LOCUS       NM_175175               2956 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family F (with
            FYVE domain) member 2 (Plekhf2), mRNA.
ACCESSION   NM_175175
VERSION     NM_175175.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2956)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2956)
  AUTHORS   Klein,A.D., Ferreira,N.S., Ben-Dor,S., Duan,J., Hardy,J., Cox,T.M.,
            Merrill,A.H. Jr. and Futerman,A.H.
  TITLE     Identification of Modifier Genes in a Mouse Model of Gaucher
            Disease
  JOURNAL   Cell Rep 16 (10), 2546-2553 (2016)
   PUBMED   27568557
REFERENCE   4  (bases 1 to 2956)
  AUTHORS   Matsuda-Lennikov,M., Suizu,F., Hirata,N., Hashimoto,M., Kimura,K.,
            Nagamine,T., Fujioka,Y., Ohba,Y., Iwanaga,T. and Noguchi,M.
  TITLE     Lysosomal interaction of Akt with Phafin2: a critical step in the
            induction of autophagy
  JOURNAL   PLoS One 9 (1), e79795 (2014)
   PUBMED   24416124
  REMARK    GeneRIF: These findings establish that lysosomal accumulation of
            Akt and Phafin2 is a critical step in the induction of autophagy
            via an interaction with phosphatidylinositol 3 phosphate.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2956)
  AUTHORS   Li,C., Liu,Q., Li,N., Chen,W., Wang,L., Wang,Y., Yu,Y. and Cao,X.
  TITLE     EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein,
            facilitates TNF-alpha-triggered cellular apoptosis through
            endoplasmic reticulum-mitochondrial apoptotic pathway
  JOURNAL   J Mol Med (Berl) 86 (4), 471-484 (2008)
   PUBMED   18288467
  REMARK    GeneRIF: Results demonstrate that EAPF/Phafin-2 facilitates
            TNF-alpha-induced cellular apoptosis through an ER-mitochondrial
            apoptotic pathway.
REFERENCE   6  (bases 1 to 2956)
  AUTHORS   Gohlke,J.M., Armant,O., Parham,F.M., Smith,M.V., Zimmer,C.,
            Castro,D.S., Nguyen,L., Parker,J.S., Gradwohl,G., Portier,C.J. and
            Guillemot,F.
  TITLE     Characterization of the proneural gene regulatory network during
            mouse telencephalon development
  JOURNAL   BMC Biol 6, 15 (2008)
   PUBMED   18377642
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2956)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY167298.1, AK033666.1 and BC016134.1.
            
            On May 9, 2009 this sequence version replaced NM_175175.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016134.1, SRR1660817.99624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY167298.1         3-10
            9-2232              AK033666.1         3-2226
            2233-2462           BC016134.1         2173-2402
            2463-2956           BC016134.1         2404-2897
FEATURES             Location/Qualifiers
     source          1..2956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 4.86 cM"
     gene            1..2956
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /note="pleckstrin homology domain containing, family F
                     (with FYVE domain) member 2"
                     /db_xref="GeneID:71801"
                     /db_xref="MGI:MGI:1919051"
     exon            1..227
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /inference="alignment:Splign:2.1.0"
     exon            228..2920
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..991
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /note="PH domain-containing family F member 2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family F
                     member 2"
                     /protein_id="NP_780384.1"
                     /db_xref="CCDS:CCDS17962.1"
                     /db_xref="GeneID:71801"
                     /db_xref="MGI:MGI:1919051"
                     /translation="MVDRLANSEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTK
                     LCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLI
                     KTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMR
                     CQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSTGDMAA
