LOCUS       NM_138752               4968 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family G (with
            RhoGef domain) member 2 (Plekhg2), transcript variant 1, mRNA.
ACCESSION   NM_138752
VERSION     NM_138752.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4968)
  AUTHORS   Nishikawa,M., Ito,H., Tabata,H., Ueda,H. and Nagata,K.I.
  TITLE     Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange
            Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes
  JOURNAL   Cells 11 (4), 696 (2022)
   PUBMED   35203342
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4968)
  AUTHORS   Nishikawa,M., Ito,H., Noda,M., Hamada,N., Tabata,H. and Nagata,K.I.
  TITLE     Expression analyses of PLEKHG2, a Rho family-specific guanine
            nucleotide exchange factor, during mouse brain development
  JOURNAL   Med Mol Morphol 54 (2), 146-155 (2021)
   PUBMED   33492483
  REMARK    GeneRIF: Expression analyses of PLEKHG2, a Rho family-specific
            guanine nucleotide exchange factor, during mouse brain development.
REFERENCE   4  (bases 1 to 4968)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   5  (bases 1 to 4968)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   6  (bases 1 to 4968)
  AUTHORS   Himmel,K.L., Bi,F., Shen,H., Jenkins,N.A., Copeland,N.G., Zheng,Y.
            and Largaespada,D.A.
  TITLE     Activation of clg, a novel dbl family guanine nucleotide exchange
            factor gene, by proviral insertion at evi24, a common integration
            site in B cell and myeloid leukemias
  JOURNAL   J Biol Chem 277 (16), 13463-13472 (2002)
   PUBMED   11839748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149606.6.
            
            On Dec 30, 2022 this sequence version replaced NM_138752.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            CCDS Note: The coding region has been updated to represent an
            alternative 5' splice pattern, resulting in the extension of the
            N-terminus to one that is better supported by available transcript
            and homology data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-718               AC149606.6         140767-141484
            719-849             AC149606.6         142099-142229
            850-1109            AC149606.6         142847-143106
            1110-1210           AC149606.6         143183-143283
            1211-1277           AC149606.6         144457-144523
            1278-1324           AC149606.6         144619-144665
            1325-1475           AC149606.6         144903-145053
            1476-1613           AC149606.6         145233-145370
            1614-1814           AC149606.6         145509-145709
            1815-1907           AC149606.6         147799-147891
            1908-1994           AC149606.6         147976-148062
            1995-2028           AC149606.6         148394-148427
            2029-2130           AC149606.6         148518-148619
            2131-2178           AC149606.6         148712-148759
            2179-2217           AC149606.6         148835-148873
            2218-2234           AC149606.6         149030-149046
            2235-2408           AC149606.6         150345-150518
            2409-3309           AC149606.6         150636-151536
            3310-4968           AC149606.6         152083-153741
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.71 cM"
     gene            1..4968
