LOCUS       NM_001159942            7356 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family G (with
            RhoGef domain) member 1 (Plekhg1), transcript variant 1, mRNA.
ACCESSION   NM_001159942
VERSION     NM_001159942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7356)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   2  (bases 1 to 7356)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7356)
  AUTHORS   Huisman,C., Kim,Y.A., Jeon,S., Shin,B., Choi,J., Lim,S.J.,
            Youn,S.M., Park,Y., K,C. M, Kim,S., Lee,S.K., Lee,S. and Lee,J.W.
  TITLE     The histone H3-lysine 4-methyltransferase Mll4 regulates the
            development of growth hormone-releasing hormone-producing neurons
            in the mouse hypothalamus
  JOURNAL   Nat Commun 12 (1), 256 (2021)
   PUBMED   33431871
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7356)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   5  (bases 1 to 7356)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7356)
  AUTHORS   Shu,P., Wu,C., Liu,W., Ruan,X., Liu,C., Hou,L., Zeng,Y., Fu,H.,
            Wang,M., Chen,P., Zhang,X., Yin,B., Yuan,J., Qiang,B. and Peng,X.
  TITLE     The spatiotemporal expression pattern of microRNAs in the
            developing mouse nervous system
  JOURNAL   J Biol Chem 294 (10), 3444-3453 (2019)
   PUBMED   30578296
REFERENCE   7  (bases 1 to 7356)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 7356)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   9  (bases 1 to 7356)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   10 (bases 1 to 7356)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034403.1, AK135923.1 and AC153570.9.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1185317.1,
                                           SRR10662772.1370176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1379              AK034403.1         2-1380
            1380-4602           AK135923.1         1216-4438
            4603-7356           AC153570.9         107633-110386
FEATURES             Location/Qualifiers
     source          1..7356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.06 cM"
     gene            1..7356
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /note="pleckstrin homology domain containing, family G
                     (with RhoGef domain) member 1"
                     /db_xref="GeneID:213783"
                     /db_xref="MGI:MGI:2676551"
     exon            1..164
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            165..225
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            226..740
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..4505
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 1"
                     /protein_id="NP_001153414.1"
                     /db_xref="CCDS:CCDS56671.1"
                     /db_xref="GeneID:213783"
                     /db_xref="MGI:MGI:2676551"
                     /translation="MELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFH
                     QDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSGTPQTTA
                     DSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKLPLVTEDRAALFG
                     NIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECM
                     RNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVL
                     DAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKA
                     KKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQ
                     HTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGE
                     MKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQ
                     PGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFV
                     PSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPE
