LOCUS       NM_001113471            1879 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus perilipin 1 (Plin1), transcript variant 2, mRNA.
ACCESSION   NM_001113471
VERSION     NM_001113471.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Traynor,S., Bhattacharya,S., Batmanov,K., Cheng,L., Weller,A.,
            Moore,N., Flesher,C. and Merrick,D.
  TITLE     Developmental regulation of dermal adipose tissue by BCL11b
  JOURNAL   Genes Dev 38 (15-16), 772-783 (2024)
   PUBMED   39266447
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Desgrouas,C., Thalheim,T., Cerino,M., Badens,C. and
            Bonello-Palot,N.
  TITLE     Perilipin 1: a systematic review on its functions on lipid
            metabolism and atherosclerosis in mice and humans
  JOURNAL   Cardiovasc Res 120 (3), 237-248 (2024)
   PUBMED   38214891
  REMARK    GeneRIF: Perilipin 1: a systematic review on its functions on lipid
            metabolism and atherosclerosis in mice and humans.
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Rao,J., Djeffal,Y., Chal,J., Marchiano,F., Wang,C.H., Al
            Tanoury,Z., Gapon,S., Mayeuf-Louchart,A., Glass,I., Sefton,E.M.,
            Habermann,B., Kardon,G., Watt,F.M., Tseng,Y.H. and Pourquie,O.
  TITLE     Reconstructing human brown fat developmental trajectory in vitro
  JOURNAL   Dev Cell 58 (21), 2359-2375 (2023)
   PUBMED   37647896
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Wei,X., Li,L., Zhao,J., Huo,Y., Hu,X., Lu,J., Pi,J., Zhang,W.,
            Xu,L., Yao,Y. and Xu,J.
  TITLE     BAP31 depletion inhibited adipogenesis, repressed lipolysis and
            promoted lipid droplets abnormal growth via attenuating Perilipin1
            proteasomal degradation
  JOURNAL   Int J Biol Sci 19 (6), 1713-1730 (2023)
   PUBMED   37063427
  REMARK    GeneRIF: BAP31 depletion inhibited adipogenesis, repressed
            lipolysis and promoted lipid droplets abnormal growth via
            attenuating Perilipin1 proteasomal degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Garcia,A., Sekowski,A., Subramanian,V. and Brasaemle,D.L.
  TITLE     The central domain is required to target and anchor perilipin A to
            lipid droplets
  JOURNAL   J Biol Chem 278 (1), 625-635 (2003)
   PUBMED   12407111
  REMARK    GeneRIF: the central 25% of the perilipin A sequence contains all
            of the amino acids necessary to target and anchor the protein to
            lipid droplets
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Souza,S.C., Muliro,K.V., Liscum,L., Lien,P., Yamamoto,M.T.,
            Schaffer,J.E., Dallal,G.E., Wang,X., Kraemer,F.B., Obin,M. and
            Greenberg,A.S.
  TITLE     Modulation of hormone-sensitive lipase and protein kinase
            A-mediated lipolysis by perilipin A in an adenoviral reconstituted
            system
  JOURNAL   J Biol Chem 277 (10), 8267-8272 (2002)
   PUBMED   11751901
  REMARK    GeneRIF: perilipin expression and phosphorylation state are
            critical regulators of lipid storage and hydrolysis in ACS1/FATP1
            cells.
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Lu,X., Gruia-Gray,J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Londos,C. and Kimmel,A.R.
  TITLE     The murine perilipin gene: the lipid droplet-associated perilipins
            derive from tissue-specific, mRNA splice variants and define a gene
            family of ancient origin
  JOURNAL   Mamm Genome 12 (9), 741-749 (2001)
   PUBMED   11641724
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Tansey,J.T., Sztalryd,C., Gruia-Gray,J., Roush,D.L., Zee,J.V.,
            Gavrilova,O., Reitman,M.L., Deng,C.X., Li,C., Kimmel,A.R. and
            Londos,C.
  TITLE     Perilipin ablation results in a lean mouse with aberrant adipocyte
            lipolysis, enhanced leptin production, and resistance to
            diet-induced obesity
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6494-6499 (2001)
   PUBMED   11371650
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Martinez-Botas,J., Anderson,J.B., Tessier,D., Lapillonne,A.,
            Chang,B.H., Quast,M.J., Gorenstein,D., Chen,K.H. and Chan,L.
