LOCUS       NM_013746               2076 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family B
            (evectins) member 1 (Plekhb1), transcript variant 1, mRNA.
ACCESSION   NM_013746
VERSION     NM_013746.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Marques,R.F., Engler,J.B., Kuchler,K., Jones,R.A., Lingner,T.,
            Salinas,G., Gillingwater,T.H., Friese,M.A. and Duncan,K.E.
  TITLE     Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1
            in mutant TDP-43 amyotrophic lateral sclerosis models
  JOURNAL   Hum Mol Genet 29 (16), 2647-2661 (2020)
   PUBMED   32686835
  REMARK    GeneRIF: Motor neuron translatome reveals deregulation of SYNGR4
            and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
REFERENCE   2  (bases 1 to 2076)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   3  (bases 1 to 2076)
  AUTHORS   Lee,A.R., Lamb,R.R., Chang,J.H., Erdmann-Gilmore,P., Lichti,C.F.,
            Rohrs,H.W., Malone,J.P., Wairkar,Y.P., DiAntonio,A., Townsend,R.R.
            and Culican,S.M.
  TITLE     Identification of potential mediators of retinotopic mapping: a
            comparative proteomic analysis of optic nerve from WT and Phr1
            retinal knockout mice
  JOURNAL   J Proteome Res 11 (11), 5515-5526 (2012)
   PUBMED   22985349
  REMARK    GeneRIF: increased levels of PHR1 target proteins may be
            instructive for retinotopic mapping of retinofugal projections
REFERENCE   4  (bases 1 to 2076)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   5  (bases 1 to 2076)
  AUTHORS   Culican,S.M., Bloom,A.J., Weiner,J.A. and DiAntonio,A.
  TITLE     Phr1 regulates retinogeniculate targeting independent of activity
            and ephrin-A signalling
  JOURNAL   Mol Cell Neurosci 41 (3), 304-312 (2009)
   PUBMED   19371781
  REMARK    GeneRIF: a key presynaptic regulator of retinogeniculate layer
            placement independent of activity, segregation, or ephrin-A
            signaling
REFERENCE   6  (bases 1 to 2076)
  AUTHORS   Etournay,R., El-Amraoui,A., Bahloul,A., Blanchard,S., Roux,I.,
            Pezeron,G., Michalski,N., Daviet,L., Hardelin,J.P., Legrain,P. and
            Petit,C.
  TITLE     PHR1, an integral membrane protein of the inner ear sensory cells,
            directly interacts with myosin 1c and myosin VIIa
  JOURNAL   J Cell Sci 118 (Pt 13), 2891-2899 (2005)
   PUBMED   15976448
  REMARK    GeneRIF: The PHR1 is expressed in the vestibular and cochlear
            sensory cells, its direct interactions with the myosin 1c and VIIa
            tails are likely to play a role in anchoring the actin cytoskeleton
            to the plasma membrane of these cells.
REFERENCE   7  (bases 1 to 2076)
  AUTHORS   Xu,S., Wang,Y., Zhao,H., Zhang,L., Xiong,W., Yau,K.W., Hiel,H.,
            Glowatzki,E., Ryugo,D.K. and Valle,D.
  TITLE     PHR1, a PH domain-containing protein expressed in primary sensory
            neurons
  JOURNAL   Mol Cell Biol 24 (20), 9137-9151 (2004)
   PUBMED   15456885
  REMARK    GeneRIF: Results describe the expression of specific Phr1 splice
            forms in olfactory receptor neurons and vestibular and cochlear
            hair cells as well as in photoreceptors, and show that mice lacking
            PHR1 do not have overt sensory deficits.
REFERENCE   8  (bases 1 to 2076)
  AUTHORS   Andrews,K.L., Potdar,P.D., Nettesheim,P. and Ostrowski,L.E.
  TITLE     KPL1, which encodes a novel PH domain-containing protein, is
            induced during ciliated cell differentiation of rat tracheal
            epithelial cells
  JOURNAL   Exp Lung Res 26 (4), 257-271 (2000)
   PUBMED   10923244
REFERENCE   9  (bases 1 to 2076)
  AUTHORS   Xu,S., Ladak,R., Swanson,D.A., Soltyk,A., Sun,H., Ploder,L.,
            Vidgen,D., Duncan,A.M., Garami,E., Valle,D. and McInnes,R.R.
  TITLE     PHR1 encodes an abundant, pleckstrin homology domain-containing
            integral membrane protein in the photoreceptor outer segments
  JOURNAL   J Biol Chem 274 (50), 35676-35685 (1999)
   PUBMED   10585447
REFERENCE   10 (bases 1 to 2076)
  AUTHORS   Krappa,R., Nguyen,A., Burrola,P., Deretic,D. and Lemke,G.
  TITLE     Evectins: vesicular proteins that carry a pleckstrin homology
            domain and localize to post-Golgi membranes
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4633-4638 (1999)
   PUBMED   10200314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124531.5, BC024756.1 and CD773826.1.