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /note="pleckstrin homology domain containing, family G
                     (with RhoGef domain) member 2"
                     /db_xref="GeneID:101497"
                     /db_xref="MGI:MGI:2141874"
     exon            1..718
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            719..849
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     CDS             741..4766
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /note="isoform a is encoded by transcript variant 1;
                     common-site lymphoma/leukemia GEF; pleckstrin homology
                     domain-containing family G member 2; PH domain-containing
                     family G member 2; common site lymphoma/leukemia guanine
                     nucleotide exchange factor"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 2 isoform a"
                     /protein_id="NP_620091.2"
                     /db_xref="CCDS:CCDS21040.2"
                     /db_xref="GeneID:101497"
                     /db_xref="MGI:MGI:2141874"
                     /translation="MPEGARGLSLPKPSLRLGCGHQGEVCDCAAVSDTPTAAQAATTM
                     ASPRGSGSSTSLSTVGSEGDPSPACSASRPEPLPEPPIRLHLLPVGIQGSVKPSRLER
                     VAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELL
                     EDLEGCSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQERQA
                     QLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWY
                     INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLL
                     FLFSRMLLVAKRRGPEYTYKGHIFCCNLSVSETPRDPLGFKVSDLTIPKHRHLFQAKN
                     QEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRP
                     RDAPGFTPGRRNPAPSPRLSGSRRGRRQSEPAKEAYVIFPQNDKPQVKHAGSEGELHP
                     SSELQPVSASGPPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDSGPATHDIPKFP
                     RDSRVPVESEPLPFQSLPSRESSEEEEEEDLETDEREPSPLHVLEGLEGSSAAEIPCI
                     PSLTDIPSEVPSLPEIPEAPCLPCLSDISGVFEVPCLSPTSTVPDIPSLATTPSFPCG
                     SWLPGPLQEAAQPQATRRELLSGSNPGRLSESPSESREGQEDDTEGVSFSAVQREAGT
                     SVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLRGGSTSGKTGMP
                     HSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVLAQPQPSPCPPQEEAEP
                     GALPAFGHVLVCELAFPLNCTQESVPLGPAVLVQAATPLCIQGDDLSGQNLNVSDLSK
                     QGHLSSNSIPPPVPLPGQSNFQNIQVPSTSLLPKQEPPDVQVPTASTLPDTSQLQSQV
                     PAATPSAGHRNCVEIQVQSTTSLPGQECQADTVALSKQEGHEDSQNPNKAPGAEQRDV
                     SIDQGLAVVGGRPVSPLPVCTSSPDQQIPATTPLPLSTDFPDMEGPGALPLPTQEGRP
                     DCSIPCNPLPSLSQDVQVPAVIPVSQLQGLTDTRATVPLSSHKQEDAPECLGPEPSLT
                     DTPAPRLLSSLGQQNTTDGPVSAAAVPLTEQGCSQDLQGLITSPVQTTMELPKPRGLV
                     SRVATSESLDLTPPHSPSLSTRQLLGPSAAALSRYLAASYISQSLARRQGPGGEGTVA
                     SQGHWSSSAPTSRAPSPPPQPQPPAPPARRLSYATTVSIQVGGGGRLRPAKAQVRLNH
                     PALLAAPHPGAVGPSQGPGGS"
     exon            850..1109
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1210
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1277
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1324
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1475
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1613
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1814
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1907
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1994
