LOCUS       NM_001039493            8562 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family M,
            member 3 (Plekhm3), mRNA.
ACCESSION   NM_001039493
VERSION     NM_001039493.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8562)
  AUTHORS   Zhang,X., Yuan,S., Li,H., Zhan,J., Wang,F., Fan,J., Nie,X.,
            Wang,Y., Wen,Z., Chen,Y., Chen,C. and Wang,D.W.
  TITLE     The double face of miR-320: cardiomyocytes-derived miR-320
            deteriorated while fibroblasts-derived miR-320 protected against
            heart failure induced by transverse aortic constriction
  JOURNAL   Signal Transduct Target Ther 6 (1), 69 (2021)
   PUBMED   33597502
  REMARK    GeneRIF: The double face of miR-320: cardiomyocytes-derived miR-320
            deteriorated while fibroblasts-derived miR-320 protected against
            heart failure induced by transverse aortic constriction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8562)
  AUTHORS   Virtanen,C., Paris,J. and Takahashi,M.
  TITLE     Identification and characterization of a novel gene, dapr, involved
            in skeletal muscle differentiation and protein kinase B signaling
  JOURNAL   J Biol Chem 284 (3), 1636-1643 (2009)
   PUBMED   19028694
  REMARK    GeneRIF: DAPR is a novel gene that binds to PKB/AKT and is a
            critical component for the differentiation of skeletal muscle
            myoblast cells into myotubes.
REFERENCE   3  (bases 1 to 8562)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063098.1 and AC101915.7.
            
            [WARNING] On Jul 10, 2024 this sequence was replaced by
            NM_001039493.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.130385.1, AK034959.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3631              BC063098.1         1-3631
            3632-8562           AC101915.7         4948-9878
FEATURES             Location/Qualifiers
     source          1..8562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.76 cM"
     gene            1..8562
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /note="pleckstrin homology domain containing, family M,
                     member 3"
                     /db_xref="GeneID:241075"
                     /db_xref="MGI:MGI:2443627"
     exon            1..130
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            131..973
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2646
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /note="differentiation associated protein; PH
                     domain-containing family M member 3"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family M
                     member 3"
                     /protein_id="NP_001034582.1"
                     /db_xref="CCDS:CCDS15009.1"
                     /db_xref="GeneID:241075"
                     /db_xref="MGI:MGI:2443627"
                     /translation="MEALEVDDISPALEVTEDFFSTFDSKLEKAVQQAEVYGIQEVPE
                     LVGHEVLGNIADNGALRSVASLGKGTMIWDHCKSRLLETKAQNVFPAKEQLMVQRGTA
                     PDNLSWMAQKEASTFNFFNICQRRRDRPRSVNDLLDETTTFKPGHARSRSDVTHVDWR