                     VRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLM
                     VAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQS
                     VHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQD
                     SLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYI
                     KKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGK
                     SRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENP
                     DPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAIL
                     EEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGA
                     GEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSD
                     PLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSL
                     DSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVV
                     NRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDP
                     DCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLR
                     EKFQCLSSSSFA"
     exon            741..841
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            842..911
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            912..958
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1109
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1241
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1424
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1520
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1613
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1647
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1731
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1770
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1793
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..3453
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..7356
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7330..7335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /note="hexamer: AATAAA"
     polyA_site      7351
                     /gene="Plekhg1"
                     /gene_synonym="D10Ertd733e; Gm521; mKIAA1209"
                     /note="major polyA site"
ORIGIN      
        1 caggcgagct gcagggctcg gggccgccgg agccggcgct ggagcgcagc gcaccgcgga
       61 gccagcgctc gggagccgcc cctctcccgt aagctccgcc gagactattc cagggaccag
      121 acaagggaag ccggggacct cggccacgcg ccccgaatct gcaggtgagg actgacatta
      181 gaagccgtgg tgaagacatt agaaacgtga gctttaacta taaagaaaca gatggacacc
      241 gccatttgca actggacgtg ccttcagctg taagtctagt tcctgatcca aggaccacag
      301 cggaaccctc cgagtcccca gaaccaaaaa ctatggagct ttccgacagc gaccgaccca
      361 tcagcttcgg ctccacctca tcctcggcct cctccaggga cagccacggt tcctttggca
      421 gcagaatgac tttggtttca aacagccact tgggcttatt tcaccaggat aaagaagctg
      481 gggccataaa gctggagctg gtaccagcac gaccattttc cagcagcgaa ctgcagaggg
      541 acaagcctgc cggaccacaa aacatgaatg gggtcagcga gaagcagcct aggactccat
      601 ggagaatgga cacgagtggg acaccacaaa ccactgcaga ctcggccacc agccccaagc
      661 tcctctatgt agatagagtt gtacaggaaa tcctggagac agagaggacc tacgtgcaag
      721 atctaaaaag catcgtggag ggttacctgg aatgcatacg ggaccaaacc aaacttcccc
      781 tggtgaccga agacagggct gctctttttg gaaatataca ggatatctac cacttcaata
      841 gtgaacttct tcaagatctg gaaaactgtg aaaacgatcc tgtggccata gcagaatgtt
      901 ttgtgtccaa gagtgaagag ttccacattt atacccagta ttgcaccaat tacccaaggt
      961 ctgtggccgt gctaactgag tgcatgagga acaagatact caccaagttc ttccgggagc
     1021 gccaggaaac tctgagacac tcactacccc tagggtccta cctcctaaaa ccagtccagc
     1081 ggattctcaa atatcatctc cttcttcatg aaatagagaa ccaccttgat aaggccacgg
     1141 aaggctacga tgttgtgctg gatgccatag acacgatgca gcgagtggcc tggcacatca
     1201 atgacatgaa acggaagcat gagcatgctg tccgcttgca ggagatccag agcttgctaa
     1261 ccaactggga ggggcctgac ctcaccagct atggggagct ggtgcttgaa ggaaccttcc
