LOCUS       NM_008877               2755 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus plasminogen (Plg), mRNA.
ACCESSION   NM_008877 XM_619429
VERSION     NM_008877.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2755)
  AUTHORS   Ballard-Kordeliski,A., Lee,R.H., O'Shaughnessy,E.C., Kim,P.Y.,
            Jones,S.R., Pawlinski,R., Flick,M.J., Paul,D.S., Mackman,N.,
            Adalsteinsson,D.A. and Bergmeier,W.
  TITLE     4D intravital imaging studies identify platelets as the predominant
            cellular procoagulant surface in a mouse hemostasis model
  JOURNAL   Blood 144 (10), 1116-1126 (2024)
   PUBMED   38820498
REFERENCE   2  (bases 1 to 2755)
  AUTHORS   Guo,C., Wang,T., Huang,H., Wang,X., Jiang,Y. and Li,J.
  TITLE     Plasminogen degrades alpha-synuclein, Tau and TDP-43 and decreases
            dopaminergic neurodegeneration in mouse models of Parkinson's
            disease
  JOURNAL   Sci Rep 14 (1), 8581 (2024)
   PUBMED   38615036
  REMARK    GeneRIF: Plasminogen degrades alpha-synuclein, Tau and TDP-43 and
            decreases dopaminergic neurodegeneration in mouse models of
            Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2755)
  AUTHORS   Bareja,A., Lee,D.E., Ho,T., Waitt,G., McKay,L.H., Hannou,S.A.,
            Orenduff,M.C., McGreevy,K.M., Binder,A., Ryan,C.P., Soderblom,E.J.,
            Belsky,D.W., Ferrucci,L., Das,J.K., Banskota,N., Kraus,V.B.,
            Huebner,J.L., Kraus,W.E., Huffman,K.M., Baht,G.S., Horvath,S.,
            Parmer,R.J., Miles,L.A. and White,J.P.
  TITLE     Liver-derived plasminogen mediates muscle stem cell expansion
            during caloric restriction through the plasminogen receptor Plg-RKT
  JOURNAL   Cell Rep 43 (3), 113881 (2024)
   PUBMED   38442019
  REMARK    GeneRIF: Liver-derived plasminogen mediates muscle stem cell
            expansion during caloric restriction through the plasminogen
            receptor Plg-RKT.
REFERENCE   4  (bases 1 to 2755)
  AUTHORS   Ohira,T., Ino,Y., Kawao,N., Mizukami,Y., Okada,K., Matsuo,O.,
            Hirano,H., Kimura,Y. and Kaji,H.
  TITLE     Plasminogen deficiency exacerbates skeletal muscle loss during
            mechanical unloading in developing mice
  JOURNAL   J Appl Physiol (1985) 136 (3), 643-658 (2024)
   PUBMED   38328826
  REMARK    GeneRIF: Plasminogen deficiency exacerbates skeletal muscle loss
            during mechanical unloading in developing mice.
REFERENCE   5  (bases 1 to 2755)
  AUTHORS   Chowdhury,N.N., Yang,Y., Dutta,A., Luo,M., Wei,Z., Abrahams,S.R.,
            Revenko,A.S., Shah,F., Miles,L.A., Parmer,R.J., de Laat,B.,
            Wolberg,A.S., Luyendyk,J.P., Fishel,M.L. and Flick,M.J.
  TITLE     Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma
            disease progression
  JOURNAL   Mol Oncol 18 (1), 113-135 (2024)
   PUBMED   37971174
  REMARK    GeneRIF: Plasminogen deficiency suppresses pancreatic ductal
            adenocarcinoma disease progression.
REFERENCE   6  (bases 1 to 2755)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   7  (bases 1 to 2755)
  AUTHORS   Cebra-Thomas,J.A., Tsai,J.Y., Pilder,S.H., Copeland,N.G.,
            Jenkins,N.A. and Silver,L.M.
  TITLE     Localization of the Mas proto-oncogene to a densely marked region
            of mouse chromosome 17 associated with genomic imprinting
  JOURNAL   Genomics 13 (2), 444-446 (1992)
   PUBMED   1612602
  REMARK    Erratum:[Genomics 1992 Sep;14(1):208]
REFERENCE   8  (bases 1 to 2755)
  AUTHORS   Blanche,H., Wright,L.G., Vergnaud,G., de Gouyon,B., Lauthier,V.,
            Silver,L.M., Dausset,J., Cann,H.M. and Spielman,R.S.