                     VVLSTMPLQQQQQQQQASLQGIHFPGPSFLLSSPSKVEDAQGNTEHKQTFPNILKKGY
                     LEIRKNHDSYWQSCYAELSPYNLNFYSLDSSGNQNLYATYQLSHFQSISVLGNLEARM
                     VDTVLYDNSQLQLKAESPWEALDWGQKLWEVVHAAVPNYMGRQGEMANSPGLIHHGDC
                     AQNHCLQKKSSGLLASPVLDSPKQYQNILKSGTLYRLTVQNNWKAFTFVLSKAYLMAF
                     HPGKLDEDPLLSYNVDVCLAVQIDNLDGCDSCFQVIFPQDVLRLRAETRQRAQEWMEA
                     LKTAANAARSSEQNLQVTLRNKPKDQLDGRELRKNKRQSVTTSFLSILTTLSLERGLT
                     AQSFKCAGCQRSIGLSNGKAKVCNYSGWYYCSSCHVDDSFLIPARIVHNWDTSKYKVS
                     KQAKEFLEYVYEEPLIDIQQENPMLYLHAEPLATVVRLRQRLKSLRAYLFSCRAAVAE
                     DLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATAHVYSCSLCSQKGF
                     ICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWRQ
                     LNVDESLEEACAMFELSYQST"
     exon            974..1906
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2052
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2246
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2310
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2468
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..8562
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8543..8548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /note="hexamer: AATAAA"
     polyA_site      8562
                     /gene="Plekhm3"
                     /gene_synonym="9430067K14Rik; A230102O09Rik; DAPR;
                     Plekhm1l"
                     /note="major polyA site"
ORIGIN      
        1 ctggaactct gtgtaatcgg atcctgttgc cgggctgccg cggggaagct tttgggcgtg
       61 ggaccgcgag aagccgcttg taaacagagc cgggccggga tggtcggcag ctggagcgca
      121 gtcgctggcg gaaactgagg attggccata cattgctttg gcaaacaccg cccgccctgc
      181 tgtcttccct gagatctcta agaacaaggc ccgtgctcct gtgcttagcc ttctctaggc
      241 agccagatga agattgcttc ctcttgtttt cacagttgta ttgctgaacc acctctctct
      301 gttggctgag tgttcatgac acctcttcct gaagcaggtt agaagcttgg accctgtgtc
      361 atggaagctt tggaagtaga tgacatcagc cccgccttag aggttactga ggatttcttt
      421 agtacttttg acagtaagct ggaaaaggct gtccaacaag cagaggttta cgggatccaa
      481 gaagtccctg aactggtggg gcatgaggta cttggtaaca tagcagataa tggtgcttta
      541 agaagcgttg cttccctggg caaggggaca atgatttggg accactgtaa gagcaggctt
      601 ttagaaacca aagctcaaaa tgtcttccct gccaaagaac agcttatggt ccagagaggg
      661 acagccccag ataatctttc ctggatggca caaaaggaag cgtcaacctt caattttttc
      721 aacatctgtc agcgtcggag ggacagacct cgttctgtga atgacttatt ggatgagacc
      781 acaactttca agccaggcca tgctcggtca aggtccgatg ttacccacgt agactggcgg
      841 gtagtcctta gcaccatgcc tttgcagcag cagcagcagc agcagcaggc gtcccttcaa
      901 ggcattcact ttcccgggcc atcttttctg ttgtcttcac ccagcaaggt tgaagatgct
      961 caaggaaata cagaacacaa gcagacattc ccaaacatcc tgaagaaggg ttatctggag
     1021 atcaggaaga accatgacag ttactggcag agctgttatg cagaactctc accctacaac
     1081 ttaaacttct acagccttga tagcagtggc aatcaaaacc tgtatgccac ataccagctt
     1141 tcccacttcc agagcatctc tgttttaggc aatcttgaag ctaggatggt agacactgtt
