LOCUS       NM_031256               3007 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin homology domain-containing, family A
            (phosphoinositide binding specific) member 3 (Plekha3), mRNA.
ACCESSION   NM_031256
VERSION     NM_031256.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Stumpo,D.J., Broxmeyer,H.E., Ward,T., Cooper,S., Hangoc,G.,
            Chung,Y.J., Shelley,W.C., Richfield,E.K., Ray,M.K., Yoder,M.C.,
            Aplan,P.D. and Blackshear,P.J.
  TITLE     Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger
            RNA-binding protein, results in defective hematopoiesis
  JOURNAL   Blood 114 (12), 2401-2410 (2009)
   PUBMED   19633199
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY730332.1, AF286163.1 and AL928789.4.
            
            On Apr 25, 2009 this sequence version replaced NM_031256.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286163.1, SRR7652917.187561.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               BY730332.1         1-271
            272-1486            AF286163.1         61-1275
            1487-3007           AL928789.4         7701-9221
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 45.1 cM"
     gene            1..3007
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="pleckstrin homology domain-containing, family A
                     (phosphoinositide binding specific) member 3"
                     /db_xref="GeneID:83435"
                     /db_xref="MGI:MGI:1932515"
     exon            1..320
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1174
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="PH domain-containing family A member 3;
                     phosphoinositol 4-phosphate adapter protein 1;
                     phosphatidylinositol-four-phosphate adapter protein 1;
                     FAPP-1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 3"
                     /protein_id="NP_112546.1"
                     /db_xref="CCDS:CCDS16162.1"
                     /db_xref="GeneID:83435"
                     /db_xref="MGI:MGI:1932515"
                     /translation="MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSI
                     KMAVCEIKVHPADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTAK
                     EKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHRDERHPSPSVENMNEASSLLS
                     ATCNTFITTLEECVKIANAKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSASHPGSCSS
                     ERSSCSIKEPASALHRLPQRRRRTYSDTDSCNDVPPEDPERPLHCSGNTLNGDLASAT
                     IPEESRLMAKTQSEEPLLPFS"
     exon            321..437
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..593
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..730
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..895
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..939
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1055
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..3007
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: ATTATA"
     polyA_site      1740
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="major polyA site"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2248
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="major polyA site"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2503
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      3001
                     /gene="Plekha3"
                     /gene_synonym="FAPP1"
ORIGIN      
        1 gaagcccgag gggaaggaag gcaggcgtgc aggagggcag cgccggggct cgtggagcgg
       61 tggcggagcg ggagggcggc gggcgctggg gtcgtcccgg gggtcgccgc gccgttcccg