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2028
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2130
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2178
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2217
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2234
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2408
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..3309
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..4968
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4968
                     /gene="Plekhg2"
                     /gene_synonym="Clg; Cslg"
                     /note="major polyA site"
ORIGIN      
        1 agatgcggcg ttgccgctgc ccccagagcc ccaggacact catcccggag cccgaggcgt
       61 tcatagtctt gggcccaggc gtccgggaac tctgtcccgc gttttaagag acccgcaagt
      121 cccggctccc gcagaggggc cgggacctct gatgtccagc gccccctcct ggaggagccc
      181 ggggctcggg aagtcagccc cgaggctgga ggcccgtccc gtacccggct tcgaagaccg
      241 taggatctgt ggccgtgcat ccttcccacg gggtcccaac tctgagtcca agaccccctc
      301 ctggagccac ttggggacag gacctcgcgc ctcgacttag ggctgcagca tccatcacct
      361 ccaggagacc gaggagttag ccagtccttg cggtccctcc cggaggtgac ttcactcctg
      421 cccctcgggt tctggaaact ctggaatccc ggtgctcccg acaacacaca gccctaccta
      481 gaagactgag gagtttgggt ccccagcgcc ctggtctgag actcgagtag agggttgcag
      541 catcttctat ttagaacacc gagacttcgg actccggatc ccaactctcc ccggattctg
      601 gagtccgaga accccaagtt cacgacctta agtctgggtt gtgagcctcc ccagggatcg
      661 cgcgttacgg tccagacgcg cgggactccc gaccccaagg cccgtggctc cccgggaggt
      721 cggagttgtg ccactcaatc atgcccgagg gagcccgggg attgagcctg cccaaaccca
      781 gccttaggct cgggtgtggc caccaaggtg aagtttgcga ctgcgcagca gtgagtgaca
      841 ctccaacagc agcgcaggca gccaccacca tggcttctcc aaggggttct ggcagctcca
      901 cttcgttgag cactgtgggc tccgaggggg acccatctcc agcctgctca gcctccaggc
      961 cagagcccct accggagccc cccatacgcc tgcacctgtt gcctgtggga atccagggtt
     1021 cggtgaaacc ctccaggctg gaacgagtgg ccagggagat tgtggagaca gagcgggcgt
     1081 atgttcgcga ccttcgcagc atcgtggagg actacctagg ccctctgatg gatggcaggg
     1141 ccctggggct gaacatggag caggtgggca cactgtttgc caacatcgag gacatctatg
     1201 agtttagcag tgagctcctg gaggacttgg aaggctgcag cagtgcaggg ggcatcgccg
     1261 agtgcttcgt gcaaagaagc gaagattttg acatctatac attgtactgc atgaactacc
     1321 caagctccct ggccctgctc cgagagctgt cagtgtcccc gccagccact ctgtggctac
     1381 aggagcgtca ggcccagctc cgtcactccc tgcctctgca gagcttcttg ctgaagcctg
     1441 ttcagcgcat cctgaagtac catctcctgc tgcaggaact gggcaagcac tgggcagagg
     1501 gcccagacag tggagggcga gagatggtgg aggaagccat tgtatccatg actgcagtgg
     1561 cctggtacat caatgacatg aagcgcaagc aagagcatgc tgcacgcctg caggaagtgc
     1621 agcggaggct gggtggctgg actggcccgg agctcagcgc ctttggagag ctagtactgg
     1681 aaggcacttt ccgaggggga ggcgggggag gccccaggct tcgtgggggt gagcgcctcc
     1741 tcttcttgtt ctcccggatg ctgctggttg ccaagcgtcg ggggcctgaa tacacctaca
     1801 agggccacat cttttgctgt aacctcagcg taagcgagac tccgcgggac cccttaggat
     1861 ttaaggtgtc agacctgacc atccccaagc acagacacct gttccaggcc aagaaccagg
     1921 aagagaaacg gctgtggatc cactgtctcc agcgcctctt ctttgagaac cacccggctt
     1981 ccatccctgc caaggcaaag caagttctct tggaaaacag cctacattgt gctccaaaga
     2041 gcaaacatat cccagaaccc ccaacatccc cactggactc tccccgacct cgagatgctc
     2101 caggttttac ccccggcaga agaaacccag ctccatctcc aagactttct ggcagtcgcc
     2161 gtggccgcag gcagtctgag ccagcaaagg aagcttatgt catttttccc cagaatgata