     1201 ctctatgaca attctcaact gcagctaaag gcagagtctc catgggaggc attggactgg
     1261 gggcagaagc tctgggaagt cgtgcatgct gctgtaccca attacatggg acggcagggt
     1321 gagatggcaa actctccagg actcatccat catggtgact gtgcacagaa ccactgttta
     1381 cagaagaaat ccagtgggct gctggcctcc cctgtcttgg atagccccaa acagtaccaa
     1441 aatatcctca aatcagggac actctacaga ctgactgtcc aaaacaactg gaaggccttt
     1501 acatttgtgc tgagcaaggc ctatcttatg gctttccacc ccggcaagct agacgaagat
     1561 cccctgttga gctacaatgt ggatgtgtgt ctggctgtgc agatagacaa cctggatggt
     1621 tgtgactctt gctttcaagt catttttccc caggatgtcc tccgcctccg ggctgagacc
     1681 cgacagaggg ctcaggaatg gatggaggct ctgaagacag cagccaacgc tgcaaggagt
     1741 tctgagcaaa acctgcaagt cacactgcgg aacaagccca aggatcagct agatggccgc
     1801 gagctgcgga agaacaaacg ccagtctgtg accaccagct tcctgagcat cctgaccacg
     1861 ctgtctttgg agcgaggact cactgctcag agtttcaaat gtgcagggtg ccagcgatct
     1921 attggtctct ctaacggaaa ggccaaggtg tgcaattata gcgggtggta ctactgcagc
     1981 agctgccatg tggacgacag ctttctcatc ccagcacgca tagttcacaa ctgggacacc
     2041 tcaaaataca aggtatccaa gcaggccaag gagtttctgg agtatgtgta cgaagaacct
     2101 ctgatcgaca tccagcagga gaaccccatg ctgtacctcc atgctgagcc actggccacc
     2161 gttgtacggc ttcgacagcg gttgaagtca ctccgggcct atttgttcag ctgccgggca
     2221 gcagtggcgg aggatctgcg ccgcagaatt ttccccagag aatatctcct tcaacagatc
     2281 cacctgtact ctctcgctga cctgcagcag gtgatagagg gaaagctggc tccattcttg
     2341 ggaaaggtca ttaaattcgc caccgcgcat gtctacagct gcagtctctg tagccagaaa
     2401 gggttcatct gtgagatctg taacaacggc gagatcctct accccttcga ggacatttca
     2461 acaagcagat gtgaaagctg tggagctgtc ttccattctg agtgcaaaga aaagtctgtc
     2521 ccctgcccac ggtgtgtccg acgggaactg cagaagaagc agaagtcctt ctggcggcag
     2581 ctgaacgtgg acgagagcct ggaggaggca tgcgccatgt tcgagctgtc ctaccaaagc
     2641 acctgactgt aggccaggat gcactctcca ccgcccaagg ggctgcccgt gcccatgcag
     2701 atgaggctgt tccttcttca gctagatgta gatagataag ttatttattt atattatata
     2761 cacctatacg tcctgtacgt atgatgcttt gtataactca ttgtccaaga agttcacaaa
     2821 gatcttgtgg atgaactcct acagatagct gagttaccct tggccatgac atttgctgct
     2881 tgctcccagc aaatgtgatt gacacacatt gctctgtagt tcagacccct tcatacacac
     2941 tggctctcag ggccagttga ctgcacaagt attggaggaa acacctctca cagcaaagct
     3001 ttgcattgct actgacattt agcctttgct ggggaaactg aggtagagcc attgtcatct
     3061 gcttcacaag gacatcccta aaacacaaga atgtttctgg atacttccag gcccagagtc
     3121 tttggcagag atgggaagag tgaagcagag ccacatagca gaaagcgaga ggccccttcc
     3181 ttcaacagag agcatcagga actgagctgc gttgggtgtg aactcagtcc ctgagagaga
     3241 gtacagaaag cgaggacctc agtggccagt cacttcatgt cgttgtctgt tggctggtac
     3301 gaagcccagc accttcctga tgatcagagt ctacaatgcc tgccagagag tgcacatggg
     3361 tgccctaaga acagttccaa gcgtggaatg gaggacactg gtcatgtttt tcacggtgct
     3421 gcccaggagg aagtgtccca ggattgcact caagcgcatc agtgcatagt ctgctaggta
     3481 gagtttactg cacgcatctt ggaggaccgg atgtttcctt ccccagagcc ctccatcggc
     3541 aggacccacc tgtcgtttga atgttttatt tctccttgtc cttcacagca cttttgacct
     3601 ttattcagtc cgcgtaacta ctcttgcttt tgtatcctgg atgttttgtt tgtttgggat
