LOCUS       NM_025836               2159 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus perilipin 3 (Plin3), mRNA.
ACCESSION   NM_025836 XM_914280
VERSION     NM_025836.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Bao,X., Ma,X., Huang,R., Chen,J., Xin,H., Zhou,M., Li,L., Tong,S.,
            Zhang,Q., Shui,G., Deng,F., Yu,L., Li,M.D. and Zhang,Z.
  TITLE     Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and
            steatohepatitis caused by hepatocyte CGI-58 deletion in mice
  JOURNAL   J Mol Cell Biol 14 (8) (2022)
   PUBMED   36107452
  REMARK    GeneRIF: Knockdown of hepatocyte Perilipin-3 mitigates hepatic
            steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion
            in mice.
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Gu,Y., Yang,Y., Cao,X., Zhao,Y., Gao,X., Sun,C., Zhang,F., Yuan,Y.,
            Xu,Y., Zhang,J., Xiao,L. and Ye,J.
  TITLE     Plin3 protects against alcoholic liver injury by facilitating lipid
            export from the endoplasmic reticulum
  JOURNAL   J Cell Biochem 120 (9), 16075-16087 (2019)
   PUBMED   31119787
  REMARK    GeneRIF: Plin3 protects against alcoholic liver injury by
            facilitating lipid export from the endoplasmic reticulum.
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Lee,Y.K., Sohn,J.H., Han,J.S., Park,Y.J., Jeon,Y.G., Ji,Y.,
            Dalen,K.T., Sztalryd,C., Kimmel,A.R. and Kim,J.B.
  TITLE     Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes
            Through PPARalpha Activation
  JOURNAL   Diabetes 67 (5), 791-804 (2018)
   PUBMED   29440067
  REMARK    GeneRIF: These data suggest that Plin3 acts as an intrinsic
            protective factor preventing futile beige adipocyte formation by
            limiting lipid metabolism and thermogenic gene expression.
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Ferguson,D., Zhang,J., Davis,M.A., Helsley,R.N., Vedin,L.L.,
            Lee,R.G., Crooke,R.M., Graham,M.J., Allende,D.S., Parini,P. and
            Brown,J.M.
  TITLE     The lipid droplet-associated protein perilipin 3 facilitates
            hepatitis C virus-driven hepatic steatosis
  JOURNAL   J Lipid Res 58 (2), 420-432 (2017)
   PUBMED   27941027
  REMARK    GeneRIF: our studies demonstrate that the lipid droplets (LDs)
            scaffold protein, PLIN3, is essential for HCV core-induced hepatic
            steatosis and provide new insights into the pathogenesis of HCV.
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   Kaushik,S. and Cuervo,A.M.
  TITLE     Degradation of lipid droplet-associated proteins by
            chaperone-mediated autophagy facilitates lipolysis
  JOURNAL   Nat Cell Biol 17 (6), 759-770 (2015)
   PUBMED   25961502
REFERENCE   6  (bases 1 to 2159)
  AUTHORS   Russell,T.D., Palmer,C.A., Orlicky,D.J., Bales,E.S., Chang,B.H.,
            Chan,L. and McManaman,J.L.
  TITLE     Mammary glands of adipophilin-null mice produce an amino-terminally
            truncated form of adipophilin that mediates milk lipid droplet
            formation and secretion
  JOURNAL   J Lipid Res 49 (1), 206-216 (2008)
   PUBMED   17921437
REFERENCE   7  (bases 1 to 2159)
  AUTHORS   Schaiff,W.T., Knapp,F.F. Jr., Barak,Y., Biron-Shental,T.,
            Nelson,D.M. and Sadovsky,Y.
  TITLE     Ligand-activated peroxisome proliferator activated receptor gamma
            alters placental morphology and placental fatty acid uptake in mice
  JOURNAL   Endocrinology 148 (8), 3625-3634 (2007)
   PUBMED   17463056
REFERENCE   8  (bases 1 to 2159)
  AUTHORS   Wolins,N.E., Quaynor,B.K., Skinner,J.R., Schoenfish,M.J., Tzekov,A.
            and Bickel,P.E.
  TITLE     S3-12, Adipophilin, and TIP47 package lipid in adipocytes
  JOURNAL   J Biol Chem 280 (19), 19146-19155 (2005)
   PUBMED   15731108
  REMARK    GeneRIF: the non-lipid droplet pools of S3-12, adipophilin, and
            TIP47 constitute a ready reservoir of coat proteins to permit rapid
            packaging of newly synthesized triacylglycerol and to maximize
            energy storage during nutrient excess
REFERENCE   9  (bases 1 to 2159)
  AUTHORS   Hickenbottom,S.J., Kimmel,A.R., Londos,C. and Hurley,J.H.
  TITLE     Structure of a lipid droplet protein; the PAT family member TIP47
  JOURNAL   Structure 12 (7), 1199-1207 (2004)
   PUBMED   15242596
REFERENCE   10 (bases 1 to 2159)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004970.1 and AK167214.1.