      121 ctggggatgt ccgcgcctcg cggcctccga gcagcacggg gcgcccgccg gccgggcctc
      181 tgagggccgc cgggtcgggg cggagggctg cgggcccgcg cctccgcagc agcgcggccg
      241 gcgccgggcc aggaggatgc gcggcgccgg gctctgaagc atggaggggg ttctgtacaa
      301 gtggaccaac tatctcacag gttggcagcc tcgatggttt gttctggata atggaatcct
      361 gtcctactat gactcacagg atgatgtctg caaagggagc aaagggagta taaagatggc
      421 ggtctgtgag attaaagtcc atcccgcaga caacacaaga atggagttaa tcattccagg
      481 agagcagcat ttctacatga aggcagtaaa tgccgccgag agacagaggt ggctggttgc
      541 ccttgggagc tccaaagcgt gtttgaccga cacgaggact gcaaaagaga aagaaataag
      601 tgagaccagt gaatctctga aaaccaaaat gtctgaactt cgcctctact gtgacctcct
      661 gatgcagcag gttcatacga tccaggaatt cgtccaccgt gatgagaggc atccctctcc
      721 cagtgtggag aacatgaatg aagcctcctc cttgctcagt gccacctgta acacattcat
      781 cacaaccctg gaggagtgtg tgaagatcgc caacgccaag tttaaacctg agatgtttca
      841 actgcctcat ccggatcccc tggtctctcc cgtgtcgcct tctcctgttc agatgatgaa
      901 gcgttcagcc agccaccctg gttcctgcag ttccgagagg agcagctgct ccatcaaaga
      961 accagcatct gccctccacc gacttcctca gcgacgccgc agaacctact cggacacaga
     1021 ctcttgtaat gatgttcccc ctgaagaccc agagagacct cttcactgtt caggaaacac
     1081 acttaatgga gatttggcat cagcaaccat tccggaagaa agcagactca tggccaagac
     1141 acaatctgaa gaacctcttc tgcccttctc ctgaggaaac agacatgccc agcttcctcc
     1201 tgaggaaaca gacatgccca gcttcctcct gaggaaacag acatgcccag cttcctcctg
     1261 aggaaacaga catgcccagc ttcctctgag tgtcgctatg caaaagctgc tgtaattaaa
     1321 ctcggtctgg gctagctttg ccctctcctt aggatttctc tgcactttat agaatattgt
     1381 aaacaaacaa cccacatact tttgaagtgt attttatctt tctatagttt acttgcaaga
     1441 gtattttcct aataacttca cagtatgaat gtgcatcttt tttttttttt aaacaaatga
     1501 tggtgtaaca ttttgacatc cataaggaca aatgtagata tttttctaaa aaactgtgag
     1561 ggactgacag cttggtcagt gtgtattgta gtatataaac atgaaatctc gccagattta
     1621 tttgacagaa atgtgagaga tgtaacttgt gccatggacc aaaaggtcac ttcaccccag
     1681 cttaaaatta attaccatag cagcttgatg gtgattatat catattcctt taagcaaaaa
     1741 ggaaacgctt aatattctaa aggtctttag cccaaatacc atgacatatt gagcattttt
     1801 ttttaaaaag cagactccgc tgtccttcat atgtgaagtt gacatctact gatttgtcaa
     1861 taccaaacat cagattacag tatttaattt ttatttattt attttcttat tgcatcagaa
     1921 gatggttatg tcctaacttt tatggcctcc ccaatttaag atgtatatgc atagttgtta
     1981 ttacgttgtt ctaagataca tgaggcaagt gtcccagtga tcttgttccc ttacacgaga
     2041 gaagtaaaca gctttcaatg ggaatggagt tcagtgcttt tcagaaaata ggcagcaagc
     2101 tgctgttgta aggtatgatt tgcagctctt tggcatatct agagacattt ttaatttatg
     2161 aatatttata caaaaagcaa ttctgtcaag atgactgttc tatatcactt gagaatggca
     2221 ttatttaatt aaagaacaat ttgcagtttt tggtagtgcc tgttgtatct atcgctgggt
     2281 tactcctcta cactgtattt cttttaagtc actttggggt gttgatttta tcccggagtt
     2341 agaatgatca gcactttaac aaaaattggc cttgtgtttt taagttagtc atattttact
     2401 aatacatggt ttttacattc aaattcatca tataatacat tgtgtctttt acattcattg
     2461 atactctgtc tagtctatta aatacctttt gtgttcttca tgattttatt ttgtttattg
     2521 tgttcgagcc taaaggtgag catacatcaa tgtttggctt gtcttttcta tgagtttaga
     2581 atgggagcca agtatctagt aaatacttga tatttagtct gtacctttcc ccaagtttaa
     2641 aatgtctata cctattaact gttccaaagt gcttgtcatt ttaactagca aatggctcac
     2701 tagagaatcc tttgtccagt ggaatcagcc cacctgtaac ttgcgtttca tatgttcagt
     2761 ttggaaaaaa atgatgatgt gggcagtctt ttttttaaac catacaaact tgcagaatat
     2821 ggtgcttctg atagtttctc tggtagttgt tcccccttgg tagtaggttt ataatgaata
     2881 ttacaagctt ttgaacttgt aggaatagag gaaattccat tttttattgc tttacccaaa
     2941 tagacatgtt tgtgaatgat ttctttgtaa atattttaaa aataaaaggc agtcgttttt
     3001 agtttgc
//