     3661 ggggacatat tttaagacag ggtcctgcta tatatccctg gctggcctct aacctgtgac
     3721 cctgctgcct catcctccaa atgctgggac tataggtatg caccatcata cctggcttta
     3781 cttgttttta attattttta aaaaatattt aaaagtaaaa attatgtaat tattaaaagt
     3841 tattaagaag taacattttg aaaaatacaa acctaaacta ttaagaaaat accaaacata
     3901 aatagaatta atgaattaat attatcgaaa taagtagata tatacatata taattgccac
     3961 cttacagtaa cacaaagagt aactagcgtg gtaggaatgg gaagtggatc acttcgctct
     4021 ttggagggta gtgtactccc actgtgatcc ccttccttgt aagagcctgc atagttgtca
     4081 ctgtgaccaa gatggctgct aggaaggcac tgagaccctg gcggccagca ttccttcttc
     4141 cttaactctt tccaaggcag gagaatggac tcaccaggaa gtacttgttt gtgtctttca
     4201 cctggagctg gtgttgccca ctgccgccca tgcttctgtc ctttgggatt ttcactgctg
     4261 ttcagatcag gggaaacact ggctcacaga gaacgcaggg gttcaactcc aagttgctcc
     4321 cacaggcacc agctctcgat gcttcagtct agtgggagac attcagctga cttgtgcagt
     4381 tagaggcaag catttcacct cttggcccac accatttcct ttggccccag accatgcagt
     4441 tgaacgccac acgtgtgttc atttcctagc tacccggaag ctatagccaa ggcatgaaac
     4501 ttggtaaaag gccagggccc tatttaccag acacctcacg gtgcctttta taaactcttg
     4561 ggaaggcagg ttgacctcac tggaatgagt ggtagggaat gttgcgcata aaggacaaag
     4621 gtgggaagtc tcaaacactt ggcaaaacag acaaacagat ttgagtctct ctcttcctcc
     4681 tcttgttcat gaaatacagt atttatattt tccagcctca gagaacagaa catgatcttt
     4741 cactggagaa ttctagacct gcttattatg aaacagatgt gctcccgtgg cacagtgcct
     4801 tctccctcca cccccagtcc ctgtcaccgt agcttactct tgacctttgc tgaaactaat
     4861 gtatctgtga ttctgactgt cagagacgcc attcccagca cactgagcac agagacttga
     4921 agaacagagc ccccgacccc aggttggccc catgtcctgc cccaactcac aggtgcccaa
     4981 gattagacct aataaaagcc gagggtgaaa tctggatccc tgtttagcac acctgagttg
     5041 tctgtcccca ctgcccctta gagggccttg ctgtgtgtga gcggaccttg gacactccta
     5101 agacctttcc ctggacattg cttcgtgttt attttttaaa gggaaagata agcatgctgt
     5161 cactcatgat ctggaattgg agccatgtcc tgctacttct gttttcacta tggtccatgc
     5221 ccgctcagga ctcacaacag cgttctctgc caccaccacc ggaatctgat aggacaccgt
     5281 ggagccagat caggagttgg atctgccatg aaaattcaaa attgctattt tcagcccaga
     5341 atgtctcaga gtgcatgaag gcccttactg ttttcaggtc taacaaatga cttggtgcag
     5401 tgttaggtag ttgttccact gcttagaaac catcgaaaca aaagcaagcc tgtgcatttc
     5461 cacctccttt tttttcatct cagtaaatac catacacgta aagcataatg gaaaacggtc
     5521 cattaatctc ctggagctgc ttgcaaagcc cagggaacgg cttttcacta aacagccatt
     5581 ccctggtgta gcacaagaat tccctcctgc tagtgccaga aactcatgtg tgacaccatc
     5641 cagcccgggg gaagtgttgg cacccaaccc caccgttaag aaaccagttc ctaaaataga
     5701 cctgcatttg caccgcagta ggaaggctgc agggtgctcc aaaggcagtc agctctgatg
     5761 ggagaggagt tctttccagg gctgcctgtt cccaaagttg gacacagcct tatatgaaaa
     5821 ccatgcaaac tctgtcttcc ccctgacttc atgtgctgaa taacagccat cttttgggag
     5881 tttttacatt tgatgagctg aaaggttaac tgcttcttga ttcttctata ataggcctct
     5941 accaaaaaaa aaaaaaggag tgtgtgatta cagtgcctcg ggattcgaag gttccaatac
     6001 agtctgaaat agccccgtgc tgtgattccc ctcagctgcc ccaaaacaaa ggtgtctgtg
     6061 tcactctgtc actgtggctg agttgcagca caccctcggt gaggtctggc ctgtctctgc
