LOCUS       NM_153119               5127 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family O member
            2 (Plekho2), mRNA.
ACCESSION   NM_153119
VERSION     NM_153119.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5127)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5127)
  AUTHORS   Zhou,C., Zhang,X., Yang,C., He,Y. and Zhang,L.
  TITLE     PLEKHO2 inhibits TNFalpha-induced cell death by suppressing RIPK1
            activation
  JOURNAL   Cell Death Dis 12 (8), 714 (2021)
   PUBMED   34272357
  REMARK    GeneRIF: PLEKHO2 inhibits TNFalpha-induced cell death by
            suppressing RIPK1 activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5127)
  AUTHORS   Zhang,P., Zhou,C., Lu,C., Li,W., Li,W., Jing,B., Chen,W., Zha,Y.,
            Zhang,P., Bai,C., Liu,H. and Zhang,L.
  TITLE     PLEKHO2 is essential for M-CSF-dependent macrophage survival
  JOURNAL   Cell Signal 37, 115-122 (2017)
   PUBMED   28627369
  REMARK    GeneRIF: PLEKHO2-deficient bone marrow-derived macrophages
            displayed increased apoptotic cell death in the absence of
            Macrophage-colony stimulating factor, although PLEKHO2 deficiency
            did not affect macrophage differentiation and proliferation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY193678.1, AK028069.1, AK158288.1 and AC135108.3.
            
            On Mar 13, 2013 this sequence version replaced NM_153119.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028908.1, AK170479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN04095719
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY193678.1         1-10
            11-1321             AK028069.1         2-1312
            1322-3700           AK158288.1         1290-3668
            3701-5127           AC135108.3         67251-68677         c
FEATURES             Location/Qualifiers
     source          1..5127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.38 cM"
     gene            1..5127
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="pleckstrin homology domain containing, family O
                     member 2"
                     /db_xref="GeneID:102595"
                     /db_xref="MGI:MGI:2143132"
     exon            1..150
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1626
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="PH domain-containing protein homolog; PH
                     domain-containing family O member 2; PH domain-containing
                     family Q member 1; pleckstrin homology domain containing,
                     family Q member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family O
                     member 2"
                     /protein_id="NP_694759.1"
                     /db_xref="CCDS:CCDS23294.1"
                     /db_xref="GeneID:102595"
                     /db_xref="MGI:MGI:2143132"
                     /translation="MEEESIKEGSEKPRGARTADKAGWIKKSSGGLLGLWKDRYLLLC
                     QAQLLVYENEDEQKCVETVELGSYEKCQDLRTLLKRKHHRFILLRSPGNKVSDIKFQA
                     PSGEEKESWIKALNEGINRGKNKAFDEVKVDKTCALEHVTRNRVRGGQRRRPPTRIHL
                     KEVASAASDGLSRLDLDVPDSGPPVFAPLSDISEDQPQEPPRALMPPVKPSPGPETSA
                     VEDSKETPAGERALTPDSASSGANPESQEDAETPAKEDSDVKSLPNSTLSEKLKVSWE
                     NPSPEKPSAPESAQLSSSETPEATPRESKKPPAPPPKILSEKMKACMSGVDASGSSQS
                     SEAPETTSPEPTQVSVNGMDDGPESALQAMGIPGPAPEDAAASPALPFSDLPSQFHPR
                     SSSLGDLLRESPQHPRLPKEKLYRAQLEVKVASKQTEKLLNQVLGSEPPPVCAESLLS
                     QAVEQLRQATQVLQEMRDLGELNQETPGLVQKRKELVTLYRRSAP"
     exon            151..300
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..420