  TITLE     Genetic mapping of three human homologues of murine t-complex genes
            localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG
  JOURNAL   Genomics 12 (4), 826-828 (1992)
   PUBMED   1572657
REFERENCE   9  (bases 1 to 2755)
  AUTHORS   Schweifer,N. and Barlow,D.P.
  TITLE     The mouse plasminogen locus maps to the recombination breakpoints
            of the tLub2 and TtOrl partial t haplotypes but is not at the tw73
            locus
  JOURNAL   Mamm Genome 2 (4), 260-268 (1992)
   PUBMED   1543918
REFERENCE   10 (bases 1 to 2755)
  AUTHORS   Barlow,D.P., Stoger,R., Herrmann,B.G., Saito,K. and Schweifer,N.
  TITLE     The mouse insulin-like growth factor type-2 receptor is imprinted
            and closely linked to the Tme locus
  JOURNAL   Nature 349 (6304), 84-87 (1991)
   PUBMED   1845916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131661.1, AK132254.1 and J04766.1.
            
            On Sep 9, 2009 this sequence version replaced NM_008877.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132254.1, BC014773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY131661.1         1-32
            33-1160             AK132254.1         2-1129
            1161-1632           J04766.1           1126-1597
            1633-2755           AK132254.1         1602-2724
FEATURES             Location/Qualifiers
     source          1..2755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.5 cM"
     gene            1..2755
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /note="plasminogen"
                     /db_xref="GeneID:18815"
                     /db_xref="MGI:MGI:97620"
     exon            1..108
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2498
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /EC_number="3.4.21.7"
                     /note="angiostatin; plasmin light chain B; plasmin heavy
                     chain A"
                     /codon_start=1
                     /product="plasminogen precursor"
                     /protein_id="NP_032903.3"
                     /db_xref="CCDS:CCDS28390.1"
                     /db_xref="GeneID:18815"
                     /db_xref="MGI:MGI:97620"
                     /translation="MDHKEVILLFLLLLKPGQGDSLDGYISTQGASLFSLTKKQLAAG
                     GVSDCLAKCEGETDFVCRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSE
                     CKTGIGNGYRGTMSRTKSGVACQKWGATFPHVPNYSPSTHPNEGLEENYCRNPDNDEQ
                     GPWCYTTDPDKRYDYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQAWDSQSPHAHG
                     YIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPTKRWEYCDIPRCTTPPPPPSPTYQCL
                     KGRGENYRGTVSVTVSGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPW
                     CYTTDSQLRWEYCEIPSCESSASPDQSDSSVPPEEQTPVVQECYQSDGQSYRGTSSTT
                     ITGKKCQSWAAMFPHRHSKTPENFPDAGLEMNYCRNPDGDKGPWCYTTDPSVRWEYCN
                     LKRCSETGGSVVELPTVSQEPSGPSDSETDCMYGNGKDYRGKTAVTAAGTPCQGWAAQ
                     EPHRHSIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTTNPRKLYDYCDIPLCASASSF
                     ECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFTGQHFCGGTLIAPEWVLTAAH
                     CLEKSSRPEFYKVILGAHEEYIRGLDVQEISVAKLILEPNNRDIALLKLSRPATITDK
                     VIPACLPSPNYMVADRTICYITGWGETQGTFGAGRLKEAQLPVIENKVCNRVEYLNNR
                     VKSTELCAGQLAGGVDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRV
                     SRFVDWIEREMRNN"
     exon            109..244
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            245..351
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            352..466
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            467..606
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            607..727
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            728..846
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1009
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1152
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1315
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1497
