LOCUS       NM_001177503            3527 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family D (with
            coiled-coil domains) member 1 (Plekhd1), mRNA.
ACCESSION   NM_001177503 XM_126991 XM_905281
VERSION     NM_001177503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3527)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI747346.1, AK028383.1, AC134537.3 and CF353072.1.
            
            On or before Apr 14, 2010 this sequence version replaced
            XM_905281.3, XM_126991.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028383.1, BC137602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AI747346.1         1-51
            52-2085             AK028383.1         2-2035
            2086-2086           AC134537.3         157083-157083
            2087-3523           AK028383.1         2037-3473
            3524-3527           CF353072.1         316-319
FEATURES             Location/Qualifiers
     source          1..3527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 36.96 cM"
     gene            1..3527
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /note="pleckstrin homology domain containing, family D
                     (with coiled-coil domains) member 1"
                     /db_xref="GeneID:217682"
                     /db_xref="MGI:MGI:3036228"
     exon            1..427
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1796
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /note="PH domain-containing family D member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family D
                     member 1"
                     /protein_id="NP_001170974.1"
                     /db_xref="CCDS:CCDS49100.1"
                     /db_xref="GeneID:217682"
                     /db_xref="MGI:MGI:3036228"
                     /translation="MFTSKSNSVSPSPSLEQADADALDISTKVQLYGVLWKRPFGRSS
                     AKWSRRFFIIKESFLLYYSESERKSFETNKYFNIHPKGVIPLGGCLVEAREEPSMPYA
                     MKISHQDFHGNVLLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLA
                     KEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRVEQEQIKRE
                     LELTARCLKGVEQEKKELRHLTESLQHTLEELSIEKKKTLEMLEEDKNQPQPLTNQSE
                     QPPASDGLHSNLRQIEERMQELLAEKLLAEKRMKENEERSRALEEEREFYSSQSQALQ
                     NSLQELTAEKQQAERELKAEVKVRMDLERRLREAEAALRSLEQGLNSKVRNKEKEERM
                     RADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWND
                     MKPSQSFMTSQLEANNIEELKEVAKRLSRDQRFRESIYHIMATQPGASALPRGGK"
     exon            428..521
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..611
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..688
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..780
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..833
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..928
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1022
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1201
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1334
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1479
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1629
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..3527
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3525
                     /gene="Plekhd1"
                     /gene_synonym="3830431G21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcacgggagg ggaggagggg ggtgatgctg cgagcctgcg gcggagctgc cctccccgcg
       61 gagttccctc ccggccaaca gcgctctgga gcttcgcccc agccgctggc taagcttccc
      121 gcgcccctcc gctctccgct ccgctcgtcg ggatacgcgc cccgacggcg ttcccagctg
      181 cctgcactcg ccgtgcccac tgcttcccac tgtcctccct gtcccttcca gtcccacgaa
      241 gggagtgggc ccggccaggg cacagtcttc gagatacgat gttcacatcc aagtccaact
      301 ccgtgtcgcc atcgccgtcc ctggagcagg cggacgcgga cgcgctggac atcagcacca
      361 aagtgcagct ctacggggtt ctgtggaaac ggccgttcgg gagatcctcg gccaagtggt