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..525
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..624
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..5127
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3300..3305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="hexamer: AATAAA"
     polyA_site      3320
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="major polyA site"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="hexamer: ATTAAA"
     polyA_site      3853
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
     regulatory      4764..4769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
                     /note="hexamer: AACAAG"
     polyA_site      4787
                     /gene="Plekho2"
                     /gene_synonym="Plekhq1"
ORIGIN      
        1 gaagtttctt gggccccggg cgcccggcgg gacagaagac agcaagccgc cgcccggctg
       61 cgcgtagatg gagcaagcgg agcccgcgca acgcgggcag cagtaagcgg cgaagccgcc
      121 ggaccttgca aactcgccat ggaggaggag agtataaagg aggggagcga gaagcctcgt
      181 ggagcacgga ctgcagacaa ggctggctgg atcaagaaga gcagtggggg gcttctgggt
      241 ttatggaaag accgctactt gcttctctgc caagcccagc tgctggtcta cgagaatgag
      301 gatgagcaga aatgtgtaga gacggtggaa cttgggagct atgagaagtg ccaggatctc
      361 cggactctcc tcaagcggaa acatcaccgc tttatcctgc tgcgatcccc agggaacaag
      421 gtcagtgaca tcaaattcca ggcccccagt ggggaagaaa aggaatcctg gatcaaagct
      481 ctcaacgaag ggatcaaccg aggcaagaac aaggcttttg atgaggtaaa agtagacaag
      541 acctgtgccc tagagcatgt gacacggaac cgggtacgtg ggggccagcg gcggcggcca
      601 ccaacaagaa tccacttaaa ggaggtagcc agtgcggctt ctgatgggct ttcacggctg
      661 gacctcgatg tcccagacag tggaccacca gtgtttgctc ctctcagtga catcagtgaa
      721 gaccagcccc aggagccacc tcgggctctc atgcctcctg tcaagccttc cccaggacca
      781 gagacctctg cagttgagga cagcaaggag actcctgcag gagagagagc cctaacccct
      841 gactctgcaa gctctggggc caatcctgag agccaagagg atgcagagac cccagcaaag
      901 gaggacagtg acgtgaaaag tctccccaac agcaccttgt ctgagaaact gaaggtgagc
      961 tgggagaacc ccagcccaga gaagccttct gctcctgaga gtgcacagtt gtcctcttcg
     1021 gagactccag aggctacccc cagggagagc aaaaagcccc ctgcaccccc tcccaagatc
     1081 ctgtcggaga agatgaaggc ttgtatgagt ggagtggatg cttctggttc atcccagagt
     1141 tctgaggccc ccgagaccac ttccccagag ccgacccagg tgtctgtgaa tggcatggat
     1201 gatggtcctg agtcggcctt acaggccatg ggcatccctg gacctgcccc agaggatgcg
     1261 gcagcatccc cagcactgcc cttctcggac ttgccatccc agtttcatcc tcgctcctct
     1321 tcccttgggg acctactcag agaaagccct cagcatccac gactgcccaa ggagaagttg
     1381 tatcgggccc agctggaagt caaggtggct tcgaaacaga cagagaaatt gttgaaccag
     1441 gtgctgggca gcgaaccacc gcctgtgtgt gccgagtcat tgctcagcca ggctgtagag
     1501 caactgaggc aggccacaca agtcctgcag gaaatgaggg atttgggaga actgaaccaa
     1561 gaaacccctg ggctagtgca aaaacggaag gagctggtga ccctctacag gagaagtgca
     1621 ccctaggcct gctaagccct aggcacctac cccccaagta cccccatctg tcactaccca
     1681 accttgctaa gaaatgagct acagctcaga ctgtagacgc accactgggt acatcaagtt
     1741 tggccaggac ttgaggctcc tgatggcctt tctactctac cctagcctgg ggctacctgt
     1801 ctggcctctt ctctaggctc tgggcttggg atggagcata gtcctgtggt ctgtgtggtt
     1861 gatgcagact gcccccaggg ctttggcacc atggttggag tttccaggat ggcaccgtct
     1921 gttctcactg ccaacggttt acattcctga cttccgggta gagcccagct gacctgcctg
     1981 aggctcccat cttctggtct tcaggcagat tcccaccagc cacacccact taagagtatc
     2041 tagaggggcc ttgggtctgg ctgtagtgaa atatgtggcc tttagctgga gcctaaagat
     2101 ggctaagggt ctgggtgaag gggctcttta ctctggtttg ttgccctctc tgcaaatcga
     2161 gggtcttctc tgcagcatcc ctacccctgt tggagagctg taattagatg ctcagatctc
