LOCUS       NM_001364406            4820 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 (Plekhg4), transcript variant 2, mRNA.
ACCESSION   NM_001364406 XM_017312498
VERSION     NM_001364406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4820)
  AUTHORS   Takenaka N, Yasuda N, Nihata Y, Hosooka T, Noguchi T, Aiba A and
            Satoh T.
  TITLE     Role of the guanine nucleotide exchange factor in Akt2-mediated
            plasma membrane translocation of GLUT4 in insulin-stimulated
            skeletal muscle
  JOURNAL   Cell Signal 26 (11), 2460-2469 (2014)
   PUBMED   25025572
  REMARK    GeneRIF: Role of the guanine nucleotide exchange factor in
            Akt2-mediated plasma membrane translocation of GLUT4 in
            insulin-stimulated skeletal muscle.
REFERENCE   2  (bases 1 to 4820)
  AUTHORS   Gupta M, Kamynina E, Morley S, Chung S, Muakkassa N, Wang H,
            Brathwaite S, Sharma G and Manor D.
  TITLE     Plekhg4 is a novel Dbl family guanine nucleotide exchange factor
            protein for rho family GTPases
  JOURNAL   J Biol Chem 288 (20), 14522-14530 (2013)
   PUBMED   23572525
  REMARK    GeneRIF: Plekhg4 is an aggregation-prone member of the Dbl family
            GEFs and regulation of GTPase signaling is critical for proper
            cerebellar function
REFERENCE   3  (bases 1 to 4820)
  AUTHORS   Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM,
            Beamer WG and Hammer GD.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On Jun 15, 2018 this sequence version replaced XM_017312498.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AC124584.5         19617-20207         c
            592-738             AC124584.5         18580-18726         c
            739-1130            AC124584.5         17624-18015         c
            1131-1226           AC124584.5         17368-17463         c
            1227-1350           AC124584.5         17166-17289         c
            1351-1444           AC124584.5         16966-17059         c
            1445-1519           AC124584.5         16811-16885         c
            1520-1636           AC124584.5         16614-16730         c
            1637-1735           AC124584.5         16344-16442         c
            1736-1884           AC124584.5         16106-16254         c
            1885-2023           AC124584.5         15802-15940         c
            2024-2140           AC124584.5         15596-15712         c
            2141-2323           AC124584.5         14997-15179         c
            2324-2829           AC124584.5         14293-14798         c
            2830-3076           AC124584.5         13978-14224         c
            3077-3166           AC124584.5         13267-13356         c
            3167-3388           AC124584.5         12964-13185         c
            3389-3559           AC124584.5         12707-12877         c
            3560-3737           AC124584.5         12451-12628         c
            3738-3854           AC124584.5         11968-12084         c
            3855-4079           AC124584.5         11621-11845         c
            4080-4195           AC124584.5         11423-11538         c
            4196-4820           AC124584.5         10619-11243         c
FEATURES             Location/Qualifiers
     source          1..4820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..4820
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /note="pleckstrin homology domain containing, family G
                     (with RhoGef domain) member 4"
                     /db_xref="GeneID:102075"
                     /db_xref="MGI:MGI:2142544"
     exon            1..591
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1130
