LOCUS       NM_001403718            2584 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus perilipin 2 (Plin2), transcript variant 9, mRNA.
ACCESSION   NM_001403718
VERSION     NM_001403718.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Wang,Y., Zhou,J., Yang,Q., Li,X., Qiu,Y., Zhang,Y., Liu,M. and
            Zhu,A.J.
  TITLE     Therapeutic siRNA targeting PLIN2 ameliorates steatosis,
            inflammation, and fibrosis in steatotic liver disease models
  JOURNAL   J Lipid Res 65 (10), 100635 (2024)
   PUBMED   39187042
REFERENCE   2  (bases 1 to 2584)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2584)
  AUTHORS   Stokes,G., Li,Z., Talaba,N., Genthe,W., Brix,M.B., Pham,B.,
            Wienhold,M.D., Sandok,G., Hernan,R., Wynn,J., Tang,H., Tabima,D.M.,
            Rodgers,A., Hacker,T.A., Chesler,N.C., Zhang,P., Murad,R.,
            Yuan,J.X., Shen,Y., Chung,W.K. and McCulley,D.J.
  TITLE     Rescuing lung development through embryonic inhibition of histone
            acetylation
  JOURNAL   Sci Transl Med 16 (732), eadc8930 (2024)
   PUBMED   38295182
REFERENCE   5  (bases 1 to 2584)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   6  (bases 1 to 2584)
  AUTHORS   Rinchik,E.M., Bell,J.A., Hunsicker,P.R., Friedman,J.M.,
            Jackson,I.J. and Russell,L.B.
  TITLE     Molecular genetics of the brown (b)-locus region of mouse
            chromosome 4. I. Origin and molecular mapping of radiation- and
            chemical-induced lethal brown deletions
  JOURNAL   Genetics 137 (3), 845-854 (1994)
   PUBMED   7916309
REFERENCE   7  (bases 1 to 2584)
  AUTHORS   Eisinger,D.P. and Serrero,G.
  TITLE     Structure of the gene encoding mouse adipose
            differentiation-related protein (ADRP)
  JOURNAL   Genomics 16 (3), 638-644 (1993)
   PUBMED   8325636
REFERENCE   8  (bases 1 to 2584)
  AUTHORS   Colon-Teicher,L., Wise,L.S., Martino,J.J., Baskin,L., Sakoulas,G.,
            Pollack,R.E. and Chen,S.
  TITLE     Genomic sequences capable of committing mouse and rat fibroblasts
            to adipogenesis
  JOURNAL   Nucleic Acids Res 21 (9), 2223-2228 (1993)
   PUBMED   8502564
REFERENCE   9  (bases 1 to 2584)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   10 (bases 1 to 2584)
  AUTHORS   Jiang,H.P. and Serrero,G.
  TITLE     Isolation and characterization of a full-length cDNA coding for an
            adipose differentiation-related protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7856-7860 (1992)
   PUBMED   1518805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL824707.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.5246350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AL824707.7         219469-219929       c
            462-517             AL824707.7         218585-218640       c
            518-713             AL824707.7         218302-218497       c
            714-796             AL824707.7         214364-214446       c
            797-1076            AL824707.7         211869-212148       c
            1077-1258           AL824707.7         210023-210204       c
            1259-1393           AL824707.7         208516-208650       c
            1394-1684           AL824707.7         207049-207339       c
            1685-2584           AL824707.7         197615-198514       c
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..2584
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="perilipin 2"
                     /db_xref="GeneID:11520"
                     /db_xref="MGI:MGI:87920"
     exon            1..461
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            462..517
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..1765
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="isoform 2 is encoded by transcript variant 9;
                     adipose differentiation-related protein; adipophilin"
                     /codon_start=1
                     /product="perilipin-2 isoform 2"
                     /protein_id="NP_001390647.1"
                     /db_xref="GeneID:11520"
                     /db_xref="MGI:MGI:87920"
                     /translation="MAAAVVDPQQSVVMRVANLPLVSSTYDLVSSAYVSTKDQYPYLR
                     SVCEMAEKGVKTVTSAAMTSALPIIQKLEPQIAVANTYACKGLDRMEERLPILNQPTS
                     EIVASARGAVTGAKDVVTTTMAGAKDSVASTVSGVVDKTKGAVTGSVERTKSVVNGSI
                     NTVLGMVQFMNSGVDNAITKSELLVDQYFPLTQEELEMEAKKVEGFDMVQKPSNYERL
