LOCUS       NM_026362                843 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus plasminogen receptor, C-terminal lysine transmembrane
            protein (Plgrkt), mRNA.
ACCESSION   NM_026362
VERSION     NM_026362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 843)
  AUTHORS   Samad,F., Bai,H., Baik,N., Haider,P., Zhang,Y., Rega-Kaun,G.,
            Kaun,C., Prager,M., Wojta,J., Bui,Q., Chakrabarty,S., Wang,J.,
            Parmer,R.J. and Miles,L.A.
  TITLE     The plasminogen receptor Plg-RKT regulates adipose function and
            metabolic homeostasis
  JOURNAL   J Thromb Haemost 20 (3), 742-754 (2022)
   PUBMED   34897983
  REMARK    GeneRIF: The plasminogen receptor Plg-RKT regulates adipose
            function and metabolic homeostasis.
REFERENCE   2  (bases 1 to 843)
  AUTHORS   Whyte,C.S., Morrow,G.B., Baik,N., Booth,N.A., Jalal,M.M.,
            Parmer,R.J., Miles,L.A. and Mutch,N.J.
  TITLE     Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT,
            on activated human and murine platelets
  JOURNAL   Blood 137 (2), 248-257 (2021)
   PUBMED   32842150
  REMARK    GeneRIF: Exposure of plasminogen and a novel plasminogen receptor,
            Plg-RKT, on activated human and murine platelets.
REFERENCE   3  (bases 1 to 843)
  AUTHORS   Ny,L., Parmer,R.J., Shen,Y., Holmberg,S., Baik,N., Backman,A.,
            Broden,J., Wilczynska,M., Ny,T. and Miles,L.A.
  TITLE     The plasminogen receptor, Plg-RKT, plays a role in inflammation and
            fibrinolysis during cutaneous wound healing in mice
  JOURNAL   Cell Death Dis 11 (12), 1054 (2020)
   PUBMED   33311441
  REMARK    GeneRIF: The plasminogen receptor, Plg-RKT, plays a role in
            inflammation and fibrinolysis during cutaneous wound healing in
            mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 843)
  AUTHORS   Vago,J.P., Sugimoto,M.A., Lima,K.M., Negreiros-Lima,G.L., Baik,N.,
            Teixeira,M.M., Perretti,M., Parmer,R.J., Miles,L.A. and Sousa,L.P.
  TITLE     Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate
            Macrophage Phenotypic, and Functional Changes
  JOURNAL   Front Immunol 10, 1458 (2019)
   PUBMED   31316511
  REMARK    GeneRIF: Plasminogen and the Plasminogen Receptor, Plg-RKT,
            Regulate Macrophage Phenotypic, and Functional Changes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 843)
  AUTHORS   Miles,L.A., Baik,N., Bai,H., Makarenkova,H.P., Kiosses,W.B.,
            Krajewski,S., Castellino,F.J., Valenzuela,A., Varki,N.M.,
            Mueller,B.M. and Parmer,R.J.
  TITLE     The plasminogen receptor, Plg-RKT, is essential for mammary
            lobuloalveolar development and lactation
  JOURNAL   J Thromb Haemost 16 (5), 919-932 (2018)
   PUBMED   29495105
  REMARK    GeneRIF: Plg-RKT is essential for lactogenesis and functions to
            maintain the appropriate stromal extracellular matrix environment,
            regulate epithelial cell proliferation and apoptosis, and, by
            regulating fibrinolysis, preserve alveolar and ductal patency.
REFERENCE   6  (bases 1 to 843)
  AUTHORS   Miles,L.A., Baik,N., Lighvani,S., Khaldoyanidi,S., Varki,N.M.,
            Bai,H., Mueller,B.M. and Parmer,R.J.
  TITLE     Deficiency of plasminogen receptor, Plg-RKT, causes defects in
            plasminogen binding and inflammatory macrophage recruitment in vivo
  JOURNAL   J Thromb Haemost 15 (1), 155-162 (2017)
   PUBMED   27714956
REFERENCE   7  (bases 1 to 843)
  AUTHORS   Lighvani,S., Baik,N., Diggs,J.E., Khaldoyanidi,S., Parmer,R.J. and
            Miles,L.A.