     1321 gcatccagaa ggccaaaaag gagaggactc tttttctcct ggaccagctg ctgctcatca
     1381 caaaaaagag agatgacacg tttacataca aggctcacat cctgtgtggc aacctcatgc
     1441 ttgtagaggt cataccaaaa gaaccgctca gcttcagtgt cttccactac aagaacccca
     1501 agcttcagca cacagttcag gccaaatccc agcaagacaa acgtctctgg gttctgcacc
     1561 tgaagagatt aattctggag aaccacgcag cagcagcaaa gatcccagct aaggccaagc
     1621 aagcgattct tgaaatggac gccatccact atccaggctt ctgttacagt cctgagggag
     1681 agatgaagac accatgtggt tctgcacccc atcggctgag acggaagtca gaaccttcct
     1741 cgagatcaca caaagtgttg aagaccagcg aaacttcaca agatatccag aaggtttcta
     1801 gagaggaaag cccttcccag ctgacttctg ccgtgcctgc ccagaggaac tgccagcccg
     1861 gcagcgctgc cgttatcaat atgcttcgcg ggggaggcgg tgttagaagc ccatggacag
     1921 atcaccacat caggcagcgg acggatcacc acatccggca gcccttgttt ccaagccgcc
     1981 ggtctccaca ggagaatgag gacgatgacg acgattacca gatgttcgtc ccgtcctttt
     2041 cttcctcgga tctcaactcc accaggttgt gtgaagagaa cgcttcaagt cgcccttgca
     2101 gctggcatct gggcctcatc gaacccacag agatctccag ctctggtcac aggatagtcc
     2161 gacgggccag tagtgcaggt gaaagcaacg catgccctcc tgaagtaaga attagagact
     2221 gtgatgactc tcagtactgt cccgggagac agctgcagaa cagtcctcga ccaggaggag
     2281 agagggggat gactccctat gggtcgtctg tagagttgac cattgatgat atagaccatg
     2341 tctatgataa cataagtttt gaagacttaa agttaatggt tgctaagcgg gatgaaactg
     2401 aatgttcttt ctccaaacca tccagagact ctgttcgccc caagagtacc ccagagttag
     2461 ccttctcaaa gagacaggtt agccacagta caagctctct ccactcaagg aaagaggcag
     2521 gcctcggtgg tcaagaggca tccacccaaa gcgtacatga acaccaggaa gtggaagaaa
     2581 acatctatga caccataggg cttccagacc caccatcgat gaacttgaac cacagcagcc
     2641 ttcatcagcc caaaaggagc accttcctgg gtctggaagc tgattttgca tgctgtgaca
     2701 gcctgagacc atttgtctcc caggatagcc tccagttcag tgaggatgac atatcttacc
     2761 accagggacc ctccgatact gaatatttga gtttgttata tgactctccc cgctgtaatc
     2821 tgcctattgc agataaggct ctgtccgaca aattgtctga agaagtagat gaaatctgga
     2881 atgatctgga aaattacatc aagaaaaatg aagacaaatc aagagaccgc ctccttgcgg
     2941 cctttcctgt gagcaaagac gatgcaccag agaggctata tgttgacagc acccatgagc
     3001 tgggcaggga tacaggacat gccacatcta tgctggccct tcctacaagc cagactttcc
     3061 tcctgcctgg gaagagcaga gttgtcagag ctagcagggc caactgctcc ctggataatg
     3121 acattatttc aacagaaggt tccttcctga gtcttaacca actctctctg gccagtgatg
     3181 ggcctcctgt ggacaatccc tatgacctgg ccaactgcag cctgccccag acagacccag
     3241 aaaaccctga ccccgggatg gaggtcacag acaagactaa gagcagggtc tttatgatgg
     3301 ccaggcagta tagtcaaaag atcaagaagg taaatcagat tttgaaagtg aaaagcccag
     3361 agttggagca accaccgtcc agtcagcata ggcccagtca caaagacctg gtggccatct
     3421 tggaagagaa gaggcaagga gggcccgcca ttggtgccag gatcgctgaa tattcccaac
     3481 tgtatgacca gattgtgttc agagagacac cccttaaagc tcagaaggat ggctgggcca
     3541 gcccccaagg acccaccctc cacaggcctg tgtcacctcc ccaggcccag ggcgctggtg
     3601 aggactggct ctggcattcg ccctacagta acggagagtt ggcagatttc tctccccaga
     3661 cagaacaaga ctcaaaatca aaatacccca tcacattaga gagcaccaca aaaattaggc
     3721 ccaggcagtt gtcgggtgct tgttcggtgc cgtctctcca agtgtcggac cctctgctgg
     3781 gctctgtgca gcagagatgc agcgtggtgg tcagccagcc ccacaaagag aactcaggtc
     3841 agagtcctct ttacaactcg ctgggtcgca aagcaatcag cgctaaaccc cagccttata
     3901 gcaggcctca gtcatcttcc tcaatcttga taaacaaatc tctggactct atcaactacc
     3961 ccagtgagac agagacgaag caactactct cttcacagaa aagtcccaga ggcgcgagcc
     4021 agcaggattt gccgtcaggg ctagcaaact catgtcaaca ggacaggggc aaacggtccg
     4081 atctcacgct ccaagactcg cagaaggttc tcgtggtaaa tagaaattta cccttaagcg
     4141 ctcaaatagc gacgcagaac tacttttgta atttcaaaga tcccgaggga gatgaagatg
     4201 actatgtgga aatcaagtca gaagaggacg aagtgcgtct ggatctctct ccaaggcggg
     4261 gcaggaagtc tgacccacag accccggacc ctgactgttc ggatagcatc tgtagccaca
