LOCUS       NM_023320               1507 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family O member
            1 (Plekho1), transcript variant 1, mRNA.
ACCESSION   NM_023320
VERSION     NM_023320.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Dong,B., Xue,R., Li,J., Ling,S., Xing,W., Liu,Z., Yuan,X., Pan,J.,
            Du,R., Shen,X., Zhang,J., Zhang,Y., Li,Y. and Zhong,G.
  TITLE     Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac
            dysfunction by activating CaMKK2/AMPK/cTNI pathway
  JOURNAL   Mol Biomed 5 (1), 23 (2024)
   PUBMED   38871861
  REMARK    GeneRIF: Ckip-1 3'UTR alleviates prolonged sleep deprivation
            induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Xiao,J., Huang,X., Wang,H., Peng,Y., Liu,H., Huang,H., Ma,L.,
            Wang,C., Wang,X. and Cao,Z.
  TITLE     CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal
            Soft Tissues by Inhibiting Autophagy
  JOURNAL   Inflammation 46 (5), 1997-2010 (2023)
   PUBMED   37351817
  REMARK    GeneRIF: CKIP-1 Promotes P. gingivalis-Induced Inflammation of
            Periodontal Soft Tissues by Inhibiting Autophagy.
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Li,L., Xie,P., Bi,C.S., Wang,T.Y., Wang,N., Lin,W.W., Zhang,C.,
            An,W. and Zhan,Y.T.
  TITLE     [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty
            liver disease]
  JOURNAL   Zhonghua Nei Ke Za Zhi 62 (1), 43-48 (2023)
   PUBMED   36631036
  REMARK    GeneRIF: [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic
            fatty liver disease].
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Yang,Y., Xiao,H., Lin,Z., Chen,R., Li,S., Li,C., Sun,X., Hei,Z.,
            Gong,W. and Huang,H.
  TITLE     The ubiquitination of CKIP-1 mediated by Src aggravates diabetic
            renal fibrosis (original article)
  JOURNAL   Biochem Pharmacol 206, 115339 (2022)
   PUBMED   36347273
  REMARK    GeneRIF: The ubiquitination of CKIP-1 mediated by Src aggravates
            diabetic renal fibrosis (original article).
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Huang,X., Ma,L., Wang,X., Wang,H., Peng,Y., Gao,X., Huang,H.,
            Chen,Y., Zhang,Y. and Cao,Z.
  TITLE     Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast
            Mineralization
  JOURNAL   J Dent Res 101 (5), 599-608 (2022)
   PUBMED   34875910
  REMARK    GeneRIF: Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast
            Mineralization.
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Ling,S., Sun,Q., Li,Y., Zhang,L., Zhang,P., Wang,X., Tian,C.,
            Li,Q., Song,J., Liu,H., Kan,G., Cao,H., Huang,Z., Nie,J., Bai,Y.,
            Chen,S., Li,Y., He,F., Zhang,L. and Li,Y.
  TITLE     CKIP-1 inhibits cardiac hypertrophy by regulating class II histone
            deacetylase phosphorylation through recruiting PP2A
  JOURNAL   Circulation 126 (25), 3028-3040 (2012)
   PUBMED   23151343
  REMARK    GeneRIF: CKIP-1 was found to be an inhibitor of cardiac hypertrophy
            by upregulating the dephosphorylation of HDAC4 through the
            recruitment of protein phosphatase 2A.
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Baas,D., Caussanel-Boude,S., Guiraud,A., Calhabeu,F., Delaune,E.,
            Pilot,F., Chopin,E., Machuca-Gayet,I., Vernay,A., Bertrand,S.,
            Rual,J.F., Jurdic,P., Hill,D.E., Vidal,M., Schaeffer,L. and
            Goillot,E.
  TITLE     CKIP-1 regulates mammalian and zebrafish myoblast fusion
  JOURNAL   J Cell Sci 125 (Pt 16), 3790-3800 (2012)
   PUBMED   22553210
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Lu,K., Yin,X., Weng,T., Xi,S., Li,L., Xing,G., Cheng,X., Yang,X.,
            Zhang,L. and He,F.
  TITLE     Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1
            for activation by CKIP-1
  JOURNAL   Nat Cell Biol 10 (8), 994-1002 (2008)
   PUBMED   18641638
  REMARK    GeneRIF: CKIP-1 functions as the first auxiliary factor to enhance
            the activation of Smurf1.
            Erratum:[Nat Cell Biol. 2010 Jun;12(6):625]
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Canton,D.A., Olsten,M.E., Niederstrasser,H., Cooper,J.A. and
            Litchfield,D.W.
  TITLE     The role of CKIP-1 in cell morphology depends on its interaction
            with actin-capping protein
  JOURNAL   J Biol Chem 281 (47), 36347-36359 (2006)
   PUBMED   16987810
  REMARK    GeneRIF: CKIP-1 has a role in cell morphology that depends on its
            interaction with actin-capping protein
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39.
