LOCUS       NM_001164263            2385 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family S member
            1 (Plekhs1), transcript variant 2, mRNA.
ACCESSION   NM_001164263
VERSION     NM_001164263.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Chessa,T.A.M., Jung,P., Anwar,A., Suire,S., Anderson,K.E.,
            Barneda,D., Kielkowska,A., Sadiq,B.A., Lai,I.W., Felisbino,S.,
            Turnham,D.J., Pearson,H.B., Phillips,W.A., Sasaki,J., Sasaki,T.,
            Oxley,D., Spensberger,D., Segonds-Pichon,A., Wilson,M., Walker,S.,
            Okkenhaug,H., Cosulich,S., Hawkins,P.T. and Stephens,L.R.
  TITLE     PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null
            prostate
  JOURNAL   Mol Cell 83 (16), 2991-3009 (2023)
   PUBMED   37567175
  REMARK    GeneRIF: PLEKHS1 drives PI3Ks and remodels pathway homeostasis in
            PTEN-null prostate.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166746.7 and AK036908.1.
            
            Transcript Variant: This variant (2) uses two alternate in-frame
            splice sites in the 5' coding region, compared to variant 1.
            Although the variants have slightly different sequences, their
            lengths are the same. Variant 2 encodes isoform 2, which has a
            slightly different sequence but is the same length as isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC166746.7         40974-40976
            4-2381              AK036908.1         2-2379
            2382-2385           AC166746.7         66063-66066
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.86 cM"
     gene            1..2385
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /note="pleckstrin homology domain containing, family S
                     member 1"
                     /db_xref="GeneID:226245"
                     /db_xref="MGI:MGI:2443041"
     exon            1..61
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            62..107
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1504
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /note="isoform 2 is encoded by transcript variant 2; PH
                     domain-containing protein C10orf81 homolog; PH
                     domain-containing family S member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family S
                     member 1 isoform 2"
                     /protein_id="NP_001157735.1"
                     /db_xref="CCDS:CCDS57148.1"
                     /db_xref="GeneID:226245"
                     /db_xref="MGI:MGI:2443041"
                     /translation="MEARPPKGPGKQFTFDYENEVHKRDYFIKSPPPQLFFSGTSWKK
                     RLFILSQSRGTGLSLSYYKDHQHRGSIEIDGSTVEVGINCQEKMQSVQKMFKCHPDEV
                     MSIRTANRDYFLIGHDREKIKDWVSFMTPYCQGVKATHQRAEQEKLSLGDRRPVSDPS
                     PFLGLCSIPEGIRLASPRASLPEHLIQKSLQRFRQAHLHQDHDFHSEPTQDTEEEYYL
                     TPRSLEACLELENIAGPNDSGDSIESNSPDQGFKRAESNYVSMRSLRTCLLKESTSAS
                     ADDNDGQAEFQTESELGPPHQDSGTGSDPCLSPPNSKAQTTDDQKGSASLTVVKLSIL
                     LNNIPDESQVETLNVFLSPRDAIDYLALVEAAGQICVARWEGPPRLGCLFYHGDHILA
                     VNDLKPQSLEEVSLFLTRCIQKEKVKLSIGRIPNSEKLHASPCACSLRHQLAESVQRD
                     LPELERTPKRSPAIKKSQKEAAGE"
     exon            108..196
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            197..303
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..435
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            436..511
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            512..628
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            629..763