     4321 gcacacctta ctctttgaag gagccagtga gtggcaggct tgggcttcct ccttacctga
     4381 cagcatgtaa ggactctgat aaactgaatg attatctgtg gagggggccc tcacccaatc
     4441 agcaaaacat tgtccaatct ctgagggaga aatttcagtg tcttagctca agcagctttg
     4501 cctaggtttc tagaactgtc caaattagct ccctaggctt acaaattacc atacgaatga
     4561 ggttgttttt tctgtatttt ctttcagtat atgcactggt ttaaaacaat tttgtaataa
     4621 caaaagggta aaatgtgctt tcgcttatag cacaactctt tgagctggcc caccatgaca
     4681 tttaccgccc cgacccccat gtcctaacag tggtacccac tcatagaata ccttctctcc
     4741 acatcccaag gagttttata ctgtgactca gaggcaccac aagtgaatct ctctctcacg
     4801 gttttttaaa aaaagagact agagttattt aaagagtcat gcttatatgt ggcatctcta
     4861 tatttgacaa gactcaagaa tgatgcatgc cagagaccac tggttagact gtagccttgt
     4921 cacgtatttt aaggacacca tgctggtgtc ctgatcacat ttcctttaga tgccaacata
     4981 ctgtgactat tgaagaggtt aaaatgtagc cctagcacca acttgctatt gggaaaaaca
     5041 aaatgttttt acttgtgttc caggacaagg cccagatggt gtgccactat ttatgataag
     5101 tctacagttt ccggggtaaa atataaacta tttctttcat gtcataaaga aagccaatct
     5161 taataaaata caagccaagt tgattattag ataagatagg gagacttctg aaaacaccct
     5221 atttcttcat attacaagta aaggggaatt gcctctgtaa agacaacaac aggagaagac
     5281 atgactgtag acacctgcct cctatcagta cagggtaaat cttcaggtaa aataagacaa
     5341 aatgcattta aatgcccctg tcaagagcag ttcttcattg gcactttcct gggcttgagg
     5401 ttcaactgaa tgcccacttg agaagtcctg gccacagtat tgggcaagag tgtattttct
     5461 aaacagctaa taacccaggg cctttcgatg ttttggaata tacagaacgg agactctggt
     5521 tgctggattc cgactagtaa cttcccttac cctgtactta cagtctcgta cagcacctca
     5581 ctgtgatgcc acacctgtct aactccttgt agacaggaat ggaagatgaa aagcaaggca
     5641 ctgtgattca aaggaaaacg agagaaacgt aaaagcgtct tcctgaaggc cccgtgcgta
     5701 cagtcagaat aggctctcta tttctgttcc catttctaca cattcgggac tcctccttca
     5761 ctccttcacc ctctcagtct cagttttaac gtttcttttt attagaatta ggcaacctgc
     5821 tccatttcaa gaagatatga tgataaacac actactgagt gttgttgagt gtccagagtg
     5881 tgtttcatcg ctttgcacat ctttggctac agagctcagt cctactttgt gttgttcaag
     5941 tgtctaatct tgggattaga ctggtgagat tatctttcct gattttgcta agagatttct
     6001 tcagaactca taacttgtga ggagagcctg taaattggaa cctaattcta gaatagcttg
     6061 tccttttccc acatcatctg aaagaacatc actgtgcaca taactcttgg ttccaggtta
     6121 aaagtagtct ctgagctagt acaagtatta agacttaggt gaccgacttc ttctggatgg
     6181 gtttcaatgc cactcaacct ctgaaaagaa tcccataaca gatttttatg tgtagaaggc
     6241 tcactgcaag aagcatgtga gtaattggaa cacagtcctc tttatttcta cccatcgcat
     6301 ctactccact gcccacaaca ggggagaatg cctccatttg tctagtttct gaaagcctgg
     6361 tggttgcaca ttctaaatct tgcttacaaa tcattttctt atttaccaag tctgacacat
     6421 cttctgttgg gggttcactg gtctgactta ttaccagatg tttctgaagt gcaccttgaa
     6481 gctgatccgg aacagctttc tcttcaggca aataagacca atcaaaatct gggcaaaaaa
     6541 atagccaggc taaattccct ctgattctgc agtatcgatg aagactctga cgacacttct
     6601 caagctttca catccactag agccccatct gaacttctgt tctcttcagt ttcgacagct
     6661 tttctccatg agctcctgct ctcagttatc aaggtttctg gagtctggag aatttgtttc
     6721 ctggttaaga agggatagaa attaaagtgt caactagctc ctccaattcg acttcttttc
     6781 cctcctgatt tttttttcct ttttagtctc tatggcccac atcccagtac agttcatgtt
     6841 actgtcctgt ttgagtctca gaaatgagta attcttcaca ccagtgtttc attgcatggt
     6901 ttggtgtcac ctgcaaaggg gaatgtcaca ttgtacaaaa cgtcttatgt aagtggtcct
     6961 ttaggctcta ggataaagct gtagttttat tgatcatgtc tgtggaccag gctgcagact
     7021 ttgagagcct gtgtgtgtgt gtgtgtgagt gtgtgcttag atgttccctc aatgttatca
     7081 gttcaatgct tttgtttaaa atagtttctt ctgaaggtgg gggtggggat gtacataact
     7141 gggaacgttt tatgtactta aatgttctta ctgggttcct gtactgaagg gtccaatttt
     7201 tcttttttat ataagttcac ttttcaccta ctttttgtct tcatgggggg gggggaaagt
     7261 tgtgcatctt ggaaaacata ctttaaatac tgtatataag acaatgaaac ttagtaatac
     7321 ccattattta ataaagtttg taaagtggaa agtaaa
//