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1226
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1350
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1444
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1519
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1636
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1735
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1884
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2023
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2140
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2323
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2829
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3076
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3166
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3388
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3559
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3737
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3854
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..4079
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4195
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4820
                     /gene="Plekhg4"
                     /gene_synonym="4931414L13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgaagcta gaggaaggag agatggaaga catgcctagg agctggggct ggagaaggac
       61 aactccaagg ccagccttgc cccttgctct tcagaatctg ccttagagtc agagatgggt
      121 ggggacgcct gttgtttcta ccatggctgc agctgataac tagattcatg aaggaatcgc
      181 ctgacttaga gccagggaag gcattatgtc cagtgtcctc tcctcccagg gaccaaggcc
      241 atggtgtggg ggctacatgc ctttgtctgg ttgcacagat aacctttttc ttatgatctt
      301 tccacaaatt caagagtgtt aggccaggcc cacttcctcc aaaaggaccc cagactttag
      361 agttaagaac gagtaggggt ctcccagcta tcccagtgtc tttcatcagt tcaagattcc
      421 ctaacgaagg gtgaagtggg aaggcagggc atgaacacag atatctgatc catccatcag
      481 gatttccctg gtccatcggg caaccccagg agaaaagaat gcttttcttg tcttacagga
      541 gaggaagatg aggtgcaaag agaaaagggt ccctggaaca gcccacaaga gagcggcgcc
      601 ttccggaaga acctgtgatt cggtcctcca gcccctagag agcgccgcgt ccacagcggc
      661 cttgcggccc ttcgagccac cagaaggtgg cgcccttgga atctgggcag cctcgctgta
      721 cccatcctcg aggctgcgtt tcaggaacac ccggaaggag gaggaacctg ctcacgagat
      781 acaggctatg gacccaagac cttcaagacc agcagcaggg gcaacccaag gcgtagggct
      841 acagggggat ttcttggcca aggagcctca atcgcttccg gaacaaaggg ctgaggatgg
      901 gccacggggc taccagagga gcataatagg agccccccca acccagtcag aggagccagc
      961 cttctctgaa ttggaaaacc tcttgtgttc tgggtcctct caccttaacc tgacacaggg
     1021 tgacaatgac tatcgagggg aaggcttgat aggggaccca ggtccaggca gaacgctgcc
     1081 agctggctgt agccctttat cagagacatc accaaagcta ctggaggcag accctagtgg
     1141 atccagcttc cctaagcctg ctgactgtct cctagctcga gacctcgcct gggagctact
     1201 ggccagtggc atggctgccc taccagggac acgggatgtc gaaggccgag cggtgttgct
     1261 tctgtgtgcc cacagcccag cttggctcca tcccaagtct aatagccatg agctgctgag
     1321 ccttttgttt tacctgcgag gcatccccag gcctgaagtg caggcactgg gcctgaccgt
     1381 actagtcgat gcccgagtct gctcgccgag ctcttccctc acctggggcc tcagccggct
     1441 acaggaagca tccccggggt ctgtacaaca agtgctgctc attggaaaga tgccagagga
     1501 cgtgcctgtc gggcttcagt ggaagcagct acgttctcac cagagcctgc tgacccacat
     1561 tcctaacgtg gagttgccta cttcgctagg agggagcctg tcttactgcc accaaggctg
     1621 gctggatttc cggatgcgtc tggaagccct gcagcagagt tgccaggtgg cttgtgccct
     1681 gcttcagggt gtcattgaca gtatgaaggc actgcggcca cccatggagt ctggagaagt
     1741 cgctcagctg ctacagcaga cacagtccct catgcagcag gtattagatt cgccacagtt
     1801 gtcatggtta caaagccagg gaagccagga gctggcatgg ttgaagcaag ggacgccccg
     1861 ggtgaccctg agccccgatt acaggtctgc agtagacaag gctgatgcgc tctacggtca