  TITLE     Absence of perilipin results in leanness and reverses obesity in
            Lepr(db/db) mice
  JOURNAL   Nat Genet 26 (4), 474-479 (2000)
   PUBMED   11101849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ060785.1, BC096685.1 and BC037748.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               CJ060785.1         14-127
            115-1851            BC096685.1         116-1852
            1852-1879           BC037748.1         626-653
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.11 cM"
     gene            1..1879
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /note="perilipin 1"
                     /db_xref="GeneID:103968"
                     /db_xref="MGI:MGI:1890505"
     exon            1..35
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            36..94
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1603
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /note="perilipin A; perilipin B; lipid droplet-associated
                     protein"
                     /codon_start=1
                     /product="perilipin-1"
                     /protein_id="NP_001106942.1"
                     /db_xref="CCDS:CCDS21385.1"
                     /db_xref="GeneID:103968"
                     /db_xref="MGI:MGI:1890505"
                     /translation="MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNST
                     KEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKI
                     PALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKET
                     AEYAANTRVGRLASGGADLALGSIEKVVEFLLPPDKESAPSSGRQRTQKAPKAKPSLV
                     RRVSTLANTLSRHTMQTTAWALKQGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQS
                     EVRVPWLHNLAASQDESHDDQTDTEGEETDDEEEEEESEAEENVLREVTALPNPRGLL
                     GGVVHTVQNTLRNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGV
                     TDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPSAEAERKGSGARPASPESTPRPGQPR
                     GSLRSVRGLSAPSCPGLDDKTEASARPGFLAMPREKPARRVSDSFFRPSVMEPILGRA
                     QYSQLRKKS"
     exon            95..299
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            300..382
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            383..644
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            645..817
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1018
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1264
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1860
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /note="hexamer: TATAAA"
     polyA_site      1860
                     /gene="Plin1"
                     /gene_synonym="6030432J05Rik; Peri; Plin"
                     /note="major polyA site"
ORIGIN      
        1 tgggctgtct gagactgagg tggcggtctg ctgcacgtgg agagtaagga tgtcaatgaa
       61 caagggccca accctgctgg atggagacct ccctgagcag gagaacgtgc tccagagagt
      121 tctgcagctg cctgtggtga gcgggacctg tgagtgcttc cagaagacct acaacagcac
      181 caaagaagcc caccccctgg tggcctctgt gtgcaatgcc tatgagaagg gtgtacaggg
      241 tgccagcaac ctggctgcct ggagcatgga gccggtggtc cgtcggctgt ccacccagtt
      301 cacagctgcc aatgagttgg cctgcagagg cctggaccac ctggaggaaa agatcccggc
      361 tcttcaatac cctccagaaa agatcgcctc tgaactgaag ggcaccatct ctacccgcct
      421 tcgaagcgcc aggaacagca tcagtgtgcc cattgcaagc acctctgaca aggttctggg
      481 ggccactctg gccggctgcg agcttgcctt ggggatggcc aaagagacag cagaatatgc
      541 cgccaacacc cgggttggcc gactggcctc tggaggggct gatctggctc tgggaagcat
      601 cgagaaggtg gtagagttcc tcctgccacc agacaaggag tcagcccctt cttccggacg
      661 gcagaggacc cagaaggctc ccaaggccaa accaagcctt gtgaggaggg tcagcaccct
      721 ggccaacact ctttctcgac acaccatgca aaccacagca tgggccctga agcagggcca
      781 ctctctggcc atgtggatcc cgggtgtggc acccctgagc agcctggccc agtggggcgc
      841 atcggcagcc atgcaggtgg tgtcccggcg gcagagtgag gtgcgggtgc cctggctgca
      901 caacctggca gcctctcagg atgagagcca tgacgaccag acagacacag agggagagga
      961 gacagacgac gaggaggagg aagaagagtc cgaggctgag gagaacgtgc tcagagaggt
     1021 tacagccctg cccaacccga gaggcctcct gggtggtgtg gtacacaccg tgcagaacac
     1081 tctccggaac accatctccg cagtgacctg ggcacctgcg gctgtgctgg gcacggtggg
     1141 aaggatcctg cacctcacac cagcccaggc tgtctcctct accaaaggga gggccatgtc
     1201 cctatccgat gccctgaagg gtgttacgga taacgtggta gacactgtgg tacactatgt
     1261 gccgcttccc aggctgtccc tgatggagcc cgagagcgaa ttccgagaca tcgataaccc
     1321 ttcagcagag gcggagcgca aagggtccgg ggcgcggccc gccagcccgg agtccacccc
     1381 gcgcccgggc cagccccgcg gcagcttgcg cagcgtgcgg ggtctcagcg cgccctcctg
     1441 ccccggcctg gacgacaaaa ccgaggcgtc agcgcgtccc ggcttcctgg ctatgcccag
     1501 agagaagcct gcgcgcagag tcagcgacag cttcttccgg cccagcgtca tggagcccat
     1561 cctgggccgc gcgcagtaca gccagctgcg caagaagagc tgagcagact gcgcccctgc
     1621 tcgccccacg ggaaggtcgc ttctcgtcaa gggcctttcc tttagggtgg cctgagccac
     1681 gaccccacga tgctctcgag gcacacatca tgtctaaagc atcctttggg ggcttgacca
     1741 tcagaaccaa tttttaaggg gcaccagagc cgcggtcgac tctcctttct cgtgggcaga
     1801 ttctctcatg gcttcttctt cctcttcttt ttttaaaaac tataaaagca attgattgtt
     1861 aaaaaaaaaa aaaaaaaaa
//