            
            On May 4, 2007 this sequence version replaced NM_025836.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004970.1, AK132313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1613              AK004970.1         2-1614
            1614-2159           AK167214.1         1614-2159
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.25 cM"
     gene            1..2159
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /note="perilipin 3"
                     /db_xref="GeneID:66905"
                     /db_xref="MGI:MGI:1914155"
     exon            1..58
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            59..141
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1389
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /note="mannose-6-phosphate receptor binding protein 1;
                     cargo selection protein TIP47"
                     /codon_start=1
                     /product="perilipin-3"
                     /protein_id="NP_080112.1"
                     /db_xref="CCDS:CCDS28901.1"
                     /db_xref="GeneID:66905"
                     /db_xref="MGI:MGI:1914155"
                     /translation="MSSNGTDAPAEAQAAMEEPVVQPSVVDRVAGLPLISSTYGMVSA
                     AYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAHRGLDR
                     LQESLPILQQPTEKVLADTKELVSSTVSGAQEMVSSSVSSAKETVATRVTGAVDVTLG
                     AVQNSVDKTKSAMTSGVQSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALI
                     ATPPEDSDMASLQQQRQEQNYFVRLGSLSERLRNHAYEHSLGKLQNARQKAQETLQQL
                     TSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMF
                     RDITQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLA
                     QTRERIARAREALDNTVEYVAQNTPAMWLVGPFAPGITEKTPEGK"
     exon            142..340
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            341..423
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            424..721
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            722..921
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1047
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..2159
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /note="putative"
     polyA_site      2159
                     /gene="Plin3"
                     /gene_synonym="1300012C15Rik; M6prbp1; Tip47"
                     /note="putative"
ORIGIN      
        1 agatccaagc tggacttggt aggggaggtt tcctcgcttg gacgacctga ggactttgca
       61 actgctgctg agaccatgtc tagcaatggt acagatgcgc ctgccgaagc tcaagctgct
      121 atggaggaac ctgttgtgca gcccagcgtg gtggatcgtg ttgccggcct gcctcttatc
      181 agttccacgt atgggatggt gagcgccgcc tacacctcca ccaaggagaa ctacccccac
      241 gtcaggactg tgtgcgatgt ggctgagaaa ggcgtcaaga ccctcaccac ggccgctgtc
      301 agcacagcac agcccatcct gtccaagctg gagccccaga ttgcgacggc cagtgagtat
      361 gcacaccgag ggctggacag actgcaggaa agcctgccca tcctccagca gccgactgag
      421 aaggttttgg cggatactaa ggaactggtg tcatctacag tgtctggggc tcaagaaatg
      481 gtatctagct cagtgtctag tgcgaaggaa acagtggcca cccgggtcac aggagcggtg
      541 gatgtgaccc tcggggctgt gcagaacagc gtggacaaga ccaagtcagc aatgaccagc
      601 ggtgtccaat cagtcatggg ctcacgtgtg ggacagatgg tgattagcgg agtggacaga
      661 gtgcttgtga aatcagaggc ctgggcagac aatcgcctgc ccctgacaga ggcggagcta
      721 gctctgattg ccacaccccc ggaggactcg gacatggcct cactgcagca gcagcgacag
      781 gagcagaact actttgtccg gttgggctct ctctctgaga ggctgcgcaa tcacgcctat
      841 gaacactccc tcggcaagct gcagaatgcc aggcagaagg cacaggagac gctgcagcag
      901 ctaacaagtg tgctcggcct gatggaatcc gtgaaacagg gtgtggacca gaggctgggg
      961 gaggggcagg agaagctgca ccagatgtgg ctcagctgga accagaagac cccacaggat
     1021 gctgaaaagg acccagctaa gccagagcag gtggaggccc gggcactcag catgttcagg
     1081 gacatcaccc agcagctgca gagcatgtgt gtggccctgg gggccagcat ccagggcttg
     1141 cccagccacg tcagggagca ggcacagcag gcccgcagcc aggtgaacga ccttcaggcc
     1201 accttctccg gcattcactc cttccaggac ctctcagccg gcgttcttgc ccaaactcgg
     1261 gagcgcatag ccagagcccg ggaggcccta gacaacactg tggagtacgt ggcccagaac
     1321 actccagcca tgtggctggt gggccccttc gctcctggaa tcacagagaa aacccctgaa
     1381 gggaagtagg gagaaggttc agggccaaca tctatctggc ttgactgctt ttcccaacag
     1441 tccaattgca caacaggtcc tcccctactg agtctgaatg agacatgtgt ttaacctatt
     1501 cccatcagtc ttttaaagca attttttttc tagaatgttc caggggtaaa aagatccaga
     1561 acattctaga aaaaaaaaat gtttttttcc taaaaaaaaa aaaaaaaaaa aaatgaggaa
     1621 tgagggtaat gaatagtgat agcactagtc tgtcatcctg tgtcagcact gtggtataga
     1681 ggcaagaggg tcacaggttc aaagcccggc tgccacatca caaattcagt gatagtctaa
     1741 gctacattag accttgtctt gaagtaaaaa aaggcataat gatttttcac tccgggtttc
     1801 ttttctacat catggcccac aatagcaaga gcttttcttg tttgtttttt tttttttttt
     1861 cctgagacag ggtttctctg tatagcccct ggctgtcctg gaactcactt tgtagaccag
     1921 gctggccttg aactcagaaa tccacctgcc tctgcctcct gagtgctggg attaaaggcc
     1981 ggctagcaag agcttttcta acagaccctg atacctggcc caagaaccca gcaactgtga
     2041 caggatagac agctgggatg ttgcaattgt ttcagatgag aaagtgaggg ccgagtacac
     2101 tgttcctcaa atcctggggc tcagtattgc cttaataaat tttatatgca tcagaggcc
//