                     CQPTRSDSYSQSLKSPLNDASDDDDDDDSSD"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /note="hexamer: AATAAA"
     polyA_site      2920
                     /gene="Plekhf2"
                     /gene_synonym="1110070J07Rik; ZFYVE18"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcgcgc aggagggaag ccagccggag cggccgttgt cgggttcgac tggaggggcg
       61 gtgaagtcac ctgcgagcgg ctgcgcccgc cgcgtccgga tcgcgccggc ctcgcggggc
      121 cccacgcaac cctgcgaggc tggggtcggg gagcaggcgg agtccgcgcc cggagtcggc
      181 gactaggagg actcgcaccc tcggcgccgc cgcccgcgcg gggtcgggtt attagcaaaa
      241 gatggtggat cgcctggcaa acagtgaggc gaatactaga cgcataagta ttgtggagag
      301 ctgttttgga gccgctggtc agcccttgac catccctggg cgagtgctta ttggagaagg
      361 agtgttgact aagttgtgca gaaagaagcc taaagcaagg cagtttttct tatttaatga
      421 tattctagta tacggcaata ttgttatcca gaagaaaaaa tacaacaaac agcatattat
      481 tcccttggaa aatgtcacca ttgattccat caaagatgaa ggggaattac ggaatggatg
      541 gcttattaag acaccgacta agtcgtttgc agtttatgct gccactgcca cggagaagtc
      601 agagtggatg aatcacataa ataagtgtgt cactgattta ctctccaaaa gtgggaagac
      661 gcccagcaac gagcatgctg ctgtctgggt tcctgactct gaggccaccg tgtgtatgcg
      721 ctgtcagaaa gcaaaattca caccagtcaa tcggcggcac cattgccgca aatgtggctt
      781 tgttgtttgt ggtccctgct ctgaaaagcg atttcttctt cccagccagt cttctaagcc
      841 tgtgcggatt tgtgacttct gctatgacct gctttccacg ggggacatgg ccgcgtgtca
      901 gccgactaga tcagactctt atagtcagtc gttgaagtct cctttaaatg atgcatctga
      961 tgacgacgac gatgatgata gcagtgacta aggatatgct gtgaagtatt taattgactg
     1021 cctgagagtc agctttgggg gcgctctcag tttgctttag ccatgactgc ctgagaagtc
     1081 ttaacctctg tgcctctctg tatcctatgg aaagcagccc catgctttct gctcccctct
     1141 gcactctctc acagggacaa acttgcagat acatccgata gggtcttggc tttctactgt
     1201 ccttatttct agattatttc cttgtaagtt ggaaagaatg tttatttaac agatcttgta
     1261 ttacatttat ttccccctga tgtggaaaat ctaaaagcac agaatgatgg gaacaagagt
     1321 atgatgtgct tggtatctgg cttttcccca agcagtcgat gtcaaggtta cgacaccagt
     1381 gacagagcat ggtttggaaa tcctttattc tcttttctca ataccaagtg gtgccttact
     1441 gtggcagcag tgtcactgtc actgaaataa acgtaagccc taccttcttt cttgtttgat
     1501 tgatttagac acactggtgc tcttacaggt ggagaatgag tgtttgatgg atataggtaa
     1561 gcatatttat ttgacagcta tgaggaacta aatttagagg tttctccaat cttatatgaa
     1621 tatttttcat aaaatagttg tgattatatt tttacatctt ttatgcacca aattataatg
     1681 gtcacatatg tttagcccgt tgccactgtt cgggattcga tttgaaactc atcactagta
     1741 tagaagtggc atatcccact agcttctact ttcctgatat atttttacaa ataactttat
     1801 ttgctttaca ttatttctaa aaggaaaaat ctgaggaaac ccttatattt tccaacaggg
     1861 ttcctctgtg tagctttgct tatcctggaa ctcgatttgt tgaccaggct ggccttgaat
     1921 tctcaaaaat ccatctgcct ctgcctttgc ctccccaggc accactacca cctgacaaaa
     1981 atgaaaagtc ttaagaaaat cctcccagga gaacatggag tcttagagat ctggaagaga
     2041 tcggagtttg actaggtttc ctgtctgcaa gtcaattttt tttgtgaaat tatcttgatt
     2101 tacaacgtgg tattgtattt tacagagttc atgaagcccc aaacaatttt tatttttgta
     2161 aaacaattgt atgtttaatc tgtttctgaa atcattttgc aatatatgga aatagagtag
     2221 cagttgatat ttctaaattg tgaccattgt ccgagattgc tttgagaact ggtagttatt
     2281 ctctttatgt ttggaggcag ccattaggct gtaggcctgc ttactgcata gcactggacg
     2341 tgccaggcac attctggccc ctggcatgct taagtaacta ggttttcaaa tgtgggaaac
     2401 caagctgaaa ggtctgtttt gttttgttgt tgttttgttt tggtttgttt tttttttttt
     2461 ttcagagttc ttttcaaacc cagtttccct ttttcaaact ttaaaacctg cataattctg
     2521 cagatgtcct agggtttgag tcagtaactt gtgaatgaaa gtcattggta tttggctttg
     2581 tggttacagt actaatttta ctttgctgct cagttttgaa agtgtgtgag ctacataggt
     2641 ctccctgtag gaaatgtgaa aaaaagcaca atagaaccag gctaggggct ttgttcctgc
     2701 tttttgtttt gtttggtttt actatcagat ggatggattt gtgtttgtct cagagcagca
     2761 tatacatgca gtcagtaagc atgtttgaaa ggaccataaa aaccagagaa atgctgatgg
     2821 gaacttggaa gttcagaaac caaggggaaa tgtcctgaga taacatttgc attgtcgacc
     2881 tcagttgact gtttttacaa taaaaatatt ttgcagctta aaaaaaaaaa aaaaaaaaaa
     2941 aaaaaaaaaa aaaaaa
//
