEAELAVLAAEAEGPEVGTVEEQRQQQGYFVRLGS
                     LSARLRHLAYEHSLGKLRQSKHRTQEMLAQLQETLELIQHMQRGASPSPTFHPPKTQE
                     LWGSWSPCLENGRSHSEVELETLALSRSLTLELQNAVDALAGCVRGLPPSAQAKVAEV
                     QRSVDALQATFADAHCLGDVAPTALAEGRGSVARAHACVDEFLDLVLRAMPLPWLVGP
                     FAPILVEQSEPLINLATCVDEVVGDPDPRWAHMDWPAQKRAWEAESADPGGQEAEPPR
                     GQGKHTMMPELDF"
     exon            217..277
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..473
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..556
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..737
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..937
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1051
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1992
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1992
                     /gene="Plin5"
                     /gene_synonym="2310076L09Rik; Lsdp5; MLDP; PAT-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcatgagcc ctgaggtcag cgtccctgtc accgtggaca gctgagggtg acctcggagc
       61 tccacgtgca atctttgcct caactttcct gcccgtcaaa gggatctgat tctctgaccg
      121 ctgcccccac ctctgcaacg ggggctggtg tgcgggtctg tccctactgg aaatggacca
      181 gagaggtgaa gacaccaccc tagcgccaca cagcagaatg tccggtgatc agacagctca
      241 ggaccctgga tccagcctgg gagaactgga ccagcagaat gtggtgaatc gagtggtggc
      301 tttgcccctg gtcaaggcca cgtgcactgc cgtgtccagt gcttacaact cggccaagga
      361 caggcacccg ctgctgggct ccgcctgccg ccttgctgag cactgtgtgt gtagtgtgac
      421 tacctgtgcc ctggaccacg cacagccact gctggagcac ctgcagcccc agttggccac
      481 agtgaatgat cttgcctgca ggggactaga caaattggaa gagaagctgc ccttcctgca
      541 gcagccatca gacatggtgg tgacatcagc caaggataca gtggccaaaa gtgtcacagg
      601 catggtggac ctggcccaaa ggggccggcg ttggagtggg gagctgaggc gctccatgag
      661 tcaagccatg gacatggtgc tgggcaagtc ggagaagctg gtggaccgct tcctgcccat
      721 gactgaggct gagctagcag tcctggcagc tgaggccgag ggcccagaag tgggcacagt
      781 ggaggagcag aggcagcaac agggctactt tgtgcgtctg gggtccctat cggcacgcct
      841 ccgccatctc gcctatgaac actctttggg gaaactgagg cagagcaaac accgtaccca
      901 ggagatgctg gcccagctgc aggaaacgct ggagctgatc cagcatatgc agagaggggc
      961 aagccctagc cctactttcc atcccccaaa gactcaggag ctgtggggga gctggagccc
     1021 gtgtctagag aatggccgca gccacagtga ggtggagctg gagacactgg ctctgtctcg
     1081 aagtttgacc ctggagctgc agaatgcagt ggatgccctg gcaggctgtg ttcggggcct
     1141 gccacctagt gcccaggcca aggtggctga ggtgcagcgc agcgtggatg ctctacaggc
     1201 cacctttgct gatgcacact gccttggtga tgtggcaccc actgctctgg ctgagggccg
     1261 gggcagtgtg gcccgggcac atgcctgtgt ggatgagttc ctggatttgg tcctgcgggc
     1321 catgccactg ccctggcttg tggggccctt tgcacccatc ctggtggaac agtcggagcc
     1381 cctgatcaac ctggccacct gtgtggacga ggtggtgggt gaccctgatc ctcgctgggc
     1441 acacatggac tggccagccc agaagagggc ctgggaggct gagtctgcag atcctggggg
     1501 gcaagaggct gagcccccaa gggggcaagg caagcacaca atgatgccag agctggactt
     1561 ctgactatcg aggtctctac tgccccctgg tggtcatgtg acagcactca cgcaggctag
     1621 ggcttctgtt cccttccctg ccctggatga ttttgaggtc taagtggacc tcagcaggtc
     1681 actttcaacc tcataggaga atctccctcc cttatgatcc tgtccttacc cccaaagttg
     1741 atacatgagg ctgaggcagg aggattgaga gtctgagttc agtttgagct gccttatcaa
     1801 gattgtctca aaaacaaaca aacaaacaaa caaacaaaca aggaaaagaa aggtggctgg
     1861 aggaagacct ggtgcccaca tcatctacct gggggctcag aactcctaga atcaaatgct
     1921 tttggctggt gtccagagac tcaattgctt tgctgtttgt ggtcctgaat aaatatgttt
     1981 gatgtggtct gaaa
//
