LOCUS       NP_001390647             425 aa            linear   ROD 10-DEC-2024
DEFINITION  perilipin-2 isoform 2 [Mus musculus].
ACCESSION   NP_001390647
VERSION     NP_001390647.1
DBSOURCE    REFSEQ: accession NM_001403718.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 425)
  AUTHORS   Wang,Y., Zhou,J., Yang,Q., Li,X., Qiu,Y., Zhang,Y., Liu,M. and
            Zhu,A.J.
  TITLE     Therapeutic siRNA targeting PLIN2 ameliorates steatosis,
            inflammation, and fibrosis in steatotic liver disease models
  JOURNAL   J Lipid Res 65 (10), 100635 (2024)
   PUBMED   39187042
REFERENCE   2  (residues 1 to 425)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 425)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 425)
  AUTHORS   Stokes,G., Li,Z., Talaba,N., Genthe,W., Brix,M.B., Pham,B.,
            Wienhold,M.D., Sandok,G., Hernan,R., Wynn,J., Tang,H., Tabima,D.M.,
            Rodgers,A., Hacker,T.A., Chesler,N.C., Zhang,P., Murad,R.,
            Yuan,J.X., Shen,Y., Chung,W.K. and McCulley,D.J.
  TITLE     Rescuing lung development through embryonic inhibition of histone
            acetylation
  JOURNAL   Sci Transl Med 16 (732), eadc8930 (2024)
   PUBMED   38295182
REFERENCE   5  (residues 1 to 425)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   6  (residues 1 to 425)
  AUTHORS   Rinchik,E.M., Bell,J.A., Hunsicker,P.R., Friedman,J.M.,
            Jackson,I.J. and Russell,L.B.
  TITLE     Molecular genetics of the brown (b)-locus region of mouse
            chromosome 4. I. Origin and molecular mapping of radiation- and
            chemical-induced lethal brown deletions
  JOURNAL   Genetics 137 (3), 845-854 (1994)
   PUBMED   7916309
REFERENCE   7  (residues 1 to 425)
  AUTHORS   Eisinger,D.P. and Serrero,G.
  TITLE     Structure of the gene encoding mouse adipose
            differentiation-related protein (ADRP)
  JOURNAL   Genomics 16 (3), 638-644 (1993)
   PUBMED   8325636
REFERENCE   8  (residues 1 to 425)
  AUTHORS   Colon-Teicher,L., Wise,L.S., Martino,J.J., Baskin,L., Sakoulas,G.,
            Pollack,R.E. and Chen,S.
  TITLE     Genomic sequences capable of committing mouse and rat fibroblasts
            to adipogenesis
  JOURNAL   Nucleic Acids Res 21 (9), 2223-2228 (1993)
   PUBMED   8502564
REFERENCE   9  (residues 1 to 425)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   10 (residues 1 to 425)
  AUTHORS   Jiang,H.P. and Serrero,G.
  TITLE     Isolation and characterization of a full-length cDNA coding for an
            adipose differentiation-related protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7856-7860 (1992)
   PUBMED   1518805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL824707.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.5246350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     Protein         1..425
                     /product="perilipin-2 isoform 2"
                     /note="adipose differentiation-related protein;
                     adipophilin"
                     /calculated_mol_wt=46445
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q99541; propagated from
                     UniProtKB/Swiss-Prot (P43883.2)"
     Region          6..403
                     /region_name="Perilipin"
                     /note="Perilipin family; pfam03036"
                     /db_xref="CDD:460784"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99541; propagated from
                     UniProtKB/Swiss-Prot (P43883.2)"
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q99541; propagated from
                     UniProtKB/Swiss-Prot (P43883.2)"
     CDS             1..425
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /coded_by="NM_001403718.1:488..1765"
                     /note="isoform 2 is encoded by transcript variant 9"
                     /db_xref="GeneID:11520"
                     /db_xref="MGI:MGI:87920"
ORIGIN      
        1 maaavvdpqq svvmrvanlp lvsstydlvs sayvstkdqy pylrsvcema ekgvktvtsa
       61 amtsalpiiq klepqiavan tyackgldrm eerlpilnqp tseivasarg avtgakdvvt
      121 ttmagakdsv astvsgvvdk tkgavtgsve rtksvvngsi ntvlgmvqfm nsgvdnaitk
      181 sellvdqyfp ltqeelemea kkvegfdmvq kpsnyerles lstklcsray hqalsrvkea
      241 kqksqetisq lhstvhlief arknmhsanq kiqgaqdkly vswvewkrsi gyddtdeshc
      301 vehiesrtla iarnltqqlq ttcqtvlvna qglpqniqdq akhlgvmagd iysvfrnaas
      361 fkevsdgvlt sskgqlqkmk esldevmdyf vnntplnwlm ldfpaadsts dtdevpdiip
      421 leadd
//