     2221 agcctcaagt caagcatgct ggcagtgaag gagagctcca cccctcatct gagctgcagc
     2281 cagtgtctgc ttctggccct cctgaagacc tggaggatgc tgggcctccc acgttggacc
     2341 cgtcggggac ttccataact gaggagatcc tagaactgct gaaccagaga ggcctcaggg
     2401 actcggggcc agccacccac gacattccca agttccccag agactcccgg gtgccagttg
     2461 aaagcgaacc cctcccgttc caatccctgc ccagccgaga gtcttcagaa gaggaggagg
     2521 aggaggacct ggagacagat gaacgcgagc cttccccact gcacgtctta gaggggctgg
     2581 aaggttcgag cgcagctgaa attccctgca ttcccagcct tactgacatt cccagtgaag
     2641 tgcccagcct tccagaaatt cctgaggctc cctgccttcc ctgtctctct gatatctctg
     2701 gtgtttttga ggtaccctgc ctttcaccca catccactgt gcctgacatt cccagcttgg
     2761 ccaccacccc ctcctttccc tgtggctcct ggctccctgg acccctgcag gaggcagccc
     2821 agcctcaagc caccaggagg gaactgttga gtgggagcaa tccaggaaga ctgagtgagt
     2881 ccccctcaga aagcagagag gggcaggagg atgacacaga aggcgtgtca ttctcagctg
     2941 tgcagaggga ggctggcacc tcggtccaag gattcccgga agaactggaa taccgctctt
     3001 gttcagaaat ccggagtgcc tggcaagctc tggagcaggg gcagctggcc cggcctggct
     3061 tcccagaacc tctgctcatc ctggaggact ctgatcttag aggaggcagc accagcggga
     3121 agacaggaat gccacattca gagcggtcag catcgcgggt gcgagagttg gctcggctct
     3181 acagtgagcg tatccagcag atgcaacgag ctgagactag ggcatccacc aatgcacccc
     3241 gccgcagacc tcgagtcctg gcccaacccc agccatcccc ttgcccaccc caggaagagg
     3301 ctgaaccagg ggccctgcct gcatttggac atgtgcttgt atgtgagctg gctttcccac
     3361 tgaactgcac ccaggagtct gtccctctgg gccctgctgt tctggttcaa gctgccacac
     3421 ctttgtgtat tcaaggagat gacctgagtg gccagaatct aaatgtttca gatttgtcca
     3481 agcaaggcca tctgagtagt aactccattc caccgcctgt ccctttacct gggcaaagca
     3541 acttccagaa catacaggtt ccctctacat cccttttgcc taagcaagag cctccagatg
     3601 tccaggtccc aactgcctca accttgcctg atacaagcca gctccaaagc caagttcccg
     3661 ctgccactcc atcagctggg catagaaact gtgtggagat ccaggttcag tccaccacct
     3721 cccttcctgg ccaagagtgt caggcagaca ctgtggcatt gtccaagcaa gaaggtcatg
     3781 aagacagcca gaacccaaac aaggccccag gagccgagca aagagacgtc agcattgatc
     3841 agggtctagc tgttgttggt ggccggcctg tcagcccttt gccagtgtgc acaagtagcc
     3901 ctgaccagca gatcccagcc accaccccac tgccattgtc aactgacttc ccagacatgg
     3961 agggtcctgg tgccttacct ctgcccacac aggaaggtcg tccggactgc agcatcccat
     4021 gcaaccctct accatctttg tcccaagacg ttcaggtgcc agcggtcatc cctgtgtccc
     4081 agctgcaagg ccttacagac accagggcca cagtgcccct gtcttcccac aagcaggagg
     4141 acgctccaga gtgtctgggt ccagagccca gcctcacaga cacaccagct cccagactct
     4201 tatcttcact gggccaacag aacaccacag atggccctgt ttcagcagct gccgtgcctt
     4261 tgactgaaca aggatgctct caggatctgc aaggcctaat tacttcccca gttcagacaa
     4321 ccatggagtt acccaaacca aggggtttag tctctcgtgt tgccacctca gagtctttgg
     4381 acttgacccc accgcatagc ccctcgctct ccactcgcca gctcctgggc cccagtgcag
     4441 ctgccctttc aaggtacctg gcagcttcat acatcagcca gagcttggct aggcgccagg
     4501 gacctggggg agagggcacg gtagcctccc agggtcactg gtcctcctct gcccccacat
     4561 cacgggcacc ttcaccacca cctcagcccc agcccccagc ccctccagcc aggaggctca
     4621 gctatgccac cacagttagt attcaggtag gaggtggtgg gcggctacga ccagccaaag
     4681 ctcaggtccg gctaaaccac cctgctctct tggcagcccc tcacccggga gccgttgggc
     4741 cttcccaggg cccaggaggc tcctgatgcc gctctccgta tgtaagcctg gacattaggc
     4801 ttcctaagct tcaagaactt tcttcaccag gtgccaccta tccttatgac atccagagcc
     4861 tggacgcagg tccagaaatg gctgtagctt tctagcccag gagtctgtgt ccacagatgg
     4921 ccctcctgag gtcatggtta ttttgttaat taattttatg aaacgctg
//