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1646
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1740
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1864
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1942
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2083
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2190
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2336
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2755
                     /gene="Plg"
                     /gene_synonym="Pg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaagtcaa caccaggaac taggacacag ttgtccaggt gctgttggcc agtcccaaca
       61 tggaccataa ggaagtaatc cttctgtttc tcttgcttct gaaaccagga caaggggact
      121 cgctggatgg ctacataagc acacaagggg cttcactgtt cagtctcacc aagaagcagc
      181 tcgcagcagg aggtgtctcg gactgtttgg ccaaatgtga aggggaaaca gactttgtct
      241 gcaggtcatt ccagtaccac agcaaagagc agcaatgcgt gatcatggcg gagaacagca
      301 agacttcctc catcatccgg atgagagacg tcatcttatt cgaaaagaga gtgtatctgt
      361 cagaatgtaa gaccggcatc ggcaacggct acagaggaac catgtccagg acaaagagtg
      421 gtgttgcctg tcaaaagtgg ggtgccacgt tcccccacgt acccaactac tctcccagta
      481 cacatcccaa tgagggacta gaagagaact actgtaggaa cccagacaat gatgaacaag
      541 ggccttggtg ctacactaca gatccggaca agagatatga ctactgcaac attcctgaat
      601 gtgaagagga atgcatgtac tgcagtggag aaaagtatga gggcaaaatc tccaagacca
      661 tgtctggact tgactgccag gcctgggatt ctcagagccc acatgctcat ggatacatcc
      721 ctgccaaatt tccaagcaag aacctgaaga tgaattattg ccgcaaccct gacggggagc
      781 caaggccctg gtgcttcaca acagacccca ccaaacgctg ggaatactgt gacatccccc
      841 gctgcacaac acccccgccc ccacccagcc caacctacca atgtctgaaa ggaagaggtg
      901 aaaattaccg agggaccgtg tctgtcaccg tgtctgggaa aacctgtcag cgctggagtg
      961 agcaaacccc tcataggcac aacaggacac cagaaaattt cccctgcaaa aatctggaag
     1021 agaactactg ccggaaccca gatggagaaa ctgctccctg gtgctatacc actgacagcc
     1081 agctgaggtg ggagtactgt gagattccat cctgcgagtc ctcagcatca ccagaccagt
     1141 cagattcctc agttccacca gaggagcaaa cacctgtggt ccaggaatgc taccagagcg
     1201 atgggcagag ctatcggggt acatcgtcca ctaccatcac agggaagaag tgccagtcct
     1261 gggcagctat gtttccacac aggcattcga agaccccaga gaacttccca gatgctggct
     1321 tggagatgaa ctactgcagg aacccggatg gtgacaaggg cccttggtgc tacaccactg
     1381 acccgagcgt caggtgggaa tactgcaacc tgaagcggtg ctcagagaca ggagggagtg
     1441 ttgtggaatt gcccacagtt tcccaggaac caagtgggcc gagcgactct gagacagact
     1501 gcatgtatgg gaatggcaaa gactatcggg gcaaaacggc cgtcactgca gctggcaccc
     1561 cctgccaggg atgggctgcc caggagcccc acaggcacag catcttcacc ccacagacaa
     1621 acccacgggc aggtctggaa aagaactact gccgaaaccc agatggggat gtgaatggtc
     1681 cttggtgcta tacaacaaac cccagaaaac tttatgacta ttgtgacatc cccctgtgtg
     1741 catcagcatc atcctttgag tgcgggaaac ctcaggtgga accgaagaaa tgccctggga
     1801 gggtggtggg tggctgcgtg gccaaccctc actcctggcc ctggcaaatc agccttagaa
     1861 caagatttac cggacagcac ttctgtggcg gtactttaat agccccagag tgggttctga
     1921 ctgctgccca ctgtttggag aaatcttcaa gacctgaatt ctacaaggtt atcctgggtg
     1981 cgcacgaaga atatatccgt gggttggatg ttcaggaaat atcagtagcc aaactgatct
     2041 tggagcccaa caaccgtgac attgccctgc tgaaactaag ccgcccagcc accatcacgg
     2101 ataaagtcat tccagcttgt ctgccatctc caaattacat ggttgctgac cggacaatat
     2161 gttacatcac cggctgggga gagactcaag ggactttcgg tgccggtcgt ctcaaggagg
     2221 ctcagctgcc tgtgattgag aacaaggtgt gcaaccgcgt cgagtatctg aacaacagag
     2281 tcaaatccac ggagctctgt gccgggcaac tggctggtgg cgtcgacagc tgccagggcg
     2341 acagtggagg acctctggtt tgcttcgaga aggacaagta cattttacaa ggagtcactt
     2401 cttggggtct tggctgtgct cgccccaata agcctggtgt ctacgttcgt gtctcacggt
     2461 ttgttgattg gattgaaagg gagatgagga ataactgact aggtggaagg ccgagcaaaa
     2521 cctctgctta ctaaagctta ctgaatatgg ggagagggct tagggtgttt ggaaaaactg
     2581 acagtaatca aactgggaca ctacactgaa ccacagcttc ctgtcgcccc tcagcccctc
     2641 cccttttttt gtattattgt gggtaaaatt ttcctgtctg tggacttctg gattttgtga
     2701 caatagacca tcactgctgt gacctttgtt gaaaataaac tcgatactta ctttg
//