     1921 ggtggatgaa cttttgcatc agctagccct gaagagcaac cagcgaatcc gggccctcga
     1981 gctcctgcaa gcgctggaag cccaggaggg tgtgctgcgc cagattgaag tatggttaca
     2041 ggaggtgggt tggccaggag tggaggaacc aggggagccc tcgctcgaca cgctgctcca
     2101 ggctcaaggc ccttttcaag agctggacct ggttgcccag gaacaggtca cgcaagggga
     2161 gaagttactg cagcccctgg ttggcttgga ggctgctgaa ctggggtccc ctggaaagcg
     2221 ttttctggcc ctgagatccc agctgacgga attttccaga gctttggccc agcggcgcca
     2281 gcggttggca gatgctgaga agctctttca gttcttcaag caggcctcga cgtggaccga
     2341 ggaggggcgg cggctactga cagagctgga gcaggagcgc ccagaggtgg tgctgcagcg
     2401 gctgcagctg cactggacca gacaccctga cttgccccct gcccacttcc ggaaaatgtg
     2461 ggctctggcc acaggcctgg gctctgaagg catccgccag gaatgtcgct gtgcctgggc
     2521 acagtgccag gacacctggt tggctctgga ccaaaagcgt gaggctgcac tgaagccgat
     2581 gccagcaacg aacaacaccg ctactttgta tgtcaggcgg gctcctgctg tacccactgt
     2641 ccctccactg cggaaggcct acagcttcga ccggaatctg gggaggcatc tccaagatgt
     2701 ttccagtcgt ggccactgtg cagccattgt tactgactgc cacagacctg aggccagagg
     2761 aggtgtccgg cccaggtcgt ctcctcctgt gcctctttca ggcagctctg acttcaggag
     2821 ccccaacagg ctacagctag tattggcgga gatggtggcc acagagcgtg agtatgtccg
     2881 ggcccttgac tataccatac agaactactt ccctgagtta gatcgacccg atgtgcccca
     2941 gggcctccgt ggccagcgtg cgcacctctt tggcaacctt gaaaagcttc gggacttcca
     3001 ctacaatttc ttcctgcgtg agctagaggc ttgcacccgg cacccacctc gagtggctca
     3061 tgccttcctg cgccataggg tgcagtttgg aatgtatgcc ctctacagca agaacaaacc
     3121 tcgttctgat gctctgatga caaactatgg tcacaccttc tttaaggaga agcagcaagc
     3181 actgggggac cacctggact tggcttccta cctactgaag cccatccagc acatgagcaa
     3241 gtatgcctta ctgctgcagg agctggcaag ggcctgtggg ggcccagcgc aagagctggg
     3301 tgccctccag gcagcccaga gccttgtgca cttccagctg agacacggca atgacctgct
     3361 agccatggat gccatccagg gctgtgacgt aaacctcaag gaacagggcc agttggtacg
     3421 gcaggatgag ttcacagtgc gggctgggcg ccacaaagcc tgtcgtcgcg ttttcctgtt
     3481 tgaggagctg ctgctcttca gcaagccccg ccgtgggcct gcaggggttg acatattcac
     3541 ctacaagcga tccttcaaaa tggcagacct cggcctcact gagtgctgtg gggaaagcca
     3601 actgcgcttt gaaatctggt tccgacgacg caaggccagg gacctgtttg tgctgcaggc
     3661 ctccgatgtg gccaccaaac aagcctggac agccgatatc tcccgtctcc tgtggagaca
     3721 ggctgtccat aacaaggagg tgcgcatggc tgagatggca tccatgggtg tggggagcaa
     3781 agccttctgg gacattgccc ccagtgagga agctatcaat gaccgcaaca tcaactatgt
     3841 gctgaagaga cgagatgttc gctctagggc ctccattgct gtggccccat ttgactgtga
     3901 caacccttat ctgggtgcct tgggctccct tcctggagac cgtgcctctg gctctgttct
     3961 gggctctctt aatctacacc tgtacagaga tccagctctt atgggtggtc actggtcctt
     4021 gtatccaccc aacttctcag aggaagcatc actagatttg ggcagccagc cttctttgac
     4081 tcccgaggac tcagaggtct catcccagtg cccatcagcc agtggctcta gtgattctga
     4141 cagcagctgt gtgtcagggc agaccatggg cagaggcctt gaggatttgt cctgtgtttg
     4201 agtccggcct gaagatgaac agcactcagt aactccaagg aataccaggc ctttgaatgt
     4261 gctataatca gagcaccctc atacccaata ggaatatcct tgttgattat cctttctgat
     4321 gtctgtagcc atcaaccgac agccctaggg cctctccaag ggcatctggc tgcagagact
     4381 agttacacac cttgggtccc aggacccttc tgtcccctct ccaactacct ccccaattgt
     4441 gagttaagga catgataggg cagaggggag tatttctaga ctgcaggctg gtagagtagt
     4501 gtggagctct cggaagtcat gaaggacaca agtggattcc cagcggctgt tcctcaaccc
     4561 ttgggtaaca ctaatctctc caaacacagg gcctagcctg gccctatagc ccccttattc
     4621 ttgaattcct tggcaaaccc atcgccaacc tcttgttttt ggggccccct tggtcatttt
     4681 gacttgatgc ttttggttag agttgtctac tggtttcact ggcagtgaca ctctgttttc
     4741 tcagagaaga aatctaggca tttttcttgt tatttacttt tttatttgtt tataataaaa
     4801 aataagtgat ttgcaccgtt
//