  TITLE     Regulation of macrophage migration by a novel plasminogen receptor
            Plg-R KT
  JOURNAL   Blood 118 (20), 5622-5630 (2011)
   PUBMED   21940822
  REMARK    GeneRIF: Plg-R(KT) plays a key role in the plasminogen-dependent
            regulation of macrophage invasion, chemotactic migration, and
            recruitment in the inflammatory response.
REFERENCE   8  (bases 1 to 843)
  AUTHORS   Bai,H., Baik,N., Kiosses,W.B., Krajewski,S., Miles,L.A. and
            Parmer,R.J.
  TITLE     The novel plasminogen receptor, plasminogen receptor(KT)
            (Plg-R(KT)), regulates catecholamine release
  JOURNAL   J Biol Chem 286 (38), 33125-33133 (2011)
   PUBMED   21795689
  REMARK    GeneRIF: Plg-R(KT) was highly expressed in bovine adrenomedullary
            chromaffin cells, human pheochromocytoma tissue, PC12
            pheochromocytoma cells, and murine hippocampus.
REFERENCE   9  (bases 1 to 843)
  AUTHORS   Andronicos,N.M., Chen,E.I., Baik,N., Bai,H., Parmer,C.M.,
            Kiosses,W.B., Kamps,M.P., Yates,J.R. 3rd, Parmer,R.J. and
            Miles,L.A.
  TITLE     Proteomics-based discovery of a novel, structurally unique, and
            developmentally regulated plasminogen receptor, Plg-RKT, a major
            regulator of cell surface plasminogen activation
  JOURNAL   Blood 115 (7), 1319-1330 (2010)
   PUBMED   19897580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017215.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026362.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017215.1, SRR1660817.11136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-843               AK017215.1         2-844
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.85 cM"
     gene            1..843
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /note="plasminogen receptor, C-terminal lysine
                     transmembrane protein"
                     /db_xref="GeneID:67759"
                     /db_xref="MGI:MGI:1915009"
     exon            1..75
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            76..186
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            187..273
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            274..404
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            405..514
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            515..843
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /note="hexamer: AATAAA"
     polyA_site      821
                     /gene="Plgrkt"
                     /gene_synonym="1110007H22Rik; 5033414D02Rik; Plg-R(KT);
                     Plg-RKT"
                     /note="major polyA site"
ORIGIN      
        1 actgtccctg cgctgatcgc tctggagctc tggctagagg cctctgctgc ggtcaccgtc
       61 cccgcaccgt gtcgcgtgag atctccagag ggacactcct gtttgccttc tatatttaac
      121 cgtgtacctg agatttcccc cgacacatcc aaagtccaag tccaagagag caaggcccag
      181 aaggaggtca agatggggtt tatattctcg aaatctatga acgaaaacat gaaaaaccaa
      241 caggagttca tggttacgca tgctcggctt cagctggaaa ggcatctgac catgcagaat
      301 gagatgagag aaaggcaaat ggctatgcag atcgcctggt ctcgggaatt cctcaaatat
      361 tttggaacgt tttttggcat tgcaaccatc tctttagcaa ctggagcact aaagcgaaag
      421 aagccagcct ttctcgttcc tatagtcccg ctaagcttca tcttcaccta ccagtatgac
      481 ctgggctacg gaactctcct acagagaatg aaaagtgaag ctgaggacat attggaaaca
      541 gaaaagacga agctggagct gccaaaagga ctgatcacct ttgaaagcct tgagaaagcc
      601 agaagggagc agagtaaact cttctcagac aaatgaagtc acagttatcc tcagagcaca
      661 tatcgtgtct caaaagcaca aagttgttgg cttgaatcat ggtgtttaca gttttttaaa
      721 tgatcaagat tttgatatga tgcattttta ttttagaata ttaaaattca aaatgaattt
      781 gttgaactat tttaaaataa aatttctaac actccaccaa atcatggcag tattctaaac
      841 agc
//