     6121 ttgtcatgtg tgcacactgc acatgagcac tgacagattg ctttctgcaa ctcctccagg
     6181 aagcttggct tgcagccctg caagttcatt ctccatccgt ggcccagaga tctccagaca
     6241 caaactacct atgatagcag gagcacagtg atacaggacc acagtaatgc cacacaccct
     6301 gagcaccaag agcaaagccc gctgccagca aggaagtaga gaaaagttct gctgctagtt
     6361 caggggagct ctgccctctc accctgcaga tcagctctgg gtcttctccc aagctttgct
     6421 gaaatagtca gattagaaat taggctttga cccttagttg gaatactgcc tgttcccaac
     6481 acagactatt ttattttgtt tgatttggtt tttcttatgg taaataggga agtgtgcaat
     6541 attgttttgg gagttttcta catgactttt catcttctga aataatgtgg agatgtcagg
     6601 aatttgagac aaaggggaaa gaagctagcc ctttcttcct tggccacttc tccctggagc
     6661 ctctggccct tgtcatccat tccttggtac tgactcagta gtggtggtgg gcattaggaa
     6721 cgtggctcac tgctctgcct gtcccactcg cctgacccca gcatactaca agctacgtga
     6781 gtaaacccct cagctaatct aaccaatgct gatctctgtc acagggacag tttcttaaca
     6841 gttaagtttt agcacccagt agtctctctg taggcacttc tgtcctttag attcaaaact
     6901 ctctgacttg aggttgtttg tttgtttgtt tgtttgtttt ctggtatgtt ttagtgggtg
     6961 cggggctaaa acaaaaaaat ctacatcact gtaaaactct gggtgaaagg gaaaatgtag
     7021 ctgagcctct ccagcatttg ccagtgtgtt ttatgtaaga tgggttcctg gtgaccatgg
     7081 catgtagcac tgtctccata gagtaggctc tgatgtgatg ggaggcacta gtgagaggga
     7141 cccaggctgc tctgctaggg ctctgctctg agggaaaaga gacgctggct gctgtcgttt
     7201 tagaaagctc cctagtgaag ccacttgttt cccaggccag atgaacaaga cacctaggac
     7261 agctcttcca cagttgggcc catctggcca gccttggaag ctgtaaccca gccctgtccc
     7321 ctcccatgat tgccttgcct gcttgcttcc tcagccctgg gccaggtttg aggctcatgt
     7381 taataaacca cctagagacc aactggccag cggcccttcc ttcccaccgg ttcatctccc
     7441 tgtaggagtg ccttatagtc tagtctagtc tctgacccac ttgaagcctg caggaccctt
     7501 caaccaacta tggatccctt cgcgcttccc tgctggctct tgttcagtac acagcccacc
     7561 tggagcctgt gtattccgag atgcacgtcc acctttgctt aacctggtgc cttaacttca
     7621 caagtaaagg gattcacatt gcaaacgcat tatctgagtg aaacatcagt ttcttcggtg
     7681 ccattggcac ttttaccagg aaatacaata ggcataatca tacaatgttt tgactttatt
     7741 ttatgatgtt tctcagccac tctttgtttg cttgctttca ttaaccaaac tcaggggaat
     7801 gtcatgtcac cacagtcaat ggggaaagaa agaaaactag ctatgcagaa gtgaatgaca
     7861 aagtctgtga acttagtctt tactaggttc agaagtgaca tcaacaggag gatttttttc
     7921 ctttattgta taaagattct ctttacttgc cacctgtgtt ccacgtagaa ggtgggaagc
     7981 ctcggggatg tgtgtggatg acagtgtccc tattttcgcc ggggcagtcc accaagccac
     8041 cggatcaggc cctcattgca gtgagctctg cctctggtta cctgtccggc tcttactgta
     8101 aacagtcctt acctgtctcc aaggaatgat aaagggagga ggacgccaag actgcaggtg
     8161 aagagcaaga gtgtgtgacg tggatggtcc tgtatagctc gttctcgggc tcctagctca
     8221 gatccgagtc attccccttc cttctgctca tgcggtacag aagcaatcag gatgtgcctt
     8281 tgagctgttc cttctctctg ttagttattc gcaatagcta atgtgctagt ttacgtggtc
     8341 cctgttgtct ggatctgatt gccttttttg gttaatttat ccatattttt gtttacatta
     8401 tttttaaagc tagtaactgt aatagtataa aattgaagtt gtgctgttga caggacatct
     8461 ctctctctct ttttttttta catttatctg tcacaataat ttaagtgcac ctgttcctaa
     8521 tgtataaagt tctctccctc tcaataaatg acaatggaag ta
//