     2221 aaggcttccg aggggggaag agaaactcag gcttcctggt acagtctctg cttctgggcc
     2281 agcttctgtc cagccttgca cattcctgaa gatgaaaacc ctagagtggg cctgtgttaa
     2341 cagttgaaaa gcctgtatga aattatcatt aatcaacctt tagaggcccc accccccacc
     2401 cctgccttct gtgcctccca gatgggattt atcagagtct ctgtggttct tcctcagctg
     2461 gaaccgttct gatagccacc cctttttttc cacatgctgg agtctgatcc acctatcagg
     2521 cccctggtgg gctgcccctc ctttacttcc tagtgagagg agtgttttct ctcctccctt
     2581 tccctcctcc cttccccgtt gcctctggct ctctgagcga cccttgagtc tccagcacac
     2641 tgctgtggca gccagcagga ctgggcagga cctcgctgga ggaaggagcg gtcacagaat
     2701 ctgccctgag gattccgcgt gtgcactttg tttactggaa gagaagggag ggtcacagcc
     2761 acatgatggc ctttcctctc accctgctcc cagtcgccag ttgtgcccac caaggcctgc
     2821 caaccagtgc aggttgatgc cttcattatt gtactggccc tttctagctg tggggagtgg
     2881 acaggggcag agtaaacagc cttgtcttgc ctcacggccc ctccccccac ccccgtcagc
     2941 ctcaaacctc actccttggg ctcctatgcc agcctgcctt tccctccatc tcctgtacaa
     3001 gagcaagaat gtcctcaggt gtccagtctt gatcccctgc catcttccct tgggaacaat
     3061 catcccctac agcaacaagg gtgctgtact tcttccaagt cacctgcttc caggaattag
     3121 agcccggccg tgctgtcaag cgactagtca agtcgactag tcgggcaagt agttctgggg
     3181 ttactgcctt catggccagt gccattgcca ttggtcccca tgctggtggg gtggagtggg
     3241 gatggggact gccaaggctg tctccctgcc cttacgatcc acctttcttg tcatttggca
     3301 ataaacctca ttttatggaa cttctctggc ccaagcctgt atgttgtcat gggagctagc
     3361 ctgaggctgg actccaggga gtaaagggct gtggccgctg accagtggta tcaccagcct
     3421 tgcaaactca gttccataaa ggtagtcctc acggtccttt aaacacttaa atatgtactt
     3481 gtaaaaaata agtcaatcta gactgggcag tggtggcaca ggcctttaat cctagcactt
     3541 gggaggcaga ggcaggtaca tctcttgagt tccaggccag cctggatttg gaatatacag
     3601 agataatagc agatgtaaag ttagtttaat atttgttgga gttctttctt tcttttactc
     3661 ttcctttctt tctttctttc tttctttctt tctttctttc aagacagggt ctcaccatgt
     3721 agtgctggtt gttgtggaac tcaaatagct ctatagacac agagaactgt atagaccagg
     3781 ggtgggttca actcacagag gccttcctac ctctgtcttc caagttgtgg gattaaaggc
     3841 atgcaccatc acacccagta gccatttatt tatttattta ttattctgta gccttagctg
     3901 gccacagatt cacagcagtt ctcctgcctc agcctccaga gtgctggaat tcaggtatgc
     3961 actacctctg cccagttttt gttatttttg ttttgtttga aacagagttt cactatatag
     4021 tcctgggtgg cctggaattg cctatgtaga ccacatgcta gcctgaaact cagagatcta
     4081 ctatcttctt tatcctcctt tttaatttga gacagataga atcttgatat aaagcacaaa
     4141 ctggctttaa actcggatcc ttcggcctca gcctttctag caccaaggag atagatatgt
     4201 accacagctg ttgtgcccta accccttagg ctttttaaaa ttaactcagc ctgaccttta
     4261 actctagctt aagatgaatt taaagtcctt atgtatccac ctctgaagtc ctgggattac
     4321 aaaaatgtgt gcctagatga cagccagccc tctcttatta gtaataaacc tcttttgagc
     4381 ttggggtttt gtcatgatta agctggagcc tggcatggtg gcacatacct ttgatcccat
     4441 cacttgggag gcagaggcag gcagatctct gagtttgagg ccaatctggt ctacagagtg
     4501 agttccagga cttccagaaa ccctgtctca aggagacaaa caagtaaaaa gagaaagaga
     4561 agaaattccc agctggaaga ctatatgggt cctaacagtt tttcatccag gtttcctgtc
     4621 cggagaccca gatccttgac atcctgtgcc tcagtgaaga tgtccttctg gggattgaac
     4681 ctgtggcctt gaacatgctg taagtattct ttccaccatg aagctccgcc tccagcatta
     4741 gtgtttattg taatcacctg agcaacaagt ctgattttta ttttccactg tgtaatgttt
     4801 ttctttgatt gttttttttt ccttttgtaa caagtgctct gggaagtata gaagaccaag
     4861 ggtagtatgt tgtacctcac tgcatggccc cccactatct actgacaaca cttgcagaac
     4921 aggtgtttac atcagtgatt ccaaaatggt ggaaagttag ctgtctaact ttcagagatt
     4981 gggcctggtt aggggtgaac ctggcccact gccatcaaag ccccatgaac aggagtgctc
     5041 aggaaagccc tgggctagag ctcaggtcag gctgtcagga tggaagtccc acccaggaac
     5101 ttgtctgtga ggctcaactt taaggcg
//