      421 cccggcggtt tttcatcatc aaagaaagct ttctgcttta ctactctgag agtgagagaa
      481 agagctttga aaccaataag tacttcaata ttcatcctaa gggtgtcatt ccactgggtg
      541 gctgcctggt ggaggccaga gaagagccca gtatgcccta tgccatgaag atctcacacc
      601 aggacttcca tgggaatgtc ttgttggctg cggagtctga gtttgagcag acacaatggc
      661 tggagatgtt gcaggagtct gggaaggtga cctggaaaaa tgcccagcta ggggaagcta
      721 tgatcaaaag cctggaggca caggggctac agctggctaa ggaaaagcag gaatatttag
      781 acaagctgat ggaggagaca gaagaactgt gccttcagag ggaacagaga gaggagcttg
      841 agcgcctgaa ccaagtgctg gaggccgaga aacagcagtt tgaggaggtg gtgcaagagc
      901 tgagagtgga gcaggagcag atcaaaaggg agctagaact cactgcaaga tgcctcaagg
      961 gcgtggaaca agagaagaag gagctgagac acctcacaga gtccttacag catacgctgg
     1021 aggaactctc catagagaag aagaaaaccc tagagatgct ggaggaagat aagaaccagc
     1081 cacagccctt gaccaaccag agtgagcagc caccggccag tgatggtctc catagcaacc
     1141 tcaggcagat cgaagagcgg atgcaggagc tattggcgga gaagcttctg gctgagaagc
     1201 ggatgaagga gaatgaggaa cgctctcggg ctctggagga ggaacgggaa ttctactcaa
     1261 gccagtccca agccctgcag aactcgctgc aggagctcac tgcagagaag cagcaggcgg
     1321 agcgggaact caaggctgaa gtgaaagtac gcatggacct tgagaggcgg cttcgggagg
     1381 cagaggcggc cttgcggagc ctggaacaag gcctcaattc caaggttcgg aacaaggaga
     1441 aggaagaacg gatgcgggcg gacgtgagcc acctgaaaag gttcttcgag gagtgcatcc
     1501 ggaatgcaga gctggaggcc aagatgccgg tcatcatgaa gaactccgtg tacatccata
     1561 aggcagccac tcgccgcatc aaaagctgcc gattccaccg ccgccggtcc agtacttcct
     1621 ggaatgacat gaagccatcc cagtccttca tgacctccca gctagaagcc aacaacatag
     1681 aggagctgaa ggaggtagcc aagcggctaa gcagagacca gcgcttccgg gaatccatct
     1741 atcacatcat ggctacccag cctggggcct ctgcacttcc ccggggagga aagtaatggg
     1801 aactcctact ccggcctcct atctttcctt ggtggggcag cagggaggtc tgacgcccct
     1861 gggtcttctc caccagagca ctgctgggtg tgagggggca ccctcattct cgaaggaggc
     1921 gataccccct ctgcctcacc cagagccctg accttggagg tcagaagaga atattgggtt
     1981 ccctacaact ggagtcgtgg atggttgtaa gctaccgtgt gggtgctgga aatcaaacct
     2041 gggtctcctg gaagagcaac aagtgctctt aaccactgag ccatctctcc atgcccgagc
     2101 cctgactttg ggtctaccct aggtgaggtg ggtccacact gggtgctacc tagttgccat
     2161 gatgaggcct ggctctgtgt ggtatatctg ttggtcaaga agataaattg tctgttccat
     2221 gaggactgaa tagttcctct ggtacctacc atacccctcg gtgactctac tgtgctgacc
     2281 ctggtcacat aacaccccct aactctctct tcgttcctga tcctccagta caacatttgt
     2341 ccatgccctg cacttattcc atgttcttgg agagggaaaa ggaggctcta agatataacc
     2401 ccaggttcac agcaccccac accctctctg cagtattcct gggggctgtc ctggctgtaa
     2461 ggccacccag gcctcctatt cacaaatggg tttctccata tatagctcca gcaacctgct
     2521 ggagggtgca ggagaagtgt gggatcccac tttgttcttt tccagccccg attgagagtc
     2581 cttgacccca gggtttccca aagtccgcac agccagatct ggaagaagct ccggtgttac
     2641 ccacagtcag gcctgttgtg accctgctgc cctgagagcg cagaggtctg tctctctccc
     2701 agctggctca ccttgctgcc tcctctccct gcagcagact cactcagtgg accaatgcag
     2761 ccaggaaccc accacatggg aacatgggcc tgtggggaac tagtagccat tgtttggtag
     2821 agcattgtca gagtgacact gtaacaccag cctgcgggtt ttatggaaga ccactaccct
     2881 tcaggaggcc aaggactgag gcgtgtgctc cttatctgtg acagtctttt ggggcccatc
     2941 cctcagaagc tgcctgagtc tatcagtctc gacaaacaag acttggggag ggggcggaga
     3001 tgtggacagt ggttaagagc acttgtttct ctctttcggg gcacccagac ttggttccca
     3061 gcacccacat ggtagctcaa aaccaaccat atgtgacttc atttgccagg agatccaaca
     3121 ccttctcctg accttcacag gcaccgggca ctcacatggt acatgtacat acatgcagac
     3181 aaaacatcca tacacttaca tctttttttt ttttaaagac cctttaaaag ggggcagggt
     3241 gctaagacag tgctagatca aaggcatcca ttttctgtcc agaagactga agcatcttga
     3301 ggaagggacg gaagtagccc cgtggaagaa cccttgtcaa gatctgagct gccctcttct
     3361 ccgtggtccc ttcttggtga gggtggtctt aggtagggtg ttttggaatc agtgtgtccg
     3421 aatgtaaata taaagctata aatgtgtata aacctgcata aacccagagc ttgtctgcaa
     3481 aatatgaatg tggaatggac tttgaaatga agaggcataa aactaga
//