                     ESLSTKLCSRAYHQALSRVKEAKQKSQETISQLHSTVHLIEFARKNMHSANQKIQGAQ
                     DKLYVSWVEWKRSIGYDDTDESHCVEHIESRTLAIARNLTQQLQTTCQTVLVNAQGLP
                     QNIQDQAKHLGVMAGDIYSVFRNAASFKEVSDGVLTSSKGQLQKMKESLDEVMDYFVN
                     NTPLNWLMLDFPAADSTSDTDEVPDIIPLEADD"
     exon            518..713
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            714..796
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1076
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1258
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1393
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1684
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..2584
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="hexamer: AATATA"
     polyA_site      1878
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="major polyA site"
     polyA_site      1987
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
     polyA_site      2099
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="hexamer: AATAAA"
     polyA_site      2584
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
ORIGIN      
        1 gtggtgatct ggaccgtgcg gacttgctcg tccctcagct ctcctgttag gtaggtcctg
       61 caccagatct ggccctcagg ccgctgctgc tctgcctgca ctgggctcgg aactgcagca
      121 atgggtcggt gggggaggag gggggaggga gcagccccgg gctggttggg aaagctctcg
      181 cttttgttct agagttttcc tttctgtttg cacgtccttc tgtggtagag caacttgcat
      241 ttgtccggtc gaggttttat ttaaatggaa acacctcaca gaagaactta taaggtgcat
      301 agtgagaatt gtctgggttt cctttagtgt cccactaggc agcactggct gcccgcaggc
      361 tctctatggt ccaagctggg ctgaaactct tgctcctcct ctgcctcagc cccacctcac
      421 ccttggaaaa cggaaggaga tattttatgg gctgctcctt ggcgtctctt ttctccagga
      481 ggaaaaaatg gcagcagcag tagtggatcc gcaacagagc gtggtgatga gagtggccaa
      541 cctgcccttg gtgagctcta cctacgacct tgtgtcctcc gcttatgtca gtacaaagga
      601 tcagtacccg tatttgagat ccgtgtgtga gatggccgag aagggcgtga agaccgtgac
      661 ctctgcggcc atgacaagtg ccctgcccat catccagaag ctggagccac aaattgcggt
      721 tgccaatacc tatgcctgca aggggctaga caggatggag gaaagactgc ctattctgaa
      781 ccagccaacg tccgagattg ttgccagtgc cagaggtgcc gtaactgggg cgaaggatgt
      841 ggtgacgact accatggctg gagccaagga ttctgtagcc agcacagtct caggggtggt
      901 ggataagacc aaaggagcag tgactggcag cgtggaaagg accaagtctg tggtcaatgg
      961 cagcatcaat acagttttgg ggatggtgca gttcatgaac agtggagtag ataatgccat
     1021 caccaagtcg gagctgctgg tagaccagta cttccctctc actcaggagg agctggagat
     1081 ggaagcaaaa aaggtggaag gatttgatat ggttcagaag ccgagcaact atgaacggct
     1141 ggagtccctg tctaccaagc tctgctctcg ggcttatcac caggctctca gcagggttaa
     1201 agaggccaaa caaaagagcc aggagaccat ttctcagctc cactccactg tccacctgat
     1261 tgaattcgcc aggaagaata tgcacagtgc caaccagaaa attcagggtg ctcaggataa
     1321 gctctatgtc tcgtgggtgg agtggaagag aagcatcggc tacgacgaca ccgatgagtc
     1381 ccactgtgtt gagcacatcg agtcacgtac tctggctatc gcccgcaacc tgacccagca
     1441 gctccagact acatgccaga ctgtcctggt caacgcccaa gggttaccac agaacattca
     1501 agatcaggcc aaacacttgg gggtgatggc aggcgacatc tactccgtat tccgcaatgc
     1561 tgcctccttt aaggaagtgt ccgatggcgt cctcacatct agcaaggggc agctgcagaa
     1621 aatgaaggaa tccttagatg aagttatgga ttactttgtt aacaacacgc ctctcaactg
     1681 gctgatgctt gacttccctg ctgctgactc gacatctgac actgacgaag ttcctgatat
     1741 tattccgttg gaagcggatg attgaaccca atgaccacac actcacagcc ctgtcctctt
     1801 aaggcaaaag accacccaac taacacaagg aaagacacta ttttattgaa aatgtaatat
     1861 atatcttttt tttttaaatg gttgcctctg ttttattcct gtgtctttgg tgaacattca
     1921 tctactattt ggctgcttga tcttagttgt aaatgatgtg aactttcgta agagatcttg
     1981 ttatgcatcc tgtgtcattt tatagaattc tttaatgttt aattgctgaa atgcctttat
     2041 aataatattg ggctgtagac ctgtgagttg gcttaatggg taaaagtgct tcctgcccag
     2101 cctgatggtc tgagtttgac tctttcaaac tgtgagaccc cgacttagag catttctccc
     2161 tgaaaggtaa agcccctaaa acattccccc aagcttgttt tccccatctc tggggataca
     2221 gccagaaaga agctctttgt tctttatagc tagcaaaaag ccttttttgt ttctgtgcct
     2281 ttcaaccata gatgtgataa ttgtaggaag acctagccag gcacttgctt ggctccctgt
     2341 gccaaggaca gggagataga cgctggagag gagctacagc tcaccccccc ccccaccgct
     2401 cgccagagag gagctgcagc caactctcct cccaactcct cccaactctt ctcccaactc
     2461 ctcccaattc ctcacttttc cttaaaaagc cccctactgc taccactcag ggtcgaactc
     2521 ccctgccctg cacagcgaaa ggagttcatc ctcagctagc tgataataaa gcctcttgca
     2581 gtta
//