            
            On Jul 10, 2009 this sequence version replaced NM_013746.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024756.1, AF000272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC124531.5         97110-97148
            40-2059             BC024756.1         1-2020
            2060-2076           CD773826.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.36 cM"
     gene            1..2076
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /note="pleckstrin homology domain containing, family B
                     (evectins) member 1"
                     /db_xref="GeneID:27276"
                     /db_xref="MGI:MGI:1351469"
     exon            1..237
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..311
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1025
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /note="isoform a is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family B member 1;
                     evectin-1; PH domain-containing family B member 1; PH
                     domain-containing protein in retina 1; pleckstrin homology
                     domain retinal protein 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family B
                     member 1 isoform a"
                     /protein_id="NP_038774.1"
                     /db_xref="CCDS:CCDS21504.1"
                     /db_xref="GeneID:27276"
                     /db_xref="MGI:MGI:1351469"
                     /translation="MSPATPVPPDSILESPFEEMALVRGGWLWRQSSILRRWKRNWFA
                     LWLDGTLGYYHDETAQDEEDRVVIHFNVRDIKVGQECQDVQPPEGRSRDGLLTVNLRE
                     GSRLHLCAETRDDAIAWKTALMEANSTPAPAGATVPPRSRRVCPKVRCTTLSWNPCKV
                     ERRIWVRVYSPYQDYYEVVPPNAHEATYVRSYYGPPYAGPGVTHVIVREDPCYSSGAP
                     LAMGMLAGAATGAALGSLMWSPCWF"
     exon            312..387
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..540
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..643
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..683
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..788
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..888
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..2062
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="Plekhb1"
                     /gene_synonym="evt-1; PHR1; Phret1"
                     /note="major polyA site"
ORIGIN      
        1 ctgggtcaag attaaagaga ccggggagcc aagaagggag acttaaggag ccaggccgca
       61 cagccacgac tggggagatg gagatggaca cagcctgcta ggcctcagaa tgaaaactta
      121 gccctgccct aaactgggcc agagaacctg ccttgcccca tctccagtct cctttattcc
      181 accctcctcc ctaccctatc ttggagacct ggatcaacac cacctcggaa tcaccagagt
      241 caagccccac ttctggaacc ttcttgggga tgcagctctg accatcagga accatgagcc
      301 cggcaacccc ggttccaccc gactccatcc tggaaagtcc ttttgaagaa atggccctgg
      361 tgaggggcgg ctggctgtgg agacagagct ccatcctccg ccgctggaag cggaattggt
      421 tcgctctgtg gttggatggc acactgggtt actaccatga cgagacggca caggacgagg
      481 aggaccgagt agtcatccac ttcaatgtcc gagacataaa ggtcggccaa gagtgtcagg
      541 atgtgcagcc cccagagggc aggagccgag atggcctgct gacagtgaac ctgcgggagg
      601 gttcccgcct gcacctgtgc gctgagaccc gggatgatgc catagcatgg aagactgccc
      661 tgatggaggc aaattccacc ccggccccag ctggagccac cgtcccaccc aggagccgtc
      721 gggtttgccc taaggtcagg tgtacgaccc tctcatggaa cccctgtaag gttgagaggc
      781 ggatctgggt acgcgtctac agcccgtatc aggactacta tgaggtggtg ccacccaacg
      841 cacatgaagc cacatatgtc cgcagctact atgggccacc ttatgcaggt cctggtgtga
      901 cacacgtgat agttcgagag gacccctgct acagctcagg cgcccctttg gccatgggca
      961 tgcttgctgg ggctgccacg ggtgctgctc ttggttcact tatgtggtcg ccttgttggt
     1021 tctgagccct ggggctctga cttctggatg tgcatgtaga acacaagaag acccttttct
     1081 tctggatcct ctgctagcta ccatctaaac tgtcccattt tgaccccttt ctccccatta
     1141 agccctctac gcttggccca ttactcccac catttatcct cttttccgtc tcaaaggaag
     1201 ctaacatctc aggcacagac atagccaaaa gtccatacac ccattgccag gcactcccat
     1261 aagtcacatg tgaattttct ctacacatag caaacataac ttcatttggc tctaagtgtc
     1321 tgaggaatgg agctcacaag agagcaaaca acaaagctac agttatctgt ctggtaagga
     1381 taagtcgggg caaggagcga ggtctgggtg cccaaagaat caaataacag ttggcttggt
     1441 gttgtggcag gggttggttg tagtggttct agctctatgt gaaggagctt gctggataaa
     1501 ggcacgatgg ggctttttat ggagtaaagt ttcttgattt caactataat gaatactttg
     1561 cctgtctagt tagtactggc aggacatacc cttaaccaaa acatggaatt tggcaccttt
     1621 tcctcacttg tagcttccct atgatagctg agctaaccct aaggtttcct agctgtggga
     1681 agaggtgagt tctttgagac ctccggcctt aggaagttgc ttccattagg aaatgccttt
     1741 ctgatcccag gagctcagct cgactgttaa catctgaagc ttattctctt ccttcccgct
     1801 ggggggagac ggcattatct tgttctgggg cctgacccac cttggcacca gcctggggaa
     1861 cccctcatgt gcctgtctat aggtagcaag caatctctcc atttgatcct gttccaaact
     1921 attccatcat cctgtcccaa ttgccaatag aaaagctaaa atccctggct cagttgctag
     1981 agtgcctagt aaaattccta gcatatgtga gcgctccatt ggctcagcac agacactaat
     2041 aaagacatga ttggccccag aaaaaaaaaa aaaaaa
//
