LOCUS       NM_001368639            2177 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family N member
            1 (Plekhn1), transcript variant 2, mRNA.
ACCESSION   NM_001368639
VERSION     NM_001368639.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Nishino,T., Matsunaga,R., Jikihara,H., Uchida,M., Maeda,A., Qi,G.,
            Abe,T., Kiyonari,H., Tashiro,S., Inagaki-Ohara,K., Shimamoto,F. and
            Konishi,H.
  TITLE     Antagonizing effect of CLPABP on the function of HuR as a regulator
            of ARE-containing leptin mRNA stability and the effect of its
            depletion on obesity in old male mouse
  JOURNAL   Biochim Biophys Acta 1861 (11), 1816-1827 (2016)
   PUBMED   27616329
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01066807.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.62700.1,
                                           SRR11927934.7717418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               CAAA01066807.1     13010-13113         c
            105-204             CAAA01066807.1     12818-12917         c
            205-351             CAAA01066807.1     10127-10273         c
            352-432             CAAA01066807.1     9949-10029          c
            433-505             CAAA01066807.1     9796-9868           c
            506-630             CAAA01066807.1     9518-9642           c
            631-744             CAAA01066807.1     9326-9439           c
            745-825             CAAA01066807.1     9139-9219           c
            826-901             CAAA01066807.1     8458-8533           c
            902-1050            CAAA01066807.1     8167-8315           c
            1051-1191           CAAA01066807.1     7899-8039           c
            1192-1332           CAAA01066807.1     7542-7682           c
            1333-1473           CAAA01066807.1     7241-7381           c
            1474-1701           CAAA01066807.1     6852-7079           c
            1702-1750           CAAA01066807.1     6569-6617           c
            1751-2177           CAAA01066807.1     6057-6483           c
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 88.63 cM"
     gene            1..2177
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /note="pleckstrin homology domain containing, family N
                     member 1"
                     /db_xref="GeneID:231002"
                     /db_xref="MGI:MGI:2387630"
     exon            1..104
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1854
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable pleckstrin homology domain-containing family N
                     member 1; PH domain-containing family N member 1;
                     cardiolipin and phosphatidic acid-binding protein"
                     /codon_start=1
                     /product="probable pleckstrin homology domain-containing
                     family N member 1 isoform 2"
                     /protein_id="NP_001355568.1"
                     /db_xref="CCDS:CCDS89875.1"
                     /db_xref="GeneID:231002"
                     /db_xref="MGI:MGI:2387630"
                     /translation="MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARKLAGLFGTEAR
                     PDGDTAANRIFHYIPGTDIPGPEHHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKV
                     RLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELNICPTDGSREHAFQI
                     TGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLQRCHSAPPQGSLGDKPPWTQLRRA
                     YGCGSMSGAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLSFKGELPLSAI
                     HINLEEKEKEIRSFLIEGHLINTIRVVCASYEDYSQWLLCLRTVSRRDGAHLPPGPES
                     FPGLQKPTQLVGRGRGSLSSNGRSSWKLECPVFPTSQSLPESSVPTTIGFPAPPVPNQ
                     TDSNCVSTGQKKMKPSDSSPSPRGRAQREVSGSTVPLPLPLDLTKMSALNLDSGPEAQ
                     DHSLDIPHSPLYADPYTPPATSRHKITDIQGLDEFLCAIQTSPGPDLSSPFPPVSVSV
                     PVSESSSGISSSPGPLGSHLLTKKGALQPRASQRHRGSFKSRGPQPSDFPQLVTPARE
                     GKPSSLPPPPDEEAPIWNKTSSPSHPKWPQPRKPAVEGGFIQWI"