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..879
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1086
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1188
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1324
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2385
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /note="hexamer: AATAAA"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2375
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
                     /note="major polyA site"
     polyA_site      2383
                     /gene="Plekhs1"
                     /gene_synonym="9930023K05Rik"
ORIGIN      
        1 agtaagcagg aggagctctg gagccacacg gtgcaggtgc agagaactac ctggtgacct
       61 ggtgagaaga gccagccaga tggaagccag acctccaaaa ggcccaggca aacaatttac
      121 atttgattat gaaaatgaag tccataaacg ggattacttc attaagtcgc cgccccctca
      181 gctcttcttc tctgggacct cctggaaaaa gcgtcttttt attctgtccc agagtcgggg
      241 aacgggtctc agtctttcct attacaaaga ccatcagcac agaggttcca tcgaaattga
      301 cggctccact gtagaagttg gtataaactg ccaggaaaag atgcaatctg tgcagaagat
      361 gttcaagtgc cacccagatg aggtgatgtc catcagaact gcaaacagag actatttcct
      421 tattggccat gacagggaga agattaaaga ctgggtctcc ttcatgacac catactgcca
      481 gggtgttaaa gcaacccatc agagagcaga gcaggagaag ctttccctgg gtgacagaag
      541 gccagtttcc gaccccagtc ctttcttggg cctctgcagc atacccgagg gtatcagact
      601 tgcatcaccg agggccagtc ttccagagca tttaatacaa aaaagcctcc aaagattcag
      661 gcaagctcat cttcatcagg atcatgattt ccactcagaa cccacccaag atacagaaga
      721 agagtactat ctcactcctc gaagtttaga agcctgttta gaattagaga atattgctgg
      781 acccaatgat tctggtgact ccatcgaatc caatagtccg gaccaaggtt tcaagagagc
      841 ggagagcaat tacgtgtcaa tgagatcatt gagaacctgt ctccttaaag aatcaacctc
      901 tgcatcagcc gacgacaacg atggccaagc ggaattccag acagagtcag agctggggcc
      961 tccccaccag gacagcggca caggaagtga tccatgtctt tcacctccca attccaaagc
     1021 ccagaccaca gatgaccaaa aggggtccgc ctcactaact gttgtgaaat tgtctatatt
     1081 actcaacaac atccccgatg agagccaagt ggagactctg aacgtgttcc tctctcctcg
     1141 ggatgccatc gactacctcg ctctggtaga agcagcagga cagatctgtg tggctcgctg
     1201 ggaaggtcct ccccgactag gatgcttatt ctaccacgga gatcatatct tggccgtgaa
     1261 tgacctgaaa ccccaaagcc tggaggaggt gtccttgttt cttacccgat gtatccagaa
     1321 ggagaaagtg aaactctcca ttggccggat cccaaactca gagaagctcc acgcttcccc
     1381 ctgtgcatgc tccttaagac accagttggc tgagtctgtc cagcgggatt tgccagaact
     1441 ggagaggaca ccaaagagga gccctgccat caaaaagagt cagaaggaag ctgctgggga
     1501 gtaggctact gcaggcccag gacacagaag gatggaacct gggccacaca cagccgtgtg
     1561 actggagaca aggctgcatc tgtctctgag tcaccactga attaacagtg gggccactgg
     1621 ccccacatga aataatgact aaggagtaga gttaaaacgg aagggctgat tatctgagat
     1681 tctgccccag acacggcaga catcattcag taaatccctg gtctaattaa tagctgtgtg
     1741 cttccgaggt cacagtccac acagctggct cttcgttagc catatcattt cagggatgca
     1801 agagagtgaa cgtgtgtcgc aaccctccca gacacttcct gtggctcagc aacccaggag
     1861 tgggaagctg aggaagtttg gagctgtatc cagccaagat gtgcttgctc taaaaataaa
     1921 taggaaacta tgtttggaca ctcttaattg attggtttat tgccaaatca attctgcaaa
     1981 gccaaaagaa tcaaaggcct ttcagtaatc aggaatgaga gagaggcagt gagctgaaca
     2041 ctaatcagct tggggactgt tggtgcgaag ggggatttag aaaatgcatc ttagcaggct
     2101 gtcctttcag ggggaagaaa tgaaggcttt ggaagatagt gatactcgat cttcatgact
     2161 cttgagttct gagcggttcg gggaacagaa ccacaaatct ggtatcagct ttagaaagaa
     2221 catttccctg gcctttgcct tgtgtgtggg tttagcttag taaagacctt tggctcgcag
     2281 aggagacatt cagtacgtgt tctgttatct agattattgc cagtgtgaaa tgtgcatgtg
     2341 tacataaacc atggaaataa ataaagtgcc atgtacaact gtttc
//