            
            On Mar 15, 2023 this sequence version replaced NM_023320.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170922.1, AK170025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC092855.39        172694-172869       c
            177-323             AC092855.39        172445-172591       c
            324-464             AC092855.39        169061-169201       c
            465-569             AC092855.39        168367-168471       c
            570-671             AC092855.39        167724-167825       c
            672-1507            AC092855.39        165721-166556       c
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.65 cM"
     gene            1..1507
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /note="pleckstrin homology domain containing, family O
                     member 1"
                     /db_xref="GeneID:67220"
                     /db_xref="MGI:MGI:1914470"
     exon            1..176
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1376
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /note="isoform 1 is encoded by transcript variant 1; CK2
                     interacting protein 1; Jun zipper-associated 2; TNF
                     intracellular domain-interacting protein; PH
                     domain-containing family O member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family O
                     member 1 isoform 1"
                     /protein_id="NP_075809.1"
                     /db_xref="CCDS:CCDS17627.1"
                     /db_xref="GeneID:67220"
                     /db_xref="MGI:MGI:1914470"
                     /translation="MKKSGSGKRGPPDGNHQSAAPEKVGWVRKFCGKGIFREIWKNRY
                     VVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQP
                     GTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQ
                     HSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLA
                     GSRRRADSDRIQPSSQRASSLSRPWEKPDKGAPYTPQALKKFPSTEKSRCASLEEILS
                     QRDTAPARPLHLQAEESLPPVPAQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRK
                     AKDPPQSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDS
                     HLRQTSQHSQYRKSLM"
     exon            177..323
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..464
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..569
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..671
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1507
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1507
                     /gene="Plekho1"
                     /gene_synonym="2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2"
                     /note="major polyA site"
ORIGIN      
        1 attcggagcc cgcgacgtca gcggcggtgg ccggggccgg tgcggcgggg gcgggcatgg
       61 gcgacggggg cggcgggggc agcgggggcc cggcctgcgg ctagcacgag ccgccgagcg
      121 agcagcgggc gcggccgccc gatcccgcca tgaagaagag cggctccggc aagcgggggc
      181 ctccggatgg aaaccatcag tctgcggcgc ccgagaaggt cggctgggtc cggaaattct
      241 gcgggaaagg gattttcagg gagatttgga aaaaccgcta tgtggtgctg aaaggcgacc
      301 agctctacgt ctccgagaag gaggtaaaag atgagaaaaa cagtcaggag gtgtttgacc
      361 tgagtgacta tgagaagtgc gaagagctcc ggaaatccaa gagcaggagc aagaaaaatc
      421 acagcaagtt caccctggcc cggtgcagac agccgggcac cacggcaccc aacctcatct
      481 tcctggccgt gagtcctgaa gagaaggagt catggatcaa cgccctgagt tctgccatta
      541 ccagagctaa aaaccgtatc ttggatgagg tcaccgttga ggaggacagc tatcttgccc
      601 accctactcg agacagagca aaaatccaac actcccgccg tcctccaacc cggggacacc
      661 tcatggctgt ggcttcgacc tctacctcag atgggatgct aacattagac ctgatccaag
      721 aggaagaccc ttcccctgag gagccagcct cttgtgctga gagcttccgg gtcgatctgg
      781 acaagtctgt ggcccagctg gctggcagtc gacggagagc ggactcagac aggatccagc
      841 cctcttcgca gcgggcaagc agcctttctc ggccttggga aaaaccagac aagggagccc
      901 cctacacccc acaagcactg aagaagttcc ccagtacaga gaagagccga tgtgcctccc
      961 tggaggagat cctatcccag agggacactg ccccagcccg cccccttcac cttcaagctg
     1021 aggaatccct accccctgtc cctgcccagc cagggcagct gtcccggatc caggacctgg
     1081 tagcaaggaa actggagaag actcaggagc tgctggcaga ggttcaggga ctgggtgacg
     1141 gcaagcggaa ggccaaggac cccccacagt ctccacccga ctcggagtcg gagcagctgc
     1201 tgctggagac agagaggctg ctgggagagg cttcctccaa ctggagccag gcaaagagag
     1261 tgctgcagga agtccgggag ctgagagacc tgtacaggca gatggacctg cagaccccgg
     1321 actcccacct cagacagacc tcccagcaca gtcaataccg gaagagcctg atgtgaaagg
     1381 gggggcaggt ctgaaatttg ggggggcaca gactctttat ctccaaatgt tgcaggataa
     1441 agctttttta tttacctcaa tccaaaaaaa aaaaaaatca aattcattgc ttttgctgcc
     1501 gcctcaa
//
