LOCUS       NM_001403711            1926 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus perilipin 2 (Plin2), transcript variant 2, mRNA.
ACCESSION   NM_001403711
VERSION     NM_001403711.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Wang,Y., Zhou,J., Yang,Q., Li,X., Qiu,Y., Zhang,Y., Liu,M. and
            Zhu,A.J.
  TITLE     Therapeutic siRNA targeting PLIN2 ameliorates steatosis,
            inflammation, and fibrosis in steatotic liver disease models
  JOURNAL   J Lipid Res 65 (10), 100635 (2024)
   PUBMED   39187042
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Stokes,G., Li,Z., Talaba,N., Genthe,W., Brix,M.B., Pham,B.,
            Wienhold,M.D., Sandok,G., Hernan,R., Wynn,J., Tang,H., Tabima,D.M.,
            Rodgers,A., Hacker,T.A., Chesler,N.C., Zhang,P., Murad,R.,
            Yuan,J.X., Shen,Y., Chung,W.K. and McCulley,D.J.
  TITLE     Rescuing lung development through embryonic inhibition of histone
            acetylation
  JOURNAL   Sci Transl Med 16 (732), eadc8930 (2024)
   PUBMED   38295182
REFERENCE   5  (bases 1 to 1926)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   6  (bases 1 to 1926)
  AUTHORS   Rinchik,E.M., Bell,J.A., Hunsicker,P.R., Friedman,J.M.,
            Jackson,I.J. and Russell,L.B.
  TITLE     Molecular genetics of the brown (b)-locus region of mouse
            chromosome 4. I. Origin and molecular mapping of radiation- and
            chemical-induced lethal brown deletions
  JOURNAL   Genetics 137 (3), 845-854 (1994)
   PUBMED   7916309
REFERENCE   7  (bases 1 to 1926)
  AUTHORS   Eisinger,D.P. and Serrero,G.
  TITLE     Structure of the gene encoding mouse adipose
            differentiation-related protein (ADRP)
  JOURNAL   Genomics 16 (3), 638-644 (1993)
   PUBMED   8325636
REFERENCE   8  (bases 1 to 1926)
  AUTHORS   Colon-Teicher,L., Wise,L.S., Martino,J.J., Baskin,L., Sakoulas,G.,
            Pollack,R.E. and Chen,S.
  TITLE     Genomic sequences capable of committing mouse and rat fibroblasts
            to adipogenesis
  JOURNAL   Nucleic Acids Res 21 (9), 2223-2228 (1993)
   PUBMED   8502564
REFERENCE   9  (bases 1 to 1926)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   10 (bases 1 to 1926)
  AUTHORS   Jiang,H.P. and Serrero,G.
  TITLE     Isolation and characterization of a full-length cDNA coding for an
            adipose differentiation-related protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7856-7860 (1992)
   PUBMED   1518805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL824707.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.680028.1,
                                           SRR17253012.8640873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AL824707.7         219636-219929       c
            295-350             AL824707.7         218585-218640       c
            351-546             AL824707.7         218302-218497       c
            547-629             AL824707.7         214364-214446       c
            630-909             AL824707.7         211869-212148       c
            910-1091            AL824707.7         210023-210204       c
            1092-1226           AL824707.7         208516-208650       c
            1227-1926           AL824707.7         206640-207339       c
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..1926
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="perilipin 2"
                     /db_xref="GeneID:11520"
                     /db_xref="MGI:MGI:87920"
     exon            1..294
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            295..350
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1598
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="isoform 1 is encoded by transcript variant 2;
                     adipose differentiation-related protein; adipophilin"