     exon            105..204
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            205..351
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            352..432
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            433..505
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            506..630
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            631..744
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            745..825
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            826..901
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1050
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1191
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1332
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1473
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1701
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1750
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..2177
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /note="hexamer: AATATA"
     polyA_site      1972
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /note="major polyA site"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
                     /note="hexamer: AATACA"
     polyA_site      2174
                     /gene="Plekhn1"
                     /gene_synonym="Clpabp"
ORIGIN      
        1 acaagctagc agctgccatc catggggaac agccactgcg tccctcaggc ccccaggagg
       61 ctacgggcct ccttttccag aaagccctcg ctcaagggaa acagagaaga cagcgccagg
      121 aagctggctg gcttgtttgg caccgaggct aggcctgatg gggacaccgc ggctaacagg
      181 atcttccact acatccctgg gacggacatc ccgggcccag aacatcaccc agaaaacctg
      241 gaacagccat tcctgagtgt attcaaaaaa gggtggcgga ggacacctgt gaggaaccta
      301 ggcaaggttg ttcactactc caaggttcgg ctgcgattcc agcacagcca ggacatcagt
      361 gactgctatc tagaactgtt cccttcccac ctgtacttcc aggcccatgg ttctgaggga
      421 cttacattcc agggactgct cccactgacg gaattgaaca tctgcccgac tgatgggtcc
      481 agagaacatg ccttccagat tacaggcccg ctgcctgccc cactccttgt tctctgccac
      541 agtgaggccg agctcagcca ctggctctac cacctggaaa agcaaatggc tctcttgggt
      601 ctacaacgat gccactcggc acccccacag gggtctctgg gagataaacc cccctggacc
      661 cagctacggc gagcatatgg gtgtggttcc atgagcggcg caatctgtgc ctcaagggtc
      721 aagctgcagc atctgccctc ccaggaacag tgggaccggc ttctggtact atacccagca
      781 tccctggcca tcttctctga ggaaccagaa ggccttagct ttaaggggga gcttccacta
      841 agtgccatcc atatcaactt agaagagaag gaaaaggaga ttcgctcctt tctcatcgaa
      901 ggccacctca tcaacaccat ccgcgtggta tgtgccagtt atgaggatta tagccaatgg
      961 ctgctgtgcc tcaggactgt ctctcgcagg gatggggccc acctgccacc tggcccagag
     1021 agtttcccag gattacagaa gcccacacag cttgtaggta gaggccgagg ttcactctct
     1081 tccaatggac ggagcagctg gaaattagag tgtccagtgt tccccaccag ccagtccctc
     1141 cctgagtcct cggtgccaac cactataggc ttccctgccc ctcctgtacc taaccagacc
     1201 gactctaact gtgtcagcac tggccaaaag aagatgaagc ccagtgacag tagcccgtct
     1261 cccaggggca gagctcaaag agaagtatct ggctcaactg tcccactgcc cctgcccctg
     1321 gacctgacca agatgagtgc actgaaccta gacagtggcc cagaggctca ggatcactct
     1381 ttggacattc cacactcccc gctctatgct gatccctaca caccaccagc tacatctcgc
     1441 cacaagatta cagacatcca aggcctggat gagttcctct gtgcgataca gacatcgcct
     1501 ggacctgacc tatcaagccc gttcccccca gtgtctgtgt ctgtgcctgt ctctgaatcc
     1561 agctctggca tctccagctc gcctgggcct ctgggctccc acttactcac caagaaaggt
     1621 gccctgcaac ccagagcttc ccagagacac cggggttcct tcaagagcag aggcccacag
     1681 ccctcagact tccctcagct tgtcacccct gccagagaag gcaaacccag ttccctgccc
     1741 cctcccccag atgaagaggc tcctatctgg aacaagactt cctctccctc ccacccgaag
     1801 tggccacagc ccaggaagcc tgcagtggag gggggattca tccagtggat ctgatggccc
     1861 ccaagggggc cgctgcttct caacaacaca accagccagc accgccctgc ataagactac
     1921 gcagttatgc ccgtcctttg acttacatta aatataccag ggcctaaccc catcaggtca
     1981 aggttgtctc tagactctga ggatagaagc acctcaccag gctctagcag ctggagcagc
     2041 tgaaaggagg taactctagg aacaagccag tgaggggcat cggtaagatt ctggacagcc
     2101 ccagaggctc tgccgctagg ggaaagggga agggtgctgg agcgggtgac tgtgaaatac
     2161 agagtgctga gaaagtc
//