                     /codon_start=1
                     /product="perilipin-2 isoform 1"
                     /protein_id="NP_001390640.1"
                     /db_xref="GeneID:11520"
                     /db_xref="MGI:MGI:87920"
                     /translation="MAAAVVDPQQSVVMRVANLPLVSSTYDLVSSAYVSTKDQYPYLR
                     SVCEMAEKGVKTVTSAAMTSALPIIQKLEPQIAVANTYACKGLDRMEERLPILNQPTS
                     EIVASARGAVTGAKDVVTTTMAGAKDSVASTVSGVVDKTKGAVTGSVERTKSVVNGSI
                     NTVLGMVQFMNSGVDNAITKSELLVDQYFPLTQEELEMEAKKVEGFDMVQKPSNYERL
                     ESLSTKLCSRAYHQALSRVKEAKQKSQETISQLHSTVHLIEFARKNMHSANQKIQGAQ
                     DKLYVSWVEWKRSIGYDDTDESHCVEHIESRTLAIARNLTQQLQTTCQTVLVNAQGLP
                     QNIQDQAKHLGVMAGDIYSVFRNAASFKEVSDGVLTSSKGQLQKMKESLDEVMDYFVN
                     NTPLNWLVGPFYPQSTEVNKASLKVQQSEVKAQ"
     exon            351..546
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            547..629
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            630..909
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1091
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1226
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1926
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="Plin2"
                     /gene_synonym="Adfp; ADPH; Adrp"
                     /note="major polyA site"
ORIGIN      
        1 gtggtgatct ggaccgtgcg gacttgctcg tccctcagct ctcctgttag gtaggtcctg
       61 caccagatct ggccctcagg ccgctgctgc tctgcctgca ctgggctcgg aactgcagca
      121 atgggtcggt gggggaggag gggggaggga gcagccccgg gctggttggg aaagctctcg
      181 cttttgttct agagttttcc tttctgtttg cacgtccttc tgtggtagag caacttgcat
      241 ttgtccggtc gaggttttat ttaaatggaa acacctcaca gaagaactta taaggcgtct
      301 cttttctcca ggaggaaaaa atggcagcag cagtagtgga tccgcaacag agcgtggtga
      361 tgagagtggc caacctgccc ttggtgagct ctacctacga ccttgtgtcc tccgcttatg
      421 tcagtacaaa ggatcagtac ccgtatttga gatccgtgtg tgagatggcc gagaagggcg
      481 tgaagaccgt gacctctgcg gccatgacaa gtgccctgcc catcatccag aagctggagc
      541 cacaaattgc ggttgccaat acctatgcct gcaaggggct agacaggatg gaggaaagac
      601 tgcctattct gaaccagcca acgtccgaga ttgttgccag tgccagaggt gccgtaactg
      661 gggcgaagga tgtggtgacg actaccatgg ctggagccaa ggattctgta gccagcacag
      721 tctcaggggt ggtggataag accaaaggag cagtgactgg cagcgtggaa aggaccaagt
      781 ctgtggtcaa tggcagcatc aatacagttt tggggatggt gcagttcatg aacagtggag
      841 tagataatgc catcaccaag tcggagctgc tggtagacca gtacttccct ctcactcagg
      901 aggagctgga gatggaagca aaaaaggtgg aaggatttga tatggttcag aagccgagca
      961 actatgaacg gctggagtcc ctgtctacca agctctgctc tcgggcttat caccaggctc
     1021 tcagcagggt taaagaggcc aaacaaaaga gccaggagac catttctcag ctccactcca
     1081 ctgtccacct gattgaattc gccaggaaga atatgcacag tgccaaccag aaaattcagg
     1141 gtgctcagga taagctctat gtctcgtggg tggagtggaa gagaagcatc ggctacgacg
     1201 acaccgatga gtcccactgt gttgagcaca tcgagtcacg tactctggct atcgcccgca
     1261 acctgaccca gcagctccag actacatgcc agactgtcct ggtcaacgcc caagggttac
     1321 cacagaacat tcaagatcag gccaaacact tgggggtgat ggcaggcgac atctactccg
     1381 tattccgcaa tgctgcctcc tttaaggaag tgtccgatgg cgtcctcaca tctagcaagg
     1441 ggcagctgca gaaaatgaag gaatccttag atgaagttat ggattacttt gttaacaaca
     1501 cgcctctcaa ctggctggta ggtccctttt atcctcagtc taccgaggtg aacaaggcca
     1561 gcctgaaggt ccagcagtct gaggtcaaag ctcagtaaac ccctccttgt caccagagca
     1621 tgatgttgct ggccagatga ccccttttgc tgtattgaaa ttaacttggt agatggcttt
     1681 agcttagaaa agcagcttct tagaaccaag ggcctcatta tggtcactca cagctcagtt
     1741 atggtcttgc cccagctggc cctggcacag gagttctctt acctggctgg tgagtggcct
     1801 gtgttagtct tgtgaggacc tcgaggaacc taaaagctca gatgcactta cagtcttgtc
     1861 tgtggccttt gtattgttat tggctgtaaa cgtctgtctg gaccgaataa agattcattc
     1921 acgtgg
//
